-
1.发明授权Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes 失效用作黑色素浓缩激素拮抗剂治疗肥胖和糖尿病的多环化合物公开(公告)号：US07229987B2
公开(公告)日：2007-06-12
申请号：US10512986
申请日：2003-05-06
申请人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
发明人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
IPC分类号： A61K31/5355 , A61K31/454 , C07D401/12 , C07D403/12 , C07D263/32
CPC分类号： C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D333/18 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）; 或其药学上可接受的盐，溶剂化物，对映异构体或前药，用于治疗，预防或改善与肥胖症和相关疾病相关的症状。
-
2.发明授权Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses 失效非咪唑芳基烷基胺化合物作为组胺H3受体拮抗剂，制备和治疗用途公开(公告)号：US07314937B2
公开(公告)日：2008-01-01
申请号：US10472675
申请日：2002-03-21
申请人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Craig William Lindsley , Karen Lynn Lobb , James Arthur Nixon , Richard Todd Pickard , John Mehnert Schaus , Takako Takakuwa , Brian Morgan Watson
发明人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Craig William Lindsley , Karen Lynn Lobb , James Arthur Nixon , Richard Todd Pickard , John Mehnert Schaus , Takako Takakuwa , Brian Morgan Watson
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07D207/27 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/58 , C07D213/38 , C07D217/04 , C07D217/06 , C07D217/08 , C07D217/24 , C07D231/04 , C07D231/14 , C07D233/36 , C07D233/54 , C07D235/14 , C07D241/44 , C07D243/08 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/14 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D471/04
摘要： The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases
摘要翻译： 本发明公开了具有选择性组胺H3受体拮抗剂活性的式（I）的新型取代芳基烷基胺化合物或其药学上可接受的盐以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含这种环胺的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法
-
公开(公告)号：US06255494B1
公开(公告)日：2001-07-03
申请号：US08775538
申请日：1997-01-09
申请人： Thomas Charles Britton , Robert Frederick Bruns, Jr. , Buddy Eugene Cantrell , Philip Arthur Hipskind , Karen Lynn Lobb , James Arthur Nixon , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Anne Marie Nunes , James Jeffry Howbert
发明人： Thomas Charles Britton , Robert Frederick Bruns, Jr. , Buddy Eugene Cantrell , Philip Arthur Hipskind , Karen Lynn Lobb , James Arthur Nixon , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Anne Marie Nunes , James Jeffry Howbert
IPC分类号： C07D23512
CPC分类号： A61K31/454 , C07D235/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14
摘要： This invention provides a series of substituted benzimidazoles which are useful in treating or preventing a condition associated with an excess of neuropeptide Y. This invention also provides methods employing these substituted benzimidazoles as well as pharmaceutical formulations with comprise as an active ingredient one or more of these compounds.
摘要翻译： 本发明提供了一系列取代的苯并咪唑，其可用于治疗或预防与过量神经肽Y相关的病症。本发明还提供了使用这些取代的苯并咪唑的方法以及包含作为活性成分的一种或多种这些 化合物。
-
公开(公告)号：US08030304B2
公开(公告)日：2011-10-04
申请号：US12377733
申请日：2007-09-17
申请人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
发明人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
IPC分类号： A01N43/58 , A01N43/54 , A01N43/64 , A01N43/78 , A01N43/56 , A61K31/50 , A61K31/505 , A61K31/41 , A61K31/425 , A61K31/415 , C07D239/42 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译： 本发明涉及式（I）的化合物，其药物组合物及其作为促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂在治疗精神和神经内分泌障碍，神经系统疾病和代谢综合征中的用途。
-
公开(公告)号：US20100160406A1
公开(公告)日：2010-06-24
申请号：US11909727
申请日：2006-03-28
申请人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsman Beavers
发明人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsman Beavers
IPC分类号： A61K31/4025 , C07D403/06 , A61P31/04
CPC分类号： C07D207/09 , C07D401/06
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法和中间体。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用这些组合物治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。
-
公开(公告)号：US20100160319A1
公开(公告)日：2010-06-24
申请号：US11917941
申请日：2006-06-28
申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/5377 , C07D207/04 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/4025 , A61K31/454 , A61K31/497 , A61K31/4439 , A61P25/00
CPC分类号： C07D207/09 , C07D401/12 , C07D403/12
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)
摘要翻译： 本发明公开了具有组胺-3H受体拮抗剂或反向激动剂活性的式I化合物或其药学上可接受的盐以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。 （式I）
-
公开(公告)号：US20120316174A1
公开(公告)日：2012-12-13
申请号：US13590481
申请日：2012-08-21
IPC分类号： A61K31/502 , A61P25/02 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.
摘要翻译： 本发明提供了可用于治疗癌症的新的1,4-二取代的二嗪嗪hedgehog途径拮抗剂。
-
公开(公告)号：US08008301B2
公开(公告)日：2011-08-30
申请号：US12610954
申请日：2009-11-02
申请人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/501 , A61K31/4439 , A61K31/4245 , A61K31/4025 , C07D403/06 , C07D413/14 , C07D401/14
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine—H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor—related diseases
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法
-
公开(公告)号：US20110190304A1
公开(公告)日：2011-08-04
申请号：US13122212
申请日：2009-10-22
IPC分类号： A61K31/502 , C07D237/34 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.
摘要翻译： 本发明提供了可用于治疗癌症的新的1,4-二取代的二嗪嗪hedgehog途径拮抗剂。
-
10.发明申请公开(公告)号：US20110178093A1
公开(公告)日：2011-07-21
申请号：US13122225
申请日：2009-11-09
申请人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
发明人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
IPC分类号： A61K31/501 , C07D403/04 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention provides novel tetrasubstituted pyridazine hedgehog pathway antagonists useful in the treatment of cancer.
摘要翻译： 本发明提供可用于治疗癌症的新型四取代哒嗪猬草素途径拮抗剂。
-
-
-
-
-
-
-
-
-
搜索结果
42 条记录 (耗时 0.08 秒)
