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公开(公告)号：US5611458A
公开(公告)日：1997-03-18
申请号：US435357
申请日：1995-05-05
CPC分类号： A61M5/16809 , G01F11/086
摘要： A method and apparatus are provided for controlling the dispensing of a primary liquid from a pressurized source of primary liquid. Primary liquid is admitted through an inlet valve to a primary chamber having a primary element which is biased toward an initial position but is movable away from the initial position when subjected to the source pressure of the primary liquid. A sensor determines when the primary element has moved away from an initial position to a predetermined final position, and the inlet valve is closed in response thereto. The difference between the initial and final positions defines a predetermined dispensing volume. An outlet valve is opened to dispense the dispensing volume under the biasing force of the primary element which returns to the initial position. A sensor determines when the primary element has returned to the initial position, and the outlet valve is closed in response thereto.
摘要翻译： 提供了一种用于控制从主要液体的加压源分配初级液体的方法和装置。 初级液体通过入口阀进入主腔室，该主腔室具有朝向初始位置偏压的主要元件，但是当经受初级液体的源压力时可移动离开初始位置。 传感器确定主元件何时已经从初始位置移动到预定的最终位置，并且入口阀响应于此而关闭。 初始位置和最终位置之间的差异限定了预定的分配体积。 打开出口阀，以在初始位置的初级元件的偏置力下分配分配容积。 传感器确定主元件何时返回到初始位置，并且出口阀响应于此而关闭。
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2.发明授权Recirculation through plural pump cassettes for a solution compounding apparatus 失效通过用于溶液复合设备的多个泵盒再循环
公开(公告)号：US5306242A
公开(公告)日：1994-04-26
申请号：US991066
申请日：1992-12-15
申请人： Thomas P. Joyce , John S. Ziegler
发明人： Thomas P. Joyce , John S. Ziegler
CPC分类号： A61J3/002 , Y10T137/85954 , Y10T137/86107 , Y10T137/86139
摘要： An apparatus and method are disclosed for compounding of parenteral admixture solutions, and recirculation with the admixture solution being formed. The apparatus includes a multiple pump cassette configured for operative association with a pump driver, whereby one or more selected source solutions are delivered through a pump cassette to an associated admixture container. After pumping of each source solution, the present method contemplates that the admixture being formed is recirculated through the pump cassettes thereby diluting any source solution in the cassettes and associated tubing. In this manner, the possible mixture of incompatible source solutions, resulting in formation of precipitate, is desirably avoided.
摘要翻译： 公开了用于混合肠胃外混合溶液的装置和方法，以及与形成的混合溶液的再循环。 该设备包括配置为与泵驱动器操作关联的多泵盒，由此将一个或多个选定的源解决方案通过泵盒输送到相关联的混合容器。 在泵送每种源溶液之后，本方法设想所形成的混合物通过泵盒再循环，从而稀释盒和相关管道中的任何源溶液。 以这种方式，希望避免导致形成沉淀物的不相容的源溶液的可能混合物。
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公开(公告)号：US5171214A
公开(公告)日：1992-12-15
申请号：US634275
申请日：1990-12-26
CPC分类号： A61J1/2096 , A61M5/2429 , A61J1/201 , A61J1/2013 , Y10S604/905
摘要： A drug storage and delivery system that includes a drug containing vial assembly, a syringe assembly, and an adapter assembly for attaching the vial assembly to the adapter assembly. The vial assembly includes a vial that is provided with a pierceable stopper and a skirt member that circumscribes the outside of the vial. The syringe assembly includes a cannula extending longitudinally therethrough. The adapter assembly attaches the vial assembly to the syringe assembly in a manner that permits communication between the interior of the vial and the cannula extending through the syringe. The system also permits attachment of the syringe assembly to a container filled with a diluent and means for delivering the diluent into the vial assembly and subsequently directing the mixed solution back into the container.
