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公开(公告)号：US5071598A
公开(公告)日：1991-12-10
申请号：US448803
申请日：1989-12-11
CPC分类号： A01N1/02 , A01N1/0221 , C12N1/04 , Y10S514/971
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译： 提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰 。 还提供了使用该组合物的方法。
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公开(公告)号：US4915951A
公开(公告)日：1990-04-10
申请号：US128152
申请日：1987-12-03
CPC分类号： A01N1/0221 , A01N1/02 , C12N1/04 , Y10S436/829 , Y10T428/2984
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译： 提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰 。 还提供了使用该组合物的方法。
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公开(公告)号：US4931361A
公开(公告)日：1990-06-05
申请号：US273952
申请日：1988-11-18
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , Y10S436/829 , Y10S514/971 , Y10T428/2982
摘要： The ability of phosphoglyceride-containing membranes to withstand the disruptive effects of freezing, thawing, or freeze-drying is enhanced when treated with (a) a compound of the formula R-X-R.sub.1, wherein R is a lipid or lipophilic anchor, X is a hydrophilic linker group, and R.sub.1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid.
摘要翻译： 当使用（a）式RX-R1的化合物（其中R是脂质或亲脂性锚剂）处理时，含磷酸甘油酯的膜能够耐受冻结，解冻或冷冻干燥的破坏作用的能力增强，X是 亲水接头基团，R1是多元醇或碳水化合物基团，和（b）抗坏血酸。
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4.发明授权Method of preparing probes for sensing and manipulating microscopic environments and structures 失效制备用于感测和操纵微观环境和结构的探针的方法
公开(公告)号：US5824470A
公开(公告)日：1998-10-20
申请号：US453958
申请日：1995-05-30
IPC分类号： C01B33/18 , C12Q1/68 , G01B21/30 , G01N33/543 , G01Q60/24 , G01Q70/16 , C01B25/00 , G01N21/00 , G01N33/53
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/54373 , Y10S977/732 , Y10S977/742 , Y10S977/842 , Y10S977/86 , Y10S977/875 , Y10S977/877 , Y10S977/881
摘要： Probes for sensing and manipulating microscopic environments and structures, their method of preparation and methods of use are disclosed.
摘要翻译： 公开了用于感测和操纵微观环境和结构的探针，其制备方法和使用方法。
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公开(公告)号：US5527538A
公开(公告)日：1996-06-18
申请号：US83123
申请日：1993-06-25
CPC分类号： A61K51/1234 , A61K9/127 , A61K2123/00 , Y10S977/801 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/926 , Y10S977/927
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.
摘要翻译： 尺寸小于200纳米的脂质体靶向缺血性心肌组织，并且在不存在与脂质体结合的抗体以实现递送的情况下优先将活性剂递送至梗死区域。
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公开(公告)号：US5593688A
公开(公告)日：1997-01-14
申请号：US469292
申请日：1995-06-06
CPC分类号： A61K9/127 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10T428/2984
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas.
摘要翻译： 尺寸小于200纳米的脂质体靶向缺血性心肌组织，并优先将活性剂递送至梗死区域。
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公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译： 提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。 通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。
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8.发明授权Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 失效含有高浓度包埋离子物质的脂质体的制备和应用方法
公开(公告)号：US4310506A
公开(公告)日：1982-01-12
申请号：US123162
申请日：1980-02-20
CPC分类号： A61K51/1234 , A61K9/1278 , A61K2123/00 , Y10T428/2984
摘要： Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.
摘要翻译： 包含脂质双层的单层囊泡，掺入所述脂质双层中的离子载体，包封在囊泡内的螯合剂，以及与囊泡内的所述螯合剂结合的有效量的生理上相容的阳离子。 通过将囊泡与阳离子孵育来加载单层囊泡，终止孵育并通过色谱法回收加载的囊泡。 在本发明的一些应用中，阳离子可以是放射性示踪剂，在这种情况下，囊泡可以施用于人宿主并通过闪烁技术观察以产生可用于诊断目的的放射性图像。
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公开(公告)号：US6080586A
公开(公告)日：2000-06-27
申请号：US628875
申请日：1996-04-05
申请人： John D. Baldeschwieler , Jesse L. Beauchamp , Marcel Widmer , Stephen D. O'Connor , Dmitri Kossakovski
发明人： John D. Baldeschwieler , Jesse L. Beauchamp , Marcel Widmer , Stephen D. O'Connor , Dmitri Kossakovski
CPC分类号： G01Q30/02 , B82Y20/00 , B82Y35/00 , G01N1/4022 , G01Q60/22 , H01J49/0004 , H01J49/0463 , G01N1/44 , G01N2001/028 , G01N2001/045 , Y10S977/852 , Y10S977/862 , Y10T436/24 , Y10T436/25875
摘要： The present invention discloses an improved method and apparatus for analyzing the surface of materials using sub-micron laser desorption gas phase analysis. The method uses a combination of Near-field Optical Microscopy and Time-of Flight Mass Spectroscopy.
摘要翻译： 本发明公开了一种使用亚微米激光解吸气相分析分析材料表面的改进方法和装置。 该方法采用近场光学显微镜和飞行时间质谱联用。
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公开(公告)号：US5981733A
公开(公告)日：1999-11-09
申请号：US714867
申请日：1996-09-16
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译： 用于自动合成分子阵列的装置。 喷射装置与反应室一起使用以将合成中使用的试剂分配到基材上。 定位系统将基板从射流移动到反应室。 控制器控制衬底的移动和试剂的应用，使得根据预定程序进行合成。 该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。
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