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公开(公告)号：US20100137696A1
公开(公告)日：2010-06-03
申请号：US12688508
申请日：2010-01-15
IPC分类号： A61B5/1473 , A61N1/08
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译： 提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以使储存器盖分解，从而将传感器暴露于环境部件 。 使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。
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2.发明授权Microfabricated devices for the storage and selective exposure of chemicals and devices 有权用于化学品和设备的储存和选择性暴露的微型装置公开(公告)号：US06849463B2
公开(公告)日：2005-02-01
申请号：US10324556
申请日：2002-12-19
IPC分类号： G01N21/64 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00 , G01N33/543
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Microchip devices and methods of use are provided for the controlled exposure of a secondary device. In one embodiment, the microchip device include a substrate, a plurality of reservoirs in the substrate, a secondary device in one or more of the reservoirs, at least one barrier layer covering each of the reservoirs to isolate the secondary device from an environmental component outside the reservoirs, wherein the barrier layer is impermeable to the environmental component, and a microprocessor-controlled actuation means for rendering the barrier layer porous or permeable to the environmental component to expose the secondary device to said environmental component. The secondary device can comprise a sensor or sensing component (e.g., a biosensor). In other embodiments, microchip devices are provided for the controlled exposure of a reacting component, such as an enzyme. In still other embodiments, sensors are provided on the device outside of the reservoirs.
摘要翻译： Microchip器件和使用方法用于辅助设备的受控曝光。 在一个实施例中，微芯片装置包括衬底，衬底中的多个储存器，一个或多个贮存器中的次要装置，覆盖每个储存器的至少一个阻挡层，以将次要装置与环境部件隔离 储存器，其中阻挡层对于环境部件是不可渗透的，以及微处理器控制的致动装置，用于使阻挡层多孔或可渗透环境部件以将次级装置暴露于所述环境部件。 辅助装置可以包括传感器或感测部件（例如，生物传感器）。 在其他实施方案中，提供微芯片装置用于控制暴露于反应组分如酶。 在其他实施例中，传感器设置在储存器外部的装置上。
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公开(公告)号：US08442611B2
公开(公告)日：2013-05-14
申请号：US12688508
申请日：2010-01-15
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译： 提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以分解储存器盖，从而将传感器暴露于环境部件 。 使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。
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公开(公告)号：US07648677B2
公开(公告)日：2010-01-19
申请号：US11927092
申请日：2007-10-29
IPC分类号： C12Q1/68
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.
摘要翻译： 提供了用于操作传感器装置的方法，其可以包括（a）在现场（例如，植入患者体内）提供包括至少第一和第二储存器的装置，第一传感器和位于第一 储存器，第二传感器和位于第二储存器内的对应的第二参考传感器，封闭第一储存器中的开口的第一储存器盖和封闭第二储存器中的开口的第二储存器盖，以及电源，控制电路和电极 用于选择性地分解每个储存器盖; （b）分解第一储存器盖并操作第一传感器和参考传感器; 和（c）使用第一参考传感器来确定第一传感器是否正常工作。 如果操作不正常，则控制电路启动第二储存器盖的分解和第二传感器和参考传感器的操作。
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公开(公告)号：US06551838B2
公开(公告)日：2003-04-22
申请号：US09798562
申请日：2001-03-02
IPC分类号： G01N100
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents from one or more environmental components outside the reservoirs. The barrier layer can be selectively disintegrated or permeabilized to expose the isolated contents to the one or more environmental components. The secondary device preferably includes a sensor or sensing component, for example, a biosensor, or a light detection or imaging device, such as an optical fiber. Preferred reacting components include catalysts and reagent, which may be immobilized in the reservoirs.
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公开(公告)号：US07614135B2
公开(公告)日：2009-11-10
申请号：US11927156
申请日：2007-10-29
IPC分类号： H01R3/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said lower surface, and a plurality of reservoir caps closing off one end of said through holes at said upper surface; fabricating a plurality of sensors on an upper surface of a second substrate portion; aligning the first and second substrate portions such that each of said plurality of sensors is in alignment with each of said plurality of reservoirs; and bonding together the lower surface of said first substrate portion and the upper surface of said second substrate portion to seal each of said sensors inside the reservoir with which it is aligned.
摘要翻译： 提供了制备基于储液器的传感器装置的方法。 该方法可以包括制造第一衬底部分，其包括上表面，相对的下表面，在所述上表面和所述下表面之间限定储存器的多个通孔，以及封闭所述通孔的一端的多个贮存器盖 在所述上表面; 在第二基板部分的上表面上制造多个传感器; 对准所述第一和第二基板部分，使得所述多个传感器中的每一个与所述多个储存器中的每一个对齐; 以及将所述第一基板部分的下表面和所述第二基板部分的上表面接合在一起，以密封与所述第二基板部分对准的所述储存器内的每个所述传感器。
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公开(公告)号：US07410616B2
公开(公告)日：2008-08-12
申请号：US11850687
申请日：2007-09-06
IPC分类号： B01L11/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reservoir cap closing an opening in the at least one reservoir to isolate the sensor or sensor component from a selected environmental component outside of the at least one reservoir; at least one intermediate barrier layer disposed in the at least one reservoir between the reservoir cap and the sensor or sensor component; and means for disintegrating the reservoir cap to expose the sensor or sensor component to the selected environmental component.
摘要翻译： 设备用于传感器或传感器部件的受控曝光。 该装置可以包括基板; 设置在所述基板中的至少一个储存器; 位于所述至少一个储存器中的至少一个传感器或传感器部件; 至少一个储存器盖封闭所述至少一个储存器中的开口以将所述传感器或传感器部件与所述至少一个储存器外部的所选择的环境部件隔离; 设置在储存器盖和传感器或传感器部件之间的至少一个储存器中的至少一个中间阻挡层; 以及用于分解储存器盖以将传感器或传感器部件暴露于所选择的环境部件的装置。
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公开(公告)号：US07879019B2
公开(公告)日：2011-02-01
申请号：US11925466
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.
摘要翻译： 提供了一种用于选择性地打开容纳储存器的方法。 该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到储存器盖以使储存器盖分解或变得可渗透。 该装置可以是可植入医疗装置。 储存器可以含有用于控制释放的药物或生物传感器。
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公开(公告)号：US07776024B2
公开(公告)日：2010-08-17
申请号：US11925507
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light, which may be used to transmit power or data to the device.
摘要翻译： 提供了用于治疗或诊断患者的方法。 该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路 以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。 该装置可植入患者眼睛的巩膜或其他组织表面上或其中。 聚焦光可以是激光，其可以用于将功率或数据传输到设备。
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公开(公告)号：US06976982B2
公开(公告)日：2005-12-20
申请号：US10042996
申请日：2002-01-09
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices, such as a sensor or a component thereof. Preferably, the microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules to and into the eye of a patient in need thereof.
摘要翻译： 提供可以符合曲面的Microchip器件阵列用于控制释放或暴露储层内容物。 阵列包括两个或更多个微芯片器件元件，每个微芯片器件元件包括多个储存器，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接器件元件的装置。 储存器可以包含一种或多种药物和/或一个或多个次要装置，例如传感器或其组件。 优选地，微芯片装置包含并可控地释放出有需要的患者眼睛中的治疗，预防和诊断分子。
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