摘要翻译： 药物储存和递送系统，其包括药物容器组件，注射器组件和用于将小瓶组件附接到适配器组件的适配器组件。 小瓶组件包括设置有可刺穿塞子和围绕小瓶外部的裙部构件的小瓶。 注射器组件包括纵向延伸穿过其中的套管。 适配器组件以允许小瓶内部和延伸穿过注射器的插管之间的连通的方式将小瓶组件附接到注射器组件。 该系统还允许将注射器组件连接到填充有稀释剂的容器和用于将稀释剂输送到小瓶组件中并随后将混合溶液引导回容器的装置。
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公开(公告)号：US09205026B2
公开(公告)日：2015-12-08
申请号：US13827884
申请日：2013-03-14
IPC分类号： A61B19/00 , A61J1/20 , A61J1/14 , B65D51/00 , B65D75/58 , B65D81/32 , B65B3/00 , A61J1/10 , A61M39/00
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A medicament container having an opening that provides access to a cavity defined by the medicament container. A stopper is sealingly positioned within the opening of the medicament container and configured to be forced into the cavity to open the medicament container. The medicament container also includes a mating member configured to mate with a complementary receiver associated with a second container to connect the medicament container to a second container. The medicament container further includes a radial seal configured to engage and seal against an interior seal wall associated with a second container prior to the stopper being forced into the cavity defined by the medicament container. A system is also provided for establishing fluid communication between a first container and a second container. The system includes a first container (e.g., a medicament container) having a radial seal, a second container, and a port assembly.
摘要翻译： 一种具有开口的药物容器，该开口提供对由药物容器限定的空腔的通路。 塞子被密封地定位在药物容器的开口内并构造成被迫进入空腔以打开药物容器。 药物容器还包括配合构件，其配置成与与第二容器相关联的补充接收器配合，以将药物容器连接到第二容器。 药物容器还包括径向密封件，其构造成在止动器被迫进入由药物容器限定的空腔之前与第二容器相关联的内部密封壁接合并密封。 还提供了一种用于建立第一容器和第二容器之间的流体连通的系统。 该系统包括具有径向密封件，第二容器和端口组件的第一容器（例如，药物容器）。
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5.发明授权公开(公告)号：US08523797B2
公开(公告)日：2013-09-03
申请号：US12435074
申请日：2009-05-04
申请人： Michael G. Lowery , Marwan A. Fathallah , John S. Ziegler , Ryan R. Brumund , Brian Barclay , Frank J. Walsworth , James D. Jacobson , Yei Feng Moy , Thomas D. Johnson
发明人： Michael G. Lowery , Marwan A. Fathallah , John S. Ziegler , Ryan R. Brumund , Brian Barclay , Frank J. Walsworth , James D. Jacobson , Yei Feng Moy , Thomas D. Johnson
IPC分类号： A61M37/00 , A61M1/30 , A61M1/00 , A61M31/00 , A61M5/00 , A61M35/00 , A61B10/00 , A61D5/00 , B65D81/00
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/1486 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/15087 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14228
摘要： A point of care fluid testing system for determining properties of a fluid comprises a patient connection, a primary fluid routing portion, a pump, a secondary fluid routing portion, and a flushing fluid connection. The patient connection connects the system to a patient. The primary fluid routing portion has a pump region, a fluid transfer region, and an in-line testing region. The pump region pumps the fluid sample from the patient to the testing portion and back to the patient. The in-line testing region evaluates a first characteristic of the fluid sample. The fluid transfer region transmits a portion of the fluid sample out of the primary fluid routing portion. The secondary fluid routing portion includes an off-line testing portion that receives the portion of the fluid sample transmitted from the fluid transfer region. The off-line testing portion evaluates a second characteristic of the fluid sample.
