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    Devices for calibrating optical scanners and methods of using the same
    1.
    发明申请
    Devices for calibrating optical scanners and methods of using the same 失效
    用于校准光学扫描仪的设备及其使用方法

    公开(公告)号：US20050137280A1

    公开(公告)日：2005-06-23

    申请号：US10944457

    申请日：2004-09-16

    申请人： Nelson Holcomb ,  Russell Parker ,  Steven Lefkowitz

    发明人： Nelson Holcomb ,  Russell Parker ,  Steven Lefkowitz

    IPC分类号： G01N21/27 ,  G01N21/64 ,  G01N27/447 ,  C08L1/00

    CPC分类号： G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  Y10T428/26 ,  Y10T428/268

    摘要： Calibration devices for optical scanners and methods for their use are provided. The subject devices are characterized by having a polymeric coating with at least one fluorescent agent, where the devices have minimal local and global nonuniformities. The subject device may also include one or more photobleached regions. In using the subject devices, a surface is illuminated with at least one light source, fluorescence data is obtained from the surface and the optical system is calibrated based upon the obtained fluorescence data. The subject invention finds use in a variety of optical scanners, including biopolymeric array optical scanners. Also provided are kits for use in verifying and calibrating optical scanners.

    摘要翻译： 提供了用于光学扫描仪的校准装置及其使用方法。 本发明装置的特征在于具有至少一种荧光剂的聚合物涂层，其中装置具有最小的局部和全局不均匀性。 主体装置还可以包括一个或多个照相漂白区域。 在使用目标装置时，用至少一个光源照射表面，从表面获得荧光数据，并且基于获得的荧光数据校准光学系统。 本发明可用于各种光学扫描仪，包括生物聚合物阵列光学扫描仪。 还提供了用于验证和校准光学扫描仪的套件。

    Methods for treating at least one member of a microarray structure and methods of using the same
    2.
    发明申请
    Methods for treating at least one member of a microarray structure and methods of using the same 审中-公开
    用于治疗微阵列结构的至少一个成员的方法及其使用方法

    公开(公告)号：US20050112292A1

    公开(公告)日：2005-05-26

    申请号：US10722950

    申请日：2003-11-25

    申请人： Russell Parker ,  Duan Dutton ,  Nelson Holcomb

    发明人： Russell Parker ,  Duan Dutton ,  Nelson Holcomb

    IPC分类号： B05D3/04 ,  C23C16/00 ,  G01N33/543

    CPC分类号： G01N33/54393

    摘要： Methods for treating at least one member of a backing element/microarray assembly structure are provided. The subject methods include at least one of: (1) depositing a component on the at least one member, (2) extracting a component from the at least one member, and (3) surface modifying the at least one member, to treat the at least one member of a backing element/microarray assembly structure. Embodiments of the subject invention also include treated microarray structure members, e.g., produced in accordance with the subject methods, as well as methods for using treated microarray structure members in array assay protocols. Also provided are systems and kits for use in the subject methods.

    摘要翻译： 提供了用于处理背衬元件/微阵列组装结构的至少一个构件的方法。 主题方法包括以下中的至少一个：（1）在至少一个构件上沉积组分，（2）从至少一个构件提取组分，和（3）表面修饰至少一个构件，以处理 背衬元件/微阵列组件结构的至少一个构件。 本发明的实施方案还包括经处理的微阵列结构构件，例如根据本发明方法制备的，以及在阵列测定方案中使用经处理的微阵列结构构件的方法。 还提供了用于主题方法的系统和套件。

    Devices and methods for performing array based assays
    3.
    发明申请
    Devices and methods for performing array based assays 失效
    用于执行基于阵列的测定的设备和方法

    公开(公告)号：US20050123931A1

    公开(公告)日：2005-06-09

    申请号：US10729606

    申请日：2003-12-05

    申请人： Allen Thompson ,  George Tsai ,  Russell Parker

    发明人： Allen Thompson ,  George Tsai ,  Russell Parker

    IPC分类号： B01L3/00 ,  C12M1/34 ,  C12Q1/68

    CPC分类号： C12Q1/6837 ,  B01J2219/00333 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/508 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0822 ,  B82Y30/00

    摘要： Devices and methods for performing an array assay are provided. Embodiments of the subject array assay devices include (1) a base, (2) a cover, and (3) a clamping member for holding the cover to the base, wherein when the cover is operatively held to the base about a structure that includes an array assembly spaced-apart from a backing element, the array assembly and the backing element are deflected to substantially the same curvature. Embodiments of the subject methods include contacting a sample with a backing element and placing the backing element supported sample in contact with an array assembly to form a structure that includes the backing element and array assembly. The structure is then held together using a subject array assay device and the array substrate and the backing element are deflected to substantially the same curvature.

    摘要翻译： 提供了用于进行阵列测定的装置和方法。 本发明的阵列测定装置的实施例包括（1）底座，（2）盖子和（3）用于将盖子保持在基座上的夹紧构件，其中当盖子围绕包括 与背衬元件间隔开的阵列组件，阵列组件和背衬元件被偏转到基本上相同的曲率。 本发明方法的实施方案包括将样品与背衬元件接触并将支撑元件支撑的样品与阵列组件接触以形成包括背衬元件和阵列组件的结构。 然后使用主题阵列测定装置将结构保持在一起，并且阵列基板和背衬元件被偏转到基本上相同的曲率。

    Method and system for automated focus-distance determination for molecular array scanners
    4.
    发明申请
    Method and system for automated focus-distance determination for molecular array scanners 审中-公开
    分子阵列扫描仪的自动聚焦距离测定方法和系统

    公开(公告)号：US20050067583A1

    公开(公告)日：2005-03-31

    申请号：US10910562

    申请日：2004-08-02

    申请人： John Corson ,  Stanley Woods ,  Russell Parker ,  Xiangyang Zhou ,  Bo Curry

    发明人： John Corson ,  Stanley Woods ,  Russell Parker ,  Xiangyang Zhou ,  Bo Curry

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N2021/6463

    摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array by a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.

