公开(公告)号：US6102845A

公开(公告)日：2000-08-15

申请号：US192894

申请日：1994-02-07

申请人： John C. Woodard ,  Ronald A. Ness ,  Richard M. Romley ,  Than Nguyen ,  Herbert Chen

发明人： John C. Woodard ,  Ronald A. Ness ,  Richard M. Romley ,  Than Nguyen ,  Herbert Chen

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61M1/10 ,  A61M1/12 ,  A61M1/36

CPC分类号： A61M1/1037 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/3659 ,  A61F2/2412 ,  Y10S623/90

摘要： A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses. However, the sinuses of the inner wall member are configured to provide effective valve action by the formation of vigorous vortices in the blood flow downstream of these valves, and to avoid the formation of clots on the blood-contacting surfaces of the valved conduits.

摘要翻译： 心室辅助装置包括一对带阀的导管和通过这些导管连接到宿主患者的循环系统中的泵送部分。 泵送部分和带阀的导管被构造和构造成最小化血液在流过装置时必须穿过的材料 - 表面转变的数量。 此外，带阀的导管包括猪异种移植瓣膜，其外部由位于装置的血液接触流动路径外部的支架结构支撑。 阀门导管的柔性形状保持内壁构件不透血，但限定了可形成稳定的生物界面的多孔内表面。 此外，该内壁构件成形为不复制取出异种移植物瓣的猪窦或人主动脉窦的鼻窦。 然而，内壁构件的鼻窦构造成通过在这些瓣膜下游的血液流中形成剧烈旋涡来提供有效的瓣膜作用，并且避免在带阀导管的血液接触表面上形成凝块。

公开(公告)号：US5810708A

公开(公告)日：1998-09-22

申请号：US471438

申请日：1995-06-06

申请人： John C. Woodard ,  Ronald A. Ness ,  Richard M. Romley ,  Than Nguyen ,  Herbert Chen

发明人： John C. Woodard ,  Ronald A. Ness ,  Richard M. Romley ,  Than Nguyen ,  Herbert Chen

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61M1/10 ,  A61M1/12 ,  A61M1/36

CPC分类号： A61M1/1037 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/3659 ,  A61F2/2412 ,  Y10S623/90

摘要： A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses. However, the sinuses of the inner wall member are configured to provide effective valve action by the formation of vigorous vortices in the blood flow downstream of these valves, and to avoid the formation of clots on the blood-contacting surfaces of the valved conduits.

摘要翻译： 心室辅助装置包括一对带阀的导管和通过这些导管连接到宿主患者的循环系统中的泵送部分。 泵送部分和带阀的导管被构造和构造成最小化血液在流过装置时必须穿过的材料 - 表面转变的数量。 此外，带阀的导管包括猪异种移植瓣膜，其外部由位于装置的血液接触流动路径外部的支架结构支撑。 阀门导管的柔性形状保持内壁构件不透血，但限定了可形成稳定的生物界面的多孔内表面。 此外，该内壁构件成形为不复制取出异种移植物瓣的猪窦或人主动脉窦的鼻窦。 然而，内壁构件的鼻窦构造成通过在这些瓣膜下游的血液流中形成剧烈旋涡来提供有效的瓣膜作用，并且避免在带阀管道的血液接触表面上形成凝块。

公开(公告)号：US08858415B2

公开(公告)日：2014-10-14

申请号：US12764892

申请日：2010-04-21

申请人： Eduardo Chi Sing ,  George D. Hermann ,  Mark A. Cole ,  Mark A. Richart ,  Than Nguyen ,  Gail S. Lebovic

发明人： Eduardo Chi Sing ,  George D. Hermann ,  Mark A. Cole ,  Mark A. Richart ,  Than Nguyen ,  Gail S. Lebovic

IPC分类号： A61M36/12 ,  A61N5/10

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

公开(公告)号：US08747459B2

公开(公告)日：2014-06-10

申请号：US11952080

申请日：2007-12-06

申请人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

发明人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/915 ,  A61F2/93 ,  A61F2/95 ,  A61F2002/91591 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2250/0003 ,  A61F2250/0069

摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable prosthesis frame. The valve may be delivered transluminally or transmyocardially using a thorascopic or other limited access approach using a delivery catheter. Preferably, the initial partial expansion of the valve is performed against the native valve annulus to provide adequate anchoring and positioning of the valve as the remaining portions of the valve expand. The valve may be delivered using a retrograde or antegrade approach. When delivered using a retrograde approach, a delivery catheter with a pull-back sheath may be used, while antegrade delivery is preferably performed with a delivery catheter with a push-forward sheath that releases the proximal end of the valve first.