摘要翻译： 用于确定流体性质的护理液测试系统的一个点包括患者连接，主要流体路由部分，泵，次要流体路线部分和冲洗流体连接。 患者连接将系统连接到患者。 主流体路线部分具有泵区域，流体转移区域和在线测试区域。 泵区域将流体样品从患者泵送到测试部分并返回到患者体内。 在线测试区域评估流体样品的第一特性。 流体转移区域将一部分流体样品从主流体路线部分传出。 次流体路线部分包括离线测试部分，其接收从流体传送区域传送的流体样本的一部分。 离线测试部分评估流体样品的第二特性。
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6.发明授权Differential pressure based flow sensor assembly for medication delivery monitoring and method of using the same 有权用于药物输送监测的基于差压的流量传感器组件及其使用方法公开(公告)号：US08403908B2
公开(公告)日：2013-03-26
申请号：US12335128
申请日：2008-12-15
申请人： James D. Jacobson , Brian Barclay , Ryan Brumund , Steven T. Cho , Hrishikesh Choudhury , Marwan A. Fathallah , Tom Johnson , Patrick B. Keely , Mohammad M. Khair , Michael G. Lowery , Frank Walsworth , John S. Ziegler
发明人： James D. Jacobson , Brian Barclay , Ryan Brumund , Steven T. Cho , Hrishikesh Choudhury , Marwan A. Fathallah , Tom Johnson , Patrick B. Keely , Mohammad M. Khair , Michael G. Lowery , Frank Walsworth , John S. Ziegler
CPC分类号： A61M5/172 , A61M5/16804 , A61M5/16854 , A61M5/16886 , G01F1/42
摘要： A differential pressure based flow sensor assembly and method of using the same to determine the rate of fluid flow in a fluid system. The sensor assembly comprises a disposable portion, and a reusable portion. A flow restricting element is positioned along a fluid flow passage between an inlet and an outlet. The disposable portion further has an upstream fluid pressure membrane and a downstream fluid pressure membrane. The reusable portion has an upstream fluid pressure sensor and a downstream fluid pressure sensor. The upstream fluid pressure sensor senses the upstream fluid pressure at a location within the fluid flow passage between the inlet and the flow restricting element. The downstream fluid pressure sensor senses the downstream fluid pressure at a location within the fluid flow passage between the flow restricting element and the outlet. The process utilizes output of the sensors to calculate the flow rate of the fluid.
摘要翻译： 一种基于压差的流量传感器组件及其使用方法来确定流体系统中的流体流速。 传感器组件包括一次性部分和可重复使用的部分。 流动限制元件沿着入口和出口之间的流体流动通道定位。 一次性部分还具有上游流体压力膜和下游流体压力膜。 可再利用部分具有上游流体压力传感器和下游流体压力传感器。 上游流体压力传感器感测在入口和流动限制元件之间的流体流动通道内的位置处的上游流体压力。 下游流体压力传感器感测流量限制元件和出口之间的流体流动通道内的位置处的下游流体压力。 该过程利用传感器的输出来计算流体的流量。
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公开(公告)号：US07758560B2
公开(公告)日：2010-07-20
申请号：US11490903
申请日：2006-07-21
申请人： Edward G. Connell , Marwan Fathallah , Kenneth A. Hsu , John Norman , William L. Rudzena , Karl J. Sprague , John S. Ziegler
发明人： Edward G. Connell , Marwan Fathallah , Kenneth A. Hsu , John Norman , William L. Rudzena , Karl J. Sprague , John S. Ziegler
CPC分类号： A61J1/20 , A61J1/201 , A61J1/2055 , A61J1/2072 , A61J1/2096 , A61M5/162 , A61M39/26 , A61M2039/267
摘要： A method and system for handling hazardous materials contained in a vial includes an isolation enclosure having an opening selectively sealable about the vial, a bag body portion, and a cap portion. A latching extraction element is attached to the cap portion and has a preceding engaging member to secure the vial to the isolation enclosure, an extraction member to be inserted into the vial and remove material therefrom, and a primary engaging member to secure the vial to the extraction member. A valve is mounted outside the isolation enclosure and controls the flow of fluid from the vial. An adaptor having a reseal member permits flow when coupled to the valve and restricts flow when uncoupled from the valve. Once uncoupled, the adaptor is removably associated with a second valve located remotely from the isolation enclosure, allowing fluid to pass into the second valve.
