公开(公告)号：US5182513A

公开(公告)日：1993-01-26

申请号：US696456

申请日：1991-04-06

申请人： John D. Young ,  Kristina H. Hedengren ,  Donna C. Hurley

发明人： John D. Young ,  Kristina H. Hedengren ,  Donna C. Hurley

IPC分类号： G01N27/90 ,  G01R27/00

CPC分类号： G01R27/00 ,  G01N27/904 ,  G01N27/9046

摘要： The invention discloses an inspection system for detecting near surface flaws or defects in conductors using nondestructive eddy current testing suitable for industrial application. The system provides a method and apparatus for acquiring real time, synchronized, discrete eddy current measurement signals from a plurality of sufficiently disposed, spatially correlated eddy current probes then processing and formatting said measurement signals automatically over parallel data channels to accommodate digital processing techniques in order to produce on eddy current image. Utilizing digital image processing provides a capability for improving flaw detection limits while simultaneously enhancing image resolution.

摘要翻译： 本发明公开了一种用于检测适用于工业应用的非破坏性涡流测试的接近表面缺陷或导体缺陷的检测系统。 该系统提供了一种用于从多个充分放置的空间相关涡流探针获取实时，同步，离散的涡流测量信号的方法和装置，然后在并行数据通道上自动处理和格式化所述测量信号，从而按顺序适应数字处理技术 以涡流形象产生。 利用数字图像处理提供了改善探伤极限同时增强图像分辨率的能力。

公开(公告)号：US5006800A

公开(公告)日：1991-04-09

申请号：US431791

申请日：1989-11-06

申请人： Kristina H. V. Hedengren ,  Donna C. Hurley ,  John D. Young

发明人： Kristina H. V. Hedengren ,  Donna C. Hurley ,  John D. Young

IPC分类号： G01N27/82 ,  G01N27/90

CPC分类号： G01N27/9046 ,  G01N27/82

摘要： A phase-difference eddy current imaging system has a bridge circuit including a pair of coils with one or both coils disposed proximate an object that may contain one or more flaws. An oscillator is coupled to the bridge circuit and also to a pair of phase detectors that are coupled to the coils. A differential amplifier is coupled to the phase detectors for providing a comparison signal. A method for eddy current imaging using phase difference detection comprises providing relative movement between an object and at least one of a pair of coils, measuring the phase of the effective reactance in each of the coils, comparing the measured values, and formatting the compared values as a function of spatial position.

摘要翻译： 相位差涡流成像系统具有桥接电路，其包括一对线圈，其中一个或两个线圈设置在可能包含一个或多个缺陷的物体附近。 振荡器耦合到桥式电路，并且耦合到耦合到线圈的一对相位检测器。 差分放大器耦合到相位检测器以提供比较信号。 使用相位差检测的涡流成像方法包括提供物体与一对线圈中的至少一个线圈之间的相对运动，测量每个线圈中的有效电抗的相位，比较测量值和格式化比较值 作为空间位置的函数。

公开(公告)号：US5510709A

公开(公告)日：1996-04-23

申请号：US423489

申请日：1995-04-19

申请人： Donna C. Hurley ,  Robert S. Gilmore ,  John D. Young

发明人： Donna C. Hurley ,  Robert S. Gilmore ,  John D. Young

IPC分类号： G01N27/90 ,  G01N27/82

CPC分类号： G01N27/9013

摘要： An eddy current surface inspection array probe and method for detecting cracks and flaws in aircraft skin metal immediately surrounding rivets, without requiring rivet removal or manual scanning. The array probe includes a circular array of small sense coils positioned beneath a much larger drive coil encased in ferrite. The sense coils are differentially connected in pairs such that the signals from two sense coils located on opposite sides of the rivet (180.degree. apart) subtract to produce a resultant output signal. During operation, the probe is positioned concentrically over the rivet and data acquired from all sense coil pairs. If no cracks or other defects are present, all sense coil pairs produce a null (zero) signal. If a crack exists, some sense coil pairs (the exact number depending on the crack length, number of sense coils, and sense coil spacing) produce a non-zero signal. The probe and method can be employed to inspect a variety of other structural features which are nominally circularly symmetrical.

