Antibody fragments specific for human carcinoembryonic antigen (CEA)
    3.
    发明申请
    Antibody fragments specific for human carcinoembryonic antigen (CEA) 审中-公开
    针对人癌胚抗原(CEA)特异的抗体片段

    公开(公告)号:US20070199078A1

    公开(公告)日:2007-08-23

    申请号:US11731442

    申请日:2007-03-30

    IPC分类号: A61K51/00 C12N5/06 A61K39/395

    摘要: The invention refers to mono- and divalent (diabody) single chain Fv (scFv) antibody fragments, obtained by recombinant DNA techniques from the anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) CB/ior-CEA. 1. This antibody has high affinity for CEA and is employed in the diagnosis and follow-up of human colorectal tumors. As the original Mab, the monovalent fragment and the diabody exhibit high affinity for human CEA and recognize an epitope dependent of carbohydrate conservation. The monovalent scFv fragment and the diabody have affinity constants for CEA of (5.0±0.4)×109 L mol−1 and (2.8±0.3)×1010 L mol−1, respectively. These two fragments do not show cross reactivity with human normal cells and tissues, exception made of the normal colonic mucosa, where CEA is occasionally present. The fragments can be produced through the expression in recombinant microorganisms, starting from the cloning of the encoding variable region nucleic acid sequences obtained from the hybridoma that produces Mab CB/ior-CEA.1. As the original Mab, the monovalent scFv and the diabody have the ability to identify in vivo cells that produce human CEA and grow as tumors in mice. The monovalent scFv and the diabody have a molecular size 5 and 2.5 times lower, respectively, than the mouse Mab, and do not have Fc domains, fact this that confers them the potential to better penetrate tissues in vivo and to be less immunogenic in man.

    摘要翻译: 本发明涉及通过来自抗癌胚抗原(CEA)单克隆抗体(Mab)CB / i-CEA的重组DNA技术获得的单价和二价(双抗体)单链Fv(scFv)抗体片段。 该抗体对CEA具有高亲和力,用于诊断和追踪人结肠直肠肿瘤。 作为原始的Mab,单价片段和双抗体对人CEA表现出高亲和力,并识别依赖于碳水化合物保护的表位。 单价scFv片段和双抗体对于(5.0±0.4)×10 9 L mol -1 -1和(2.8±0.3)×10 10 -1的CEA具有亲和力常数, / SUP> L mol 。 这两个片段不显示与人正常细胞和组织的交叉反应性,例外是正常结肠粘膜,其中CEA偶尔存在。 通过从产生Mab CB / i-CEA.1的杂交瘤获得的编码可变区核酸序列的克隆开始,可以通过重组微生物中的表达产生片段。 作为原始的Mab,单价scFv和双抗体具有鉴定产生人CEA的体内细胞并在小鼠中作为肿瘤生长的能力。 单价scFv和双抗体分别具有比小鼠Mab低5和2.5倍的分子量,并且不具有Fc结构域,事实上,这赋予它们在体内更好地穿透组织的潜力并且在人中具有较少的免疫原性 。

    Method and output buffer with programmable bias to accommodate multiple
supply voltages
    5.
    发明授权
    Method and output buffer with programmable bias to accommodate multiple supply voltages 失效
    具有可编程偏置的方法和输出缓冲器,以适应多种电源电压

    公开(公告)号:US5917358A

    公开(公告)日:1999-06-29

    申请号:US987361

    申请日:1997-12-09

    IPC分类号: H03K19/0185 H03L5/00

    CPC分类号: H03K19/018585

    摘要: Output buffer (100) translates input signals from one voltage range to a second voltage range. The second voltage range may be identical to the first range or may be greater. The particular range is programmable by one of several ways. This feature makes output buffer especially suitable for use in devices which must be compatible with two voltage ranges. Output buffer uses a bias generator (110) to limit the voltage across the gate oxide of its various transistors to a level which is consistent with the first voltage range.

