公开(公告)号：US20060228722A1

公开(公告)日：2006-10-12

申请号：US11215458

申请日：2005-08-30

申请人： Jong-Bum Kim ,  Steven Lefkowitz ,  John Nobile ,  George Roth ,  Pengguang Yu

发明人： Jong-Bum Kim ,  Steven Lefkowitz ,  John Nobile ,  George Roth ,  Pengguang Yu

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/168 ,  G01N21/253 ,  G01N21/7703 ,  G02B6/08 ,  Y10S977/702 ,  Y10S977/707 ,  Y10S977/712

摘要： This invention relates to microwell array compositions which are coated with one or more thin film coatings. The invention includes the process of fabricating and using thin film coated microwell arrays.

摘要翻译： 本发明涉及用一种或多种薄膜涂层涂覆的微孔阵列组合物。 本发明包括制造和使用薄膜包被微孔阵列的方法。

公开(公告)号：US20050208541A1

公开(公告)日：2005-09-22

申请号：US11030562

申请日：2005-01-05

申请人： Steven Lefkowitz ,  Michel Perbost ,  Roy Kanemoto ,  Carol Schembri

发明人： Steven Lefkowitz ,  Michel Perbost ,  Roy Kanemoto ,  Carol Schembri

IPC分类号： B01J19/00 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00518 ,  B01J2219/00527 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00695 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00009 ,  G01N2035/00158

摘要： Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.

公开(公告)号：US20050137280A1

公开(公告)日：2005-06-23

申请号：US10944457

申请日：2004-09-16

申请人： Nelson Holcomb ,  Russell Parker ,  Steven Lefkowitz

发明人： Nelson Holcomb ,  Russell Parker ,  Steven Lefkowitz

IPC分类号： G01N21/27 ,  G01N21/64 ,  G01N27/447 ,  C08L1/00

CPC分类号： G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  Y10T428/26 ,  Y10T428/268

摘要： Calibration devices for optical scanners and methods for their use are provided. The subject devices are characterized by having a polymeric coating with at least one fluorescent agent, where the devices have minimal local and global nonuniformities. The subject device may also include one or more photobleached regions. In using the subject devices, a surface is illuminated with at least one light source, fluorescence data is obtained from the surface and the optical system is calibrated based upon the obtained fluorescence data. The subject invention finds use in a variety of optical scanners, including biopolymeric array optical scanners. Also provided are kits for use in verifying and calibrating optical scanners.

摘要翻译： 提供了用于光学扫描仪的校准装置及其使用方法。 本发明装置的特征在于具有至少一种荧光剂的聚合物涂层，其中装置具有最小的局部和全局不均匀性。 主体装置还可以包括一个或多个照相漂白区域。 在使用目标装置时，用至少一个光源照射表面，从表面获得荧光数据，并且基于获得的荧光数据校准光学系统。 本发明可用于各种光学扫描仪，包括生物聚合物阵列光学扫描仪。 还提供了用于验证和校准光学扫描仪的套件。

公开(公告)号：US20130302901A1

公开(公告)日：2013-11-14

申请号：US13838727

申请日：2013-03-15

申请人： Stuart Lindsay ,  Peiming Zhang ,  Brett Gyarfas ,  Suman Sen ,  Shuai Chang ,  Steven Lefkowitz ,  Hongbo Peng

发明人： Stuart Lindsay ,  Peiming Zhang ,  Brett Gyarfas ,  Suman Sen ,  Shuai Chang ,  Steven Lefkowitz ,  Hongbo Peng

IPC分类号： G01N27/327

CPC分类号： G01N27/3275 ,  G01N33/48721 ,  Y10T156/10 ,  Y10T436/143333

摘要： Some embodiments of the present disclosure provide methods, devices, and systems for sequencing nucleic acid polymers that utilize palladium (Pd), for example, at least in part, as an electrode material that is (i) functionalized with one or more adaptor molecules and (ii) capable for use to sense one or more chemical compositions.

摘要翻译： 本公开的一些实施方案提供了用于测序核酸聚合物的方法，装置和系统，其利用钯（Pd），例如至少部分地作为（i）用一个或多个衔接子分子官能化的电极材料，以及 （ii）能够用于感测一种或多种化学成分。