公开(公告)号：US20180346417A1

公开(公告)日：2018-12-06

申请号：US15741577

申请日：2016-07-04

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Juyeon JUNG ,  Eun Kyung LIM

IPC: C07C323/52 ,  C07C233/52 ,  G01N33/569 ,  G01N33/553

CPC classification number: C07C323/52 ,  A61P31/16 ,  C07B2200/07 ,  C07C233/52 ,  C07C323/12 ,  C07C2601/16 ,  G01N33/553 ,  G01N33/56983 ,  G01N2333/11

Abstract: An oseltamivir analogue and nanoparticles having the analogue bound thereto, of the present invention, strongly bind to oseltamivir-resistant influenza virus, and thus, the use of the same can allow detection of oseltamivir-resistant influenza viruses quickly and conveniently with the naked eye. Therefore, the present invention can be favorably utilized in promptly establishing a therapeutic schedule for a patient infected with influenza viruses.

公开(公告)号：US20230305028A1

公开(公告)日：2023-09-28

申请号：US18015189

申请日：2021-05-14

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Eun Kyung LIM ,  Soo Jin JANG ,  Seong Uk SON ,  Byung Hoon KANG ,  Tae Joon KANG ,  Kyu Sun LEE ,  Ju Yeon JUNG

IPC: G01N33/94 ,  C08L49/00 ,  C07D237/04 ,  G01N21/78

CPC classification number: G01N33/94 ,  C07D237/04 ,  C08L49/00 ,  G01N21/78 ,  G01N2800/307

Abstract: The present disclosure provides a reagent composition for detecting illicit drugs, the composition comprising: a diacetylene derivative compound represented by chemical formula 1; and at least one compound selected from among gabazine (SR-95531), an amine group-linked diacetylene derivative represented by chemical formula 2-1, and a gabazine-linked diacetylene derivative represented by chemical formula 2-2.

公开(公告)号：US20240402184A1

公开(公告)日：2024-12-05

申请号：US18666454

申请日：2024-05-16

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Eun Kyung LIM ,  Ji Sun Ki ,  Jaewoo Lim ,  Taejoon Kang ,  Juyeon Jung

IPC: G01N33/58 ,  C12N9/22 ,  C12Q1/44 ,  G01N33/52 ,  G01N33/543 ,  G01N33/569

Abstract: The present disclosure relates to a dual enzyme amplification-based colorimetric sensor system for on-site detection of pathogens. The colorimetric sensor system according to the present disclosure may comprise a combination of the CRISPR/Cas12a system with an enzymatic reaction of urease, thereby facilitating on-site detection of pathogens without separate analytical equipment by analyzing the color change through dual enzyme amplification. In addition, it is possible to selectively change the target by changing the crRNA sequence depending on the target pathogen to be detected, which has the advantage of being applicable to various types of pathogens without limitation. Further, the present disclosure can be used as a point of care service (PoC) system capable of detecting the genes of pathogens directly down to the sub-ng level without separate analysis equipment by applying the detection color value derived using the colorimetric sensor system according to the present disclosure to a smartphone application (app).

公开(公告)号：US20240002934A1

公开(公告)日：2024-01-04

申请号：US18037222

申请日：2021-11-03

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Eun Kyung LIM ,  Jae Woo LIM ,  Byung Hoon KANG ,  Tae Joon KANG ,  Seung Beom SEO ,  Soo Jin JANG ,  Ju Yeon JUNG

IPC: C12Q1/6876 ,  C12Q1/6806

CPC classification number: C12Q1/6876 ,  C12Q1/6806

Abstract: The present invention relates to a technology for analyzing and detecting/diagnosing a target nucleic acid. When the detection system according to the present invention is used, effective real-time detection or diagnosis efficiency can be obtained while problems such as noise are minimized. In particular, since, by using a house-keeping gene according to a method of use, the expression difference of the target nucleic acid can be corrected, and direct real-time target nucleic acid detection is possible, it can be effectively used for detecting various nucleic acids and diagnosing various diseases thereby.