-
公开(公告)号：US5023342A
公开(公告)日：1991-06-11
申请号：US199157
申请日：1988-05-26
申请人： K. Barry Sharpless , Yun Gao
发明人： K. Barry Sharpless , Yun Gao
IPC分类号： B01J27/13 , C07B41/02 , C07B61/00 , C07C67/30 , C07C69/675 , C07C69/732 , C07C69/78 , C07C213/02 , C07C215/20 , C07C227/32 , C07C229/24 , C07C247/12 , C07C331/14 , C07D203/08 , C07D317/28 , C07D327/10 , C07D411/14
CPC分类号： C07D203/08 , C07C213/02 , C07C215/20 , C07C227/32 , C07C247/12 , C07C331/14 , C07D317/28 , C07D327/10 , C07D411/14 , C07C2101/14
摘要： A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.
摘要翻译： 从相应的环状亚硫酸盐合成环状硫酸盐化合物的钌催化方法和通过该方法得到的环状硫酸盐反应产物。 这些环状硫酸盐与选择的亲核试剂进一步反应，得到各种取代的产物。 该方法是使用总体两步一锅反应方法以高产率从酒石酸对映异构体合成手性结构单元的有效手段。 手性化合物可以通过亲核反应转化成用于合成天然生物活性产物（如抗生素和信息素）的手性结构单元。
-
公开(公告)号：US5112990A
公开(公告)日：1992-05-12
申请号：US369189
申请日：1989-06-21
申请人： K. Barry Sharpless , Yun Gao
发明人： K. Barry Sharpless , Yun Gao
IPC分类号： B01J27/13 , C07B41/02 , C07B61/00 , C07C67/30 , C07C69/675 , C07C69/732 , C07C69/78 , C07C213/02 , C07C215/20 , C07C227/32 , C07C229/24 , C07C247/12 , C07C331/14 , C07D203/08 , C07D317/28 , C07D327/10 , C07D411/14
CPC分类号： C07D203/08 , C07C213/02 , C07C215/20 , C07C227/32 , C07C247/12 , C07C331/14 , C07D317/28 , C07D327/10 , C07D411/14 , C07C2101/14
摘要： A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.
-
公开(公告)号：US5321143A
公开(公告)日：1994-06-14
申请号：US712199
申请日：1991-06-07
申请人： K. Barry Sharpless , Yun Gao
发明人： K. Barry Sharpless , Yun Gao
IPC分类号： C07C213/02 , C07C215/20 , C07C227/32 , C07C247/12 , C07C331/14 , C07D203/08 , C07D317/28 , C07D327/10 , C07D411/14 , C07D89/08
CPC分类号： C07D203/08 , C07C213/02 , C07C215/20 , C07C227/32 , C07C247/12 , C07C331/14 , C07D317/28 , C07D327/10 , C07D411/14 , C07C2101/14
摘要： A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.
摘要翻译： 从相应的环状亚硫酸盐合成环状硫酸盐化合物的钌催化方法和通过该方法得到的环状硫酸盐反应产物。 这些环状硫酸盐与选择的亲核试剂进一步反应，得到各种取代的产物。 该方法是使用总体两步一锅反应方法以高产率从酒石酸对映异构体合成手性结构单元的有效手段。 手性化合物可以通过亲核反应转化成用于合成天然生物活性产物（如抗生素和信息素）的手性结构单元。
-
公开(公告)号：US08927736B2
公开(公告)日：2015-01-06
申请号：US13389987
申请日：2010-08-11
IPC分类号： C07D403/02 , B01J31/18 , B01J23/72 , C07D249/06 , C07D311/12 , C07D405/04
CPC分类号： B01J31/1805 , B01J23/72 , B01J31/181 , B01J2531/16 , C07D249/06 , C07D311/12 , C07D405/04
摘要： This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substituted-1-haloalkyne, in the presence of a copper catalyst and a copper-coordinating ligand (preferably a tertiary amine) in a liquid reaction medium, thereby forming a 1,4,5-substituted-1,2,3-triazole compound including a halo substituent at the 5-position of the triazole, the organic portion of the organic azide at the 1-position of the triazole, and the substituent of the 1-iodoalkyne at the 4-position of the triazole. A method for preparing 1-iodoalkynes is also provided.
