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    MALDI Imaging and Ion Source
    2.
    发明申请
    MALDI Imaging and Ion Source 有权
    MALDI成像和离子源

    公开(公告)号：US20150034814A1

    公开(公告)日：2015-02-05

    申请号：US14130453

    申请日：2012-07-06

    申请人： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

    发明人： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

    IPC分类号： H01J49/16 ,  H01J49/06 ,  H01J49/26 ,  H01J49/04

    CPC分类号： H01J49/062 ,  H01J49/0004 ,  H01J49/0463 ,  H01J49/065 ,  H01J49/164 ,  H01J49/26

    摘要： An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

    摘要翻译： 公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。 镜头具有有效的焦距＆nlE; 300 mm。 激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。 一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

    MALDI imaging and ion source
    7.
    发明授权
    MALDI imaging and ion source 有权
    MALDI成像和离子源

    公开(公告)号：US09190256B2

    公开(公告)日：2015-11-17

    申请号：US14130453

    申请日：2012-07-06

    申请人： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

    发明人： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

    IPC分类号： H01J49/26 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  H01J49/06

    CPC分类号： H01J49/062 ,  H01J49/0004 ,  H01J49/0463 ,  H01J49/065 ,  H01J49/164 ,  H01J49/26

    摘要： An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

    摘要翻译： 公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。 镜头具有有效的焦距＆nlE; 300 mm。 激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。 一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

    Mass Spectrometer
    9.
    发明申请
    Mass Spectrometer 审中-公开
    质谱仪

    公开(公告)号：US20080111071A1

    公开(公告)日：2008-05-15

    申请号：US11876108

    申请日：2007-10-22

    申请人： Jeffery Mark Brown ,  Daniel James Kenny

    发明人： Jeffery Mark Brown ,  Daniel James Kenny

    IPC分类号： H01J49/28

    CPC分类号： H01J49/405 ,  H01J49/421

    摘要： A mass filter is disclosed comprising an orthogonal acceleration electrode 9. Ions entering the mass filter are orthogonally accelerated by the orthogonal acceleration electrode 9 in a primary acceleration region 2 and enter a flight region 3. The ions 6,7,8 are then reflected by a reflectron 4 and are directed towards an exit region of the mass filter. Ions having a desired mass to charge ratio are arranged to arrive in the primary acceleration region 2 at a time when a voltage pulse applied to the orthogonal acceleration electrode 9 falls from a maximum to zero. Ions having a desired mass to charge ratio are orthogonally decelerated such that they have a zero component of velocity in the orthogonal direction. Accordingly, ions having a desired mass to charge ratio exit the mass filter in an axial direction.

    摘要翻译： 公开了一种包括正交加速电极9的质量过滤器。 进入质量过滤器的离子通过正加速电极9在主加速区域2中正交加速并进入飞行区域3。 然后离子6,7,8被反射器4反射并且被引向质量过滤器的出口区域。 具有期望的质荷比的离子被布置成在施加到正交加速电极9的电压脉冲从最大值降到零的时刻到达主加速区域2。 具有期望的质荷比的离子正交减速，使得它们在正交方向上具有零分量的速度。 因此，具有期望质荷比的离子沿轴向离开质量过滤器。

    Mass spectrometer
    10.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07199363B2

    公开(公告)日：2007-04-03

    申请号：US10964791

    申请日：2004-10-14

    申请人： Robert Harold Bateman ,  Jeffery Mark Brown ,  Daniel James Kenny

    发明人： Robert Harold Bateman ,  Jeffery Mark Brown ,  Daniel James Kenny

    IPC分类号： B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/405 ,  H01J49/0031

    摘要： A mass spectrometer is disclosed comprising an ion source 4, a field free or drift region 5 and an ion mirror 7 comprising a reflectron. Metastable parent ions which spontaneously fragment by Post Source Decay whilst passing through the field free or drift region 5 are arranged to enter the ion mirror 7 and be reflected by the reflectron towards an ion detector 8 when the reflectron is maintained at a certain voltage. The process is then repeated with the reflectron being maintained at a slightly lower voltage. Two related sets of time of flight or mass spectral data are obtained for the two different voltage settings of the reflectron. From the two data sets the different times of flight for the same species of fragment ion can be determined. The mass to charge ratio of the parent ion which fragmented to produce the particular species of fragment ion can then be determined from the times of flight of the fragment ions.

    摘要翻译： 公开了一种质谱仪，其包括离子源4，无场或漂移区5以及包括反射镜的离子镜7。 当通过场自由或漂移区域5时通过后源衰变自发分裂的亚稳态亲本离子被布置成当反射器保持在一定电压时进入离子反射镜7并被反射器反射离子检测器8。 然后重复该过程，其中反射器保持在稍低的电压。 对于反射镜的两个不同的电压设置，获得两组相关的飞行时间或质谱数据。 从两个数据集可以确定相同种类的碎片离子的不同飞行时间。 然后可以从片段离子的飞行时间确定碎片化以产生特定种类的碎片离子的母体离子的质荷比。