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1.发明申请Analyte evaluating device, method for evaluating analyte and method for manufacturing analyte evaluating device 审中-公开分析物评价装置，评价分析物的方法和制造分析物评价装置的方法公开(公告)号：US20050048551A1
公开(公告)日：2005-03-03
申请号：US10900432
申请日：2004-07-28
IPC分类号： G01N21/64 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54306 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/553
摘要： An analyte evaluating device is provided that comprises a carrier body that can be bound with an analyte having a fluorescence-labeled part that can emit fluorescence by light received when the distance between the fluorescence-labeled part and the carrier body is enlarged, wherein the distance between the fluorescence-labeled part and the carrier body can be varied by a responding part equipped on at least one of the analyte and the carrier body. It is possible to perform a high-sensitivity evaluation without introducing a fluorescence-labeled part or a radioactive material into an evaluation object. Evaluation is possible for a very small amount of sample. Furthermore, evaluation is possible even when multiple types of evaluation objects are present in a mixture. Miniaturized, complex, and integrated analyte evaluating devices can be provided.
摘要翻译： 提供了一种分析物评价装置，其包括载体主体，其可以与具有荧光标记部分的分析物结合，该荧光标记部分可以在荧光标记部分和载体主体之间的距离被扩大时由接收到的光发射荧光，其中距离 在荧光标记部分和载体之间可以通过配备在分析物和载体主体中的至少一个上的响应部分来改变。 可以在不将荧光标记的部分或放射性物质引入评价对象的情况下进行高灵敏度评价。 对于非常少量的样品，可以进行评估。 此外，即使在混合物中存在多种类型的评估对象也可以进行评估。 可以提供小型化，复杂和集成的分析物评估装置。
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公开(公告)号：US08012720B2
公开(公告)日：2011-09-06
申请号：US12654137
申请日：2009-12-11
IPC分类号： C12P19/34
CPC分类号： G01N33/5438 , G01N33/53 , G01N33/542 , G01N33/54353 , G01N33/68
摘要： A protein detecting device, which comprises: (1) a detecting unit having a bonding section, which has properties for specifically bonding to a protein to be detected, a detecting section for detecting the bonding of the protein to be detected to the bonding section, the detecting section being made up of a polynucleotide double strand and a charge separating group, and an electrode section detecting the change in electrical conductivity of, or amount of transferred charge in, the polynucleotide double strand modified by the bond of the protein, (2) a standard electrode, (3) a reference electrode, (4) a container for housing the detecting unit, the standard electrode and the reference electrode, and containing a sample solutions comprising the protein to be detected, and (5) a measuring unit for measuring the protein based on a signal detected in the detecting unit.
摘要翻译： 一种蛋白质检测装置，其特征在于，包括：（1）检测单元，具有具有特异性地结合待检测蛋白质的接合部的检测部，检测所述被检测蛋白质与接合部的接合的检测部， 检测部分由多核苷酸双链和电荷分离基团组成，电极部分检测由蛋白质键修饰的多核苷酸双链中的导电性或转移电荷量的变化（2 ）标准电极，（3）参考电极，（4）容纳检测单元，标准电极和参比电极的容器，并包含含有待检测蛋白质的样品溶液，和（5）测量单元 用于基于在检测单元中检测到的信号测量蛋白质。
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公开(公告)号：US20100144060A1
公开(公告)日：2010-06-10
申请号：US12654137
申请日：2009-12-11
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , G01N33/53 , G01N33/542 , G01N33/54353 , G01N33/68
摘要： A protein detecting device, which comprises: (1) a detecting unit having a bonding section, which has properties for specifically bonding to a protein to be detected, a detecting section for detecting the bonding of the protein to be detected to the bonding section, the detecting section being made up of a polynucleotide double strand and a charge separating group, and an electrode section detecting the change in electrical conductivity of, or amount of transferred charge in, the polynucleotide double strand modified by the bond of the protein, (2) a standard electrode, (3) a reference electrode, (4) a container for housing the detecting unit, the standard electrode and the reference electrode, and containing a sample solutions comprising the protein to be detected, and (5) a measuring unit for measuring the protein based on a signal detected in the detecting unit.
