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公开(公告)号：US20050143382A1
公开(公告)日：2005-06-30
申请号：US10978353
申请日：2004-11-02
申请人： Katharina Aulinger-Fuchs , Thomas Herz , Rolf Krauss , Michael Kubbatat , Martin Lang , Christoph Schachtele , Frank Totzke
发明人： Katharina Aulinger-Fuchs , Thomas Herz , Rolf Krauss , Michael Kubbatat , Martin Lang , Christoph Schachtele , Frank Totzke
IPC分类号： A61K31/495 , A61K31/498 , C07D491/02 , C07D498/04
CPC分类号： C07D498/04
摘要： The present invention relates to furazanopyrazine derivatives of the general formula (I): wherein: R′ represents —NR1R2 or —OR9 R″ represents —NR5—NR3R4, —NR5—ORb, —O—NR3R4; wherein R1 to R9 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.
摘要翻译： 本发明涉及通式（I）的呋喃并吡嗪衍生物：其中：R'表示-NR 1 R 2或-OR 9， R“表示-NR 5 -NR 3 R 4，-NR 5 -OR B， -O-NR 3 R 4; 其中式（I）中的R 1至R 9彼此独立地表示包含烷基，芳基，芳烷基，烷基芳基，杂芳基和单官能部分的多种不同取代基。
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公开(公告)号：US20070208012A1
公开(公告)日：2007-09-06
申请号：US11561701
申请日：2006-11-20
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A01N43/58 , C07D409/00 , A01N43/54 , A01N43/60 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/40 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/86 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/60 , C07D231/12 , C07D261/14 , C07D263/48 , C07D277/36 , C07D277/46 , C07D307/66 , C07D307/68 , C07D333/36 , C07D333/38
摘要： The present invention relates to the use of compounds of the general Formula (XIII): In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
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公开(公告)号：US20070093534A1
公开(公告)日：2007-04-26
申请号：US11560699
申请日：2006-11-16
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4192 , A61K31/416 , A61K31/4178 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/40 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/86 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/60 , C07D231/12 , C07D261/14 , C07D263/48 , C07D277/36 , C07D277/46 , C07D307/66 , C07D307/68 , C07D333/36 , C07D333/38
摘要： The present invention relates to the use of compounds of the general Formula (XIII): wherein A7 is C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13; A8 is C(R14)2, O, S, or NR12; A9 is C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13; m is 0, or 1 q is 0, or 1 r is 0, or 1 R12 is H, CH3, CH2—CH3, C6H5, OCH3, OCH2—CH3, OH, or SH; R13 is H, CH3, or CH2—CH3; R14 is H, alkyl, alkoxy, OH, or SH;
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公开(公告)号：US20100280036A1
公开(公告)日：2010-11-04
申请号：US12005810
申请日：2007-12-28
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/498 , C12N1/20 , A61K31/506 , A61K31/444 , A61K31/4436 , A61K31/426 , A61K31/425 , A61K31/421 , A61K31/42 , A61K31/4155 , A61K31/381 , C07D403/12 , C07D409/12 , C07D401/12 , C07D277/54 , C07D275/03 , C07D263/48 , C07D261/18 , C07D333/38 , A61P31/04
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2;
摘要翻译： 本发明涉及通式（I）的化合物的用途：其中在式（I）中，R为H，烷基，环烷基，芳基或杂芳基; R1是H，烷基，环烷基，芳基或杂芳基; R2是H，烷基，环烷基，芳基或杂芳基; A1和A2各自独立地表示可以含有一个或多个Z基团或可以含有一个或多个基团的单环或多环任选取代的芳族或非芳族环系的任选取代的C 1 -C 20 - 烷基 ）X，并且在多环系统的情况下，所述体系含有至少一个芳环; Z选自S，O，N，NR4，CO，CO2，CS，SO或SO2 X选自S，O，N，NR4，SO或SO2;
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公开(公告)号：US20080188536A1
公开(公告)日：2008-08-07
申请号：US12005763
申请日：2007-12-28
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/415 , C07D231/40 , A01N43/56 , A61P31/04 , A01P1/00
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2;
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公开(公告)号：US20080188491A1
公开(公告)日：2008-08-07
申请号：US12005920
申请日：2007-12-28
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/495 , C07D401/02 , C07D401/12 , A61K31/437 , A61K31/444 , C07D239/24 , A61P31/04
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2.
摘要翻译： 本发明涉及通式（I）的化合物的用途：其中在式（I）中，R为H，烷基，环烷基，芳基或杂芳基; R 1是H，烷基，环烷基，芳基或杂芳基; R 2是H，烷基，环烷基，芳基或杂芳基; A 1和A 2各自独立地表示任选取代的C 1 -C 20 -C 20 - 烷基，其可以含有 一个或多个Z基团或可以含有一个或多个基团X的单环或多环任选取代的芳族或非芳族环系统，并且在多环系统的情况下，所述体系包含至少一个 芳香环 Z选自S，O，N，NR 4，CO，CO，CS，SO或SO 2 X选自S ，O，N，NR 4，SO或SO 2。
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公开(公告)号：US20080176938A1
公开(公告)日：2008-07-24
申请号：US12005983
申请日：2007-12-28
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/341 , C07D307/34 , A01N43/08 , A61P31/04 , A01P1/00
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (1): wherein in Formula (1), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2.
