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22 条记录 (耗时 0.034 秒)

    DNA encoding human alpha 1 adrenergic receptors and uses thereof
    1.
    发明授权
    DNA encoding human alpha 1 adrenergic receptors and uses thereof 失效
    编码人α1肾上腺素能受体的DNA及其用途

    公开(公告)号：US06448011B1

    公开(公告)日：2002-09-10

    申请号：US09688415

    申请日：2000-10-16

    申请人： Jonathan A. Bard ,  Richard L. Weinshank ,  Carlos C. Forray

    发明人： Jonathan A. Bard ,  Richard L. Weinshank ,  Carlos C. Forray

    IPC分类号： C12Q1568

    CPC分类号： C12Q1/6876 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  A01K2267/0393 ,  A61K38/00 ,  C07K14/70571 ,  C12N15/85 ,  C12N15/8509 ,  C12Q1/6897 ,  C12Q2600/158 ,  G01N33/9433 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention also provides a protein, and an antibody directed to the protein and pharmaceutical compounds related to alpha 1a, alpha 1b and alpha 1c adrenergic receptors. This invention provides nucleic acid probes, and antisense oligonucleotides complementary to alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human alpha 1a, alpha 1b and alpha 1c adrenergic receptors.

    摘要翻译： 本发明提供了分离的核酸，载体，转化的哺乳动物细胞和编码并表达正常或突变的α1a，α1b和α1c肾上腺素能受体基因的非人转基因动物。 本发明还提供了一种蛋白质和针对与α1a，α1b和α1c肾上腺素能受体相关的蛋白质和药物化合物的抗体。 本发明提供核酸探针和与α1a，α1b和α1c肾上腺素能受体基因互补的反义寡核苷酸。 本发明还提供了确定配体结合，检测表达，药物筛选和治疗以减轻与人α1a，α1b和α1c肾上腺素能受体相关的异常的方法。

    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
    3.
    发明授权
    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof 有权
    编码人5-羟色胺受体（5-HT4B）的DNA及其用途

    公开(公告)号：US06300087B1

    公开(公告)日：2001-10-09

    申请号：US09450797

    申请日：1999-11-29

    申请人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    IPC分类号： C12N1518

    CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/70571

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

    摘要翻译： 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，其是哺乳动物5-HT4B受体的分离的蛋白质，载体包含编码哺乳动物的分离的核酸分子 5-HT4B受体的载体，包含编码人5-HT4B受体的分离的核酸分子的载体，包含这种载体的哺乳动物细胞，针对5-HT4B受体的抗体，用于检测编码哺乳动物或人5- HT4B受体，与编码哺乳动物或人类5-HT4B受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT4B受体相关的药物化合物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。

    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
    9.
    发明授权
    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof 失效
    编码人5-羟色胺受体（5-HT4b）的DNA及其用途

    公开(公告)号：US06376243B1

    公开(公告)日：2002-04-23

    申请号：US09450790

    申请日：1999-11-29

    申请人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    IPC分类号： C12N1512

    CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  A01K2267/0375 ,  A61K38/00 ,  C07K14/70571

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B receptor, an isolated protein which is a human 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

    摘要翻译： 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，分离的核酸分子是哺乳动物5-HT4B受体，分离的蛋白质，其是人5- HT4B受体，包含编码哺乳动物5-HT4B受体的分离的核酸分子的载体，包含编码人5-HT4B受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，针对5-HT4B受体的抗体，核酸 可用于检测编码哺乳动物或人类5-HT4B受体的核酸的探针，与编码哺乳动物或人类5-HT4B受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT4B受体相关的药物化合物，和 表达编码正常或突变的哺乳动物或人类5-HT4B受体的DNA的非人类转基因动物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。