摘要翻译： 本发明提供了一种制备1,2,3-三唑化合物的方法，包括在铜催化剂和铜配位配体（优选叔胺）的存在下使有机叠氮化物与2-取代-1-卤代炔相接触， 在液体反应介质中，由此形成在三唑的5位上含有卤素取代基的1,4,5-取代-1,2,3-三唑化合物，有机叠氮化物在1位的有机部分 的三唑，以及在三唑的4-位上的1-碘代炔的取代基。 还提供了制备1-碘代炔的方法。
-
公开(公告)号：US20100286405A1
公开(公告)日：2010-11-11
申请号：US11992696
申请日：2006-09-29
申请人： Valery Fokin , Guocheng Jia , K. Barry Sharpless
发明人： Valery Fokin , Guocheng Jia , K. Barry Sharpless
IPC分类号： C07D249/06
CPC分类号： C07D249/04 , C07F17/02
摘要： A convenient process for the regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted 1,2,3-triazoles from organic azides and alkynes employs catalytic ruthenium.
摘要翻译： 从有机叠氮化物和炔烃区域选择性合成1,5-二取代的1,2,3-三唑和1,4,5-三取代的1,2,3-三唑的方便的方法使用催化钌。
-
公开(公告)号：US20090069561A1
公开(公告)日：2009-03-12
申请号：US11631081
申请日：2005-06-30
申请人： Valery Fokin , K. Barry Sharpless , Peng Wu , Alina Feldman
发明人： Valery Fokin , K. Barry Sharpless , Peng Wu , Alina Feldman
IPC分类号： C07D249/04 , C07C247/04 , C07D403/12 , C07C43/205 , C07C317/10 , C07C205/03 , C07D251/32 , C07C247/06
CPC分类号： C08G73/00 , C07C233/05 , C07C311/16 , C07D403/12 , C07D403/14 , C08G83/003
摘要： The high efficiency and fidelity of click chemistry permits a large number of diverse dendrimers encompassing a wide variety of functionalities at the chain ends, repeat units, and/or core to be prepared. Almost quantitative yields were obtained during the synthesis. In some cases, filtration or solvent extraction was the only method required for purification. These features represent a significant advancement in dendrimer chemistry and demonstrate an evolving synergy between organic chemistry and functional materials.
摘要翻译： 点击化学的高效率和高保真性允许大量不同的树枝状聚合物，其包括在链末端，重复单元和/或待制备的核心上的各种功能。 在合成过程中获得了几乎定量的产率。 在某些情况下，过滤或溶剂萃取是纯化所需的唯一方法。 这些特征代表着树枝状大分子化学的显着进步，并展示了有机化学与功能材料之间不断发展的协同作用。
-
公开(公告)号：US6057473A
公开(公告)日：2000-05-02
申请号：US50222
申请日：1998-03-26
IPC分类号： C07C227/20 , C07C229/34 , C07C269/00 , C07F9/40 , C07C229/28
CPC分类号： C07F9/4056 , C07C227/20 , C07C269/00 , C07F9/4006 , C07C2102/10
摘要： Anthraquinone chiral ligands (AQN) are used in asymmetric aminohydroxylation addition reactions of cinnamate based olefins for synthesizing aryl serines. The anthraquinones impart a reverse regioselectivity as compared to the commonly employed phalazine chiral ligands (PHAL). Carbamates are employed as the oxidant nitrogen source. The yields and enantiomeric efficiencies are Excellent. .beta.-Hydroxyamines are obtained by deprotecting the corresponding .beta.-hydroxycarbamate.