摘要翻译： 一种用于替换不足的自然瓣膜的假体瓣膜组件包括支撑在可扩张假体骨架上的置换瓣膜。 可以使用输送导管使用胸腔镜或其他有限的进入方法来平滑地或经心肌递送瓣膜。 优选地，阀的初始部分膨胀针对天然阀环执行，以在阀的剩余部分膨胀时提供阀的适当锚固和定位。 可以使用逆行或顺行方法来递送瓣膜。 当使用逆行方法递送时，可以使用具有拉回护套的递送导管，而顺侧递送优选地使用具有首先释放瓣的近端的推进护套的递送导管进行。

公开(公告)号：US20070106108A1

公开(公告)日：2007-05-10

申请号：US11276851

申请日：2006-03-16

申请人： George Hermann ,  Eduardo Chi Sing ,  Gail Lebovic ,  Mark Cole ,  Mark Ritchart ,  Than Nguyen

发明人： George Hermann ,  Eduardo Chi Sing ,  Gail Lebovic ,  Mark Cole ,  Mark Ritchart ,  Than Nguyen

IPC分类号： A61N5/00 ,  A61M36/00

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

公开(公告)号：US06283993B1

公开(公告)日：2001-09-04

申请号：US09085944

申请日：1998-05-27

申请人： Delos M. Cosgrove ,  Than Nguyen

发明人： Delos M. Cosgrove ,  Than Nguyen

IPC分类号： A61F224

CPC分类号： A61B17/0482 ,  A61B50/20 ,  A61B90/00 ,  A61F2/2445 ,  A61F2/2448 ,  A61F2/2466 ,  Y10S623/90 ,  Y10S623/904

摘要： An assembly for holding a substantially flexible suture guide of predetermined length in a substantially taut position used to achieve a suture line having a dimension equal to the length of the suture guide, such as the circumference about a heart valve annulus. The assembly includes a rigid suture guide holder having a surface against which the length of suture guide is releasably positioned. The guide holder can have a shape or geometry, such as a circumference or circumferential segment, equivalent to the shape or geometry of the intended suture line. The shape of the guide holder can therefore be selected to hold the suture guide in the shape most advantageous to placing the desired suture line. The assembly further includes a mechanism for releasably binding the suture guide to the surface of the holder and a detachable handle extendibly attached to the holder by means of a lanyard so that the handle can be detached to afford an unobstructed view of the surgical site, but cannot be removed from the surgical site until the holder has also been removed.

摘要翻译： 用于将大致柔性的缝合线引导件保持在基本拉紧的位置，用于实现具有等于缝合线引导件长度的缝合线的缝合线，例如围绕心脏瓣膜环的圆周。 该组件包括刚性缝合线引导器保持器，该保持器具有可缝合引导件的长度可释放地定位的表面。 引导保持器可以具有等同于预期缝合线的形状或几何形状的形状或几何形状，例如圆周或周向段。 因此，可以选择引导保持器的形状以将缝合线引导件保持为最有利于放置所需缝合线的形状。 组件还包括用于将缝合线引导件可释放地结合到保持器的表面的机构和通过挂绳可伸展地附接到保持器的可拆卸手柄，使得手柄可以被拆卸以提供手术部位的无障碍视图，但是 不能从外科手术部位移除，直到手术夹具也被移除。

公开(公告)号：US06245105B1

公开(公告)日：2001-06-12

申请号：US09207783

申请日：1998-12-09

申请人： Than Nguyen ,  Hung Ly Lam ,  Jianbo Zhou ,  Carlos M. Romero ,  Ralph Kafesjian ,  Xiaoming G. Guo ,  Van Le Huynh

发明人： Than Nguyen ,  Hung Ly Lam ,  Jianbo Zhou ,  Carlos M. Romero ,  Ralph Kafesjian ,  Xiaoming G. Guo ,  Van Le Huynh

IPC分类号： A61F224

CPC分类号： A61M25/0133 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2472 ,  Y10S623/90 ,  Y10S623/91 ,  Y10S623/913

摘要： Heart valve leaflet selection methods and apparatuses which subject individual leaflets to loads and measure the resulting deflection to more reliably group leaflets of similar physical characteristics for later assembly in prosthetic heart valves. The deflection testing may be accomplished using a variety of test set ups which are designed to impart a load on the leaflet which simulates the actual loading within a heart valve. The results from a number of deflection tests are used to categorize individual leaflets, which data can be combined with other data regarding the characteristics of the leaflet to better select leaflets for assembly into a multi-leaflet heart valve. In one embodiment, the deflection test is combined with an intrinsic load test, and leaflets having similar deflection and intrinsic load values used in the same heart valve. One apparatus for testing the leaflets includes a frame for securing the arcuate cusp of the leaflet while the straight coapting edge remains free, to simulate the actual leaflet mounting configuration within the heart valve prosthesis. The frame may include a lower portion having a recess for the leaflet and plurality of receptor holes around the peripheral edge of the recess, and an upper portion having a plurality of needles which extend downward through the leaflet and into the receptor holes and secure the edges of the leaflet.

