-
1.发明申请公开(公告)号：US20110306587A1
公开(公告)日：2011-12-15
申请号：US13105860
申请日：2011-05-11
申请人： Jennifer R. ALLEN , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
发明人： Jennifer R. ALLEN , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC分类号： A61K31/4439 , A61K31/497 , C07D417/14 , A61K31/4545 , C07D413/14 , C07D409/14 , C07D491/107 , C07D487/10 , C07D405/14 , A61P25/16 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/30 , A61P25/24 , A61P3/04 , A61P25/14 , C07D401/14
CPC分类号： C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
摘要： Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。
-
2.发明授权公开(公告)号：US08957073B2
公开(公告)日：2015-02-17
申请号：US13105860
申请日：2011-05-11
申请人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
发明人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC分类号： C07D403/14 , A61K31/517 , C07D239/42 , C07D237/26 , A61K31/497 , C07D401/14 , C07D241/38 , C07D413/14 , A61K31/5355 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D487/08 , C07D487/10 , C07D491/107 , A61P3/04 , A61P7/12 , A61P25/18
CPC分类号： C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
摘要： Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。
-
公开(公告)号：US20110118234A1
公开(公告)日：2011-05-19
申请号：US12990999
申请日：2009-05-04
申请人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
发明人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
IPC分类号： A61K31/55 , C07D213/53 , A61K31/44 , C07D405/12 , A61K31/4433 , C07D413/12 , A61K31/5377 , C07D403/12 , A61K31/47 , A61K31/4439 , A61K31/444 , A61P25/28
CPC分类号： C07D213/40 , C07D213/61 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了作为γ-分泌酶调节剂的式（I）化合物，因此可用于治疗通过调节γ-分泌酶如阿尔茨海默病可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US20130157996A1
公开(公告)日：2013-06-20
申请号：US13529860
申请日：2012-06-21
申请人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
发明人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC分类号： C07D498/04 , C07D401/14 , C07D213/81 , C07D487/04 , C07D413/12 , C07D401/12 , C07D471/04
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。
-
公开(公告)号：US20110166132A1
公开(公告)日：2011-07-07
申请号：US12746902
申请日：2008-12-12
申请人： Stephen A. Hitchcock , Jian J. Chen , Mqhele Vellah Ncube , Thomas Nixey , Albert Amegadzie , Roxanne Kunz , Wenyan Qian , Ning Chen , Christopher M. Tegley , Frenel F. De Morin , Chester Chenguang Yuan , Qingyian Liu , Jiawang Zhu , Tanya A.N. Peterkin , Jeffrey A. Adams , Essa Hu , Frank Chavez, JR.
发明人： Stephen A. Hitchcock , Jian J. Chen , Mqhele Vellah Ncube , Thomas Nixey , Albert Amegadzie , Roxanne Kunz , Wenyan Qian , Ning Chen , Christopher M. Tegley , Frenel F. De Morin , Chester Chenguang Yuan , Qingyian Liu , Jiawang Zhu , Tanya A.N. Peterkin , Jeffrey A. Adams , Essa Hu , Frank Chavez, JR.
IPC分类号： A61K31/538 , C07D213/56 , C07D413/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D405/12 , C07D233/61 , C07D403/12 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/444 , A61K31/4725 , A61K31/4545 , A61K31/5377 , A61K31/4433 , A61K31/4709 , A61K31/4164 , A61K31/4178 , A61P25/28
CPC分类号： C07D213/40 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了γ-分泌酶调节剂的化合物，因此可用于治疗通过调节γ分泌酶如阿尔茨海默病可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US08778941B2
公开(公告)日：2014-07-15
申请号：US13529880
申请日：2012-06-21
申请人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
发明人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
IPC分类号： C07D401/14 , C07D213/75 , C07D213/40 , C07D405/12 , C07D413/12
CPC分类号： C07D213/53 , C07C275/30 , C07D213/40 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
-
7.发明授权公开(公告)号：US08497264B2
公开(公告)日：2013-07-30
申请号：US13047693
申请日：2011-03-14
申请人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
发明人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
IPC分类号： C07D513/10 , C07D498/20 , A61K31/547 , A61K31/5386
CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
-
公开(公告)号：US20090054460A1
公开(公告)日：2009-02-26
申请号：US12008696
申请日：2008-01-11
申请人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US07662811B2
公开(公告)日：2010-02-16
申请号：US11182216
申请日：2005-07-15
申请人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
发明人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
IPC分类号： A01N43/00 , A61K31/00 , A61K31/55 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D221/10 , C07D221/08 , C07D239/74 , C07D241/08 , C07D243/08 , C07D249/08 , C07D295/135 , C07D311/96 , C07D335/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D491/04
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US07393852B2
公开(公告)日：2008-07-01
申请号：US10874086
申请日：2004-06-21
申请人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号： A61K31/54 , A61K31/4965 , C07D241/04 , C07D265/30 , C07D279/12
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.05 秒)
