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公开(公告)号：US5866122A
公开(公告)日：1999-02-02
申请号：US821763
申请日：1997-03-20
申请人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
发明人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
IPC分类号： G01N33/86 , A61K31/435 , A61K31/60 , A61K38/00 , A61K38/36 , A61K38/43 , A61K38/48 , A61K38/55 , A61K38/57 , A61K45/00 , A61K47/48 , A61P3/14 , A61P7/02 , A61P7/04 , A61P39/02 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/64 , C12N9/74
CPC分类号： C12N9/6432 , A61K38/4833 , A61K38/4846 , A61K38/57 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/6429 , C12N9/647 , C12Y304/21005 , C12Y304/21006 , Y10S514/822
摘要： There is disclosed a pharmaceutical preparation for treating blood coagulation disorders which comprises purified prothrombinase factors, in particular purified prothrombin and optionally purified factor Xa as active component.
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公开(公告)号：US5804159A
公开(公告)日：1998-09-08
申请号：US663031
申请日：1996-06-07
申请人： Johann Eibl , Peter Turecek , Hans Peter Schwarz
发明人： Johann Eibl , Peter Turecek , Hans Peter Schwarz
摘要： There is disclosed an anti-plasma antibody preparation for treatment of a mammal, which preparation is capable of directly or indirectly inhibiting and/or eliminating several blood factors, a method of producing such a preparation and a method of evaluating substances for treating clotting disorders by using said anti-plasma antibody preparation. There is further disclosed a method of determining the bleeding characteristics of a mammal.
摘要翻译： 公开了一种用于治疗哺乳动物的抗血浆抗体制剂，该制剂能够直接或间接地抑制和/或消除多种血液因子，制备这种制剂的方法和评估用于治疗凝血障碍的物质的方法通过 使用所述抗血浆抗体制剂。 还公开了确定哺乳动物的出血特征的方法。
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公开(公告)号：US6103693A
公开(公告)日：2000-08-15
申请号：US898130
申请日：1997-07-22
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/47 , C07K14/755 , C12P21/00 , A61K38/17 , C07K14/745
CPC分类号： C07K14/755 , A61K38/00
摘要： The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.
摘要翻译： 本发明涉及一种用于分离高纯度血管性血友病因子的方法，其中重组血管性血友病因子（rvWF）通过阴离子交换色谱在季氨基型阴离子交换剂上在包含缓冲物质和任选盐的缓冲溶液中进行色谱纯化。 缓冲溶液优选不含稳定剂，氨基酸和其它添加剂。 根据该方法，可以获得高纯度的重组vWF，其不含血浆蛋白质，特别是不含因子VIII，且具有生理活性。 此外，本发明涉及含有rvWF的药物制剂，其由具有高结构完整性的多聚体组成。
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公开(公告)号：US5880265A
公开(公告)日：1999-03-09
申请号：US898129
申请日：1997-07-22
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/47 , C07K14/755 , C12P21/00
CPC分类号： C07K14/755 , A61K38/00
摘要： The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.
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公开(公告)号：US5698677A
公开(公告)日：1997-12-16
申请号：US435128
申请日：1995-05-05
IPC分类号： A61K9/127 , A61K9/14 , A61K38/43 , A61K38/48 , A61K38/55 , A61P7/02 , C12N9/64 , C12N9/96 , A61K35/14
CPC分类号： C12N9/96 , A61K38/4846 , A61K38/4866 , A61K9/127 , C12N9/6424 , C12N9/647 , C12Y304/21006 , C12Y304/21021 , C12Y304/21069
摘要： The invention relates to a stable preparation which comprises a protein that is bound in and/or on lipid vesicles and that was treated for the inactivation of potentially present viruses. Further, the invention relates to methods for the production of a stable preparation for the treatment of blood coagulation disorders, wherein a protein is bound in and/or on lipid vesicles, and the method comprises a step in which the protein lipid complex is subjected to a treatment for the inactivation of potentially present viruses.
摘要翻译： 本发明涉及一种稳定的制剂，其包含结合于脂质囊泡中和/或脂质囊泡上的蛋白质，并且被处理用于灭活潜在的存在的病毒。 此外，本发明涉及生产用于治疗凝血障碍的稳定制剂的方法，其中蛋白质与脂质囊泡中和/或结合，该方法包括将蛋白质脂质复合物经受 用于灭活潜在存在的病毒的治疗。
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6.发明授权Method of chromatographically purifying or fractionating, respectively, von Willebrand factor from a VWF-containing starting material 失效分别从含VWF的起始材料中色谱纯化或分馏von Willebrand因子的方法公开(公告)号：US06414125B1
公开(公告)日：2002-07-02
申请号：US09355865
申请日：1999-10-21
申请人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
发明人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
IPC分类号： A23J100
CPC分类号： C07K14/755
摘要： Disclosed is a method of chromatographically purifying or fractionating, respectively, von Willebrand factor (vWF) from a vWF-containing starting material, comprising the following steps: adsorbing the vWF from the starting material on avid collagen immobilized on a carrier, separating the non-adsorbed portion and, optionally, washing the carrier, eluting the vWF from immobilized collagen, and recovering the purified vWF, as well as a pharmaceutical preparation comprising biologically active vWF which is bound to collagen in a stable manner.
