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公开(公告)号：US5702934A
公开(公告)日：1997-12-30
申请号：US238130
申请日：1994-05-04
申请人： Sven Hastrup , Sven Branner , Birthe Ravn J.o slashed.rgensen , Tove Christensen , Birgitte Bojer J.o slashed.rgensen , Jeffrey R. Shuster , Mark Madden , Donna L. Moyer , Claus Fuglsang
发明人： Sven Hastrup , Sven Branner , Birthe Ravn J.o slashed.rgensen , Tove Christensen , Birgitte Bojer J.o slashed.rgensen , Jeffrey R. Shuster , Mark Madden , Donna L. Moyer , Claus Fuglsang
IPC分类号： A61K39/12 , A61K39/395 , A61P31/04 , C07K14/025 , C12N20060101 , C12N9/00 , C12N9/54 , C12N9/58 , C12N15/09 , C12N15/37 , C12N15/62 , C12N15/80 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/69 , C12R1/77 , C12N1/15 , C12N9/76
CPC分类号： C12N9/58 , C07K14/005 , C12N15/80 , C12N15/86 , C12N7/00 , C12N9/54 , C12P21/06 , C07K2319/00 , C07K2319/40 , C12N2710/20022 , C12N2710/24143
摘要： The present invention is related to a process for producing an active enzyme comprising fermenting the proform of the active enzyme in the present of a proteolytic enzyme different from the active enzyme and capable of converting the proenzyme into an active enzyme as well as to host cells, recombinant expression vectors and host cells suitable for use in the process.
摘要翻译： 本发明涉及一种生产活性酶的方法，其包括在不同于活性酶的蛋白水解酶存在下发酵活性酶的形式并能够将酶转化为活性酶以及宿主细胞， 重组表达载体和适用于该过程的宿主细胞。
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公开(公告)号：US5807729A
公开(公告)日：1998-09-15
申请号：US442859
申请日：1995-05-17
IPC分类号： C12N15/09 , C12N1/19 , C12N9/58 , C12N9/62 , C12N15/00 , C12N15/57 , C12Q1/34 , C12Q1/37 , C12R1/69 , C12R1/77 , C12N15/80
CPC分类号： C12N9/58 , C12N9/62 , Y10S435/975
摘要： The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells comprising said nucleic acid fragments.
摘要翻译： 本发明涉及从具有增加的蛋白水解活性的真菌获得的新的金属蛋白酶。 此外，本发明涉及编码所述金属蛋白酶的分离的核酸片段以及载体，DNA构建体和包含所述核酸片段的重组宿主细胞。
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公开(公告)号：US5843753A
公开(公告)日：1998-12-01
申请号：US398489
申请日：1995-03-03
IPC分类号： C12N15/09 , C12N1/19 , C12N9/58 , C12N9/62 , C12N15/00 , C12N15/57 , C12Q1/34 , C12Q1/37 , C12R1/69 , C12R1/77
CPC分类号： C12N9/58 , C12N9/62 , Y10S435/975
摘要： The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells comprising said nucleic acid fragments.
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公开(公告)号：US5691162A
公开(公告)日：1997-11-25
申请号：US443104
申请日：1995-05-17
IPC分类号： C12N15/09 , C12N1/19 , C12N9/58 , C12N9/62 , C12N15/00 , C12N15/57 , C12Q1/34 , C12Q1/37 , C12R1/69 , C12R1/77
CPC分类号： C12N9/58 , C12N9/62 , Y10S435/975
摘要： The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells comprising said nucleic acid fragments.
摘要翻译： 本发明涉及从具有增加的蛋白水解活性的真菌获得的新的金属蛋白酶。 此外，本发明涉及编码所述金属蛋白酶的分离的核酸片段以及载体，DNA构建体和包含所述核酸片段的重组宿主细胞。
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公开(公告)号：US6060305A
公开(公告)日：2000-05-09
申请号：US816915
申请日：1997-03-13
CPC分类号： C12N15/80 , C12N9/20 , C12N9/2437 , C12N9/58 , C12N9/6427 , C12Y302/01004
摘要： The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.
摘要翻译： 本发明涉及Discolor部分或其同义词的无毒非毒性非致病重组镰孢宿主细胞，其包含编码与启动子有效连接的异源蛋白质的核酸序列。
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6.发明授权Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein 失效无毒，非产生，非致病性镰孢表达系统及其中使用的启动子和终止子
公开(公告)号：US5837847A
公开(公告)日：1998-11-17
申请号：US921426
申请日：1997-08-29
IPC分类号： C12N15/09 , C12N1/15 , C12N9/20 , C12N9/24 , C12N9/58 , C12N9/76 , C12N15/80 , C12P21/00 , C12P21/02 , C12R1/77 , C12N15/11
CPC分类号： C12P21/00 , C12N15/80 , C12N9/20 , C12N9/58 , C12N9/6427 , C12P21/02 , Y10S435/929
摘要： The invention is related to a non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium, e.g., Fusarium graminearum host cell comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter. The invention further relates to a method for the production of recombinant proteins using such Fusarium host cells. The invention also relates to a promoter and terminator sequence which may be used in such cells.
摘要翻译： 本发明涉及无毒，非产生，非致病重组镰刀菌，例如禾谷镰孢宿主细胞，其包含编码与启动子可操作连接的异源蛋白质的核酸序列。 本发明还涉及使用这种镰刀菌宿主细胞生产重组蛋白质的方法。 本发明还涉及可用于这种细胞中的启动子和终止子序列。
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公开(公告)号：US07163804B1
公开(公告)日：2007-01-16
申请号：US09461537
申请日：1999-12-15
CPC分类号： C12N15/80 , C12N9/20 , C12N9/2437 , C12N9/58 , C12N9/6427 , C12Y302/01004
摘要： The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.
摘要翻译： 本发明涉及Discolor部分或其同义词的无毒非毒性非致病重组镰孢宿主细胞，其包含编码与启动子有效连接的异源蛋白质的核酸序列。
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