摘要翻译： 本发明涉及通式（1）的化合物的用途：其中在式（1）中，R为H，烷基，环烷基，芳基或杂芳基; R 1是H，烷基，环烷基，芳基或杂芳基; R 2是H，烷基，环烷基，芳基或杂芳基; A 1和A 2各自独立地表示任选取代的C 1 -C 20 -C 20 - 烷基，其可以含有 一个或多个Z基团或可以含有一个或多个基团X的单环或多环任选取代的芳族或非芳族环系统，并且在多环系统的情况下，所述体系包含至少一个 芳香环 Z选自S，O，N，NR 4，CO，CO 2，CS，SO或SO 2 X 选自S，O，N，NR 4，SO或SO 2。
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公开(公告)号：US20100280034A1
公开(公告)日：2010-11-04
申请号：US12005783
申请日：2007-12-28
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A61K31/5375 , C12N1/20 , A61K31/495 , A61K31/47 , A61K31/445 , A61K31/4545 , A61K31/426 , A61K31/421 , A61K31/4168 , A61K31/415 , A61K31/403 , A61K31/404 , A61K31/4015 , A61K31/381 , A61K31/341 , A61K31/196 , A61K31/167 , C07D295/185 , C07D215/08 , C07D401/06 , C07D211/16 , C07D277/46 , C07D263/48 , C07D261/14 , C07D231/40 , C07D209/86 , C07D209/08 , C07D207/27 , C07D333/38 , C07D307/68 , C07C229/56 , C07C235/00 , A01N43/56 , A01P15/00 , A61P31/04 , A01N43/10 , A01N43/78 , A01N43/80 , A01N43/50 , A01N43/08 , A01N43/40 , A01N43/42 , A01N43/60 , A01N43/84 , A01N43/36 , A01N43/38 , A01N37/22 , A01N37/46
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D261/14 , C07D263/48 , C07D275/03 , C07D277/46 , C07D277/54 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (XIII): wherein A7 is C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13; A8 is C(R14)2, O, S, or NR12; A9 is C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13; m is 0, or 1 q is 0, or 1 r is 0, or 1 R12 is H, CH3, CH2—CH3, C6H5, OCH3, OCH2—CH3, OH, or SH; R13 is H, CH3, or CH2—CH3; R14 is H, alkyl, alkoxy, OH, or SH;
摘要翻译： 本发明涉及通式（XIII）化合物的用途：其中A 7为C = O，C = S，SO 2，CH-OR 13，C = NR 12或CH 2 -CHOR 13; A8为C（R14）2，O，S或NR12; A9为C = O，C = S，SO2，CH-OR13，C = NR12或CH2-CHOR13; m为0或1 q为0或1 r为0，或1 R 12为H，CH 3，CH 2 -CH 3，C 6 H 5，OCH 3，OCH 2 -CH 3，OH或SH; R 13是H，CH 3或CH 2 -CH 3; R 14是H，烷基，烷氧基，OH或SH;
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公开(公告)号：US07335779B2
公开(公告)日：2008-02-26
申请号：US10429875
申请日：2003-05-06
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： C07D231/00 , C07D233/00 , C07D233/02
CPC分类号： A01N43/54 , A01N43/56 , A61K8/49 , A61K8/4973 , A61K8/4986 , A61K31/175 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/505 , A61Q17/005 , A61Q19/00 , C07D231/16 , C07D231/40 , C07D307/68 , C07D333/38 , C07D333/70 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , Y02A50/473
摘要： The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2.
摘要翻译： 本发明涉及通式（I）的化合物的用途：其中在式（I）中，R为H，烷基，环烷基，芳基或杂芳基; R 1是H，烷基，环烷基，芳基或杂芳基; R 2是H，烷基，环烷基，芳基或杂芳基; A 1和A 2各自独立地表示任选取代的C 1 -C 20 -C 20 - 烷基，其可以含有 一个或多个Z基团或可以含有一个或多个基团X的单环或多环任选取代的芳族或非芳族环系统，并且在多环系统的情况下，所述体系包含至少一个 芳香环 Z选自S，O，N，NR 4，CO，CO 2，CS，SO或SO 2 X 选自S，O，N，NR 4，SO或SO 2。
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公开(公告)号：US20070197492A1
公开(公告)日：2007-08-23
申请号：US11560669
申请日：2006-11-16
申请人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
发明人： Aldo Ammendola , Katharina Aulinger-Fuchs , Astrid Gotschlich , Bernd Kramer , Martin Lang , Wael Saeb , Udo Sinks , Andreas Wuzik
IPC分类号： A01N43/54 , A01N43/00 , A01N43/58 , A01N43/60 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/40 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/86 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/60 , C07D231/12 , C07D261/14 , C07D263/48 , C07D277/36 , C07D277/46 , C07D307/66 , C07D307/68 , C07D333/36 , C07D333/38
摘要： The present invention relates to the use of compounds of the general Formula (XIII): In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
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