-
公开(公告)号：US5071598A
公开(公告)日：1991-12-10
申请号：US448803
申请日：1989-12-11
CPC分类号： A01N1/02 , A01N1/0221 , C12N1/04 , Y10S514/971
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译： 提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰 。 还提供了使用该组合物的方法。
-
公开(公告)号：US4915951A
公开(公告)日：1990-04-10
申请号：US128152
申请日：1987-12-03
CPC分类号： A01N1/0221 , A01N1/02 , C12N1/04 , Y10S436/829 , Y10T428/2984
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译： 提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰 。 还提供了使用该组合物的方法。
-
公开(公告)号：US4931361A
公开(公告)日：1990-06-05
申请号：US273952
申请日：1988-11-18
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , Y10S436/829 , Y10S514/971 , Y10T428/2982
摘要： The ability of phosphoglyceride-containing membranes to withstand the disruptive effects of freezing, thawing, or freeze-drying is enhanced when treated with (a) a compound of the formula R-X-R.sub.1, wherein R is a lipid or lipophilic anchor, X is a hydrophilic linker group, and R.sub.1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid.
摘要翻译： 当使用（a）式RX-R1的化合物（其中R是脂质或亲脂性锚剂）处理时，含磷酸甘油酯的膜能够耐受冻结，解冻或冷冻干燥的破坏作用的能力增强，X是 亲水接头基团，R1是多元醇或碳水化合物基团，和（b）抗坏血酸。
-
公开(公告)号：US06169109A
公开(公告)日：2001-01-02
申请号：US09148238
申请日：1998-09-04
申请人： Sang Chul Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
发明人： Sang Chul Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
IPC分类号： A61K3135
CPC分类号： C12N7/00 , A61K35/16 , A61K35/19 , A61K38/00 , A61K41/0019 , A61K41/0057 , A61L2/0011 , A61L2/0035 , A61L2/0076 , A61L2/0082 , A61L2202/22 , C07K14/755 , C12N9/644 , C12N2710/16163 , C12N2710/16663 , C12N2740/16063 , C12N2760/20263 , C12N2770/36161 , C12N2770/36163 , C12Y304/21022
摘要： Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
摘要翻译： 生物溶液中存在的病毒和细菌污染物通过将新型光敏剂之一与所述溶液混合并照射混合物来灭活。
-
公开(公告)号：US6007978A
公开(公告)日：1999-12-28
申请号：US479975
申请日：1995-06-07
CPC分类号： A01N1/0221 , A01N1/02 , Y10T436/108331
摘要： A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
摘要翻译： 提供了一种用于冷冻的方法，包括使用冷冻保护剂介质冷冻干燥细胞，细胞膜或细胞样物质，所述冷冻保护剂介质使细胞或膜稳定，用于冷冻或冷冻干燥，并允许冷冻或冷冻干燥 -60℃以上。
-
公开(公告)号：US5958670A
公开(公告)日：1999-09-28
申请号：US260165
申请日：1994-06-15
IPC分类号： A01N1/02 , A61K35/14 , A61K35/15 , A61K35/16 , A61K35/18 , A61K35/19 , A61K35/28 , C12N5/00 , G01N31/00
CPC分类号： A01N1/0284 , A01N1/02 , A01N1/0221 , A61K35/15 , A61K35/16 , A61K35/19 , A61K35/28
摘要： A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
-
公开(公告)号：US5955256A
公开(公告)日：1999-09-21
申请号：US480271
申请日：1995-06-07
IPC分类号： A61K35/14 , A61K35/16 , A61K35/18 , A61K38/00 , A61K41/00 , A61L2/00 , C07K14/755 , C12N7/06 , C12N9/64 , A01N1/02 , C12N13/00
CPC分类号： C12N7/00 , A61K35/14 , A61K35/16 , A61K41/0019 , A61L2/0011 , A61L2/0035 , A61L2/0082 , C07K14/755 , C12N9/644 , C12Y304/21022 , A61K38/00 , C12N2795/10163
摘要： Viral, bacterial and parasitic contaminants in blood and cell culture containing compositions are inactivated by adding a photosensitizer and a blocking agent to the composition and irradiating the resulting mixture with electromagnetic radiation. Blocking agents reduce photolysis of the photosensitizer by mechanisms not involving the quenching of reactive oxygen species. The blocking agents reduce photolysis which occurs by ring opening. Preferred photosensitizers are quinoline or quinolone.
