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    Controlled releases of actives in skin
    1.
    发明授权
    Controlled releases of actives in skin 有权
    皮肤活性物质的控制释放

    公开(公告)号：US08414871B2

    公开(公告)日：2013-04-09

    申请号：US12525529

    申请日：2008-01-31

    申请人： Joachim Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    发明人： Joachim Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    IPC分类号： A61K8/72

    CPC分类号： A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

    摘要： Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C—R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH═CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

    摘要翻译： 提供了局部组合物，其中通过角质层局部递送的活性化合物与具有A-B-A结构的三嵌段共聚物的纳米球络合，其中每个A端嵌段是水溶性的，亲水的和无毒的聚合物或低聚物; 疏水性中间B嵌段是具有相同或不同的具有下式结构的重复单元的疏水聚合物或低聚物：其中X是-C（= O）-R-C（= O） - 或-C （= O） - ; Z在2至约100之间（含）; R1为CH = CH或（CH2）n，其中n为0至18，包括端值; R2选自氢和含有至多18个碳原子的直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基; 并且R选自含有至多18个碳原子的键或直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基。

    CONTROLLED RELEASES OF ACTIVES IN SKIN
    2.
    发明申请
    CONTROLLED RELEASES OF ACTIVES IN SKIN 有权
    控制释放皮肤活动

    公开(公告)号：US20090317472A1

    公开(公告)日：2009-12-24

    申请号：US12525529

    申请日：2008-01-31

    申请人： Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    发明人： Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    IPC分类号： A61K9/14 ,  A61P35/00 ,  A61P31/00

    CPC分类号： A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

    摘要： Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C —R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH═CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

    摘要翻译： 提供了局部组合物，其中通过角质层局部递送的活性化合物与具有A-B-A结构的三嵌段共聚物的纳米球络合，其中每个A端嵌段是水溶性的，亲水的和无毒的聚合物或低聚物; 并且疏水性中间B嵌段是具有相同或不同重复单元的疏水性聚合物或低聚物，其具有根据下式的结构：（I）其中X是-C-C-C或-C-; Z在2至约100之间（含）; R1为CH-CH或（CH2），其中n为0至18，包括端值; R2选自氢和含有至多18个碳原子的直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基; 并且R选自含有至多18个碳原子的键或直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基。

    Chlorohydrin and cationic compounds having high affinity for pulp or paper
    6.
    发明授权
    Chlorohydrin and cationic compounds having high affinity for pulp or paper 失效
    对纸浆或纸具有高亲和力的氯醇和阳离子化合物

    公开(公告)号：US07776182B2

    公开(公告)日：2010-08-17

    申请号：US11983366

    申请日：2007-11-08

    申请人： Glen T. Cunkle ,  David Devore ,  Thomas F. Thompson

    发明人： Glen T. Cunkle ,  David Devore ,  Thomas F. Thompson

    IPC分类号： C07D211/94 ,  D21H21/14 ,  D21H17/07

    CPC分类号： C04B35/632 ,  C07D211/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/10 ,  C08K5/3435 ,  D21H21/143 ,  C08L97/00

    摘要： Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compounds are added at various points in the paper-making process, especially at the wet ends, making the need for water soluble or water dispersible materials having high affinity for pulp or paper essential. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents and metal chelating agents. Combinations of hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective.

    摘要翻译： 含有氮氧自由基或羟胺部分的选择性氯代醇和阳离子化合物在稳定纸浆或纸，特别是含有木质素的纸浆或纸张时，由于光的不利影响而防止黄变和变色，是有效的。 这些化合物在造纸过程中的各个点加入，特别是在湿端，因此需要对纸浆或纸张具有高亲和力的水溶性或水分散性材料。 通过存在选自紫外线吸收剂，聚合物抑制剂，硝酮，荧光增白剂和金属螯合剂的一种或多种共添加剂，这种性能通常进一步增强。 羟胺或其盐，苯并三唑或二苯甲酮紫外线吸收剂和金属螯合剂的组合是特别有效的。

    Chlorohydrin and cationic compounds having high affinity for pulp or paper
    9.
    发明申请
    Chlorohydrin and cationic compounds having high affinity for pulp or paper 失效
    对纸浆或纸具有高亲和力的氯醇和阳离子化合物

    公开(公告)号：US20080060775A1

    公开(公告)日：2008-03-13

    申请号：US11983366

    申请日：2007-11-08

    申请人： Glen Cunkle ,  David Devore ,  Thomas Thompson

    发明人： Glen Cunkle ,  David Devore ,  Thomas Thompson

    IPC分类号： D21C9/00 ,  C07D211/00 ,  C07D401/04 ,  D21H21/14 ,  C07D471/10

    CPC分类号： C04B35/632 ,  C07D211/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/10 ,  C08K5/3435 ,  D21H21/143 ,  C08L97/00

    摘要： Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compounds are added at various points in the paper-making process, especially at the wet ends, making the need for water soluble or water dispersible materials having high affinity for pulp or paper essential. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents and metal chelating agents. Combinations of hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective.

    摘要翻译： 含有氮氧自由基或羟胺部分的选择性氯代醇和阳离子化合物在稳定纸浆或纸，特别是含有木质素的纸浆或纸张时，由于光的不利影响而防止黄变和变色，是有效的。 这些化合物在造纸过程中的各个点加入，特别是在湿端，因此需要对纸浆或纸张具有高亲和力的水溶性或水分散性材料。 通过存在一种或多种选自紫外线吸收剂，聚合物抑制剂，硝酮，荧光增白剂和金属螯合剂的共添加剂，这种性能通常进一步增强。 羟胺或其盐，苯并三唑或二苯甲酮紫外线吸收剂和金属螯合剂的组合是特别有效的。