Method for Production of Directly Compressible Ibuprofen Formulations
    2.
    发明申请
    Method for Production of Directly Compressible Ibuprofen Formulations 有权
    生产直接可压缩布洛芬配方的方法

    公开(公告)号:US20080213361A1

    公开(公告)日:2008-09-04

    申请号:US12089416

    申请日:2006-10-05

    IPC分类号: A61K9/20 A61K31/192 A61P29/00

    摘要: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.

    摘要翻译: 一种可直接压片的布洛芬制剂,其包含a)50-99重量%的结晶布洛芬,b)1-15重量%的表面积至少为100微米/ ,和c)0-40重量%的其它赋形剂,条件是组分a)至c)的总量对应于100重量%,其中至少50%的布洛芬晶体的表面被覆盖 精细分散的赋形剂。

    Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
    8.
    发明授权
    Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms 有权
    生产用于药物剂型的稳定保护性涂料的粉末涂料组合物

    公开(公告)号:US08962064B2

    公开(公告)日:2015-02-24

    申请号:US13406641

    申请日:2012-02-28

    摘要: Described is a process for producing pulverulent, antioxidant-comprising coating compositions, comprising providing an aqueous polymer dispersions comprising one or more antioxidants and a polymer obtained by radical polymerization of a) N,N-diethylaminoethyl methacrylate, and b) at least one radically polymerizable compound selected from esters of α,β-ethylenically unsaturated mono- and dicarboxylic acids with C1-C8-alkanols, wherein the antioxidants are incorporated into the aqueous polymer dispersion in the form of a solution or of a dispersion, and spray processing the aqueous polymer dispersion to provide a powder form.

    摘要翻译: 描述了一种生产含粉末,抗氧化剂的涂料组合物的方法,其包括提供包含一种或多种抗氧化剂的聚合物水分散体和通过a)N,N-二乙基氨基乙基甲基丙烯酸酯的自由基聚合获得的聚合物,和b)至少一种可自由基聚合的 选自α,β-烯键式不饱和单羧酸和二羧酸与C 1 -C 8 - 链烷醇的化合物的化合物,其中抗氧化剂以溶液或分散体的形式引入到聚合物水分散体中,并且将水性 聚合物分散体以提供粉末形式。

    Nanoporous foamed active compound-containing preparations based on pharmaceutically acceptable thermoplastically workable polymers
    9.
    发明授权
    Nanoporous foamed active compound-containing preparations based on pharmaceutically acceptable thermoplastically workable polymers 失效
    基于药学上可接受的热塑性可加工聚合物的纳米多孔泡沫活性成分制剂

    公开(公告)号:US08636929B2

    公开(公告)日:2014-01-28

    申请号:US13111999

    申请日:2011-05-20

    IPC分类号: B29C67/20

    摘要: Process for the production of nanoporous foamed active substance-containing preparations, wherein the active substance is present embedded in a pharmaceutically acceptable polymer, wherein, in stage a) loading of a polymeric molding composition or a polymer melt with a propellant is effected at a pressure and at a temperature at which the propellant is in the supercritical state, in stage b) heating of the laden polymer molding compound or melt is carried out under pressure at a temperature which lies in the range from −40 to +60° C., preferably −20 to +55° C., and especially preferably 0 to +50° C. around the glass transition temperature of the unladen (prior to loading) polymeric molding compound and in stage c) a depressurization of the polymeric molding compound or melt laden in stage a) and heated under pressure in stage b) is effected out with a depressurization rate in the range from 15,000 to 200,000 MPa/sec.

    摘要翻译: 制备纳米多孔泡沫活性物质制剂的方法,其中活性物质包含在药学上可接受的聚合物中,其中在阶段a)聚合物模塑组合物或聚合物熔体与推进剂的加载在压力 并且在推进剂处于超临界状态的温度下,在阶段b)加载聚合物模塑料或熔体在加压下在-40至+ 60℃的温度下进行, 优选为-20至+ 55℃,特别优选为0至+ 50℃,并且在阶段c)将聚合物模塑料或熔体的减压 在步骤a)中负载并且在阶段b)中加压,以15,000至200,000MPa /秒的减压速率进行。