摘要翻译： 公开了一种从含有vWF的原料分别纯化或分馏von Willebrand因子（vWF）的方法，其包括以下步骤：将起始材料的vWF吸附在固定在载体上的avid胶原上， 吸附部分和任选地洗涤载体，从固定化胶原洗脱vWF，并回收纯化的vWF，以及包含以稳定方式与胶原结合的生物活性vWF的药物制剂。
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公开(公告)号：US6099837A
公开(公告)日：2000-08-08
申请号：US244762
申请日：1999-02-05
申请人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
发明人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
IPC分类号： G01N33/86 , A61K31/435 , A61K31/60 , A61K38/00 , A61K38/36 , A61K38/43 , A61K38/48 , A61K38/55 , A61K38/57 , A61K45/00 , A61K47/48 , A61P3/14 , A61P7/02 , A61P7/04 , A61P39/02 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/64 , C12N9/74
CPC分类号： C12N9/6432 , A61K38/4833 , A61K38/4846 , A61K38/57 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/6429 , C12N9/647 , C12Y304/21005 , C12Y304/21006 , Y10S514/822
摘要： There is disclosed a pharmaceutical preparation for treating blood coagulation disorders which comprises purified prothrombinase factors, in particular purified prothrombin and optionally purified factor Xa as active component.
摘要翻译： 公开了一种用于治疗凝血障碍的药物制剂，其包括纯化的凝血酶原因子，特别是纯化的凝血酶原和可选地纯化的因子Xa作为活性成分。
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公开(公告)号：US6068838A
公开(公告)日：2000-05-30
申请号：US656589
申请日：1996-05-31
IPC分类号： A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/02 , A61P7/04 , C07K14/755 , C07K16/18 , C12N9/64 , C12Q1/37 , A61K38/48 , C12N9/48 , C12N9/50
CPC分类号： C07K14/755 , C12N9/6421 , A61K38/00 , Y10S435/814
摘要： There is disclosed a purified multimerase having an indirect and a direct proteolytic activity, which converts vWF having a singlet structure to vWF having a satellite structure and is active in the presence of the serine protease inhibitor DFP or the calpain protease inhibitor Z-Leu-Leu-Tyr-CHN.sub.2, as well as a method of preparing the multimerase according to the invention.
摘要翻译： 公开了具有间接和直接蛋白水解活性的纯化多聚甲基化酶，其将具有单重结构的vWF转化为具有卫星结构的vWF，并且在丝氨酸蛋白酶抑制剂DFP或钙蛋白酶蛋白酶抑制剂Z-Leu-Leu的存在下是有活性的 -Tyr-CHN2，以及制备根据本发明的多聚体酶的方法。
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公开(公告)号：US5877152A
公开(公告)日：1999-03-02
申请号：US898131
申请日：1997-07-22
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/47 , C07K14/755 , C12P21/00 , A61K38/17
CPC分类号： C07K14/755 , A61K38/00
摘要： The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity
摘要翻译： 本发明涉及一种用于分离高纯度血管性血友病因子的方法，其中重组血管性血友病因子（rvWF）通过阴离子交换色谱在季氨基型阴离子交换剂上在包含缓冲物质和任选盐的缓冲溶液中进行色谱纯化。 缓冲溶液优选不含稳定剂，氨基酸和其它添加剂。 根据该方法，可以获得高纯度的重组vWF，其不含血浆蛋白质，特别是不含因子VIII，且具有生理活性。 此外，本发明涉及含有rvWF的药物制剂，其由具有高结构完整性的多聚体组成
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公开(公告)号：US06224862B1
公开(公告)日：2001-05-01
申请号：US09521219
申请日：2000-03-08
申请人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
发明人： Peter Turecek , Hans-Peter Schwarz , Johann Eibl
IPC分类号： A61K3848
CPC分类号： C12N9/6432 , A61K38/4833 , A61K38/4846 , A61K38/57 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/6429 , C12N9/647 , C12Y304/21005 , C12Y304/21006 , Y10S514/822 , A61K2300/00
摘要： There is disclosed a pharmaceutical preparation for treating blood coagulation disorders which comprises purified prothrombinase factors, in particular purified prothrombin and optionally purified factor Xa as active component.
摘要翻译： 公开了一种用于治疗凝血障碍的药物制剂，其包括纯化的凝血酶原因子，特别是纯化的凝血酶原和可选地纯化的因子Xa作为活性成分。
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