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    Methods for analyzing interactions between proteins and sugar chains
    2.
    发明授权
    Methods for analyzing interactions between proteins and sugar chains 有权
    分析蛋白质与糖链之间相互作用的方法

    公开(公告)号：US08008094B2

    公开(公告)日：2011-08-30

    申请号：US10596692

    申请日：2004-12-24

    申请人： Jun Hirabayashi ,  Atsushi Kuno ,  Sachiko Nakamura ,  Noboru Uchiyama

    发明人： Jun Hirabayashi ,  Atsushi Kuno ,  Sachiko Nakamura ,  Noboru Uchiyama

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54393 ,  G01N33/543 ,  Y10S435/97

    摘要： As a result of investigating the optimum conditions of methods for immobilizing proteins that interact with sugar chains onto a substrate, it was revealed that coating the surface of a slide glass with GTMS enables immobilization at a higher S/N ratio than conventionally possible. Moreover, by using a substrate to which a rubber with a number of holes was affixed to form a number of reaction vessels, and further by spotting lectins onto the substrate and washing with PBST, the weak interactions between sugar chains and lectins were successfully detected with improved sensitivity. In addition, by introducing an evanescent excitation-type scanner, it became possible to detect the interactions between lectins and sugar chains without washing away the probe solution.

    摘要翻译： 通过研究将与糖链相互作用的蛋白质固定在基质上的最佳条件的结果，显示用GTMS涂覆载玻片的表面使得能够以比传统可能的更高的S / N比固定。 此外，通过使用固定有多个孔的橡胶的基板以形成多个反应容器，并且进一步通过将凝集素点样到基板上并用PBST洗涤，成功检测到糖链和凝集素之间的弱相互作用 提高灵敏度。 此外，通过引入ev逝激发型扫描仪，可以检测凝集素和糖链之间的相互作用而不洗掉探针溶液。

    Methods For Analyzing Interactions Between Proteins And Sugar Chains
    3.
    发明申请
    Methods For Analyzing Interactions Between Proteins And Sugar Chains 有权
    分析蛋白质和糖链之间相互作用的方法

    公开(公告)号：US20070202535A1

    公开(公告)日：2007-08-30

    申请号：US10596692

    申请日：2004-12-24

    申请人： Jun Hirabayashi ,  Atsushi Kuno ,  Sachiko Nakamura ,  Noboru Uchiyama

    发明人： Jun Hirabayashi ,  Atsushi Kuno ,  Sachiko Nakamura ,  Noboru Uchiyama

    IPC分类号： G01N33/53 ,  C07K14/705

    CPC分类号： G01N33/54393 ,  G01N33/543 ,  Y10S435/97

    摘要： As a result of investigating the optimum conditions of methods for immobilizing proteins that interact with sugar chains onto a substrate, it was revealed that coating the surface of a slide glass with GTMS enables immobilization at a higher S/N ratio than conventionally possible. Moreover, by using a substrate to which a rubber with a number of holes was affixed to form a number of reaction vessels, and further by spotting lectins onto the substrate and washing with PBST, the weak interactions between sugar chains and lectins were successfully detected with improved sensitivity. In addition, by introducing an evanescent excitation-type scanner, it became possible to detect the interactions between lectins and sugar chains without washing away the probe solution.

    摘要翻译： 通过研究将与糖链相互作用的蛋白质固定在基质上的最佳条件的结果，显示用GTMS涂覆载玻片的表面使得能够以比传统可能的更高的S / N比固定。 此外，通过使用固定有多个孔的橡胶的基板以形成多个反应容器，并且进一步通过将凝集素点样到基板上并用PBST洗涤，成功检测到糖链和凝集素之间的弱相互作用 提高灵敏度。 此外，通过引入ev逝激发型扫描仪，可以检测凝集素和糖链之间的相互作用而不洗掉探针溶液。

    METHOD OF DETECTING SUGAR CHAINS HAVING GlcNAc TRANSFERRED BY GnT-V
    4.
    发明申请
    METHOD OF DETECTING SUGAR CHAINS HAVING GlcNAc TRANSFERRED BY GnT-V 审中-公开
    检测由GnT-V转移的GlcNAc的糖链的方法

