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    Process for the preparation of a polymerizable dental composition
    2.
    发明申请
    Process for the preparation of a polymerizable dental composition 审中-公开
    制备可聚合牙科组合物的方法

    公开(公告)号：US20080237907A1

    公开(公告)日：2008-10-02

    申请号：US12156794

    申请日：2008-06-04

    申请人： Joachim E. Klee ,  Uwe Walz ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Holger Frey ,  Ekkehard Muh

    发明人： Joachim E. Klee ,  Uwe Walz ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Holger Frey ,  Ekkehard Muh

    IPC分类号： A61C13/20

    CPC分类号： A61K6/083 ,  A61K6/093 ,  C08L33/00 ,  C08L83/10

    摘要： A process for the preparation of a polymerizable dental composition comprising the steps of (a) preparing a liquid mixture comprising (i) 1 to 99% w/w of a hybrid monomer component containing at least one hybrid monomer compound having one hydrolysable siloxane group and at least one polymerizable organic moiety, and (ii) 99 to 1% w/w of a monomer component polymerizable with the polymerizable organic moiety of the hybrid monomer compounds; and (b) adding at least a stoichiometrically sufficient amount of water to the mixture to hydrolyse the hydrolysable siloxane group of the hybrid monomer compound and to form spherical polymerizable nanoparticles having an average particle size of from 1 to 100 nm dispersed in the monomer component, whereby the nanoparticles have a structure with Si—O—Si bonds and peripherally exposed polymerizable organic moieties.

    摘要翻译： 一种制备可聚合牙科用组合物的方法，包括以下步骤：（a）制备液体混合物，其包含（i）1至99％w / w的含有至少一种具有一个可水解硅氧烷基团的杂化单体化合物的杂化单体组分和 至少一个可聚合的有机部分，和（ii）99-1％w / w的可与所述杂化单体化合物的可聚合有机部分聚合的单体组分; 和（b）向所述混合物中加入至少一种化学计量的足够量的水以水解所述杂化单体化合物的可水解硅氧烷基团并形成分散在单体组分中的平均粒度为1至100nm的球形可聚合纳米颗粒， 由此纳米颗粒具有具有Si-O-Si键和外围暴露的可聚合有机部分的结构。

    Laser curable polymerisable composition for the protection of hard tissue
    4.
    发明申请
    Laser curable polymerisable composition for the protection of hard tissue 审中-公开
    用于保护硬组织的激光可固化聚合组合物

    公开(公告)号：US20060135643A1

    公开(公告)日：2006-06-22

    申请号：US11217570

    申请日：2005-09-01

    申请人： Joachim Klee ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Martin Schmider

    发明人： Joachim Klee ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Martin Schmider

    IPC分类号： A61K6/08

    CPC分类号： A61K6/0017 ,  C08L33/00

    摘要： One-component heat-curable sealant composition having a viscosity of at most 5 Pas (23° C.) for the protection of exposed dental surfaces, comprising (a) a polymerisable monomer and/or oligomer having at least two polymerizable double bonds per molecule, and (b) an initiator system comprising a thermally stable initiator having a 10 hour half-life decomposition temperature of from 95° C. to 135° (0.1M in benzene); wherein the composition further contains a precursor for a filler which is an alkoxysilane compound undergoing polycondensation reactions during heat curing of the composition, thereby forming a filler.

    摘要翻译： 包含（a）每分子具有至少两个可聚合双键的可聚合单体和/或低聚物的单组分可热固化的密封剂组合物，其具有至多5Pa·s（23℃）的粘度，用于保护暴露的牙齿表面 ，和（b）引发剂体系，其包括具有10分钟半衰期分解温度为95℃至135℃（0.1M苯）的热稳定引发剂; 其中所述组合物还含有用于填料的前体，其是在组合物热固化期间进行缩聚反应的烷氧基硅烷化合物，从而形成填料。

    Dental cement composition
    6.
    发明授权
    Dental cement composition 有权

    公开(公告)号：US10117810B2

    公开(公告)日：2018-11-06

    申请号：US13979806

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/083 ,  A61K6/00 ,  A61K6/09 ,  C07C233/09 ,  C07C233/20 ,  C08F122/38

    摘要： Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system; optionally a polyacidic polymer having polymerizable double bonds; and optionally water.

