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公开(公告)号：US5957958A
公开(公告)日：1999-09-28
申请号：US951893
申请日：1997-10-16
CPC分类号： A61N1/0541 , A61N1/36032
摘要： An implant stimulator device uses tantalum and tantalum pentoxide as a system for the conveyance of electrical stimulation pulses from stimulus-forming circuitry contained within an hermetic enclosure to the saline fluids of body tissue to be stimulated. Internal coupling capacitors are not used, yet the danger of having DC current flow to the saline fluids is eliminated. A preferred embodiment provides a multiplicity of electrode contacts made from sintered, anodized tantalum, connected via tantalum wire leads to tantalum feedthroughs into the hermetically sealed package containing the stimulus pulse-forming electronic circuitry. One or more counter electrode contacts (for monopolar or bipolar configurations, respectively) made of activated iridium, non-activated iridium, iridium in combination with a noble or non-noble metal, platinum, gold, or other metal which forms a low impedance contact with body fluids, is/are connected via platinum or other conductive metal leads to return feedthroughs. When powered-up, the stimulus generating circuit produces a steady polarizing potential of approximately half its maximum output voltage range, which potential is applied as a positive (anodizing) voltage to each tantalum electrode and associated lead and feedthrough, with respect to the counter electrode(s), which act as the reference point for the circuit.
摘要翻译： 植入刺激装置使用钽和五氧化二钽作为用于将包含在密封外壳内的刺激形成电路的电刺激脉冲传送到待刺激的身体组织的盐水流体的系统。 不使用内部耦合电容器，但是消除了将直流电流流向盐水流体的危险。 优选实施例提供了由烧结的阳极氧化钽制成的多个电极触点，其通过钽线引线连接到钽馈通到包含刺激脉冲形成电子电路的密封封装中。 一个或多个反电极触点（分别用于单极或双极结构）由活性铱，非活化铱，铱与贵金属或非贵金属，铂，金或其它金属组合制成，形成低阻抗接触 与体液通过铂或其他导电金属引线连接以返回馈通。 当加电时，刺激产生电路产生大约其最大输出电压范围的一半的稳定极化电位，该电位作为阳极（阳极氧化）电压施加到每个钽电极和相关联的引线和馈通，相对于对电极 （s），其作为电路的参考点。
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公开(公告)号：US5193539A
公开(公告)日：1993-03-16
申请号：US812136
申请日：1991-12-18
IPC分类号： A61N1/372
CPC分类号： A61N1/372 , A61N1/37205 , H01L2224/45147 , H01L2224/48091 , H01L2224/49109
摘要： An addressable, implantable microstimulator is substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. Power and information for operating the microstimulator is received through a modulated, alternating magnetic field in which a coil is adapted to function as the secondary winding of a transformer. Electrical energy is stored in capacitor means and is released into the living body by controlled, stimulating pulses which pass through body fluids and tissue between the exposed electrodes of the microstimulator. Detection and decoding means within the microstimulator are provided for controlling the stimulating pulses in accordance with the modulation of the received, alternating magnetic field. Means for controllably recharging the capacitor is provided.
摘要翻译： 可寻址的可植入微型刺激器基本上封装在对体液惰性的气密密封的壳体中，并且能够通过皮下注射针排出而能够植入生物体中的尺寸和形状。 用于操作微型激励器的功率和信息通过调制的交变磁场接收，其中线圈适于用作变压器的次级绕组。 电能存储在电容器装置中，并通过受微刺激器暴露的电极之间通过体液和组织的受控刺激脉冲释放到生物体内。 提供了微型激励器内的检测和解码装置，用于根据所接收的交变磁场的调制来控制刺激脉冲。 提供了用于可控地对电容器充电的装置。
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公开(公告)号：US5324316A
公开(公告)日：1994-06-28
申请号：US025889
申请日：1993-03-03
CPC分类号： A61N1/372 , A61N1/37205 , H01L2224/45147 , H01L2224/48091 , H01L2224/49109
摘要： An addressable, implantable microstimulator is substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. Power and information for operating the microstimulator is received through a modulated, alternating magnetic field in which a coil is adapted to function as the secondary winding of a transformer. Electrical energy is stored in capacitor means and is released into the living body by controlled, stimulating pulses which pass through body fluids and tissue between the exposed electrodes of the microstimulator. Detection and decoding means within the microstimulator are provided for controlling the stimulating pulses in accordance with the modulation of the received, alternating magnetic field. Means for controllably recharging the capacitor is provided.