摘要翻译： 一种蛋白质检测装置，其特征在于，包括：（1）检测单元，具有具有特异性地结合待检测蛋白质的接合部的检测部，检测所述被检测蛋白质与接合部的接合的检测部， 检测部分由多核苷酸双链和电荷分离基团组成，电极部分检测由蛋白质键修饰的多核苷酸双链中的导电性或转移电荷量的变化（2 ）标准电极，（3）参考电极，（4）容纳检测单元，标准电极和参比电极的容器，并包含含有待检测蛋白质的样品溶液，和（5）测量单元 用于基于在检测单元中检测到的信号测量蛋白质。
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公开(公告)号：US07517646B2
公开(公告)日：2009-04-14
申请号：US10943150
申请日：2004-09-17
CPC分类号： A61K31/7115 , A61K48/00 , C07H21/00 , C12N15/1048 , C12N15/1058 , C12N15/115 , C12N2310/53
摘要： A process for producing a functional molecule includes a forming step which forms a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by introducing a substituent into a nucleoside composing a nucleic acid; and a producing step which produces a modified oligonucleotide sequence by randomly polymerizing the modified nucleotide n-mer. A preferable embodiment thereof includes a selecting step which selects a sequence having an affinity to a target from the modified oligonucleotide sequence, a determining step which amplifies the selected modified oligonucleotide sequence and determines the base sequence thereof, and a translating step which translates the sequence of the modified oligonucleotide sequence on the basis of a relation table prepared by relating at least one of 4n kinds of nucleotide n-mers, which are presented in the relation table prepared by the one-to-one combination of 4 kinds of nucleosides, to a modified nucleotide n-mer.
摘要翻译： 制备功能性分子的方法包括：形成步骤，其形成含有通过将取代基引入构成核酸的核苷中制备的修饰核苷的修饰的核苷酸n-mer（其中，n表示整数）; 以及通过随机聚合修饰的核苷酸n-mer产生修饰的寡核苷酸序列的制备步骤。 其优选实施方案包括从修饰的寡核苷酸序列中选择与靶具有亲和性的序列的选择步骤，放大所选择的修饰寡核苷酸序列并确定其碱基序列的确定步骤，以及翻译步骤， 基于通过将通过将4种核苷的一对一组合制备的关系表中存在的4n种核苷酸n-mers中的至少一种与至少一种核苷酸n-mers相关联的关系表，修饰的寡核苷酸序列与 修饰的核苷酸n-mer。
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公开(公告)号：US20050130195A1
公开(公告)日：2005-06-16
申请号：US10943150
申请日：2004-09-17
IPC分类号： A61K31/7115 , A61K48/00 , A61P3/00 , A61P7/04 , A61P21/04 , A61P25/14 , A61P35/00 , C07H21/00 , C07H21/04 , C12N15/10 , C12N15/115 , C12P19/34 , C12Q1/68
CPC分类号： A61K31/7115 , A61K48/00 , C07H21/00 , C12N15/1048 , C12N15/1058 , C12N15/115 , C12N2310/53
摘要： A process for producing a functional molecule includes a forming step which forms a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by introducing a substituent into a nucleoside composing a nucleic acid; and a producing step which produces a modified oligonucleotide sequence by randomly polymerizing the modified nucleotide n-mer. A preferable embodiment thereof includes a selecting step which selects a sequence having an affinity to a target from the modified oligonucleotide sequence, a determining step which amplifies the selected modified oligonucleotide sequence and determines the base sequence thereof, and a translating step which translates the sequence of the modified oligonucleotide sequence on the basis of a relation table prepared by relating at least one of 4n kinds of nucleotide n-mers, which are presented in the relation table prepared by the one-to-one combination of 4 kinds of nucleosides, to a modified nucleotide n-mer.
摘要翻译： 制备功能性分子的方法包括：形成步骤，其形成含有通过将取代基引入构成核酸的核苷中制备的修饰核苷的修饰的核苷酸n-mer（其中，n表示整数）; 以及通过随机聚合修饰的核苷酸n-mer产生修饰的寡核苷酸序列的制备步骤。 其优选实施方案包括从修饰的寡核苷酸序列中选择与靶具有亲和性的序列的选择步骤，放大所选择的修饰寡核苷酸序列并确定其碱基序列的确定步骤，以及翻译步骤， 所述修饰的寡核苷酸序列基于通过关联通过所述一对一组合制备的关系表中的至少一种核苷酸n-mers的至少一种而制备的关系表 的4种核苷，与修饰的核苷酸n-mer。
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公开(公告)号：US06861224B2
公开(公告)日：2005-03-01
申请号：US10284094
申请日：2002-10-31
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： G01N33/5438 , G01N33/53 , G01N33/542 , G01N33/54353 , G01N33/68
摘要： A protein detecting device, which comprises: (1) a detecting unit having a bonding section, which has properties for specifically bonding to a protein to be detected, a detecting section for detecting the bonding of the protein to be detected to the bonding section, the detecting section being made up of a polynucleotide double strand and a charge separating group, and an electrode section detecting the change in electrical conductivity of, or amount of transferred charge in, the polynucleotide double strand modified by the bond of the protein, (2) a standard electrode, (3) a reference electrode, (4) a container for housing the detecting unit, the standard electrode and the reference electrode, and containing a sample solutions comprising the protein to be detected, and (5) a measuring unit for measuring the protein based on a signal detected in the detecting unit.