摘要翻译： 用于处理容纳在小瓶中的有害物质的方法和系统包括隔离罩，其具有可围绕小瓶选择性密封的开口，袋体部分和帽部分。 闩锁提取元件附接到盖部分并且具有先前的接合构件以将小瓶固定到隔离外壳，提取构件被插入到小瓶中并从中移除材料，以及主接合构件以将小瓶固定到 提取成员。 阀门安装在隔离罩外部，并控制流体从瓶中流出。 具有重新密封构件的适配器在连接到阀时允许流动，并且当与阀脱离时限制流动。 一旦脱开，适配器可移除地与位于远离隔离外壳的第二阀相关联，允许流体进入第二阀。
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8.发明申请公开(公告)号：US20090053071A1
公开(公告)日：2009-02-26
申请号：US12194685
申请日：2008-08-20
CPC分类号： A61M5/16831 , A61M5/365 , G06F19/00
摘要： A method and pump that accurately senses air in a fluid delivery line pulses or activates and deactivates the air sensor(s) multiple times during the pumping phase of the fluid delivery cycle and can generate alarms based upon a single indication or a cumulative indication of air in the line. The pump can include multiple air sensors spaced along the delivery line so that the method can use the multiple signals therefrom to distinguish real moving air bubbles from false positives and/or air bubbles adhered to the inner wall of the line.
摘要翻译： 精确地感测流体输送管线中的空气的方法和泵在流体输送循环的泵送阶段期间脉冲或激活和停用空气传感器多次，并且可以基于空气的单一指示或累积指示产生报警 在线 泵可以包括沿着输送管线间隔开的多个空气传感器，使得该方法可以使用其中的多个信号来区分真实移动的气泡与粘附到管线的内壁上的假阳性和/或气泡区分开。
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公开(公告)号：USD515205S1
公开(公告)日：2006-02-14
申请号：US29201365
申请日：2004-03-15
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公开(公告)号：US06267154B1
公开(公告)日：2001-07-31
申请号：US09092516
申请日：1998-06-05
IPC分类号： A61J100
CPC分类号： A61J1/2096 , A61J1/2075 , A61J1/2082
摘要： A container for holding a concentrated drug for a mixing system includes a barrel with a cover structure including a delivery passage at a first end and a closing structure at an opposite, second end. A female Luer lock fitting defines the delivery passage at the first end. The closing structure and the female Luer lock fitting can each be formed integrally with the barrel, or the closing structure can be a slidable stopper. The closing structure may also include a holder. The holder is constructed to move between two positions. In the first position, the holder is in a elevated position on the second end of the barrel. The barrel can vent vapor around the cover piece. In the second position, the holder is depressed onto the barrel and it cannot vent vapor. The cover structure may include a snap-on cover piece to fit over the first end. The cover piece includes the female luer lock fitting. The cover piece functions similar to the holder. The container can be used in a mixing system which includes a diluent syringe with a barrel having a discharge passage at a first end, and a piston slidably and sealingly disposed in the diluent syringe barrel to define a diluent chamber adjacent the discharge passage. The syringe includes a male Luer lock fitting at its first end for releasably connecting to the female Luer lock fitting of the container. Diluent can be passed from the syringe into the container to mix with the concentrated drug and the resultant mixture can then be drawn from the container for administering to a patient.
摘要翻译： 用于保持用于混合系统的浓缩药物的容器包括具有盖结构的桶，其包括在第一端处的输送通道和在相对的第二端处的封闭结构。 女性Luer锁配件在第一端定义了输送通道。 闭合结构和阴式鲁尔锁定配件可以与筒形成一体，或者闭合结构可以是可滑动的止动件。 闭合结构还可以包括支架。 支架被构造成在两个位置之间移动。 在第一位置，保持器处于桶的第二端的升高位置。 桶可以在盖件周围排放蒸汽。 在第二位置，保持器被压在筒上并且不能排出蒸气。 盖结构可以包括适配在第一端上的卡扣盖。 盖件包括女性鲁尔锁配件。 盖件的功能类似于支架。容器可用于混合系统，该混合系统包括具有在第一端具有排放通道的桶的稀释注射器和可滑动并密封地设置在稀释注射器筒中的活塞， 稀释剂室邻近排放通道。 注射器包括在其第一端的公Luer锁定配件，用于可释放地连接到容器的母Luer锁定配件。 稀释剂可以从注射器进入容器以与浓缩的药物混合，然后从容器中抽出所得的混合物，以便给予患者。
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