摘要翻译： 可寻址的可植入微型刺激器基本上封装在对体液惰性的气密密封的壳体中，并且能够通过皮下注射针排出而能够植入生物体中的尺寸和形状。 用于操作微型激励器的功率和信息通过调制的交变磁场接收，其中线圈适于用作变压器的次级绕组。 电能存储在电容器装置中，并通过受微刺激器暴露的电极之间通过体液和组织的受控刺激脉冲释放到生物体内。 提供了微型激励器内的检测和解码装置，用于根据所接收的交变磁场的调制来控制刺激脉冲。 提供了用于可控地对电容器充电的装置。
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公开(公告)号：US5193540A
公开(公告)日：1993-03-16
申请号：US812051
申请日：1991-12-18
CPC分类号： A61N1/3787 , A61N1/37205
摘要： An implantable microstimulator has a structure which is manufactured to be substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. The internal structure of the microstimulator comprises a coil adapted to function as the secondary winding of a transformer and receive power and control information. Circuit means, including control electronics, a capacitor and electrodes are provided. The electrodes, which may be made one of iridium and the other of tantalum and placed on opposite ends of the microstimulator, or alternatively, an iridium electrode at each end of the microstimulator, are at least partially exposed and provide electrical, stimulating pulses to the body.
摘要翻译： 可植入微型刺激器具有被制造为基本上封装在对体液惰性的气密密封的壳体中，并且具有能够通过皮下注射针排出的能够植入生物体的尺寸和形状的结构。 微型激励器的内部结构包括适于作为变压器的次级绕组起作用并接收功率和控制信息的线圈。 提供包括控制电子器件，电容器和电极的电路装置。 可以制成铱和另一个钽并且放置在微型激励器的相对端上的电极，或者替代地，在微型激励器的每端的铱电极至少部分地暴露，并提供电刺激脉冲 身体。
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公开(公告)号：US5571148A
公开(公告)日：1996-11-05
申请号：US288289
申请日：1994-08-10
申请人： Gerald E. Loeb , Joseph H. Schulman
发明人： Gerald E. Loeb , Joseph H. Schulman
CPC分类号： A61N1/36032 , A61N1/37205
摘要： A multichannel stimulation system includes a plurality of implantable microminiature stimulators (microstimulators), each being connected to a respective implanted electrode or electrode array. Each microstimulator is selectively operable as controlled by an external (non-implanted) control unit. The electrode or electrode array is implanted so as to contact nerves and/or tissue that is to be stimulated. Operating power is inductively coupled from the control unit to the microstimulators. An information signal is also coupled to the microstimulators to control which of the microstimulators is to be activated to provide a stimulation pulse to its respective electrode. In one embodiment, the invention provides a cochlear prosthesis with an intracochlear electrode array being implanted within the human cochlea, and with selected electrodes of the array being connected to individual ones of the plurality of microstimulators. The control unit of such cochlear prosthesis includes a small external transmitter coil that is worn next to the skin where the microstimulators are implanted. The control unit generates a power signal and an information signal for powering and controlling the cochlear prosthesis.
摘要翻译： 多通道刺激系统包括多个可植入的微型激励器（微型激励器），每个激励器连接到相应的注入电极或电极阵列。 每个微型激励器可选择性地由外部（非植入）控制单元控制。 植入电极或电极阵列以接触待刺激的神经和/或组织。 工作电源从控制单元感应耦合到微型激励器。 信息信号还耦合到微型激励器，以控制哪个微型激励器被激活以向其各自的电极提供刺激脉冲。 在一个实施例中，本发明提供了一种耳蜗内假体，其具有植入人耳蜗内的耳内电极阵列，并且阵列的选定电极连接到多个微刺激器中的各个。 这种耳蜗假体的控制单元包括在植入微型刺激器的皮肤旁边佩戴的小型外部发射器线圈。 控制单元生成电力信号和用于为耳蜗假体供电和控制的信息信号。
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公开(公告)号：US5405367A
公开(公告)日：1995-04-11
申请号：US25994
申请日：1993-03-03
CPC分类号： A61N1/3787 , A61N1/37205
摘要： An implantable microstimulator has a structure which is manufactured to be substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body. The internal structure of the microstimulator comprises a coil adapted to function as the secondary winding of a transformer and receive power and control information. Circuit means, including control electronics, a capacitor and electrodes are provided. The electrodes, which may be made one of iridium and the other of tantalum and placed on opposite ends of the microstimulator, or alternatively, an iridium electrode at each end of the microstimulator, are at least partially exposed and provide electrical, stimulating pulses to the body.
