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    Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
    5.
    发明申请
    Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists 有权
    吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c] - 嘧啶腺苷A2a受体拮抗剂

    公开(公告)号：US20050239795A1

    公开(公告)日：2005-10-27

    申请号：US11108916

    申请日：2005-04-19

    申请人： Bernard Neustadt ,  Jinsong Hao ,  Hong Liu ,  Craig Boyle ,  Samuel Chackalamannil ,  Unmesh Shah ,  Andrew Stamford ,  Joel Harris

    发明人： Bernard Neustadt ,  Jinsong Hao ,  Hong Liu ,  Craig Boyle ,  Samuel Chackalamannil ,  Unmesh Shah ,  Andrew Stamford ,  Joel Harris

    IPC分类号： A61K31/519 ,  C07D487/14

    CPC分类号： C07D487/14

    摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

    摘要翻译： 具有结构式I的化合物或其药学上可接受的盐，其中R是任选取代的苯基，呋喃基，噻吩基，吡啶基，吡啶基N-氧化物，恶唑基或吡咯基，或环烯基R 1， R 3，R 3，R 4和R 5是H，烷基或烷氧基烷基; 和Z是任选取代的芳基或杂芳基。 还公开了式I化合物在治疗中枢神经系统疾病，特别是帕金森病中单独使用或与用于治疗帕金森病的其它药物组合的用途，以及包含它们的药物组合物的用途。

    Biodegradable medical implants, polymer compositions and methods of use
    8.
    发明授权
    Biodegradable medical implants, polymer compositions and methods of use 有权

    公开(公告)号：US10046085B2

    公开(公告)日：2018-08-14

    申请号：US13261054

    申请日：2010-06-01

    申请人： Mir Imran ,  Sanjay Patel ,  Joel Harris

    发明人： Mir Imran ,  Sanjay Patel ,  Joel Harris

    IPC分类号： A61L27/14 ,  A61F2/82 ,  A61L27/26 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07

    摘要： Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.

    APPARATUS AND METHOD FOR THE DETECTION AND TREATMENT OF ATRIAL FIBRILLATION
    9.
    发明申请
    APPARATUS AND METHOD FOR THE DETECTION AND TREATMENT OF ATRIAL FIBRILLATION 有权
    用于检测和治疗椎间盘突出症的装置和方法

    公开(公告)号：US20100268295A1

    公开(公告)日：2010-10-21

    申请号：US12427733

    申请日：2009-04-21

    申请人： Mir Imran ,  Joel Harris

    发明人： Mir Imran ,  Joel Harris

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

    摘要： An embodiment of the invention provides an apparatus for the detection and treatment of atrial arrhythmia comprising an electrical lead having proximal and distal portions. The distal portion is positionable in an atrial chamber and the end of the proximal portion is configured to be coupled to a pacemaker. The lead comprises a plurality of conductive wires clad with an insulative coating and has sufficient flexibility to be positioned in the atria from a percutaneous introductory site. The conductive wires are coupled to a plurality of pairs of bipolar electrodes positioned on a membrane attachable to an endocardial wall. The electrode pairs are distributed in a pattern defining an area for detecting a location of a foci of aberrant electrical activity located within or adjacent the area and sending a pacing signal to that location to prevent or stop an occurrence of atrial fibrillation caused by that foci.

    摘要翻译： 本发明的一个实施方案提供了用于检测和治疗心房心律失常的装置，其包括具有近端部分和远端部分的电引线。 远侧部分可定位在心房中，并且近端部分的端部被配置为联接到起搏器。 引线包括用绝缘涂层包覆的多个导线，并且具有足够的灵活性，以便从经皮引导位置定位在心房中。 导电线耦合到多个双极电极对，其位于可附接到心内膜壁的膜上。 电极对以限定用于检测位于该区域内或邻近该区域的异常电活动焦点的位置的区域的图案分布，并向该位置发送起搏信号以防止或停止由该焦点引起的心房颤动的发生。

    HOUSING STRUCTURE FOR A MEDICAL IMPLANT INCLUDING A MONOLITHIC SUBSTRATE
    10.
    发明申请
    HOUSING STRUCTURE FOR A MEDICAL IMPLANT INCLUDING A MONOLITHIC SUBSTRATE 有权
    包括单晶基底的医疗植入物的住房结构

    公开(公告)号：US20100114225A1

    公开(公告)日：2010-05-06

    申请号：US12265690

    申请日：2008-11-05

    申请人： Mir Imran ,  Dean Andersen ,  Joel Harris

    发明人： Mir Imran ,  Dean Andersen ,  Joel Harris

    IPC分类号： H05K5/06 ,  A61N1/00

    CPC分类号： A61N5/0622 ,  A61N1/0529 ,  A61N1/0536 ,  A61N1/36 ,  A61N1/36064 ,  A61N1/37 ,  A61N1/375 ,  A61N1/3754 ,  A61N5/0601 ,  A61N2005/063 ,  H01R13/5224 ,  H01R2201/12

    摘要： Embodiments described herein provide lid structures for medical implant (MI) housing. In one embodiment, the invention provides a lid structure for a MI housing comprising a substrate comprising a dielectric material, a conductive portion fabricated on a substrate surface or interior, a frame at least partially surrounding the substrate perimeter, a plurality of vias projecting at least partially through the substrate, a plurality of conductive pins with at least one pin projecting through a via. The frame is hermetically joined to the substrate and can be hermetically joined to the housing. The conductive portion allows electrical components, including capacitors, inductors, resistor and antennas to be fabricated on or coupled to the substrate surface or interior. The antenna comprises a conductive trace positioned on a substrate top surface and is configured to send and receive signals between an implant within a patient's body and a communication device external to the body.

    摘要翻译： 本文描述的实施例提供用于医疗植入物（MI）壳体的盖结构。 在一个实施例中，本发明提供了一种用于MI壳体的盖结构，其包括基底，其包括电介质材料，制造在基底表面或内部的导电部分，至少部分围绕基底周边的框架，至少突出的多个通孔 部分地穿过衬底，具有至少一个销突出通过通孔的多个导电销。 框架气密地接合到基板上并且可以气密地接合到壳体。 导电部分允许包括电容器，电感器，电阻器和天线的电气部件制造在衬底表面或内部上或耦合到衬底表面或内部。 天线包括位于衬底顶表面上的导电迹线，并被配置为在患者体内的植入物和身体外部的通信装置之间发送和接收信号。