    摘要翻译: 输出缓冲器(100)将输入信号从一个电压范围转换到第二电压范围。 第二电压范围可以与第一范围相同或者可以更大。 特定范围可以通过几种方式之一进行编程。 该功能使输出缓冲器特别适用于必须兼容两个电压范围的器件。 输出缓冲器使用偏置发生器(110)将其各种晶体管的栅极氧化物上的电压限制到与第一电压范围一致的水平。

    Real-time disk system
    6.
    发明授权
    Real-time disk system 失效
    实时磁盘系统

    公开(公告)号:US5396339A

    公开(公告)日:1995-03-07

    申请号:US803502

    申请日:1991-12-06

    摘要: A real-time disk system (10) stores and plays back D1 digital 10-bit 4:2:2 component video and audio signals from magnetic storage disks (12). The system (10) has a main channel subsystem (14) with an associated smooth motion option (16) and a second or key channel option subsystem (18) with an associated smooth motion option (20). Serial and parallel D1 digital video inputs (30) and (32) and outputs (34) and (36) are connected to each of the channels (14) and (18) and to control subsystem (22). In the main channel (14), the serial and parallel D1 input (30) is connected through an input board (60) to a video processing board (62). The video board (62) is connected by a bidirectional, 11.times.2 wide bus (64) to disk arrays (66) and (68). Digital video signal information is stored and retrieved in parallel to and from the disk arrays (66) and (68) without requiring any serial to parallel or parallel to serial conversion. Smooth motion option (20) processes a group of video fields by creating a plurality of additional fields between two original fields in the group of video fields by a combination of motion adaptive interpolation and frame repetition.

    摘要翻译: 实时盘系统(10)存储并播放来自磁存储盘(12)的D1数字10位4:2:2分量视频和音频信号。 系统(10)具有具有相关联的平滑运动选项(16)的主通道子系统(14)和具有相关联的平滑运动选项(20)的第二或键通道选项子系统(18)。 串行和并行D1数字视频输入(30)和(32)和输出(34)和(36)连接到每个通道(14)和(18)和控制子系统(22)。 在主通道(14)中,串行和并行D1输入(30)通过输入板(60)连接到视频处理板(62)。 视频板(62)通过双向11x2宽的总线(64)连接到磁盘阵列(66)和(68)。 数字视频信号信息与磁盘阵列(66)和(68)并行存储和检索,而不需要串行到并行或并行串行转换。 平滑运动选项(20)通过运动自适应内插和帧重复的组合在视频场组中的两个原始场之间创建多个附加场来处理一组视频场。

    Diamond UV-sensor element and manufacturing method thereof, UV-sensor unit, and method of treating diamond single crystal
    7.
    发明授权
    Diamond UV-sensor element and manufacturing method thereof, UV-sensor unit, and method of treating diamond single crystal 失效
    金刚石紫外线传感器元件及其制造方法,UV传感器单元和处理金刚石单晶的方法

    公开(公告)号:US08435597B2

    公开(公告)日:2013-05-07

    申请号:US12866554

    申请日:2009-02-09

    IPC分类号: B05D5/00

    摘要: A method of manufacturing a diamond UV sensor element improved with a UV/visible light blind ratio using a diamond single crystal as a light receiving portion and detecting a light based on the change of electric resistance caused by a light irradiated to the light receiving portion is provided, the method, including (1) a step of hydrogenating the surface of the diamond single crystal in an atmosphere substantially containing hydrogen, and (2) a step of forming a light receiving portion by exposing the hydrogenated surface of the diamond single crystal into an atmosphere containing ozone or active oxygen.

    摘要翻译: 一种使用金刚石单晶作为光接收部分的UV /可见光盲比率改进的金刚石UV传感器元件的制造方法,并且基于照射到光接收部分的光引起的电阻的变化来检测光, 提供的方法,包括(1)在基本上含有氢的气氛中氢化金刚石单晶的表面的步骤,和(2)通过将金刚石单晶的氢化表面暴露于其中形成光接收部分的步骤 含有臭氧或活性氧的气氛。

