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    Quaternised Ammonium Cyclodextrin Compounds
    5.
    发明申请
    Quaternised Ammonium Cyclodextrin Compounds 审中-公开
    季铵化环糊精化合物

    公开(公告)号：US20120004158A1

    公开(公告)日：2012-01-05

    申请号：US13234912

    申请日：2011-09-16

    申请人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    发明人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    IPC分类号： A61K38/00 ,  A61P31/04 ,  A61K31/711 ,  A61P31/10 ,  A61K31/7105 ,  A61K31/715 ,  A61P31/00

    CPC分类号： A61K31/724 ,  A61K31/196 ,  A61K31/4535 ,  C08B37/0012

    摘要： Use of a compound of formula (I): wherein the symbol cyclodextrin ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

    摘要翻译： 式（I）化合物的用途：其中符号环糊精] n表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数，表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基，羟基亚烷基，卤代亚烷基，单环亚芳基，亚环烷基和亚苯基的二价基团; R2，R3和R4各自独立地为选自烷基，环烷基，芳基，芳烷基和环戊基的基团; Xm-是一个m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中，k为n / m，作为防腐剂和渗透促进剂。

    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE
    6.
    发明申请
    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
    新生物材料，其制备和使用

    公开(公告)号：US20080299166A1

    公开(公告)日：2008-12-04

    申请号：US12178934

    申请日：2008-07-24

    申请人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy L. Kis ,  Christian Schoch

    发明人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy L. Kis ,  Christian Schoch

    IPC分类号： A61K47/30 ,  A61K47/40 ,  A61F2/00 ,  A61K38/02 ,  A61P17/02 ,  A61K31/56 ,  A61K38/43

    CPC分类号： A61K9/0024 ,  A61K9/7015 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/602 ,  A61L2300/802 ,  C08L5/16

    摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

    摘要翻译： 本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选 到另外包含所述环糊精组分的相应沉淀物。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

    Cyclodextrin inclusion complex of piperonyl butoxide
    8.
    发明授权
    Cyclodextrin inclusion complex of piperonyl butoxide 失效
    胡椒基丁醚的环糊精包合物

    公开(公告)号：US4524068A

    公开(公告)日：1985-06-18

    申请号：US550478

    申请日：1983-11-09

    申请人： Jozsef Szejtli ,  Zsuzsanna Budai ,  Erzsebet Radvany nee Hegedus ,  Laszlo Papp ,  Gyorgy Kormoczy ,  Gabriella Pap nee Imrenyi

    发明人： Jozsef Szejtli ,  Zsuzsanna Budai ,  Erzsebet Radvany nee Hegedus ,  Laszlo Papp ,  Gyorgy Kormoczy ,  Gabriella Pap nee Imrenyi

    IPC分类号： A01N43/30 ,  A61K47/48 ,  C07D317/54 ,  A61K31/73

    CPC分类号： B82Y5/00 ,  A01N43/30 ,  A61K47/48969 ,  C07D317/54

    摘要： The invention relates to new inclusion complexes of piperonyl butoxide formed with cyclodextrin.The new complex of the invention can be prepared by reacting cyclodextrin or a solution thereof formed with water and/or an organic solvent having 1-4 carbon atoms, preferably ethanol with piperonyl butoxide or a solution thereof formed with an organic solvent having 1-4 carbon atoms, preferably ethanol at a temperature between 20.degree. C. and 90.degree. C., whereby the piperonyl butoxide is used in an amount of 0.6-1.5 moles related to 1 mole of cyclodextrin.The complexes of the present invention synergize the pesticidal effect of known insecticides and fungicides to a much higher extent of known insecticides and fungicides to a much higher extent than piperonyl butoxide used per se.