摘要翻译： 一种蛋白质检测装置，其特征在于，包括：（1）检测单元，具有具有特异性地结合待检测蛋白质的接合部的检测部，检测所述被检测蛋白质与接合部的接合的检测部， 检测部分由多核苷酸双链和电荷分离基团组成，电极部分检测由蛋白质键修饰的多核苷酸双链中的导电性或转移电荷量的变化（2 ）标准电极，（3）参考电极，（4）容纳检测单元，标准电极和参比电极的容器，并包含含有待检测蛋白质的样品溶液，和（5）测量单元 用于基于在检测单元中检测到的信号测量蛋白质。
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7.发明申请Target detecting device and target capturer, device and method for molecular adsorption or desorption, and device and method for protein detection 审中-公开目标检测装置和靶捕获装置，用于分子吸附或解吸的装置和方法，以及用于蛋白质检测的装置和方法公开(公告)号：US20060003437A1
公开(公告)日：2006-01-05
申请号：US11223924
申请日：2005-09-13
申请人： Tsuyoshi Fujihara , Shozo Fujita , Shunsaku Takeishi , Kenji Arinaga , Yoshitaka Yamaguchi , Tatsuya Usuki
发明人： Tsuyoshi Fujihara , Shozo Fujita , Shunsaku Takeishi , Kenji Arinaga , Yoshitaka Yamaguchi , Tatsuya Usuki
IPC分类号： C12M3/00
CPC分类号： C12Q1/6816 , C12Q1/6825 , C12Q2565/607 , C12Q2565/107 , C12Q2523/308
摘要： The present invention provides, for example, a target detecting device comprising a target capturer, means for releasing the target capturer, light irradiating means and light detecting means, the target capturer at least partially containing a region interactive with an electrically conductive member, being capable of capturing a target, and being capable of emitting light upon irradiation with light in the case of not interacting with the electrically conductive member, the means for releasing the target capturer serving to release the target capturer from the electrically conductive member by ceasing the interaction between the target capturer and the electrically conductive member, the light irradiating means serving to apply light to the electrically conductive member, and the light detecting means serving to detect light emitted by the target capturer upon irradiation of light applied by the light irradiating means. It also provides a target capturer comprising an interacting section, a capturing section and a light emitting section, the interacting section at least partially containing a region interactive with an electrically conductive member, the capturing section capable of capturing a target, and the light emitting section capable of emitting light upon irradiation with light when the region in the interacting section does not interact with the electrically conductive member.
摘要翻译： 本发明提供例如包括目标捕获器的目标检测装置，用于释放目标捕获器的装置，光照射装置和光检测装置，目标捕获器至少部分地包含与导电构件交互的区域，能够 捕获目标，并且在不与导电构件相互作用的情况下能够在照射光时发光，所述用于释放目标捕获器的装置用于通过停止导电构件之间的相互作用而释放目标捕获器 目标捕获器和导电构件，用于向导电构件施加光的光照射装置，以及用于在由照射装置施加的光照射时检测由目标捕获器发射的光的光检测装置。 它还提供一种包括相互作用部分，捕获部分和发光部分的目标捕获器，所述相互作用部分至少部分地包含与导电部件交互的区域，所述捕获部分能够捕获目标，并且所述发光部分 当相互作用部分中的区域不与导电构件相互作用时能够用光照射发光。
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公开(公告)号：US20050266568A1
公开(公告)日：2005-12-01
申请号：US11101658
申请日：2005-04-08
申请人： Tsuyoshi Fujihara , Shozo Fujita , Shunsaku Takeishi , Kenji Arinaga , Yoshitaka Yamaguchi , Tatsuya Usuki , Ulrich Rant , Karin Buchholz , Marc Tornow
发明人： Tsuyoshi Fujihara , Shozo Fujita , Shunsaku Takeishi , Kenji Arinaga , Yoshitaka Yamaguchi , Tatsuya Usuki , Ulrich Rant , Karin Buchholz , Marc Tornow
CPC分类号： A61K48/0083
摘要： A molecule-releasing apparatus includes a releasing unit configured to release molecules, wherein the releasing unit comprises at least one conductive member and releases molecules electrically interacting with the conductive member to which a potential is applied, from the conductive member by changing the potential so as to remove the interaction. In a moleculue-releasing method, molecules electrically attracted to two or more conductive members are released by electrical repulsion from the conductive members at different times. The molecule-releasing apparatus and molecule-releasing method are capable of efficiently releasing or transferring various useful molecules such as DNA molecules, into targets such as cells and can be safely applied for use in gene therapy and other applications.