    DIAMOND UV-SENSOR ELEMENT AND MANUFACTURING METHOD THEREOF, UV-SENSOR UNIT, AND METHOD OF TREATING DIAMOND SINGLE CRYSTAL
    8.
    发明申请
    DIAMOND UV-SENSOR ELEMENT AND MANUFACTURING METHOD THEREOF, UV-SENSOR UNIT, AND METHOD OF TREATING DIAMOND SINGLE CRYSTAL 失效
    金刚石紫外线传感器元件及其制造方法,紫外线传感器单元及处理钻石单晶的方法

    公开(公告)号:US20110045173A1

    公开(公告)日:2011-02-24

    申请号:US12866554

    申请日:2009-02-09

    IPC分类号: B05D5/00

    摘要: A method of manufacturing a diamond UV sensor element improved with a UV/visible light blind ratio using a diamond single crystal as a light receiving portion and detecting a light based on the change of electric resistance caused by a light irradiated to the light receiving portion is provided, the method, including (1) a step of hydrogenating the surface of the diamond single crystal in an atmosphere substantially containing hydrogen, and (2) a step of forming a light receiving portion by exposing the hydrogenated surface of the diamond single crystal into an atmosphere containing ozone or active oxygen.

    摘要翻译: 一种使用金刚石单晶作为光接收部分的UV /可见光盲比率改进的金刚石UV传感器元件的制造方法,并且基于照射到光接收部分的光引起的电阻的变化来检测光, 提供的方法,包括(1)在基本上含有氢的气氛中氢化金刚石单晶的表面的步骤,和(2)通过将金刚石单晶的氢化表面暴露于其中形成光接收部分的步骤 含有臭氧或活性氧的气氛。

    Method, system and device for improving video quality through in-loop temporal pre-filtering
    9.
    发明申请
    Method, system and device for improving video quality through in-loop temporal pre-filtering 有权
    通过循环时间预过滤来提高视频质量的方法,系统和设备

    公开(公告)号:US20070064815A1

    公开(公告)日:2007-03-22

    申请号:US11230943

    申请日:2005-09-19

    IPC分类号: H04B1/66

    摘要: A method, system and device are provided for pre-filtering device for filtering a video signal prior to digitally encoding. The method includes receiving at least one input picture and at least one reconstructed picture from an encoding process and performing an in-loop temporal filtering process using at least one input picture and at least one reconstructed picture from an encoding process to output a pre-filtered video signal for use in an encoding process. The result is enabling an encoding process to produce an output with increased temporal correlation between adjacent pictures regardless of the coding type, since the artifacts introduced by the encoding process are also considered by the process.

    摘要翻译: 提供了一种用于在进行数字编码之前对视频信号进行滤波的预过滤装置的方法,系统和装置。 该方法包括从编码处理接收至少一个输入图像和至少一个重构图像,并且使用至少一个输入图像和至少一个来自编码处理的重构图像执行循环时间滤波处理,以输出预滤波 视频信号用于编码过程。 结果是,由于编码处理引入的伪像也被该过程考虑,所以能够使编码处理产生具有增加的相邻图像之间的时间相关性的输出,而不管编码类型如何。

    Wax container kit for auto detailing
    10.
    发明申请
    Wax container kit for auto detailing 审中-公开
    蜡容器套件,用于自动细节化

    公开(公告)号:US20070007161A1

    公开(公告)日:2007-01-11

    申请号:US11177946

    申请日:2005-07-11

    申请人: Jose Alvarez

    发明人: Jose Alvarez

    IPC分类号: B65D81/20

    CPC分类号: B65D81/2038 B65D51/24

    摘要: A wax container kit for auto detailing according to this invention comprises a wax container sealed with a disposable cap along with a second vacuum cap. Both the wax container and vacuum cap are displayed in a transparent plastic container. After opening the wax container and dispensing the wax, the disposable cap is thrown away and replaced with the vacuum cap. The vacuum cap comprises means for creating negative pressure inside the wax container to preserve the wax.

    摘要翻译: 根据本发明的用于自动细节化的蜡容器套件包括用一次性盖子和第二真空盖密封的蜡容器。 蜡容器和真空盖都显示在透明塑料容器中。 在打开蜡容器并分配蜡之后,将一次性盖子丢弃并用真空盖更换。 真空盖包括在蜡容器内产生负压以保持蜡的装置。