    摘要翻译： 本发明涉及与环糊精形成的胡椒基丁醚的新的包合络合物。 本发明的新配合物可以通过使环糊精或其与水和/或具有1-4个碳原子的有机溶剂，优选乙醇与胡椒基丁醚形成的溶液或其形成有有机溶剂的溶液， 碳原子，优选乙醇，温度在20℃至90℃之间，其中胡椒基丁醚的用量为与1摩尔环糊精有关的0.6-1.5摩尔。 本发明的配合物与已知的杀虫剂和杀真菌剂的杀虫作用相比，已知的杀虫剂和杀真菌剂的杀虫效果比本身使用的胡椒基丁醚的效果高得多。

    Sorbents of cellulose basis capable of forming inclusion complexes and a process for the preparation thereof
    9.
    发明授权
    Sorbents of cellulose basis capable of forming inclusion complexes and a process for the preparation thereof 失效
    能够形成包合物的纤维素基质的吸附剂及其制备方法

    公开(公告)号：US4357468A

    公开(公告)日：1982-11-02

    申请号：US288764

    申请日：1981-07-31

    申请人： Jozsef Szejtli ,  Bela Zsadon ,  Eva Fenyvesi ,  nee Otta; Klara Horvath ,  Ferenc Tudos

    发明人： Jozsef Szejtli ,  Bela Zsadon ,  Eva Fenyvesi ,  nee Otta; Klara Horvath ,  Ferenc Tudos

    IPC分类号： C08L1/00 ,  C08B11/08 ,  C08B15/00 ,  C08B37/16

    CPC分类号： C08B37/0012 ,  C08B11/08

    摘要： The invention relates to new sorbents of cellulose basis capable of forming inclusion complexes, as well as to a process for the preparation thereof. The new sorbents according to the invention are cellulose derivatives containing structural units of the general formula (I), ##STR1## wherein Cell is a group derived by removing m hydroxy groups from the glucose unit of the cellulose chain,m is an integer of 1 to 3,CD is a group derived by removing one hydroxy group from the .alpha., .beta. or .gamma.-cyclodextrin molecule,n is an integer of 1 to 5, andp stands for 0 or 1, which may optionally vary even within a single chain.The cellulose derivatives according to the invention are substances of loose structure, with large specific surface area and good swelling properties, which can be applied for solving the most diverse adsorption tasks. Thus e.g. the substances can be applied for the preparation of smoke filters in cigarettes, waste water purification (de-poisoning) filters, inserts for removing solvent vapors, etc., furthermore for solving specific tasks of fractionation according to molecular dimensions.

    摘要翻译： 本发明涉及能够形成包合络合物的新型纤维素基质吸附剂，以及其制备方法。 根据本发明的新吸附剂是含有通式（I），Cell {[OCH 2（CHOH）pCH 2] nOCD} m（I）的结构单元的纤维素衍生物，其中Cell是从葡萄糖中除去m个羟基衍生的基团 纤维素链的单位，m为1〜3的整数，CD为从α，β或γ-环糊精分子除去一个羟基衍生的基团，n为1〜5的整数，p为0 或1，其可以任选地在单链内变化。 根据本发明的纤维素衍生物是松散结构的物质，具有大的比表面积和良好的溶胀性能，可用于解决最多样化的吸附任务。 因此，例如 该物质可用于制备香烟中的烟雾过滤器，废水净化（去中毒）过滤器，用于除去溶剂蒸气的插入物等，此外用于根据分子尺寸解决特定的分馏任务。

    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE
    10.
    发明申请
    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
    新生物材料，其制备和使用

    公开(公告)号：US20120040901A1

    公开(公告)日：2012-02-16

    申请号：US13281033

    申请日：2011-10-25

    申请人： Lajos Szente ,  Jozsef Szejtli ,  György Lajos Kis ,  Christian Schoch

    发明人： Lajos Szente ,  Jozsef Szejtli ,  György Lajos Kis ,  Christian Schoch

    IPC分类号： A61K38/22 ,  C12N9/00 ,  A61K31/4535 ,  A23L1/48 ,  A61K31/568 ,  A61K31/5575 ,  A61P43/00 ,  A01P15/00 ,  A01N25/00 ,  A61K31/12

    CPC分类号： A61K9/0024 ,  A61K9/7015 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/602 ,  A61L2300/802 ,  C08L5/16

    摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

    摘要翻译： 本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选 到另外包含所述环糊精组分的相应沉淀物。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。