摘要翻译： 可植入微型刺激器具有被制造为基本上封装在对体液惰性的气密密封的壳体中，以及能够植入生物体中的尺寸和形状的结构。 微型激励器的内部结构包括适于作为变压器的次级绕组起作用并接收功率和控制信息的线圈。 提供包括控制电子器件，电容器和电极的电路装置。 可以制成铱和另一个钽并且放置在微型激励器的相对端上的电极，或者替代地，在微型激励器的每端的铱电极至少部分地暴露，并提供电刺激脉冲 身体。
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公开(公告)号：US08991680B1
公开(公告)日：2015-03-31
申请号：US13211233
申请日：2011-08-16
CPC分类号： B23K1/19 , A61N1/0531
摘要： The electrode array is a device for making electrical contacts with cellular tissue or organs. The electrode array includes an assembly of electrically conductive electrodes arising from a substrate where the electrodes are hermetically bonded to the substrate. A method of manufacture of an electrode array and associated circuitry is disclosed where the braze preform tab disappears during the braze bonding process and is completely drawn into the substrate feedthrough holes such that the braze perform tab is completely involved in the braze joint and is no longer connecting the adjacent electrodes.
摘要翻译： 电极阵列是用于与细胞组织或器官进行电接触的装置。 电极阵列包括由电极产生的导电电极的组件，其中电极气密地结合到衬底上。 公开了一种制造电极阵列和相关联的电路的方法，其中钎焊预成型件接头在钎焊接合过程期间消失，并且完全拉入衬底馈通孔中，使得钎焊性能接头完全参与钎焊接头并且不再 连接相邻的电极。
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公开(公告)号：US08862235B1
公开(公告)日：2014-10-14
申请号：US11983674
申请日：2007-11-09
申请人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
发明人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
CPC分类号： A61B5/0478 , A61B5/0006 , A61B5/04012 , A61B5/686 , A61N1/36003 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36082
摘要： A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.
摘要翻译： 脑植入装置包括壳体，其包含耦合到导管的通信和控制电子器件，所述导管被配置用于监测来自大脑的运动皮质的信号并向大脑的感觉皮质提供刺激信号。 脑植入装置能够通过设置在壳体中的天线与外部通信和控制信号源进行无线通信。 导管是柔性的并且可以包含上部128个电导体，其借助于从导管延伸并适于与这些部位接触的多个导电突起，在装置电子设备和电动机和/或感觉皮质之间的相关部位提供电连接 。
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公开(公告)号：US08336191B1
公开(公告)日：2012-12-25
申请号：US11833887
申请日：2007-08-03
IPC分类号： H04R31/00
CPC分类号： H03H9/54 , H01L2224/48227 , H01L2224/48465 , H03H9/1021 , H05K13/04 , Y10T29/49005 , Y10T29/49007 , Y10T29/4908 , H01L2924/00
摘要： An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.
摘要翻译： 电子滤波器电路包括直接安装到硅集成电路的表面的机电谐振器，而不是在电路板上的表面安装或引线的过滤器罐。 该滤波器电路允许集成电路电子封装显着小于常规机电谐振器封装。 机械共振器可以在加工期间和使用期间由诸如钛的材料制成的保护盖保护。 保护盖连接到集成电路芯片。
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10.发明申请Video Processing Methods for Improving Visual Acuity and/or Perceived Image Resolution 有权用于改善视觉和/或感知图像分辨率的视频处理方法公开(公告)号：US20110288612A1
公开(公告)日：2011-11-24
申请号：US13196020
申请日：2011-08-02
申请人： Robert J. Greenberg , Richard P. Willamson , Joseph H. Schulman , Reza P. Rassool , Lee J. Mandell , Abraham N. Seidman
发明人： Robert J. Greenberg , Richard P. Willamson , Joseph H. Schulman , Reza P. Rassool , Lee J. Mandell , Abraham N. Seidman
IPC分类号： A61F9/08
CPC分类号： A61N1/36046
摘要： A method and apparatus for improving visual acuity when providing a visual image from a “high” resolution input device to a “low” resolution output device. The described invention is of particular use when the output device is an array of electrodes as part of a retinal prosthesis used to restore vision to a visually-impaired patient. In that various limitations may, within the foreseeable future, limit the density of such an electrode array (and thus the resolution of the output image), the present invention teaches techniques to assign processed pixel subsets of a higher resolution image to a single electrode. By varying the pixel subsets, e.g., by jittering, and/or altering the processing criteria, the perceived visual acuity may be further improved. Alternatively and additionally, such processing may be further extended to drive neighboring electrodes in combination to thus stimulate virtual electrode sites and thus further enhance visual acuity.
摘要翻译： 当从“高”分辨率输入装置向“低”分辨率输出装置提供视觉图像时，用于提高视力的方法和装置。 当输出设备是用作将视力恢复到视觉障碍患者的视网膜假体的一部分的电极阵列时，所描述的本发明是特别有用的。 因此，在可预见的将来可能会限制这种电极阵列的密度（因此输出图像的分辨率）的各种限制，本发明教导了将更高分辨率图像的经处理的像素子集分配给单个电极的技术。 通过例如通过抖动和/或改变处理标准来改变像素子集，可以进一步改善感知的视敏度。 另外地和另外地，这样的处理可以进一步延伸以组合驱动相邻电极，从而刺激虚拟电极位置，从而进一步提高视敏度。
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