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    Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
    7.
    发明授权
    Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy 失效
    对人类GP39的不同表位有特异性的单克隆抗体及其在诊断和治疗中的应用

    公开(公告)号：US5876950A

    公开(公告)日：1999-03-02

    申请号：US379057

    申请日：1995-01-26

    申请人： Anthony W. Siadak ,  Diane L. Hollenbaugh ,  Lisa K. Gilliland ,  Marcia L. Gordon ,  Jurgen Bajorath ,  Alejandro A. Aruffo

    发明人： Anthony W. Siadak ,  Diane L. Hollenbaugh ,  Lisa K. Gilliland ,  Marcia L. Gordon ,  Jurgen Bajorath ,  Alejandro A. Aruffo

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K47/48 ,  A61P37/06 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  G01N33/577 ,  A61K39/395

    CPC分类号： C07K14/70575 ,  C07K16/2875 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

    摘要： The present invention provides monoclonal antibodies, antigen binding fragment and recombinant binding proteins specific for human gp39. These antibodies are specific for at least eight different epitopes on gp39. Hybridomas secreting specific antibodies which bind to these epitopes are also provided. Further, the present invention discloses the amino acid sequence of immunoglobulin light and heavy chain variable regions which bind to epitopes of gp39 and provide sFv and humanized antibodies which bind gp39. Also, provided are pharmaceutical compositions comprising the monoclonal antibodies, antigen binding fragments and recombinant binding proteins which bind gp39 and methods for using these compositions in diagnosing disease states, inhibiting B cell activation and for treating immunological disorders, such as autoimmune diseases, allergic responses, organ rejection and graft-versus-host disease. Antibodies of the present invention can also be used to image cells which express gp39 on their surface, such as tumor cells (e.g., lymphoma) and to target therapeutic agents to target cells.

    摘要翻译： 本发明提供了对人gp39特异的单克隆抗体，抗原结合片段和重组结合蛋白。 这些抗体对gp39上至少八个不同的表位是特异性的。 还提供了分泌结合这些表位的特异性抗体的杂交瘤。 此外，本发明公开了结合gp39的表位的免疫球蛋白轻链和重链可变区的氨基酸序列，并提供与gp39结合的sFv和人源化抗体。 此外，提供了包含单克隆抗体，抗原结合片段和结合gp39的重组结合蛋白的药物组合物，以及使用这些组合物诊断疾病状态，抑制B细胞活化和治疗免疫疾病如自身免疫性疾病，过敏反应的方法， 器官排斥和移植物抗宿主病。 本发明的抗体也可以用于在其表面上表达gp39的细胞（例如肿瘤细胞（例如淋巴瘤））成像，并将靶向治疗剂靶向靶细胞。

    Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
    8.
    发明授权
    Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity 失效
    用于调节淋巴细胞活性的抗体异源偶联物和双特异性抗体

    公开(公告)号：US6010902A

    公开(公告)日：2000-01-04

    申请号：US366401

    申请日：1994-12-29

    申请人： Jeffrey A. Ledbetter ,  Lisa K. Gilliland

    发明人： Jeffrey A. Ledbetter ,  Lisa K. Gilliland

    IPC分类号： C07K16/28 ,  C07K16/46 ,  C12P21/08 ,  C12N5/00 ,  C07K16/00 ,  C12N5/02

    CPC分类号： C07K16/2896 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/289 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/73

    摘要： The present invention relates to novel antibody heteroconjugates and bispecific antibodies and methods and compositions and their use in the enhancement or inhibition of activation and function of T or B lymphocytes. The heteroconjugates are comprised of at least two antibody molecules cross-linked to each other, each molecule being reactive with a different lymphocyte antigen on the same cell. The invention also provides bispecific antibodies comprising a first binding region reactive with an antigen on a lymphocyte and a second binding region reactive with a different antigen on the lymphocyte. The heteroconjugates, bispecific antibodies, methods and compositions of this invention are therefore useful in the regulation of lymphocyte function, resulting in the improvement of cellular immune responses in various disease states.

    摘要翻译： 本发明涉及新型抗体异源偶联物和双特异性抗体及其方法和组合物及其在增强或抑制T淋巴细胞或B淋巴细胞活化和功能中的用途。 异源偶联物由至少两个彼此交联的抗体分子组成，每个分子与相同细胞上的不同淋巴细胞抗原反应。 本发明还提供双特异性抗体，其包含与淋巴细胞上的抗原反应的第一结合区域和与淋巴细胞上的不同抗原反应的第二结合区域。 因此，本发明的异源偶联物，双特异性抗体，方法和组合物可用于调节淋巴细胞功能，导致改善各种疾病状态下的细胞免疫应答。