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    Highly porous polymeric materials comprising biologically active molecules via covalent grafting
    1.
    发明申请
    Highly porous polymeric materials comprising biologically active molecules via covalent grafting 审中-公开
    通过共价接枝包含生物活性分子的高度多孔的聚合物材料

    公开(公告)号：US20090215913A1

    公开(公告)日：2009-08-27

    申请号：US11918777

    申请日：2006-04-21

    申请人： Jens Christoph Thies ,  Sebastien Pierre ,  Neil Ronald Cameron

    发明人： Jens Christoph Thies ,  Sebastien Pierre ,  Neil Ronald Cameron

    IPC分类号： C08J9/36 ,  C08J9/00

    CPC分类号： C12N11/06 ,  C12N11/08

    摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.

    摘要翻译： 本发明涉及包含共价接枝的生物活性物质的高度多孔的聚合物材料。 本发明还涉及一种制备包含能够接枝到生物活性分子物质的官能单体的高度多孔材料的方法，包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物， （b）固化乳液和（c）任选地除去水/液滴相。 本发明还涉及将生物活性物质接枝到这种高度多孔的聚合物材料的方法，包括以下步骤：（i）将高度多孔的材料暴露于生物活性物质在合适的溶剂介质中的溶液，（ii）任选地 加入活化剂，（iii）任选地加热，和（iv）用溶剂介质漂洗多孔材料以除去未接枝的物质。 包含共价接枝的生物活性物质的高度多孔的聚合物材料可以例如使用。 作为非均相催化剂，生物传感器，色谱法，生物医学装置和植入物。

    Nano-structured surface coating process, nano-structured coatings and articles comprising the coating
    7.
    发明申请
    Nano-structured surface coating process, nano-structured coatings and articles comprising the coating 审中-公开
    纳米结构表面涂层工艺，纳米结构涂层和包含该涂层的制品

    公开(公告)号：US20060275595A1

    公开(公告)日：2006-12-07

    申请号：US10557243

    申请日：2004-05-13

    申请人： Jens Christoph Thies ,  Guido Meijers ,  Atze Nijenhuis ,  Edwin Currie ,  Christopher Tronche ,  John Southwell

    发明人： Jens Christoph Thies ,  Guido Meijers ,  Atze Nijenhuis ,  Edwin Currie ,  Christopher Tronche ,  John Southwell

    IPC分类号： B05D1/12 ,  C08F2/46 ,  B32B3/00

    CPC分类号： C03C17/007 ,  C03C2217/425 ,  C04B41/009 ,  C04B41/4584 ,  C04B41/81 ,  C08K3/20 ,  C08K3/36 ,  C08K9/08 ,  C09D4/00 ,  C09D7/62 ,  G02B1/11 ,  C04B41/483 ,  C04B41/4842 ,  C04B35/14 ,  C08F220/10

    摘要： The invention relates to a new process for the preparation of nano-structured and/or nano-porous surfaces, coatings having a nano-structured and/or nano-porous surface and articles comprising said coatings. The invention also relates to the use of coatings according to the invention, in particular as anti-reflective coatings. The process for the preparation of the surface nano-structured and/or nano-porous coatings is a process comprising the steps of: a) applying a mixture to a substrate which mixture comprises: i) reactive nano-particles; ii) at least one solvent; iii) optionally a compound having at least one polymerisable group, in an amount that results in an increase in the transmission of at least 0.5%, for at least part of the electromagnetic spectrum between 400 and 800 nm, after the mixture has been applied and cured on a transparent substrate, in comparison with the same substrate without a coating; b) inducing crosslinking and/or polymerisation in the mixture applied to the substrate.

    摘要翻译： 本发明涉及一种用于制备纳米结构和/或纳米多孔表面的新方法，具有纳米结构和/或纳米多孔表面的涂层和包含所述涂层的制品。 本发明还涉及根据本发明的涂层的用途，特别是抗反射涂层。 用于制备表面纳米结构和/或纳米多孔涂层的方法是包括以下步骤的方法：a）将混合物施加到基材上，该混合物包含：i）反应性纳米颗粒; ii）至少一种溶剂; iii）任选地具有至少一个可聚合基团的化合物，其量在使用混合物之后导致400至800nm之间的至少部分电磁谱的透射率至少为0.5％，并且 与没有涂层的相同基板相比，在透明基板上固化; b）在施加到基底上的混合物中诱导交联和/或聚合。

    SOL-GEL PROCESS WITH A PROTECTED CATALYST
    9.
    发明申请
    SOL-GEL PROCESS WITH A PROTECTED CATALYST 审中-公开
    具有保护催化剂的溶胶凝胶工艺

    公开(公告)号：US20110021335A1

    公开(公告)日：2011-01-27

    申请号：US12747975

    申请日：2008-12-15

    申请人： Pascal Jozef Paul Buskens ,  Jens Christoph Thies ,  Nanning Joerg Arfsten

    发明人： Pascal Jozef Paul Buskens ,  Jens Christoph Thies ,  Nanning Joerg Arfsten

    IPC分类号： C04B35/00 ,  C09D1/00 ,  B05D3/02

    CPC分类号： C04B41/4537 ,  C03C1/008 ,  C03C17/009 ,  C03C23/0005 ,  C03C2218/111 ,  C03C2218/113 ,  C04B41/009 ,  C04B41/81 ,  C08K3/22 ,  C08K5/0008 ,  C09D7/61 ,  C09D7/63 ,  C04B35/00

    摘要： The invention provides a sol-gel process for preparing a mixture of metal-oxide-metal compounds wherein at least one metal oxide precursor is subjected to a hydrolysis treatment to obtain one or more corresponding metal oxide hydroxides, the metal oxide hydroxides so obtained are subjected to a condensation treatment to form the metal-oxide-metal compounds, which process is carried out in the presence of a catalyst which comprises a labile protecting group (P9) and a base (B) which are covalently linked, whereby the covalent link between the protecting group and the base is cleavable by exposure to an external stimulus, and wherein the base released after exposure to such external stimulus is capable of catalyzing the condensation of the metal-hydroxide groups that are present in the metal oxide hydroxides so obtained.

    摘要翻译： 本发明提供了一种用于制备金属氧化物 - 金属化合物的混合物的溶胶 - 凝胶法，其中至少一种金属氧化物前体进行水解处理以获得一种或多种相应的金属氧化物氢氧化物，所得到的金属氧化物氢氧化物 进行缩合处理以形成金属氧化物 - 金属化合物，该方法在包含不稳定保护基（P9）和共价连接的碱（B）的催化剂的存在下进行，由此共价连接 保护基和碱可以通过暴露于外部刺激而被切割，并且其中在暴露于这种外部刺激之后释放的碱能够催化如此获得的金属氧化物氢氧化物中存在的金属氢氧根的缩合。