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1.发明申请Treatment Of Diabetic Patients With A Drug Eluting Stent And A Drug Coated Balloon 审中-公开治疗糖尿病患者药物洗脱支架和药物涂层气球公开(公告)号：US20130261723A1
公开(公告)日：2013-10-03
申请号：US13436662
申请日：2012-03-30
CPC分类号： A61K31/427 , A61F2/958 , A61F2250/0067 , A61K45/06 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/61 , A61M25/104 , A61M2025/0183 , A61M2025/105 , A61K2300/00
摘要： Embodiments of the present invention include methods for the treatment, prevention, or amelioration of vascular disease and/or disorder in diabetic patients. The methods include implantation of a stent including a drug, and the use of a drug coated balloon. The DES may be a DES having a metal body and a coating including the drug, or a bioabsorbable stent with drug in the body of the stent, in a coating on the stent, or both in the body of the stent and in a coating on the stent.
摘要翻译： 本发明的实施方案包括治疗，预防或改善糖尿病患者血管疾病和/或病症的方法。 所述方法包括植入包括药物的支架以及使用药物涂覆的气囊。 DES可以是具有金属体和包含药物的涂层，或者在支架的体内具有药物的生物可吸收支架，在支架的涂层中，或者在支架的主体中以及涂层中的涂层 支架
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2.发明申请Treatment Of Diabetic Patients With A Drug Eluting Stent And Adjunctive Therapy 有权治疗糖尿病患者药物洗脱支架和辅助治疗公开(公告)号：US20130224255A1
公开(公告)日：2013-08-29
申请号：US13403709
申请日：2012-02-23
IPC分类号： A61F2/82 , A61K31/426 , A61K31/4709 , A61K31/4365 , A61K31/519 , A61P7/00 , A61K31/573 , A61K31/565 , A61K38/44 , A61K31/45 , A61K31/506 , A61K31/553 , A61K31/65 , A61K31/436
CPC分类号： A61K38/28 , A61F2/82 , A61F2250/0067 , A61K31/426 , A61K31/436 , A61K31/4365 , A61K31/45 , A61K31/4709 , A61K31/506 , A61K31/519 , A61K31/553 , A61K31/565 , A61K31/573 , A61K31/65 , A61K35/58 , A61K38/58 , A61K45/06 , A61K2300/00
摘要： Embodiments of the present invention include methods for the treatment, prevention, or amelioration of vascular disease in diabetic patients. The methods include both implantation of a stent including a first drug. Some embodiments include additional therapy, such as the co-administration of another drug. Some embodiments involve different stent selection for a diabetic patient compared to a non-diabetic patient.
摘要翻译： 本发明的实施方案包括用于治疗，预防或改善糖尿病患者血管疾病的方法。 所述方法包括植入包括第一药物的支架。 一些实施方案包括另外的治疗，例如另一种药物的共同给药。 与非糖尿病患者相比，一些实施方案涉及糖尿病患者的不同支架选择。
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3.发明申请Regional delivery of therapeutic agents for the treatment of vascular diseases 审中-公开用于治疗血管疾病的治疗剂的区域递送公开(公告)号：US20080146489A1
公开(公告)日：2008-06-19
申请号：US11639512
申请日：2006-12-15
申请人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
发明人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译： 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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公开(公告)号：US20120263759A1
公开(公告)日：2012-10-18
申请号：US13224515
申请日：2011-09-02
IPC分类号： C07K2/00 , C07K7/06 , C07K9/00 , A61K31/336 , A61K31/565 , A61K38/44 , A61K31/4468 , A61K31/436 , A61K31/573 , A61K38/58 , A61K31/506 , A61K31/553 , A61K38/18 , A61P35/00 , A61P29/00 , A61P9/10 , A61P7/02 , A61P9/00 , A61P7/04 , A61P1/00 , A61P13/00 , C08G73/06 , C08G69/48 , C08G63/91 , A61K9/00
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.
摘要翻译： 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。 共聚物可以用作支架上的涂层。 还提供了使用涂覆有共聚物的支架的方法。
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公开(公告)号：US20120046640A1
公开(公告)日：2012-02-23
申请号：US13225165
申请日：2011-09-02
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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公开(公告)号：US20110066223A1
公开(公告)日：2011-03-17
申请号：US12559396
申请日：2009-09-14
申请人： Syed F.A. Hossainy , David C. Gale
发明人： Syed F.A. Hossainy , David C. Gale
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2250/0071 , A61L31/148
摘要： A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state
摘要翻译： 公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。 支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态
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7.发明申请COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 有权包含乳酸聚合物的可植入装置的涂料及其制造方法公开(公告)号：US20110027336A1
公开(公告)日：2011-02-03
申请号：US12762718
申请日：2010-04-19
申请人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
发明人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
IPC分类号： A61F2/00 , B05D1/00 , A61K31/436 , A61P9/00 , A61F2/82
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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8.发明申请Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response 审中-公开生物可吸收的支架和治疗引发时变主机材料反应公开(公告)号：US20100198330A1
公开(公告)日：2010-08-05
申请号：US12506121
申请日：2009-07-20
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067
摘要： Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation. Upon complete absorption of the stent, the section moves and functions in a manner that is the same, more similar to, or substantially as a normal blood vessel. In particular, the section can have an increased diameter allowing increased blood flow and vasomotion is partially or substantially completely restored in the section.
摘要翻译： 公开了用生物可吸收支架治疗显示狭窄的患病血管的方法。 植入的支架以增加的直径支撑血管的一段时间，以允许血管愈合。 支架在径向强度足以在植入后不到6个月内支撑血管的部分。 在完全吸收支架时，该部分移动并以与正常血管更相似或基本上相同的方式起作用。 特别地，该部分可以具有增加的直径，允许血液流量增加，血管运动部分或基本上完全恢复。
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公开(公告)号：US20100168843A1
公开(公告)日：2010-07-01
申请号：US12723552
申请日：2010-03-12
申请人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/82
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US20100136213A1
公开(公告)日：2010-06-03
申请号：US12699127
申请日：2010-02-03
申请人： Syed F.A. Hossainy , Fuh-Wei Tang , Stephen D. Pacetti , Jeff Royal , Dorrie M. Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed F.A. Hossainy , Fuh-Wei Tang , Stephen D. Pacetti , Jeff Royal , Dorrie M. Happ , Kurt Scheinpflug , Ty Hu
IPC分类号： B05D3/02
CPC分类号： A61L27/34 , A61F2/91 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/146 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08L29/04
摘要： A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating.
摘要翻译： 公开了涂覆和涂覆可植入医疗装置（例如支架）的方法。 该方法包括使涂层经受诸如包含在涂层中的聚合物的玻璃化转变温度以上的温度的热条件。
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