    公开(公告)号：US20090117599A1

    公开(公告)日：2009-05-07

    申请号：US12095013

    申请日：2006-12-14

    申请人： Jun Hirabayashi ,  Sachiko Nakamura ,  Masugu Kamei ,  Junko Kominami

    发明人： Jun Hirabayashi ,  Sachiko Nakamura ,  Masugu Kamei ,  Junko Kominami

    IPC分类号： C12Q1/48 ,  C07H1/00 ,  C07H5/06

    CPC分类号： C12Q1/48 ,  C08B37/00 ,  G01N33/53 ,  G01N2333/4724 ,  G01N2333/91091 ,  G01N2400/00

    摘要： It is intended to provide a method by which sugar chains having GlcNAc transferred by GnT-V can be accurately detected, screened and purified. In this detection method, two kinds of lectins differing in detailed GlcNAc-specificity are used together. As shown in FIG. 1(I), for example, a sample containing sugar chains having GlcNAc transferred by GnT-V is screened by using a lectin GSL-II, which recognizes sugar chains having GlcNAc transferred by GnT-V, and then the screened sample is screened again by using another lectin BLL, which does not recognizes sugar chains having GlcNAc transferred by GnT-V, to thereby detect, screen and purify the sugar chains having GlcNAc transferred by GnT-V alone.

    摘要翻译： 旨在提供可以精确地检测，筛选和纯化由GnT-V转移的具有GlcNAc的糖链的方法。 在该检测方法中，两种不同的GlcNAc特异性的凝集素一起使用。 如图所示。 如图1（I）所示，通过使用凝集素GSL-II筛选含有通过GnT-V转移的GlcNAc的糖链的样品，凝集素GSL-II识别通过GnT-V转移的具有GlcNAc的糖链，然后再次筛选筛选的样品 通过使用不识别由GnT-V转移的GlcNAc的糖链的另一种凝集素BLL，从而检测，筛选和纯化仅由GnT-V转移的GlcNAc的糖链。

    Device for starting occupant crash protector
    5.
    发明授权
    Device for starting occupant crash protector 失效
    起动乘员碰撞保护装置

    公开(公告)号：US6104973A

    公开(公告)日：2000-08-15

    申请号：US722776

    申请日：1996-09-27

    申请人： Takami Sugiyama ,  Hideki Nishi ,  Sachiko Nakamura ,  Yukihiro Okimoto ,  Takashi Furui

    发明人： Takami Sugiyama ,  Hideki Nishi ,  Sachiko Nakamura ,  Yukihiro Okimoto ,  Takashi Furui

    IPC分类号： B60R21/16 ,  B60R21/01 ,  B60R21/22

    CPC分类号： B60R21/0133 ,  B60R21/0132 ,  B60R21/01332

    摘要： A device for starting an occupant crash protector can output, as a start signal, a logical product of an output of a collision determining mechanism and an output of a non-collision determining mechanism. The collision determining mechanism detects a collision including an impact that does not require a start-up. The non-collision determining mechanism detects only a collision that requires a start-up using a value obtained by subtracting a value varied with time from the output of an acceleration sensor and integrating the result of the subtraction.

    摘要翻译： 用于启动乘员碰撞保护器的装置可以作为起始信号输出碰撞确定机构的输出和非碰撞确定机构的输出的逻辑积。 碰撞确定机构检测包括不需要启动的冲击的碰撞。 非碰撞确定机构仅使用从加速度传感器的输出中减去随时间变化的值而获得的值来仅检测需要起动的碰撞，并且对减法结果进行积分。

    Resin surface treating agent and resin surface treatment
    6.
    发明授权
    Resin surface treating agent and resin surface treatment 失效
    树脂表面处理剂和树脂表面处理

    公开(公告)号：US07297757B2

    公开(公告)日：2007-11-20

    申请号：US11153968

    申请日：2005-06-16

    申请人： Sachiko Nakamura ,  Yoshinari Miyata ,  Terukazu Ishida ,  Miho Misumi

    发明人： Sachiko Nakamura ,  Yoshinari Miyata ,  Terukazu Ishida ,  Miho Misumi

    IPC分类号： C08F6/00

    CPC分类号： C08J7/06 ,  C08J7/12 ,  H05K3/381

    摘要： The present invention relates to a resin surface treating agent containing as an effective component at least one cerium compound selected from tetravalent and trivalent cerium compounds. The surface treating method of the present invention is a method of bringing a surface of a resin into contact with a surface treating agent containing as an effective component at least one cerium compound selected from tetravalent and trivalent cerium compounds, and thereafter treating the surface with an acidic aqueous solution. This activates the resin surface and thereby increases a strength of adhesion of, for instance, a polyimide-based resin film with metal wires, as well as a strength of adhesion of a polyimide-based resin film with another resin. Thus, a resin surface treating agent that provides excellent productivity and reduces processing costs, as well as a surface treating method using the same, are provided.

