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    Search for cancer markers by a novel screening method
    1.
    发明授权
    Search for cancer markers by a novel screening method 失效
    通过新的筛选方法寻找癌症标志物

    公开(公告)号：US07868137B2

    公开(公告)日：2011-01-11

    申请号：US11704252

    申请日：2007-02-09

    申请人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    发明人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    IPC分类号： A61K38/00

    CPC分类号： G01N33/574 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K16/303 ,  Y10T436/141111

    摘要： The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid condition, and eluting them under an alkali condition to concentrate the peptide. Furthermore, peptides having the amino acid sequence as set forth in SEQ ID NO: 1 or 2, and a method of screening cancer markers using antibody to these peptides, are disclosed.

    摘要翻译： 本发明涉及在无血清培养细胞的上清液中浓缩低分子量肽的方法，所述方法包括使肽在酸性条件下与强阳离子交换剂结合，并在碱性条件下将其洗脱以浓缩 肽。 此外，公开了具有SEQ ID NO：1或2所示的氨基酸序列的肽以及使用这些肽的抗体筛选癌症标记物的方法。

    Search for cancer markers by a novel screening method
    4.
    发明申请
    Search for cancer markers by a novel screening method 失效
    通过新的筛选方法寻找癌症标志物

    公开(公告)号：US20080188008A1

    公开(公告)日：2008-08-07

    申请号：US11987983

    申请日：2007-12-06

    申请人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    发明人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    IPC分类号： G01N33/574

    CPC分类号： G01N33/574 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K16/303 ,  Y10T436/141111

    摘要： The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid condition, and eluting them under an alkali condition to concentrate the peptide.Furthermore, peptides having the amino acid sequence as set forth in SEQ ID NO: 1 or 2, and a method of screening cancer markers using antibody to these peptides, are disclosed.

    摘要翻译： 本发明涉及在无血清培养细胞的上清液中浓缩低分子量肽的方法，所述方法包括使肽在酸性条件下与强阳离子交换剂结合，并在碱性条件下将其洗脱以浓缩 肽。 此外，公开了具有SEQ ID NO：1或2所示的氨基酸序列的肽以及使用这些肽的抗体筛选癌症标记物的方法。

    Search for cancer markers by a screening method
    5.
    发明授权
    Search for cancer markers by a screening method 失效
    通过筛选方法搜索癌症标志物

    公开(公告)号：US07868136B2

    公开(公告)日：2011-01-11

    申请号：US11987983

    申请日：2007-12-06

    申请人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    发明人： Kazuki Sasaki ,  Kae Sato ,  Ken Yamaguchi

    IPC分类号： A61K38/00

    CPC分类号： G01N33/574 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K16/303 ,  Y10T436/141111

    摘要： The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid condition, and eluting them under an alkali condition to concentrate the peptide.Furthermore, peptides having the amino acid sequence as set forth in SEQ ID NO: 1 or 2, and a method of screening cancer markers using antibody to these peptides, are disclosed.

    摘要翻译： 本发明涉及在无血清培养细胞的上清液中浓缩低分子量肽的方法，所述方法包括使肽在酸性条件下与强阳离子交换剂结合，并在碱性条件下将其洗脱以浓缩 肽。 此外，公开了具有SEQ ID NO：1或2所示的氨基酸序列的肽以及使用这些肽的抗体筛选癌症标记物的方法。

    Elbow prosthesis
    7.
    再颁专利
    Elbow prosthesis 有权
    肘假体

    公开(公告)号：USRE42805E1

    公开(公告)日：2011-10-04

    申请号：US11801429

    申请日：2007-05-09

    申请人： Alain Tornier ,  Shawn O'Driscoll ,  Graham King ,  Ken Yamaguchi ,  Yves Alain Ratron ,  Bruno Scialom

    发明人： Alain Tornier ,  Shawn O'Driscoll ,  Graham King ,  Ken Yamaguchi ,  Yves Alain Ratron ,  Bruno Scialom