摘要翻译： 一种涡流表面检测阵列探头和方法，用于检测立即围绕铆钉的飞机皮肤金属中的裂纹和缺陷，无需拆除或手动扫描。 阵列探头包括位于铁氧体内包围的较大驱动线圈下面的小感测线圈的圆形阵列。 感测线圈成对地差分连接，使得来自位于铆钉（180°）相对侧上的两个感测线圈的信号减去以产生合成的输出信号。 在操作期间，探头同心地位于铆钉上，并从所有感测线圈对获得的数据。 如果没有出现裂纹或其他缺陷，则所有感测线圈对产生零（零）信号。 如果存在裂纹，则某些感测线圈对（根据裂纹长度，感测线圈数量和感测线圈间隔的精确数量）产生非零信号。 探头和方法可用于检查名义上圆形对称的各种其他结构特征。

公开(公告)号：US07108848B2

公开(公告)日：2006-09-19

申请号：US10894769

申请日：2004-07-20

申请人： John D. Young ,  Alberto Hoyo

发明人： John D. Young ,  Alberto Hoyo

IPC分类号： A61K8/00 ,  A61K8/18 ,  A61K9/00 ,  A61Q3/00 ,  A01N59/08

CPC分类号： A61K8/042 ,  A61K8/0291 ,  A61K8/25 ,  A61K9/7015 ,  A61K35/08 ,  A61Q3/00

摘要： A gel formulation is combined with a fungicidal concentrate which is a liquid mixture of about 1.2 to 16 ml parts by volume of ultra pure water having an electrical resistance of 16–26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 16 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943, together with one liter of a gel formulation ingredient containing 10% by weight urea, based on the weight of the gel formulation. The fungicidal liquid concentrate is applied directly to a fungal nail to soften the fungal nail and control the growth of fungi.

摘要翻译： 将凝胶制剂与杀真菌浓缩物组合，所述杀真菌浓缩物是约1.2至16ml体积的电阻为16-26兆欧的超纯水的液体混合物，总溶解固体小于0.04百万分率的特定 电导小于0.10毫摩尔，约1.2至16体积份的Willard水按照美国专利No. 连同1升含有10重量％尿素的凝胶制剂成分，基于凝胶制剂的重量。 将真菌液体浓缩物直接施用于真菌指甲，以软化真菌指甲并控制真菌的生长。

公开(公告)号：US6003305A

公开(公告)日：1999-12-21

申请号：US922176

申请日：1997-09-02

申请人： Richard J. Martin ,  John D. Stilger ,  Mark R. Holst ,  John D. Young ,  Michael P. Barkdoll ,  Bradley L. Edgar

发明人： Richard J. Martin ,  John D. Stilger ,  Mark R. Holst ,  John D. Young ,  Michael P. Barkdoll ,  Bradley L. Edgar

IPC分类号： B01D53/94 ,  F01N3/01 ,  F01N3/023 ,  F01N3/025 ,  F01N3/037 ,  F01N3/20 ,  F01N3/26 ,  F01N3/28 ,  F01N9/00 ,  F01N13/02 ,  F01N3/00

CPC分类号： F01N9/002 ,  B01D53/9431 ,  F01N13/0097 ,  F01N3/0253 ,  F01N3/027 ,  F01N3/035 ,  F01N3/037 ,  F01N3/26 ,  F01N3/2882 ,  F01N2240/02 ,  F01N2240/16 ,  F01N2330/08 ,  F01N2610/02 ,  F01N2610/03 ,  Y02T10/24 ,  Y02T10/47