摘要翻译： 分子释放装置包括配置成释放分子的释放单元，其中释放单元包括至少一个导电构件，并且通过改变电位从导电构件释放与施加电位的导电构件电相互作用的分子，从而 去除互动。 在分子释放方法中，电吸引到两个或更多导电构件的分子在不同时间通过电导电从导电构件释放。 分子释放装置和分子释放方法能够有效地将诸如DNA分子的各种有用分子释放或转移到诸如细胞的靶中，并且可以安全地应用于基因治疗和其它应用中。
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公开(公告)号：US20050123985A1
公开(公告)日：2005-06-09
申请号：US11035726
申请日：2005-01-18
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： G01N33/5438 , G01N33/53 , G01N33/542 , G01N33/54353 , G01N33/68
摘要： A protein detecting device, which comprises: (1) a detecting unit having a bonding section, which has properties for specifically bonding to a protein to be detected, a detecting section for detecting the bonding of the protein to be detected to the bonding section, the detecting section being made up of a polynucleotide double strand and a charge separating group, and an electrode section detecting the change in electrical conductivity of, or amount of transferred charge in, the polynucleotide double strand modified by the bond of the protein, (2) a standard electrode, (3) a reference electrode, (4) a container for housing the detecting unit, the standard electrode and the reference electrode, and containing a sample solutions comprising the protein to be detected, and (5) a measuring unit for measuring the protein based on a signal detected in the detecting unit.
摘要翻译： 一种蛋白质检测装置，其特征在于，包括：（1）检测单元，具有具有特异性地结合待检测蛋白质的接合部的检测部，检测所述被检测蛋白质与接合部的接合的检测部， 检测部分由多核苷酸双链和电荷分离基团组成，电极部分检测由蛋白质键修饰的多核苷酸双链中的导电性或转移电荷量的变化（2 ）标准电极，（3）参考电极，（4）容纳检测单元，标准电极和参比电极的容器，并包含含有待检测蛋白质的样品溶液，和（5）测量单元 用于基于在检测单元中检测到的信号测量蛋白质。
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10.发明授权Lamination structure, wiring structure, manufacture thereof, and semiconductor device 失效层压结构，布线结构，制造及半导体装置公开(公告)号：US06376048B1
公开(公告)日：2002-04-23
申请号：US09227527
申请日：1999-01-08
申请人： Shunsaku Takeishi
发明人： Shunsaku Takeishi
IPC分类号： B32B904
CPC分类号： H01L21/022 , B32B7/12 , H01L21/02118 , H01L21/0212 , H01L21/02129 , H01L21/02131 , H01L21/0214 , H01L21/02164 , H01L21/0217 , H01L21/02274 , H01L21/02282 , H01L21/02304 , H01L21/312 , H01L21/3127 , H01L21/314 , H01L21/3146 , H01L21/31629 , H01L21/76829 , H01L21/76835 , H01L23/53223 , H01L23/53228 , H01L23/53257 , H01L23/5329 , H01L23/53295 , H01L2924/0002 , Y10T428/24917 , Y10T428/31663 , H01L2924/00
摘要： A first layer is disposed on the principal surface of a substrate. An adhesive layer made of Si containing fluorocarbon is disposed on the first layer. A second layer is disposed on the adhesive layer. One of the first and second layers is made of a material selected from a group consisting of a material whose main component is Si containing inorganic material, a metal, and an inorganic metal compound, and the other is made of an organic insulating film. Tight contactness of the organic layer to the layer whose main component is inorganic material can be improved.
摘要翻译： 第一层设置在基板的主表面上。 由含氟碳的Si制成的粘合剂层设置在第一层上。 第二层设置在粘合剂层上。 第一层和第二层之一由选自由主要成分为含有无机材料的Si的材料，金属和无机金属化合物组成的组中的材料制成，另一个由有机绝缘膜制成。 可以提高有机层与主要成分为无机材料的层的紧密接触性。
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