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    Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue
    1.
    发明授权
    Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue 有权
    将光谱测量与对比增强组织的数字图像相关联的方法

    公开(公告)号：US07463345B2

    公开(公告)日：2008-12-09

    申请号：US11647195

    申请日：2006-12-29

    申请人： Jeffrey K. Cohen ,  John Maier ,  Robert Schweitzer

    发明人： Jeffrey K. Cohen ,  John Maier ,  Robert Schweitzer

    IPC分类号： G01J3/26

    CPC分类号： G01N21/65 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/12 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

    摘要： A system and method of correlating Raman measurements with digital images of a treated sample to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. Information about the field of view is stored. The sample is removed from the field of view and treated. The treated sample is repositioned in the field of view using the stored information. A digital image of the treated sample is obtained and the spectroscopic data set is linked with the digital image. A database is provided having a plurality of spectroscopic data sets. Each data set is linked to a corresponding digital image, and associated with the known sample. Each corresponding digital image is associated with the known treated samples. The database is searched to identify and match a data set of a known sample and the sample.

    摘要翻译： 将拉曼测量与经处理样品的数字图像相关联以将样品的疾病状态分类的系统和方法。 对于位于分光装置的视野中的样品获得光谱数据集。 存储有关视野的信息。 将样品从视野中移除并进行处理。 使用存储的信息，在视野中重新定位被处理的样品。 获得经处理样品的数字图像，并将光谱数据集与数字图像相连。 提供具有多个光谱数据集的数据库。 每个数据集都链接到相应的数字图像，并与已知样本相关联。 每个相应的数字图像与已知的处理样品相关联。 搜索数据库以识别和匹配已知样本和样本的数据集。

    Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue
    6.
    发明申请
    Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue 有权
    将光谱测量与对比增强组织的数字图像相关联的方法

    公开(公告)号：US20070127022A1

    公开(公告)日：2007-06-07

    申请号：US11647195

    申请日：2006-12-29

    申请人： Jeffrey Cohen ,  John Maier ,  Robert Schweitzer

    发明人： Jeffrey Cohen ,  John Maier ,  Robert Schweitzer

    IPC分类号： G01J3/28

    CPC分类号： G01N21/65 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/12 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

    摘要： A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.

    摘要翻译： 将拉曼测量与处理的样品的数字图像相关联并使用该相关性来分类样品的疾病状态的系统和方法。 对于位于分光装置的视野中的样品获得光谱数据集。 存储关于视场的位置信息。 从样品中取出样品后，用对比度增强剂处理样品。 使用所存储的视场的位置信息，处理的样品在分光装置的视场中重新定位。 获得定位在视场中的被处理样品的数字图像。 通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。 提供了具有多个光谱数据集的数据库，用于具有良好表征的病理学的样本。 每个光谱数据集与相应的数字图像相关联，并且每个光谱数据集与已知样本相关联。 每个相应的数字图像与用对比度增强剂处理的已知样品相关联。 对于样本的光谱数据集，搜索数据库以识别与样本的光谱数据集匹配的已知样本的光谱数据集。

    System and method for diagnosis tissue samples using fluorescence and raman techniques
    10.
    发明申请
    System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
    使用荧光和拉曼技术诊断组织样本的系统和方法

    公开(公告)号：US20120078524A1

    公开(公告)日：2012-03-29

    申请号：US13136366

    申请日：2011-07-29

    申请人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    发明人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    IPC分类号： G01N33/48 ,  G01N21/64 ,  G01J3/44

    CPC分类号： A61B5/0059 ,  A61B5/417 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/6458 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/16 ,  G02B21/365 ,  G06F19/325 ,  G16H50/70

    摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.

    摘要翻译： 用于确定测试生物样品的诊断的系统和方法。 一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生 所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。 一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。 可以评估该拉曼数据集以确定样品的诊断。 诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。