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    Human antibodies interacting with HIV gp41
    1.
    发明授权
    Human antibodies interacting with HIV gp41 有权
    人类抗体与HIV gp41相互作用

    公开(公告)号：US07744887B2

    公开(公告)日：2010-06-29

    申请号：US11628164

    申请日：2005-05-31

    申请人： John W. Shiver ,  Michael D. Miller ,  Romas Geleziunas ,  Daria J. Hazuda ,  Peter S. Kim ,  Debra M. Eckert ,  Michael J. Root ,  Simon N. Lennard ,  Elisabetta Bianchi

    发明人： John W. Shiver ,  Michael D. Miller ,  Romas Geleziunas ,  Daria J. Hazuda ,  Peter S. Kim ,  Debra M. Eckert ,  Michael J. Root ,  Simon N. Lennard ,  Elisabetta Bianchi

    IPC分类号： A61K39/42 ,  G01N33/53 ,  A61K39/395 ,  C12P16/00

    CPC分类号： G01N33/56988 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  G01N2500/00

    摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as VH and VL chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.

    摘要翻译： 披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹，N-螺旋卷曲螺旋结构与构象表位相互作用。 显示出这些抗体以及IgG转化中和多种HIV分离物。 还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段（例如VH和VL链）的纯化形式。 在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。 这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

    Controlling lithium deposition during manufacture of a battery
    6.
    发明授权
    Controlling lithium deposition during manufacture of a battery 有权
    在电池制造期间控制锂沉积

    公开(公告)号：US09219293B2

    公开(公告)日：2015-12-22

    申请号：US12782548

    申请日：2010-05-18

    申请人： Ignacio Chi ,  Michael J. Root

    发明人： Ignacio Chi ,  Michael J. Root

    IPC分类号： H02J7/00 ,  H01M10/44 ,  H01M10/48 ,  H01M10/52

    CPC分类号： H01M10/44 ,  H01M10/448 ,  H01M10/48 ,  H01M10/52 ,  H02J7/0075

    摘要： The present subject matter provides apparatus and methods for controlling lithium deposition during manufacture of implantable medical device batteries. A method includes processing materials to form the battery and performing a discharge conditioning process step. The discharge conditioning process step includes using a reduced discharge load and applying a discharge load intermittently to decrease formation of lithium deposits on negatively charged surfaces within the battery.

    摘要翻译： 本主题提供了在可植入医疗器械电池的制造期间控制锂沉积的装置和方法。 一种方法包括处理材料以形成电池并执行放电调节处理步骤。 放电调节处理步骤包括使用减小的放电负荷并间歇地施加放电负载以减少电池内带负电的表面上的锂沉积物的形成。

    Biosorbable battery and related methods
    7.
    发明授权
    Biosorbable battery and related methods 有权
    生物可触电池及相关方法

    公开(公告)号：US08761877B2

    公开(公告)日：2014-06-24

    申请号：US12572191

    申请日：2009-10-01

    申请人： Ljiljana Liliana Atanasoska ,  Michael J. Root

    发明人： Ljiljana Liliana Atanasoska ,  Michael J. Root

    IPC分类号： A61N1/00

    CPC分类号： A61N1/378 ,  H01M2/0202 ,  H01M2/026 ,  H01M2/028 ,  H01M2/1653 ,  H01M4/36 ,  H01M4/38 ,  H01M4/50 ,  H01M4/52 ,  H01M4/5825 ,  H01M4/602 ,  H01M6/34 ,  H01M2220/00 ,  Y10T29/49108

    摘要： Embodiments of the invention are related to biosorbable batteries, amongst other things. In an embodiment, the invention includes a biosorbable battery assembly including an anode, a cathode, and a biosorbable separation element. The anode can include an anode material, wherein electrochemical oxidation of the anode material results in the formation of reaction products that are substantially non-toxic. The cathode can include a cathode material, wherein electrochemical reduction of the cathode material results in the formation of reaction products that are substantially non-toxic, the cathode material having a larger standard reduction potential than the material of the anode. The biosorbable separation element can be disposed between the anode and the cathode and can be configured to provide electrical insulation between the anode and the cathode. In an embodiment, the invention includes a medical device system including an implanted medical device and a biosorbable battery in electrical communication with the implanted medical device. Other embodiments are also included herein.

    摘要翻译： 除其他之外，本发明的实施例涉及生物可吸收电池。 在一个实施例中，本发明包括一种包括阳极，阴极和生物可吸收分离元件的生物可吸收电池组件。 阳极可以包括阳极材料，其中阳极材料的电化学氧化导致基本上无毒的反应产物的形成。 阴极可以包括阴极材料，其中阴极材料的电化学还原导致形成基本无毒的反应产物，阴极材料具有比阳极材料更大的标准还原电位。 生物可吸收分离元件可以设置在阳极和阴极之间，并且可以被配置为在阳极和阴极之间提供电绝缘。 在一个实施例中，本发明包括医疗装置系统，其包括与植入的医疗装置电通信的植入医疗装置和生物可吸收电池。 本文还包括其它实施例。

    Method and apparatus for a small power source for an implantable device
    8.
    发明授权
    Method and apparatus for a small power source for an implantable device 有权
    用于可植入装置的小型电源的方法和装置

    公开(公告)号：US08311627B2

    公开(公告)日：2012-11-13

    申请号：US12966444

    申请日：2010-12-13

    申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

    发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

    摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

    摘要翻译： 一个示例包括电池，其包括至少一个基本上平面的阳极和至少一个基本上平面的阴极的堆叠，其中堆叠限定轮廓外部，以及包围堆叠的电池壳体，电池壳体限定电池壳体外部，其中 堆叠的轮廓外形被成形为符合电池壳体的轮廓内部，其大致符合电池壳体外部，通过使用流体动力学，生物相容性壳体的外部和塑造电池的建模过程产生的电池 壳体以符合生物相容性壳体的至少一些外部。

    METHOD AND APPARATUS FOR A SMALL POWER SOURCE FOR AN IMPLANTABLE DEVICE
    10.
    发明申请
    METHOD AND APPARATUS FOR A SMALL POWER SOURCE FOR AN IMPLANTABLE DEVICE 有权
    用于可移植设备的小功率源的方法和装置

    公开(公告)号：US20130073004A1

    公开(公告)日：2013-03-21

    申请号：US13674860

    申请日：2012-11-12

    申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

    发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

    IPC分类号： A61N1/378 ,  H05K13/00

    CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

    摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

    摘要翻译： 一个示例包括电池，其包括至少一个基本上平面的阳极和至少一个基本上平面的阴极的堆叠，其中堆叠限定轮廓外部，以及包围堆叠的电池壳体，电池壳体限定电池壳体外部，其中 堆叠的轮廓外形被成形为符合电池壳体的轮廓内部，其大致符合电池壳体外部，通过使用流体动力学，生物相容性壳体的外部和塑造电池的建模过程产生的电池 壳体以符合生物相容性壳体的至少一些外部。