摘要： A process is provided for preparing oxymorphone from morphine by:(1) reacting morphine with (1a) an acyl halide or anhydride to form 3-acylmorphine, or (1b) reacting morphine with benzyl-halide to form 3-benzylmorphine;(2) Oxidizing the 6-hydroxy group of the 3-acyl or 3-benzylmorphine so as to form the corresponding 3-acyl or 3-benzylmorphinone; and thereafter either by (3a) or (3b):(3a) introducing a .beta.-oriented hydroxy group at the 14-position of the 3-acyl- or 3-benzyl-morphinone with aqueous hydrogen peroxide and an acid at a temperature of about 15.degree. to about 70.degree. C. to form the 3-acyl or 3-benzyl-14-hydroxymorphinone;(3b) acylating the 3-acyl or 3-benzyl-morphinone with an acylating agent so as to form the dienol acylate followed by oxidizing the dienol acetate to the corresponding 3-acyl or 3-benzyl-14 -hydroxymorphinone;(4) hydrogenating the 3-acyl-14-hydroxymorphinone with a catalyst so as to form the 3-acyloxymorphone;(5) hydrolyzing the 3-acyl-oxymorphone with aqueous acidic or basic solution to form oxymorphone;(6) hydrogenating the 3-benzyl-14-hydroxymorphinone with a catalyst so as to form oxymorphone.

摘要翻译： 提供了通过以下步骤制备吗啡的羟吗啡酮的方法：（1）吗啡与（1a）酰卤或酸酐反应形成3-酰基吗啡，或（1b）使吗啡与苄基卤反应形成3-苄基吗啡; （2）氧化3-酰基或3-苄基吗啡的6-羟基，形成相应的3-酰基或3-苄基吗啡酮; 然后通过（3a）或（3b）：（3a）在3-酰基 - 或3-苄基 - 吗啡酮的14位上引入β-取代的羟基与过氧化氢水溶液和酸在 约15℃至约70℃，以形成3-酰基或3-苄基-14-羟基吗啡酮; （3b）用酰化剂酰化3-酰基或3-苄基吗啡酮，以形成二烯醇酰化物，然后将乙酸烯醇氧化成相应的3-酰基或3-苄基-14-羟基吗啡酮; （4）用催化剂氢化3-酰基-14-羟基吗啡酮以形成3-酰氧基吗啡酮; （5）用酸性或碱性水溶液水解3-酰基羟基吗啡酮以形成羟吗啡酮; （6）用催化剂氢化3-苄基-14-羟基吗啡酮以形成羟吗啡酮。

公开(公告)号：US5153265A

公开(公告)日：1992-10-06

申请号：US576415

申请日：1990-08-30

申请人： Paula J. Shadle ,  Kirston E. Koths ,  Margaret Moreland ,  Nandini Katre ,  Walter J. Laird ,  Lois Aldwin ,  Danute E. Nitecki ,  John D. Young

发明人： Paula J. Shadle ,  Kirston E. Koths ,  Margaret Moreland ,  Nandini Katre ,  Walter J. Laird ,  Lois Aldwin ,  Danute E. Nitecki ,  John D. Young

IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K14/53

CPC分类号： A61K47/48215 ,  A61K47/48176 ,  C07K14/53 ,  A61K38/00

摘要： A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.

摘要翻译： PCT No.PCT / US89 / 00270 Sec。 371日期1990年8月30日 102（e）1990年8月30日PCT PCT 1989年1月23日提交PCT生物活性CSF-1蛋白通过某些氨基酸残基或碳水化合物部分选择性地与选自聚乙二醇或聚丙二醇均聚物的水溶性聚合物 ，聚氧乙烯化多元醇或聚乙烯醇。 与未缀合的蛋白质相比，得到的共轭CSF-1具有生物活性并且在哺乳动物中具有增加的循环半衰期。 缀合的CSF-1可用于刺激免疫应答或提供更多待刺激的细胞。

公开(公告)号：US06416790B1

公开(公告)日：2002-07-09

申请号：US09524493

申请日：2000-03-13

申请人： John D. Young

发明人： John D. Young

IPC分类号： A61K900

CPC分类号： A61K9/1075 ,  A61K33/14 ,  Y10S424/13 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/964 ,  Y10S514/975 ,  A61K2300/00

摘要： The concentrate is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 microhmo to about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The liquid concentrate is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.