    摘要翻译： 本发明涉及含有至少一种选自四价和三价铈化合物的铈化合物作为有效成分的树脂表面处理剂。 本发明的表面处理方法是使树脂的表面与含有选自四价和三价铈化合物的至少一种铈化合物作为有效成分的表面处理剂接触，然后用 酸性水溶液。 这激活树脂表面，从而增加例如具有金属线的聚酰亚胺系树脂膜的粘附强度，以及聚酰亚胺系树脂膜与其他树脂的粘合强度。 因此，提供了提供优异的生产率和降低加工成本的树脂表面处理剂以及使用其的表面处理方法。

    Micro-etching composition for copper or copper alloy, micro-etching method, and method for manufacturing printed circuit board
    7.
    发明授权
    Micro-etching composition for copper or copper alloy, micro-etching method, and method for manufacturing printed circuit board 有权
    用于铜或铜合金的微蚀刻组合物，微蚀刻方法和印刷电路板的制造方法

    公开(公告)号：US06746621B2

    公开(公告)日：2004-06-08

    申请号：US09912318

    申请日：2001-07-26

    申请人： Yoshihiro Kurii ,  Etsuji Kameda ,  Sachiko Nakamura

    发明人： Yoshihiro Kurii ,  Etsuji Kameda ,  Sachiko Nakamura

    IPC分类号： C09K1300

    CPC分类号： C23F1/18 ,  H05K3/383

    摘要： A micro-etching composition and a printed circuit board fabricated by using the micro-etching composition are provided. The micro-etching composition, comprising a main ingredient consisting of sulfuric acid and hydrogen peroxide and an assisting ingredient consisting of phenyltetrazole and a chloride ion source, can continuously treat the surface of copper and copper alloys to produce fine microscopic pits for improved adhesion to resins without producing a brown or black deposit. The printed circuit board exhibits excellent adhesion between inner layer circuit patterns and insulation resin layers, and is free from haloing.

    摘要翻译： 提供微蚀刻组合物和使用微蚀刻组合物制造的印刷电路板。 包含由硫酸和过氧化氢组成的主要成分的微蚀刻组合物和由苯基四唑和氯离子源组成的辅助成分可以连续地处理铜和铜合金的表面以产生精细的微观凹坑以改善与树脂的粘合性 不产生棕色或黑色沉积物。 印刷电路板在内层电路图案和绝缘树脂层之间表现出优异的粘附性，并且不会发生晕圈。

    Resin surface treating agent and resin surface treatment
    9.
    发明申请
    Resin surface treating agent and resin surface treatment 失效
    树脂表面处理剂和树脂表面处理

    公开(公告)号：US20050279253A1

    公开(公告)日：2005-12-22

    申请号：US11153968

    申请日：2005-06-16

    申请人： Sachiko Nakamura ,  Yoshinari Miyata ,  Terukazu Ishida ,  Miho Misumi

    发明人： Sachiko Nakamura ,  Yoshinari Miyata ,  Terukazu Ishida ,  Miho Misumi

    IPC分类号： C08J7/06 ,  C08J7/12 ,  C09K13/04 ,  H05K3/38 ,  C07G1/00 ,  B05D1/40 ,  B05D3/00

    CPC分类号： C08J7/06 ,  C08J7/12 ,  H05K3/381

    摘要： The present invention relates to a resin surface treating agent containing as an effective component at least one cerium compound selected from tetravalent and trivalent cerium compounds. The surface treating method of the present invention is a method of bringing a surface of a resin into contact with a surface treating agent containing as an effective component at least one cerium compound selected from tetravalent and trivalent cerium compounds, and thereafter treating the surface with an acidic aqueous solution. This activates the resin surface and thereby increases a strength of adhesion of, for instance, a polyimide-based resin film with metal wires, as well as a strength of adhesion of a polyimide-based resin film with another resin. Thus, a resin surface treating agent that provides excellent productivity and reduces processing costs, as well as a surface treating method using the same, are provided.

    摘要翻译： 本发明涉及含有至少一种选自四价和三价铈化合物的铈化合物作为有效成分的树脂表面处理剂。 本发明的表面处理方法是使树脂的表面与含有选自四价和三价铈化合物的至少一种铈化合物作为有效成分的表面处理剂接触，然后用 酸性水溶液。 这激活树脂表面，从而增加例如具有金属线的聚酰亚胺系树脂膜的粘附强度，以及聚酰亚胺系树脂膜与其他树脂的粘合强度。 因此，提供了提供优异的生产率和降低加工成本的树脂表面处理剂以及使用其的表面处理方法。