    摘要翻译： 一种用于通过分子阵列扫描仪确定用于扫描分子阵列的最佳聚焦距离的自动化方法和系统。 参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。 然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。

    Gas turbine engine combustor with improved cooling
    6.
    发明申请
    Gas turbine engine combustor with improved cooling 有权
    燃气轮机发动机燃烧器具有改进的冷却

    公开(公告)号：US20070006588A1

    公开(公告)日：2007-01-11

    申请号：US11175046

    申请日：2005-07-06

    申请人： Bhawan Patel ,  Parthasarathy Sampath ,  Russell Parker

    发明人： Bhawan Patel ,  Parthasarathy Sampath ,  Russell Parker

    IPC分类号： F23R3/42

    CPC分类号： F23R3/42 ,  F23R3/10

    摘要： A gas turbine engine combustor liner having a plurality of holes defined therein for directing air into the combustion chamber. The plurality of holes provide improved cooling efficiency in regions of the combustor dome corresponding to predetermined hotspots.

    摘要翻译： 一种燃气涡轮发动机燃烧器衬套，其具有限定在其中的多个孔，用于将空气引导到燃烧室中。 多个孔在对应于预定热点的燃烧室顶部的区域中提供改善的冷却效率。

    Methods and compositions for calibrating chemical array readers
    7.
    发明申请
    Methods and compositions for calibrating chemical array readers 审中-公开
    校准化学读数器的方法和组成

    公开(公告)号：US20050244984A1

    公开(公告)日：2005-11-03

    申请号：US10834423

    申请日：2004-04-28

    申请人： Russell Parker

    发明人： Russell Parker

    IPC分类号： G01N1/00 ,  G01N21/27 ,  G01N21/64

    CPC分类号： G01N21/6452 ,  G01N21/278

    摘要： The invention provides compositions for calibrating a fluorescence reader. The subject compositions generally relate to a solid support coated in a fluorescent agent, where the solid support has minimal local and global nonuniformities of fluorescence. Also provided by the invention are methods of calibrating a scanner using the subject compositions, and kits and programming for performing the subject methods.

    摘要翻译： 本发明提供了用于校准荧光读取器的组合物。 主题组合物通常涉及涂覆在荧光剂中的固体支持物，其中固体支持物具有最小的局部和全局荧光不均匀性。 本发明还提供了使用主题组合物校准扫描器的方法，以及用于执行主题方法的套件和编程。

    System for, and method of, irradiating articles to sterilize the articles
    10.
    发明授权
    System for, and method of, irradiating articles to sterilize the articles 失效
    用于照射物品以对物品进行消毒的系统和方法

    公开(公告)号：US06492645B1

    公开(公告)日：2002-12-10

    申请号：US09456061

    申请日：1999-12-07

    申请人： John Thomas Allen ,  Gary K. Loda ,  Russell Parker ,  George M. Sullivan ,  Colin Brian Williams

    发明人： John Thomas Allen ,  Gary K. Loda ,  Russell Parker ,  George M. Sullivan ,  Colin Brian Williams

    IPC分类号： G21K510

    CPC分类号： A61L2/087 ,  A23L3/263 ,  A61L2202/24 ,  G21K5/10

    摘要： A first robotic assembly transfers articles from carriers on a transport mechanism at a loading area to a first load conveyor. The conveyor transfers the articles to a process conveyor which moves the articles through a target region at a substantially constant speed. The process conveyor then transfers the articles to a second load conveyor. A second robotic assembly then transfers the articles to article carriers on the transport mechanism at an unloading area. The load and process conveyors may be divided into two tracks. First and second radiation sources respectively disposed at first and second gaps in the process conveyor in the target region respectively irradiate the articles in both tracks in opposite directions from positions above and below the articles. Articles on the tracks may be (a) diverged on the first load conveyor to separate the articles from the dividers, (b) converged on the process conveyor to minimize the width of the radiation sources and (c) diverged on the second load conveyor. If one of the radiation sources is not operative, the other source may irradiate the opposite sides of the articles during article movements sequentially on the first tracks of the first load conveyor, the process conveyor and the second load conveyor and then sequentially on the second tracks of the first load conveyor, the process conveyor and the second load conveyor. The articles are inverted during their transfer from the first track of the second load conveyor to the second track of the first load conveyor.

    摘要翻译： 第一机器人组件将载物上的物品从装载区域上的运送机构转移到第一负载输送机。 输送机将物品转移到以基本上恒定的速度移动物品穿过目标区域的处理输送机。 然后，处理输送机将物品转移到第二负载输送机。 然后，第二机器人组件在卸载区域将物品转运到运送机构上的物品承载件。 负载和过程输送机可以分成两个轨道。 分别设置在目标区域中的处理输送机中的第一和第二间隙处的第一和第二辐射源分别在物品上方和下方的相反方向照射两个轨道中的物品。 轨道上的物品可能是（a）在第一负载输送机上分开，以将物品与分隔器分离，（b）会聚在过程输送机上，以使辐射源的宽度最小化，（c）在第二负载输送机上分散。 如果其中一个辐射源不起作用，另一个源可以在物品移动期间顺序地照射在第一负载输送机，处理输送机和第二负载输送机的第一轨道上的物品的相对侧，然后依次在第二轨道 的第一负载输送机，过程输送机和第二负载输送机。 物品在从第二负载传送带的第一轨道传送到第一负载输送机的第二轨道期间被倒转。