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1.发明授权Method of preparing probes for sensing and manipulating microscopic environments and structures 失效制备用于感测和操纵微观环境和结构的探针的方法
公开(公告)号：US5824470A
公开(公告)日：1998-10-20
申请号：US453958
申请日：1995-05-30
IPC分类号： C01B33/18 , C12Q1/68 , G01B21/30 , G01N33/543 , G01Q60/24 , G01Q70/16 , C01B25/00 , G01N21/00 , G01N33/53
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/54373 , Y10S977/732 , Y10S977/742 , Y10S977/842 , Y10S977/86 , Y10S977/875 , Y10S977/877 , Y10S977/881
摘要： Probes for sensing and manipulating microscopic environments and structures, their method of preparation and methods of use are disclosed.
摘要翻译： 公开了用于感测和操纵微观环境和结构的探针，其制备方法和使用方法。
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公开(公告)号：US5527538A
公开(公告)日：1996-06-18
申请号：US83123
申请日：1993-06-25
CPC分类号： A61K51/1234 , A61K9/127 , A61K2123/00 , Y10S977/801 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/926 , Y10S977/927
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.
摘要翻译： 尺寸小于200纳米的脂质体靶向缺血性心肌组织，并且在不存在与脂质体结合的抗体以实现递送的情况下优先将活性剂递送至梗死区域。
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3.发明授权Labeling of molecules using the perturbed angular correlation of gamma radiation 失效使用伽马辐射的角度相关的分子标记
公开(公告)号：US3665192A
公开(公告)日：1972-05-23
申请号：US3665192D
申请日：1969-11-28
摘要： A method of studying molecular motion and orientation by labeling a molecule with a radio active tracer having a half life of an excited state generally comparable to the nuclear relaxation time in this state and measuring the rotational correlation time of a molecule from the perturbed angular correlation.
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公开(公告)号：US5593688A
公开(公告)日：1997-01-14
申请号：US469292
申请日：1995-06-06
CPC分类号： A61K9/127 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10T428/2984
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas.
摘要翻译： 尺寸小于200纳米的脂质体靶向缺血性心肌组织，并优先将活性剂递送至梗死区域。
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公开(公告)号：US5071598A
公开(公告)日：1991-12-10
申请号：US448803
申请日：1989-12-11
CPC分类号： A01N1/02 , A01N1/0221 , C12N1/04 , Y10S514/971
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译： 提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰 。 还提供了使用该组合物的方法。
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公开(公告)号：US6080586A
公开(公告)日：2000-06-27
申请号：US628875
申请日：1996-04-05
申请人： John D. Baldeschwieler , Jesse L. Beauchamp , Marcel Widmer , Stephen D. O'Connor , Dmitri Kossakovski
发明人： John D. Baldeschwieler , Jesse L. Beauchamp , Marcel Widmer , Stephen D. O'Connor , Dmitri Kossakovski
CPC分类号： G01Q30/02 , B82Y20/00 , B82Y35/00 , G01N1/4022 , G01Q60/22 , H01J49/0004 , H01J49/0463 , G01N1/44 , G01N2001/028 , G01N2001/045 , Y10S977/852 , Y10S977/862 , Y10T436/24 , Y10T436/25875
摘要： The present invention discloses an improved method and apparatus for analyzing the surface of materials using sub-micron laser desorption gas phase analysis. The method uses a combination of Near-field Optical Microscopy and Time-of Flight Mass Spectroscopy.
摘要翻译： 本发明公开了一种使用亚微米激光解吸气相分析分析材料表面的改进方法和装置。 该方法采用近场光学显微镜和飞行时间质谱联用。
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公开(公告)号：US5981733A
公开(公告)日：1999-11-09
申请号：US714867
申请日：1996-09-16
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译： 用于自动合成分子阵列的装置。 喷射装置与反应室一起使用以将合成中使用的试剂分配到基材上。 定位系统将基板从射流移动到反应室。 控制器控制衬底的移动和试剂的应用，使得根据预定程序进行合成。 该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。
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公开(公告)号：US4581222A
公开(公告)日：1986-04-08
申请号：US465360
申请日：1983-02-09
IPC分类号： G01N33/534 , A61K43/00 , G01T1/00
CPC分类号： G01N33/534 , Y10S436/804 , Y10S436/827
摘要： An immunoassay method for detection of antigen is disclosed. The method employs complement mediated lysis of vesicles loaded with In-111 or other gamma-emitting cation, and quantitative detection of the lysis by gamma-ray perturbed angular correlation (PAC) spectroscopy. The vesicles are labeled with a substance competitive to the antigen to be measured, and the concentration of the antigen in the sample measured by assessing the diminution in lysis due to the presence of the competing antigen.The method may also be used to assess the immunologic competence of a subject by injecting suitably sensitized vesicles and monitoring the in vivo lysis pattern by (PAC).
摘要翻译： 公开了一种用于检测抗原的免疫测定方法。 该方法使用负载有In-111或其他γ发射阳离子的囊泡的补体介导的裂解，以及通过γ射线扰动角度相关（PAC）光谱定量检测裂解。 囊泡用与要测量的抗原竞争的物质标记，并且通过评估由于竞争性抗原的存在引起的裂解减少来测量样品中抗原的浓度。 该方法还可以用于通过注射适当敏化的囊泡和通过（PAC）监测体内裂解模式来评估受试者的免疫能力。
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9.发明授权Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances 失效含有碳水化合物表面的脂质囊泡作为治疗和诊断物质的淋巴导向载体
公开(公告)号：US4310505A
公开(公告)日：1982-01-12
申请号：US92342
申请日：1979-11-08
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 1-thio-.alpha.-D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.beta.-D-galactopyranoside; or 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.alpha.-D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.
摘要翻译： 包含脂质双层的脂质囊泡，其包括细胞表面受体的类似物，例如磷酸二鲸蜡酯; 硬脂胺 6-（5-胆甾烯-3β-氧代）己基1-硫代-β-L-吡喃葡萄糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-α-D-吡喃甘露糖苷; 6-（5-胆甾烯-3-基氧基）己基2-乙酰氨基-2-脱氧-1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-β-D-吡喃半乳糖苷; 或6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-α-D-吡喃甘露糖苷; 胆固醇和二硬脂酰磷脂酰胆碱，以及有效量的生理相容的放射性示踪剂，细胞毒性剂或治疗剂作为囊泡的一部分。 本发明的囊泡可以施用于人宿主，并且已经被发现以预定的方式（即控制释放）释放囊泡的内容物，并且在一些情况下快速浓缩在淋巴系统和/或肝脏中 ，肺或脾脏的主机。
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公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译： 提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。 通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。
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