公开(公告)号：US20060229694A1

公开(公告)日：2006-10-12

申请号：US11392163

申请日：2006-03-29

申请人： Joseph Schulman ,  Charles Byers ,  John Gord ,  Rajiv Shah ,  Lyle Canfield

发明人： Joseph Schulman ,  Charles Byers ,  John Gord ,  Rajiv Shah ,  Lyle Canfield

IPC分类号： A61N1/05

CPC分类号： A61N1/36585 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0219 ,  A61M5/1723 ,  A61N1/05 ,  A61N1/372 ,  A61N1/3754 ,  H01L23/3107 ,  H01L29/0657 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/00

摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensor may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.

摘要翻译： 可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。 保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。 电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。 其上形成有电子电路和电极的基板是与其上形成集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。 这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。 在一个实施例中，两个这样的衬底传感器可以背靠背放置，电极面向外。 根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。

公开(公告)号：US20050233172A1

公开(公告)日：2005-10-20

申请号：US11150547

申请日：2005-06-10

申请人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

发明人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

IPC分类号： A61L2/00 ,  A61N1/02 ,  B05D3/00 ,  B32B9/00 ,  C23C14/00 ,  C23C14/04 ,  G03F1/00 ,  G03F7/20 ,  H01L21/308 ,  H01L23/29 ,  H05K3/28

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。

公开(公告)号：US20050106366A1

公开(公告)日：2005-05-19

申请号：US10969758

申请日：2004-10-20

申请人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

发明人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

IPC分类号： A61L2/00 ,  A61N1/02 ,  B05D3/00 ,  B32B9/00 ,  C23C14/00 ,  C23C14/04 ,  G03F1/00 ,  G03F7/20 ,  H01L21/308 ,  H01L23/29 ,  H05K3/28 ,  B32B15/04 ,  C23C14/32

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

公开(公告)号：US06671554B2

公开(公告)日：2003-12-30

申请号：US10033720

申请日：2001-12-27

申请人： Scott R. Gibson ,  Rajiv Shah ,  Edward Chernoff ,  Charles Byers

发明人： Scott R. Gibson ,  Rajiv Shah ,  Edward Chernoff ,  Charles Byers

IPC分类号： A61N1375

CPC分类号： A61N1/3752 ,  A61N1/05 ,  Y10S439/909

摘要： An implantable coaxial lead includes a cable with male and female connectors. The cable includes inner and outer helical coils separated by an inner insulator tube, with an outer insulator tube surrounding the outer helical coil. The male connector includes an outer conductive cylinder, a conductive pin and an insulator molded in between. For increased strength, a braided cylinder, infused with rubber, is included at the juncture of the male connector and the cable. The female connector includes a cylinder formed by two conducting body elements and an intervening insulating body element. The female connector includes respective conductive tension elements configured to engage the male connector. A first seal is provided between the conductive tension members for electrical isolation and tactile feedback. An insertion tool includes a cylinder with a hollow bore and detachable head, and a rod for pulling the lead through the cylinder.

公开(公告)号：US20070067007A1

公开(公告)日：2007-03-22

申请号：US11380877

申请日：2006-04-28

申请人： Joseph Schulman ,  Guangqiang Jiang ,  Charles Byers

发明人： Joseph Schulman ,  Guangqiang Jiang ,  Charles Byers

IPC分类号： A61N1/00

CPC分类号： A61N1/0526 ,  A61N1/0531

摘要： The electrode array is a device for making electrical contacts with cellular tissue or organs. The electrode array includes an assembly of electrically conductive electrodes arising from a substrate where the electrodes are hermetically bonded to the substrate. The electrodes also include an insulating layer which leaves at least one zone or at least one hole exposed for making focused electrical contact with the tissue. A hole passing completely or partially through the electrode may further provide an anchor to the living tissue, thereby stabilizing the array with respect to the tissue being examined. Also, a method of manufacture of an electrode array and associated circuitry is disclosed.

摘要翻译： 电极阵列是用于与细胞组织或器官进行电接触的装置。 电极阵列包括由电极产生的导电电极的组件，其中电极气密地结合到衬底上。 电极还包括绝缘层，其离开暴露以用于与组织聚焦的电接触的至少一个区域或至少一个孔。 完全或部分穿过电极的孔可以进一步向活组织提供锚定，从而使阵列相对于被检查的组织稳定。 此外，公开了一种制造电极阵列和相关电路的方法。

公开(公告)号：US20050193860A1

公开(公告)日：2005-09-08

申请号：US11096818

申请日：2005-03-31

申请人： Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

发明人： Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

IPC分类号： A61B5/00 ,  C22B4/00 ,  C21C5/52

CPC分类号： A61B5/14865 ,  A61B5/14532

摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

公开(公告)号：US20050189848A1

公开(公告)日：2005-09-01

申请号：US11111306

申请日：2005-04-20

申请人： Charles Byers ,  Joseph Schulman ,  Gary Schnittgrund

发明人： Charles Byers ,  Joseph Schulman ,  Gary Schnittgrund

IPC分类号： H03H3/02 ,  H03H9/10 ,  H01L41/053

CPC分类号： H03H9/54 ,  H01L2224/48227 ,  H01L2224/48465 ,  H03H9/1021 ,  H05K13/04 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/4908 ,  H01L2924/00

摘要： An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.

