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公开(公告)号:US3969501A
公开(公告)日:1976-07-13
申请号:US580341
申请日:1975-05-23
CPC分类号: A61K38/164 , A61K35/742 , Y10S435/833
摘要: A new antibiotic, 342-14-I, bein useful as a medicament and veterinary drug for inhibiting the growth of gram-positive pathogenic microorganism, and a process for preparing the same, being characterized by cultivating a 342-14-I-producing strain of microorganism belonging to the Genus Bacillus in an aqueous nutrient medium under aerobic conditions.
摘要翻译: 一种新的抗生素342-14-I可用作抑制革兰氏阳性病原微生物生长的药物和兽药及其制备方法,其特征在于培养产生342-14-I的菌株 的属于芽孢杆菌属的微生物在有氧条件下的水性营养培养基中。
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公开(公告)号:US4292241A
公开(公告)日:1981-09-29
申请号:US115278
申请日:1980-01-25
申请人: Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
发明人: Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
IPC分类号: C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04 , C12P17/18 , C12R1/465
CPC分类号: C07D477/20 , C12P17/184 , C12R1/465
摘要: A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.
摘要翻译: 具有β-内酰胺酶抑制活性的新型抗生素PA-31088-IV可用作药物和用于抑制革兰氏阳性和革兰氏阴性致病微生物生长的兽药及其制备方法,其特征在于 培养链霉菌(Toreptomyces tokunonensis sp。) nov。 在合适的培养基中回收PA-31088-IV。
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公开(公告)号:US4362665A
公开(公告)日:1982-12-07
申请号:US211715
申请日:1980-12-01
申请人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号: C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号: C07D477/20 , C12P17/184 , C12R1/465 , Y10S435/886
摘要: A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.1 of the formula: ##STR1## being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and recovering PA-39504-X.sub.1 from the cultured broth.
摘要翻译: 具有β-内酰胺酶抑制活性的新型抗生素,下式的PA-39504-X1可用作药物和用于抑制革兰氏阳性和革兰氏阴性病原微生物生长的兽药,以及制备方法 其特征在于在合适的培养基中培养链霉菌PA-39504或链霉菌Tokunonensis PA-31088,并从培养液中回收PA-39504-X1。
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公开(公告)号:US4256835A
公开(公告)日:1981-03-17
申请号:US15869
申请日:1979-02-27
IPC分类号: C12P1/06 , C07D501/57 , C12P35/08
CPC分类号: C12P35/08 , Y10S435/886
摘要: A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium and recovering cephamycin C from the fermentation broth.
摘要翻译: 一种用于制备头孢霉素C的新型方法,已知的抗生素可用作药物和兽药,其特征在于培养链霉菌属(Streptomyces todorominensis sp。 nov。 在合适的培养基中并从发酵液中回收头霉素C。
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公开(公告)号:US4456686A
公开(公告)日:1984-06-26
申请号:US421580
申请日:1982-09-22
申请人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号: C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465
CPC分类号: C07D477/20 , C12P17/184 , C12R1/465 , Y10S435/886
摘要: A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.1 of the formula: ##STR1## being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and recovering PA-39504-X.sub.1 from the cultured broth.
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公开(公告)号:US4387052A
公开(公告)日:1983-06-07
申请号:US286757
申请日:1981-07-27
申请人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人: Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号: C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号: C07D477/20 , C12P17/184
摘要: A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.3 of the formula: ##STR1## and the pharmaceutically acceptable slats being useful as a drug, a animal drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and isolating PA-39504-X.sub.3 from the cultured broth.
摘要翻译: 具有β-内酰胺酶抑制活性的新型抗生素,下式的PA-39504-X3:药物可接受的片剂可用作药物,动物药物和用于抑制革兰氏阳性和革兰氏阳性菌生长的消毒剂, 阴性致病微生物及其制备方法,其特征在于在合适的培养基中培养棒状链霉菌PA-39504或链霉菌Tokunonensis PA-31088,并从培养液中分离PA-39504-X3。
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公开(公告)号:US5171836A
公开(公告)日:1992-12-15
申请号:US545565
申请日:1990-06-29
IPC分类号: C12N1/20 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/06 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/38
CPC分类号: C07K7/06
摘要: This invention provides a novel compound of the formula: ##STR1## wherein X is L-HyPro or L-Pro, R is --CH.sub.3 or --CH(CH.sub.3).sub.2, and n is an integer from 9 to 12, or its salt, a process for producing the compound which comprises cultivating a microorganism which belongs to the genus Pseudomonas and produces the compound in a medium and recovering the compound from the medium and a biologically pure culture of Pseudomas sp. PB-6250 producing the compound.
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公开(公告)号:US5011952A
公开(公告)日:1991-04-30
申请号:US516982
申请日:1990-04-30
申请人: Tadashi Yoshida , Keizo Inoue , Hitoshi Arita , Shigeru Matsutani , Jun'ichi Shoji , Yoshimi Kawamura
发明人: Tadashi Yoshida , Keizo Inoue , Hitoshi Arita , Shigeru Matsutani , Jun'ichi Shoji , Yoshimi Kawamura
IPC分类号: C12P1/02 , A61K38/55 , A61P3/00 , A61P7/00 , A61P9/02 , A61P25/08 , C07D311/82 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/41 , C12N9/99 , C12P17/06 , C12R1/645
CPC分类号: C12R1/645 , C07D311/82 , C12P17/06
摘要: A compound of the formula: ##STR1## wherein the wave line means .alpha.-bond or .beta.-bond, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.
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