    Dental composition
    7.
    发明授权
    Dental composition 有权

    公开(公告)号：US09603780B2

    公开(公告)日：2017-03-28

    申请号：US13979811

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： B29C47/92 ,  A61K6/083 ,  A61K6/00 ,  A61K6/02 ,  C07C233/31 ,  C08F290/06 ,  C07C233/20

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0835 ,  C07C233/20 ,  C08L33/00

    摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R′ represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L1, L2, and L3 which may be the same or different, independently represent a single bond, or a C2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L1 and L2 are present, each of L1 and L2 may be the same or different; Q1 and Q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

    DENTAL COMPOSITION
    9.
    发明申请
    DENTAL COMPOSITION 审中-公开
    牙科成分

    公开(公告)号：US20140039088A1

    公开(公告)日：2014-02-06

    申请号：US13979815

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/087 ,  A61K6/083

    CPC分类号： A61K6/0091 ,  A61K6/0023 ,  A61K6/08 ,  A61K6/083 ,  A61K6/0835 ,  A61K6/087 ,  A61K6/09 ,  C07C231/02 ,  C08L33/00 ,  C08L75/16 ,  C08L33/10 ,  C07C233/38

    摘要： Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond, a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system.

    摘要翻译： 牙科组合物，其包含（i）颗粒填料; （ii）下式（1）的可聚合水解稳定化合物AXn其中A是至少含有n个氮原子和任选一个或多个酸性基团的连接基团，X是含有可聚合双键并形成酰胺键的部分 与A的氮原子一起，X可以相同或不同，并由下式（2）表示，其中R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m Z，其中Z为COOM，OPO3M2，PO3M2，SO3M和M独立地为氢原子或金属原子，m为0-6的整数，L为键，C1-6亚烷基 ; n为1以上的整数。 条件是至少一个X不能是（甲基）丙烯酰基; 和（iii）引发剂体系。

    DENTAL COMPOSITION
    10.
    发明申请
    DENTAL COMPOSITION 有权
    牙科成分

    公开(公告)号：US20140039087A1

    公开(公告)日：2014-02-06

    申请号：US13979811

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/083

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0835 ,  C07C233/20 ,  C08L33/00

    摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R′ represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L1, L2, and L3 which may be the same or different, independently represent a single bond, or a C2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L1 and L2 are present, each of L1 and L2 may be the same or different; Q1 and Q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

    摘要翻译： 1.一种牙科用组合物，其含有下述式（1）所示的水溶性聚合性化合物：式中，A为下述通式（3）所示的直链或支链连接基团，其中，所述末端中的至少2个的氮原子形成酰胺键 与X部分; 其中R'表示氢原子或取代或未取代的脂族或脂环族烃基，其中每个R可以相同或不同，可以相同或不同的L1，L2和L3独立地表示单键，或C2 -20个直链，支链或环状烃基，任选地含有1至6个选自氮原子和氧的杂原子在烃基的主链中，以及任选地1-6个选自羧酸基团或其盐的官能团，羟基 基团，硫醇基和氨基，并且在存在多个L1和L2的情况下，L1和L2中的每一个可以相同或不同; Q1和Q2可以相同或不同，独立地表示单键或选自酰胺，氨基甲酸酯，脲和硫脲键的键; k是至少为0的整数，X是含有可聚合双键并与A的氮原子形成酰胺键的部分，其中每个X可以相同或不同，并由下式（2）表示：其中 R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m -COOM，其中M表示氢原子或金属原子，m表示0〜 6，L是键或C1-6亚烷基; 且n为至少2的整数; （ii）引发剂体系; 任选的多酸聚合物; 任选的水和/或水溶性溶剂; 和任选的颗粒填料。