摘要翻译： 电子滤波器电路包括直接安装到硅集成电路的表面的机电谐振器，而不是在电路板上的表面安装或引线的过滤器罐。 该滤波器电路允许集成电路电子封装显着小于常规机电谐振器封装。 机械共振器可以在加工期间和使用期间由诸如钛的材料制成的保护盖保护。 保护盖连接到集成电路芯片。

公开(公告)号：US20060293762A1

公开(公告)日：2006-12-28

申请号：US11419898

申请日：2006-05-23

申请人： Joseph Schulman ,  Charles Byers

发明人： Joseph Schulman ,  Charles Byers

IPC分类号： A61F2/78

CPC分类号： A61F2/78 ,  A61F2002/546 ,  A61F2210/009

摘要： Permanent magnets or electromagnets or a combination of such magnets are provided to retain a prosthetic device on an extremity, such as an arm. The prosthesis utilizes the opposing forces, which are developed by virtue of like magnetic poles being in proximity to each other, to urge the prosthesis to remain attached to the extremity. The prosthesis is prevented from rotation by virtue of a centering force that is provided by an attachment magnet in the prosthesis being placed between two implanted magnets. A removable mounting ring is placed over the prosthesis straps to maintain them in proximity to the extremity.

摘要翻译： 提供永磁体或电磁体或这种磁体的组合以将修复装置保持在诸如臂的末端上。 假体利用由彼此靠近的相似磁极而开发的相对的力，以促使假体保持附接到肢体。 通过由放置在两个植入的磁体之间的假体中的附接磁体提供的定心力来防止假体旋转。 可拆卸的安装环放置在假体带上方以将其保持在靠近肢体的位置。

公开(公告)号：US20070047520A1

公开(公告)日：2007-03-01

申请号：US11217014

申请日：2005-08-31

申请人： Charles Byers ,  Stuart Goldman ,  Richard Krock ,  Karl Rauscher ,  James Runyon

发明人： Charles Byers ,  Stuart Goldman ,  Richard Krock ,  Karl Rauscher ,  James Runyon

IPC分类号： H04L12/66

CPC分类号： H04M7/006 ,  H04M3/42357 ,  H04M3/5322 ,  H04M3/53375 ,  H04M2203/205 ,  H04M2242/04

摘要： The present invention provides a method for calling multimedia IP units about an impending emergency situation. A multimedia IP communication network or government authority forecasts the path of an impending emergency situation to create an impending impact area. The VoIP communication network determines the multimedia IP units that are located within the impending impact area. The multimedia IP communication network calls the multimedia IP units that are located within the impending impact area about the impending emergency situation, providing multi-media instructions to the users of the multimedia IP units.

摘要翻译： 本发明提供了一种用于呼叫即将到来的紧急情况的多媒体IP单元的方法。 多媒体IP通信网络或政府机构预测即将发生的紧急情况的路径，以创造即将到来的影响区域。 VoIP通信网络确定位于即将到来的冲击区域内的多媒体IP单元。 多媒体IP通信网络呼叫即将到来的紧急情况下即将到来的影响区域内的多媒体IP单元，向多媒体IP单元的用户提供多媒体指令。

公开(公告)号：US20050175293A1

公开(公告)日：2005-08-11

申请号：US10772957

申请日：2004-02-05

申请人： Charles Byers ,  Albert Holliday ,  Claudio Spinelli

发明人： Charles Byers ,  Albert Holliday ,  Claudio Spinelli

IPC分类号： G02B6/36 ,  G02B6/44

CPC分类号： G02B6/4439

摘要： An electronic shelf contains a plurality of circuit board assemblies mounted adjacent each other. Each circuit board assembly includes a circuit board with an attached front faceplate having a recessed wall that defines a rearward extending recess between a bottom edge and a top edge of the circuit board. An optical fiber is connected to the circuit board. A bail is mounted adjacent each of the front faceplates, each bail being movable from a seated position to an extended position. The optical fibers are held by an associated bail at an intermediate location along a length of the optical fiber. The optical fibers have a first portion that is contained within the rearward extending recess with the associated bail in its seated position. The first portion of the optical fiber is pulled forwardly from within the recess and away from the associated front faceplate with the associated bail in its extended position. This arrangement facilitates the easy removal of a circuit board without optical fibers of other circuit boards being in the way.

摘要翻译： 电子货架包含彼此相邻安装的多个电路板组件。 每个电路板组件包括具有附接的前面板的电路板，该前面板具有凹陷壁，该凹壁在电路板的底部边缘和顶部边缘之间限定向后延伸的凹部。 光纤连接到电路板。 在每个前面板附近安装保释环，每个吊环可从就座位置移动到延伸位置。 光纤通过沿着光纤的长度的中间位置处的相关吊环保持。 光纤具有第一部分，其包含在向后延伸的凹部内，相关联的吊环处于其就位位置。 光纤的第一部分从凹槽内向前拉，并远离相关的前面板，相关联的吊环处于伸出位置。 这种布置有助于轻松地去除电路板，而不会妨碍其它电路板的光纤。