摘要翻译： 蒽醌手性配体（AQN）用于肉桂酸酯类烯烃合成芳基丝氨酸的不对称氨基羟基化反应。 与常用的哒嗪手性配体（PHAL）相比，蒽醌赋予反向区域选择性。 使用氨基甲酸酯作为氧化剂氮源。 产率和对映体效率优异。 通过脱保护相应的β-羟基氨基甲酸酯获得β-羟基胺。
-
8.发明授权Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group 失效ADH的配体：通过平面芳族间隔基团连接的cinchona生物碱和中等大小的有机取代基
公开(公告)号：US5260461A
公开(公告)日：1993-11-09
申请号：US775683
申请日：1991-10-10
申请人： Jens Hartung , K. Barry Sharpless
发明人： Jens Hartung , K. Barry Sharpless
IPC分类号： C07B53/00 , C07B61/00 , C07C29/04 , C07C29/48 , C07C31/00 , C07C33/26 , C07C67/31 , C07C69/675 , C07C69/732 , C07D453/02 , C07D453/04 , C07C215/34 , C07C31/20 , C07C33/02 , C07C69/734 , C07C69/735 , C07D67/313
CPC分类号： C07C67/31 , C07C29/48 , C07D453/02 , C07D453/04 , C07B2200/07 , C07C2101/14 , C07C2101/18
摘要： Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, an aqueous solution, a base, a ferricyanide salt and an osmium-containing compound are combined. The chiral ligand is an alkaloid or alkaloid derivative linked to an organic substituent of at least 300 daltons molecular weight through a planar aromatic spacer group. The organic substituent can be another alkaloid or alkaloid derivative. With the described chiral ligands, asymmetric dihydroxylation of olefins with high yields and enantiomeric excesses are achieved.
摘要翻译： 讨论了添加到烯烃中的锇催化方法。 在本发明的不对称二羟基化方法中，合并烯烃，手性配体，有机溶剂，水溶液，碱，铁氰化物盐和含锇化合物。 手性配体是通过平面芳族间隔基团与至少300道尔顿分子量的有机取代基连接的生物碱或生物碱衍生物。 有机取代基可以是另一种生物碱或生物碱衍生物。 使用所述手性配体，可以实现高产率和对映异构体过量的烯烃的不对称二羟基化。
-
9.发明授权Optically active enantiomers of substituted glyceraldehydes or glycidaldehydes formed as subtituted 1,5- dihydro-3H-2,4-benzodioxepines 失效由取代的1,5-二氢-3H-2,4-苯并二氧杂环庚三烯形成的取代的甘油醛或缩水甘醛的光学活性对映异构体
公开(公告)号：US5162554A
公开(公告)日：1992-11-10
申请号：US716902
申请日：1991-06-18
申请人： K. Barry Sharpless , Ryu Oi
发明人： K. Barry Sharpless , Ryu Oi
IPC分类号： C07D321/10 , C07D407/04 , C07D411/04
CPC分类号： C07D407/04 , C07D321/10 , C07D411/04
摘要： Stable, optically active enantiomers of substituted glyceraldehydes or glycidaldehydes are synthesized by using osmium-catalyzed asymmetric dihydroxylation of an olefin which is a substituted 1,5-dihydro-3H-2,4-benzodioxepine. For example, the protected glyceraldehyde, 3-(1,2-dihydroxyethyl)-1,5-dihydro-3H-2,4-benzodioxepine and the protected glycidaldehyde, 3-(1,2-epoxyethyl)-1,5-dihydro-3H-2,4-benzodioxepine have been synthesized and the optical enantiomer has been recovered. In the synthetic and isolation methods, enantiomers with high enantiomeric excess are recovered from the mother liquor following a recrystallization step.
摘要翻译： 通过使用锇催化的不对称二羟基化的烯烃（其是取代的1,5-二氢-3H-2,4-benzodioxepine）来合成取代的甘油醛或缩水甘醛的稳定的旋光活性对映异构体。 例如，保护的甘油醛，3-（1,2-二羟乙基）-1,5-二氢-3H-2,4-苯并二氧杂环庚烯和被保护的缩二醛，3-（1,2-环氧乙基）-1,5-二氢 -3H-2,4-苯并二氧杂环庚烯，并回收了光学对映体。 在合成和分离方法中，在重结晶步骤后从母液中回收具有高对映体过量的对映异构体。
-
公开(公告)号：US20090182151A1
公开(公告)日：2009-07-16
申请号：US11989072
申请日：2006-07-18
申请人： Peng Wu , Valery V. Fokin , K. Barry Sharpless
发明人： Peng Wu , Valery V. Fokin , K. Barry Sharpless
IPC分类号： C07D403/14
CPC分类号： C08G63/06 , C08G83/003
摘要： A series of AB-type amphiphilic dendritic polyesters have been prepared divergently, in which two hybrids were coupled via the copper(1)-catalyzed triazole formation.
摘要翻译： 已经分散制备了一系列AB型两亲性树枝状聚酯，其中两种杂交体通过铜（1）催化的三唑形成物偶联。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.037 秒)