摘要翻译： 心脏瓣膜小叶选择方法和装置，其使各个小叶负载并测量所得到的偏转以更可靠地组合具有类似物理特征的传单，以便以后在假体心脏瓣膜中组装。 偏转测试可以使用各种测试设置来实现，所述测试设置被设计成在模拟心脏瓣膜中的实际负载的小叶上施加负载。 许多偏转测试的结果被用于分类单独的单张，哪些数据可以与关于小叶特征的其他数据相结合，以更好地选择用于组装成多叶心脏瓣膜的小叶。 在一个实施例中，偏转测试与本征负载测试结合，并且具有在相同心脏瓣膜中使用的类似偏转和固有负载值的小叶。 用于测试传单的一种装置包括用于固定小叶的弓形尖点的框架，同时直线的平滑边缘保持游离，以模拟心脏瓣膜假体内的实际小叶安装配置。 框架可以包括具有用于小叶的凹部和围绕凹部的周边边缘的多个接收孔的下部，以及具有多个针的上部，所述多个针向下延伸穿过小叶并进入接收孔并固定边缘 的传单。

公开(公告)号：US5104407A

公开(公告)日：1992-04-14

申请号：US587486

申请日：1990-09-20

申请人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

发明人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

IPC分类号： A61F2/00 ,  A61F2/24

CPC分类号： A61F2/2448 ,  A61F2250/0018

摘要： An annuloplasty ring prosthesis which is formed from a selectively flexible body element having at least one defined length about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material through which sutures can be drawn to suture the prosthesis to the heart valve annulus.

摘要翻译： 瓣膜成形术假体由选择性柔性的身体元件形成，该身体元件具有围绕其圆周的至少一个限定长度，其基本上是刚性的。 身体元素的其余部分的灵活性逐渐增加。 身体元件是被设计成被缝合到心脏瓣膜的环的基本环形的身体元件。 身体元件由非腐蚀性的抗磁性材料形成，并且被包裹在材料中，通过该材料可以将缝线拉出以将假体缝合到心脏瓣膜环。

公开(公告)号：US09517131B2

公开(公告)日：2016-12-13

申请号：US14724424

申请日：2015-05-28

申请人： Than Nguyen

发明人： Than Nguyen

IPC分类号： A61F2/24

CPC分类号： A61F2/246 ,  A61F2/2412 ,  A61F2/2454 ,  A61F2230/0008 ,  A61F2230/0054 ,  A61F2230/0056

摘要： A cardiac valve repair device has a membrane assembly and a frame. The frame has a central structure that defines a central separation, a pair of sleeves positioned below the central structure, and a pair of atrial alignment expansion beams. Each atrial alignment expansion beam has a curved section and inner section at each opposite end that defines a scissor-crossing where they overlap each other to form a separate lower expansion clip beam at each of the opposite ends thereof. The cardiac valve repair device also includes a pair of upper expansion clip beams. A V-shaped ventricular expansion curved beam extends below the two sleeves, with the membrane assembly secured to the V-shaped ventricular expansion curved beam. A pair of ventricular alignment stabilizing beams extends downwardly from the two sleeves.

摘要翻译： 心脏瓣膜修复装置具有膜组件和框架。 框架具有限定中心分离的中心结构，位于中心结构下方的一对套筒和一对心房对准扩张梁。 每个心房对准扩张束具有弯曲部分和在每个相对端处的内部部分，其限定剪叉交叉，在那里它们彼此重叠，以在其相对端的每一端处形成单独的下部扩张夹子束。 心脏瓣膜修复装置还包括一对上部扩张夹子梁。 V形心室扩张弯曲梁在两个袖子的下方延伸，膜组件固定在V形心室扩张弯曲梁上。 一对心室对准稳定杆从两个袖子向下延伸。

公开(公告)号：US20090156882A1

公开(公告)日：2009-06-18

申请号：US12277286

申请日：2008-11-24

申请人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  George D. Hermann ,  Than Nguyen ,  Doug S. Sutton

发明人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  George D. Hermann ,  Than Nguyen ,  Doug S. Sutton

IPC分类号： A61N5/00 ,  A61M36/12

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。