摘要翻译： 浓缩物是约1000体积份的电阻为16-26兆欧的超纯水的液体混合物，总溶解固体含量小于0.04ppm，比电导小于0.10微摩尔至约1.2至3 Willard Water的体积份数按照美国专利 3,893,943号。 将液体浓缩物直接施用于具有烧伤或其它皮肤病变的皮肤表面区域，以保护该区域免受细菌污染。

公开(公告)号：US5830452A

公开(公告)日：1998-11-03

申请号：US273364

申请日：1994-07-11

申请人： Robert J. Bauer ,  Jeffrey L. Winkelhake ,  John D. Young ,  Robert Zimmerman

发明人： Robert J. Bauer ,  Jeffrey L. Winkelhake ,  John D. Young ,  Robert Zimmerman

IPC分类号： A61K38/20 ,  A61K45/05

CPC分类号： A61K38/2013

摘要： The present application relates to a method for enhancing the therapeutic index of a compound that is useful to treat tumors. More specifically, the present invention relates to a method for administering IL-2 to a tumor patient to maximize the therapeutic efficacy and minimize the toxicity.

摘要翻译： 本申请涉及增强可用于治疗肿瘤的化合物的治疗指数的方法。 更具体地，本发明涉及向肿瘤患者施用IL-2以使治疗功效最大化并使毒性最小化的方法。

公开(公告)号：US5063779A

公开(公告)日：1991-11-12

申请号：US524415

申请日：1990-05-17

申请人： James D. Landry ,  Mark A. Joyce ,  John D. Young ,  Robert S. Gilmore ,  Frederick C. Schoenig, Jr.

发明人： James D. Landry ,  Mark A. Joyce ,  John D. Young ,  Robert S. Gilmore ,  Frederick C. Schoenig, Jr.

IPC分类号： G01N29/11 ,  G01N29/30 ,  G21C17/06

CPC分类号： G01N29/30 ,  G01N29/11 ,  G21C17/06 ,  G01N2291/044 ,  G01N2291/2634 ,  G01N2291/2675

摘要： Nuclear fuel cladding tube end plug welds are ultrasonically scanned to develop data indicative of weld thickness, weld penetration, and the existence and size of any included feature, such as pores. A computer analyzes the data to determine critical weld characteristics which are then tested against established quality assurance standards to see if the end plug weld is acceptable, all on an automated production line basis.

摘要翻译： 超声波扫描核燃料包覆管端塞焊缝，以形成指示焊缝厚度，焊缝穿透度以及所包含的特征（如孔隙）的存在和尺寸的数据。 计算机分析数据以确定关键的焊接特性，然后根据既定的质量保证标准进行测试，以查看终端焊缝是否可接受，全部采用自动化生产线。

公开(公告)号：US5006801A

公开(公告)日：1991-04-09

申请号：US360687

申请日：1989-06-02

申请人： John D. Young

发明人： John D. Young

IPC分类号： G01N27/90

CPC分类号： G01N27/9046

摘要： The present invention is an inspection instrument of the type which reacts to induced eddy currents in a workpiece to be inspected and includes a probe having at least a first probe coil. The instrument further includes a bridge circuit having the first probe coil connected in a first bridge arm. The bridge circuit also has input and output terminals. Connecting cable connects the instrument to a remote signal interpretation unit, and individual buffers connected between each of the output terminals and the cable isolate the capacitive of the cable from the bridge circuit.

摘要翻译： 本发明是一种对要检测的工件中的感应涡流产生反应的类型的检查仪器，并且包括具有至少第一探针线圈的探针。 该仪器还包括具有连接在第一桥臂中的第一探针线圈的桥接电路。 桥接电路还具有输入和输出端子。 连接电缆将仪器连接到远程信号解释单元，并且连接在每个输出端子和电缆之间的各个缓冲器将电缆的电容与桥接电路隔离。