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公开(公告)号：US06615072B1
公开(公告)日：2003-09-02
申请号：US09315982
申请日：1999-05-21
申请人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka , Jiro Narita
发明人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka , Jiro Narita
IPC分类号： A61B600
CPC分类号： A61B5/6852 , A61B5/0066 , G01B9/02002 , G01B9/0205 , G01B9/02061 , G01B9/02069 , G01B9/02091 , G01B2290/65 , G01B2290/70
摘要： An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.
摘要翻译： 光学相干断层扫描（OCT）装置以低相干光照射生物组织，通过与来自组织的散射光的低相干干涉获得组织内部的高分辨率断层图像，并且设置有包括 光纤具有用于引入低相干光的柔性和薄的插入部分。 当光学探针插入血管或患者的体腔时，OCT使医生能够观察高分辨率的断层图像。 在光学探针中，通常根据光纤的弯曲发生双折射的波动，并且这种干涉对比度根据插入的条件而变化。 本发明的OCT在光学探针的发光侧设置有诸如法拉第旋转器的偏振补偿装置，使得OCT可以获得稳定的干涉输出，而不管弯曲的状态如何。
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公开(公告)号：US06564089B2
公开(公告)日：2003-05-13
申请号：US10087907
申请日：2002-03-05
申请人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka
发明人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka
IPC分类号： A61B600
CPC分类号： A61B5/6852 , A61B5/0066 , G01B9/02002 , G01B9/0205 , G01B9/02061 , G01B9/02069 , G01B9/02091 , G01B2290/65 , G01B2290/70
摘要： An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.
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公开(公告)号：US6006128A
公开(公告)日：1999-12-21
申请号：US88562
申请日：1998-06-02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , A61B5/7257 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体的位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。
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公开(公告)号：US06735463B2
公开(公告)日：2004-05-11
申请号：US09468674
申请日：1999-12-21
IPC分类号： A61B502
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/7257 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。
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公开(公告)号：USRE42641E1
公开(公告)日：2011-08-23
申请号：US10020041
申请日：2001-12-14
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35
摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
摘要翻译： 描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中， 样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。
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公开(公告)号：US6002480A
公开(公告)日：1999-12-14
申请号：US88519
申请日：1998-06-02
CPC分类号： G01J3/4412 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35
摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
摘要翻译： 描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中， 样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。
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7.发明授权
公开(公告)号：US5994690A
公开(公告)日：1999-11-30
申请号：US40128
申请日：1998-03-17
CPC分类号： A61B5/7257 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01N21/4795 , A61B5/0536 , G01B2290/35
摘要： The present invention provides an improved optical coherence tomography system and involves estimating the impulse response (which is indicative of the actual reflecting and scattering sites within a tissue sample) from the output interferometric signal of an interferometer according to the following steps: (a) acquiring auto-correlation data from the interferometer system; (b) acquiring cross-correlation data from the interferometer system having the biological tissue sample in the sample arm; and (c) processing the auto-correlation data and the cross correlation data to produce an optical impulse response of the tissue. The impulse response may be obtained from the cross-correlation and auto-correlation data by: (d) obtaining an auto-power spectrum from the auto-correlation data by performing a Fourier transform on the auto-correlation data; (e) obtaining a cross-power spectrum from the cross-correlation data by performing a Fourier transform on the cross-correlation data; (f) obtaining a transfer function of the LSI system by taking a ratio of the cross-power spectrum to the auto-power spectrum; and (g) obtaining the optical impulse response of the LSI system by performing an inverse-Fourier transform on the transfer function. Preferably, coherent demodulation is used in combination with the above deconvolution technique to resolve closely-spaced reflecting sites in the sample. By utilizing both the magnitude and phase data of the demodulated interferometric signals, the OCT system of the present invention is able to distinguish between closely spaced reflecting sites within the sample.
摘要翻译： 本发明提供了一种改进的光学相干断层摄影系统，并且包括根据以下步骤从干涉仪的输出干涉测量信号估计脉冲响应（其指示组织样本内的实际反射和散射位置）：（a）获取 来自干涉仪系统的自相关数据; （b）从具有样品臂中的生物组织样品的干涉仪系统获取互相关数据; 和（c）处理自相关数据和互相关数据以产生组织的光脉冲响应。 脉冲响应可以通过以下方式从互相关和自相关数据获得：（d）通过对自相关数据执行傅里叶变换，从自相关数据获得自动功率谱; （e）通过对互相关数据执行傅立叶变换从互相关数据获得交叉功率谱; （f）通过将交叉功率谱与自动功率谱的比率取得来获得LSI系统的传递函数; 和（g）通过对传递函数执行傅立叶逆变换获得LSI系统的光脉冲响应。 优选地，相干解调与上述反褶积技术组合使用以解决样品中紧密间隔的反射部位。 通过利用解调的干涉信号的幅度和相位数据，本发明的OCT系统能够区分样本内的紧密间隔的反射部位。
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8.发明授权Optical coherence imaging systems having a mechanism for shifting focus and scanning modality 有权具有用于移动焦点和扫描模态的机构的光学相干成像系统公开(公告)号：US08908188B2
公开(公告)日：2014-12-09
申请号：US13366604
申请日：2012-02-06
摘要： Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein.
摘要翻译： 本发明的一些实施例提供用于后置成像系统的适配器。 适配器包括被配置为使后部成像系统适合作为前成像系统操作的镜片组。 本文还提供了相关的光学相干断层扫描系统和前置成像系统。
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9.发明授权Systems and methods for surgical microscope and optical coherence tomography (OCT) imaging 有权手术显微镜和光学相干断层扫描（OCT）成像的系统和方法公开(公告)号：US08366271B2
公开(公告)日：2013-02-05
申请号：US13010497
申请日：2011-01-20
申请人： Joseph A. Izatt , Yuankai K. Tao , Cynthia A. Toth
发明人： Joseph A. Izatt , Yuankai K. Tao , Cynthia A. Toth
CPC分类号： G01B9/02091 , A61B3/102 , A61B3/13 , G01B9/0203
摘要： A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective.
摘要翻译： 手术显微镜组件包括显微镜主要目标和显微镜成像光学元件。 显微镜主要目标和显微镜成像光学器件定义了从样品通过显微镜主要目标和显微镜成像光学器件的观察光束路径。 组件包括具有照明光束和收集光束的光学相干断层摄影（OCT）单元和在显微镜主要物镜和显微镜成像光学器件之间的分束器。 分束器被配置为将来自显微镜主物镜的光的一部分引导到显微镜成像光学器件，并将来自显微镜主物镜的另一部分光引导到OCT单元收集光束。 分束器还被配置成将来自OCT单元的照明光束引导到显微镜主目标和样品。 光束形成单元位于OCT单元和分束器之间。 光束形成单元被配置为形成OCT单元的照明光束，以便大致对应于显微镜主要物镜的尺寸。
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10.发明授权Systems for extended depth fourier domain optical coherence tomography (FDOCT) and related methods 有权扩展深度傅立叶变换光学相干断层扫描系统（FDOCT）及相关方法公开(公告)号：US08348427B2
公开(公告)日：2013-01-08
申请号：US12887891
申请日：2010-09-22
CPC分类号： A61B3/102 , G01B9/0201 , G01B9/02078 , G01B9/02091
摘要： Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
摘要翻译： 提供了用于扩展深度频域光学相干断层摄影的系统，其包括被配置为以基本相等的频率间隔对频谱元素进行采样的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。 本文还提供了相关方法。
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