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公开(公告)号:US07105509B2
公开(公告)日:2006-09-12
申请号:US10296428
申请日:2001-05-21
申请人: Jose Luis Castro Pineiro , Ian Churcher , Alexander Richard Guiblin , Timothy Harrison , Sonia Kerrard , Andrew Madin , Alan John Nadin , Andrew Pate Owens , Timothy Jason Sparey , Martin Richard Teall , Susannah Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Alexander Richard Guiblin , Timothy Harrison , Sonia Kerrard , Andrew Madin , Alan John Nadin , Andrew Pate Owens , Timothy Jason Sparey , Martin Richard Teall , Susannah Williams
IPC分类号: C07D243/24 , C07D243/12 , C07D417/04 , A61K31/55 , A61P25/28
CPC分类号: C07D401/04 , A61K31/55 , C07D243/14 , C07D243/24 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D417/06 , C07D417/12 , C07D487/04 , C07D491/10
摘要: A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by γ-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of β-amyloid, such as Alzheimer's disease
摘要翻译: 公开了一类新颖的式(I)的1,4-和1,5-苯并二氮杂。 该化合物通过γ-分泌酶调节淀粉样前体蛋白的加工,因此可用于治疗或预防与β-淀粉样蛋白沉积相关的病症,例如阿尔茨海默病
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公开(公告)号:US07598386B2
公开(公告)日:2009-10-06
申请号:US11788888
申请日:2007-04-23
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: C07D211/00 , C07D211/68 , C07D211/40 , C07D211/70 , C07D309/00
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US07595344B2
公开(公告)日:2009-09-29
申请号:US12151296
申请日:2008-05-06
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: A61K31/65
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了调节γ-分泌酶作用的唾液。 该化合物可用于治疗或预防阿尔茨海默病。
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公开(公告)号:US20090131419A1
公开(公告)日:2009-05-21
申请号:US12151296
申请日:2008-05-06
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: A61K31/54 , C07C317/14 , A61K31/10 , C07D295/14 , A61P25/28 , C07D241/04 , A61K31/495
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号:US07365196B2
公开(公告)日:2008-04-29
申请号:US10239233
申请日:2001-03-15
申请人: Patrice Charles Belanger , Ian James Collins , Joanne Claire Hannam , Timothy Harrison , Stephen John Lewis , Andrew Madin , Edward Giles McIver , Alan John Nadin , Joseph George Neduvelil , Mark Steven Shearman , Adrian Leonard Smith , Timothy Jason Sparey , Graeme Irvine Stevenson , Martin Richard Teall
发明人: Patrice Charles Belanger , Ian James Collins , Joanne Claire Hannam , Timothy Harrison , Stephen John Lewis , Andrew Madin , Edward Giles McIver , Alan John Nadin , Joseph George Neduvelil , Mark Steven Shearman , Adrian Leonard Smith , Timothy Jason Sparey , Graeme Irvine Stevenson , Martin Richard Teall
IPC分类号: C07D413/14 , C07D413/12 , C07D213/71 , C07D213/52 , C07D333/34 , C07D409/14 , C07D409/12 , C07D249/12 , C07D233/84 , C07D207/48 , C07D277/16 , C07D307/64 , A61P25/28
CPC分类号: C07D213/30 , A61K31/18 , A61K31/40 , C07C311/07 , C07C311/09 , C07C311/11 , C07C311/14 , C07C311/20 , C07C311/24 , C07C323/67 , C07C2601/08 , C07C2601/14 , C07C2602/44 , C07C2602/46 , C07C2603/72 , C07C2603/78 , C07D207/36 , C07D211/14 , C07D211/18 , C07D213/71 , C07D213/81 , C07D215/12 , C07D223/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D271/107 , C07D277/36 , C07D285/14 , C07D285/16 , C07D295/088 , C07D295/135 , C07D295/26 , C07D307/64 , C07D307/81 , C07D319/18 , C07D333/34 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D513/10
摘要: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
摘要翻译: 公开了一类化合物,其包含磺酰氨基取代的桥连双环烷基结构。 这些化合物是γ-分泌酶的抑制剂,因此可用于治疗和/或预防阿尔茨海默氏病。
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公开(公告)号:US06890956B2
公开(公告)日:2005-05-10
申请号:US10679902
申请日:2003-10-06
申请人: Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
发明人: Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
IPC分类号: A61K31/10 , A61P25/28 , C07C317/30 , C07D213/70 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/02 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34 , A61K31/18 , C07C323/23
CPC分类号: C07D213/70 , A61K31/10 , C07C317/30 , C07C2601/14 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
摘要翻译: 式I化合物:通过γ-分泌酶抑制APP的加工,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US07304094B2
公开(公告)日:2007-12-04
申请号:US11261365
申请日:2005-10-28
申请人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
发明人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
IPC分类号: A61K31/165 , C07C321/24
CPC分类号: C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公式I的新型手机被公开:
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公开(公告)号:US06984663B2
公开(公告)日:2006-01-10
申请号:US10223993
申请日:2002-08-20
申请人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
发明人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
IPC分类号: A61K31/19 , C07C317/12 , C07C317/14
CPC分类号: C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:该化合物通过γ-分泌酶调节淀粉样蛋白前体蛋白的加工,因此可用于治疗或预防阿尔茨海默氏病。
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9.
公开(公告)号:US06200982B1
公开(公告)日:2001-03-13
申请号:US09423178
申请日:2000-02-11
申请人: Ian James Collins , Stephen Robert Fletcher , Timothy Harrison , Paul David Leeson , Christopher Richard Moyes , Alan John Nadin , Michael Rowley , Timothy Jason Sparey , Martin Richard Teall
发明人: Ian James Collins , Stephen Robert Fletcher , Timothy Harrison , Paul David Leeson , Christopher Richard Moyes , Alan John Nadin , Michael Rowley , Timothy Jason Sparey , Martin Richard Teall
IPC分类号: A61K31435
CPC分类号: C07D213/64 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要: Substituted 1H-Pyridinyl-2-ones are useful as GABAA-Alpha 2/3 ligands.
摘要翻译: 取代的1H-吡啶基-2-酮可用作GABAA-α2/3配体
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10.
公开(公告)号:US06352994B2
公开(公告)日:2002-03-05
申请号:US09754092
申请日:2001-01-04
申请人: Ian James Collins , Stephen Robert Fletcher , Timothy Harrison , Paul David Leeson , Christopher Richard Moyes , Alan John Nadin , Michael Rowley , Timothy Jason Sparey , Martin Richard Teall
发明人: Ian James Collins , Stephen Robert Fletcher , Timothy Harrison , Paul David Leeson , Christopher Richard Moyes , Alan John Nadin , Michael Rowley , Timothy Jason Sparey , Martin Richard Teall
IPC分类号: A61K31435
CPC分类号: C07D213/64 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system:
摘要翻译: 根据式(I)的化合物或其盐是用于治疗中枢神经系统疾病的GABA A受体的选择性配体:
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