摘要翻译： 含有组合物的血液和细胞培养物中的病毒，细菌和寄生污染物通过向组合物中加入光敏剂和封闭剂而灭活，并用电磁辐射照射所得混合物。 封闭剂通过不涉及活性氧猝灭的机制来减少光敏剂的光解作用。 封闭剂可以减少开环产生的光解作用。 优选的光敏剂是喹啉或喹诺酮。
-
8.发明授权Method of detecting circulating antibody types using dried or lyophilized cells 失效使用干燥或冻干细胞检测循环抗体类型的方法
公开(公告)号：US5759774A
公开(公告)日：1998-06-02
申请号：US934448
申请日：1992-09-11
申请人： Roger W. Hackett , Raymond P. Goodrich, Jr. , Christine M. Williams , Jon A. Olson , Miller Cho , Richard F. Galle
发明人： Roger W. Hackett , Raymond P. Goodrich, Jr. , Christine M. Williams , Jon A. Olson , Miller Cho , Richard F. Galle
IPC分类号： A61K35/18 , G01N33/50 , G01N33/554 , G01N33/555 , A01N1/02 , C12N1/04
CPC分类号： G01N33/5005 , A61K35/18 , G01N33/554 , G01N33/555
摘要： A method is provided for qualitatively detecting in vitro the presence or absence of selected circulating antibody types using a diagnostic kit comprising reconstituted, after lyophilization or evaporative drying, red blood cell samples or other cell or cell-like material which have antigens which are recognized and bound by the selected antibody-type to be screened. Diagnostic kits containing the lyophilized blood samples according to the present invention have improved shelf life, and may comprise lyophilized samples packaged in a variety of forms convenient for manual single-test uses or automated multiple-test uses.
摘要翻译： PCT No.PCT / US92 / 00063 Sec。 371日期：1992年9月11日 102（e）1992年9月11日PCT PCT 1991年1月10日PCT公布。 公开号WO92 / 11864 日期1992年7月23日提供了一种使用诊断试剂盒在体外定性检测选择的循环抗体类型的存在或不存在的方法，所述诊断试剂盒包括在冷冻干燥或蒸发干燥后重构，红细胞样品或其它细胞或细胞样物质， 被筛选的所选抗体类型识别和结合的抗原。 包含根据本发明的冻干血液样品的诊断试剂盒具有改善的保存期限，并且可以包含以便于手动单次测试用途或自动多重测试用途的各种形式包装的冻干样品。
-
9.发明授权Storage solution containing photosensitizer for inactivation of biological contaminants 有权含有光敏剂的储存溶液用于灭活生物污染物公开(公告)号：US06548241B1
公开(公告)日：2003-04-15
申请号：US09725426
申请日：2000-11-28
IPC分类号： A01N102
CPC分类号： A61L2/0011 , A01N1/0215
摘要： A platelet/additive solution comprising bicarbonate, citrate and glucose. Additionally, a platelet/additive and treatment solution comprising bicarbonate, citrate, glucose and a photosensitizer.
摘要翻译： 包含碳酸氢盐，柠檬酸盐和葡萄糖的血小板/添加剂溶液。 另外，包含碳酸氢盐，柠檬酸盐，葡萄糖和光敏剂的血小板/添加剂和治疗溶液。
-
公开(公告)号：US5800978A
公开(公告)日：1998-09-01
申请号：US475835
申请日：1995-06-07
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0284 , Y10T436/108331
摘要： A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.028 秒)
