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108 条记录 (耗时 0.045 秒)

    Cell surface protein compounds
    5.
    发明授权
    Cell surface protein compounds 失效
    细胞表面蛋白质化合物

    公开(公告)号：US06299880B1

    公开(公告)日：2001-10-09

    申请号：US09366575

    申请日：1999-08-04

    申请人： John Edward Hodgson ,  Martin Karl Russell Burnham

    发明人： John Edward Hodgson ,  Martin Karl Russell Burnham

    IPC分类号： A61K3902

    CPC分类号： C07K14/31 ,  A61K39/00 ,  A61K48/00

    摘要： Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.

    摘要翻译： 公开了新型细胞表面蛋白多肽和编码这种新型细胞表面蛋白质的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种新型细胞表面蛋白质治疗感染，特别是细菌感染的方法。 还公开了抗这种新型细胞表面蛋白的拮抗剂及其作为治疗感染特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中新型细胞表面蛋白核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码细胞表面蛋白家族的多核苷酸并用于检测宿主中的多肽的诊断测定。

    TCTS response regulator
    9.
    发明授权
    TCTS response regulator 失效
    TCTS响应调节器

    公开(公告)号：US06217862B1

    公开(公告)日：2001-04-17

    申请号：US09354040

    申请日：1999-07-15

    申请人： John Edward Hodgson ,  Nicola Gail Wallis

    发明人： John Edward Hodgson ,  Nicola Gail Wallis

    IPC分类号： A61K3843

    CPC分类号： C07K14/31 ,  A61K38/00

    摘要： Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.

    摘要翻译： 公开了新型的响应调节剂多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸和多肽治疗感染，特别是细菌感染的方法。 还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染，特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。 还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。