    IPC分类号： A61F2/38

    CPC分类号： A61F2/3804

    摘要： A humeral component, forming a first articulating surface, and an ulnar component forming a second articulating surface adapted to be disposed around a part of the first articulating surface and to pivot about its longitudinal axis. This ulnar component is provided with structure for mounting a locking element which forms a third articulating surface extending the second and adapted likewise to be disposed around a part of the first surface. These mounting structure comprise guiding structures adapted to cooperate with complementary structure provided on the locking element in order to guide this element in translation with respect to the ulnar component, up to a position where blocking structure provided respectively on the locking element and on the ulnar component may be employed to immobilize this element on this component, these blocking structure being able to be employed only in this position.

    摘要翻译： 形成第一铰接表面的肱骨部件和形成第二铰接表面的尺骨部件，其适于围绕第一关节表面的一部分设置并围绕其纵向轴线枢转。 这种尺骨部件设置有用于安装锁定元件的结构，所述锁定元件形成延伸第二铰接表面的第三铰接表面，并且类似地被设置在第一表面的一部分周围。 这些安装结构包括适于与提供在锁定元件上的互补结构配合的引导结构，以便引导该元件相对于尺骨部件平移，直到分别设置在锁定元件和尺骨部件上的阻挡结构 可以将该元件固定在该组分上，这些阻挡结构仅能够在该位置上使用。

    Ancillary tool for fitting an ulnar component and/or a radial component of an elbow prosthesis
    8.
    发明授权
    Ancillary tool for fitting an ulnar component and/or a radial component of an elbow prosthesis 有权
    用于安装肘部假体的尺骨部件和/或径向部件的辅助工具

    公开(公告)号：US07922728B2

    公开(公告)日：2011-04-12

    申请号：US10189378

    申请日：2002-07-08

    申请人： Alain Tornier ,  Shawn O'Driscoll ,  Graham King ,  Ken Yamaguchi ,  Yves Alain Ratron ,  Bruno Scialom

    发明人： Alain Tornier ,  Shawn O'Driscoll ,  Graham King ,  Ken Yamaguchi ,  Yves Alain Ratron ,  Bruno Scialom

    IPC分类号： A61F5/00

    CPC分类号： A61B17/15 ,  A61B17/1637 ,  A61B17/1739

    摘要： An ancillary tool (10) comprising a trial humeral trochlea (202) that is representative of an anatomical humeral trochlea when the trial humeral trochlea is in place with respect to corresponding cubital (SC) and/or radial (SR) articular surfaces and a cut-out guide (30) for cutting an ulna (C) and/or a radius (R), wherein the cut-out guide (30) is adapted to be positioned with respect to the trial humeral trochlea (202). The cut-out guide (30) is also adapted to be positioned with respect to an ulna (C) and/or to a radius (R) equipped with the trial humeral trochlea (202).

    摘要翻译： 一种辅助工具（10），其包括试验肱骨滑车（202），其当所述试验肱动脉索相对于相应的肘节（SC）和/或径向（SR）关节表面就位时，其代表解剖肱动脉滑车 用于切割尺骨（C）和/或半径（R）的出口引导件（30），其中所述切口引导件（30）适于相对于所述试验肱骨滑车（202）定位。 切口引导件（30）还适于相对于尺骨（C）和/或配备有试验肱骨滑车（202）的半径（R）定位。

    Semiconductor memory device having a long data retention time with the increase in leakage current suppressed
    10.
    发明授权
    Semiconductor memory device having a long data retention time with the increase in leakage current suppressed 失效
    具有抑制了泄漏电流增加的数据保持时间长的半导体存储器件

    公开(公告)号：US6157055A

    公开(公告)日：2000-12-05

    申请号：US185633

    申请日：1998-11-04

    申请人： Ken Yamaguchi ,  Shinichiro Kimura ,  Masatada Horiuchi ,  Tatsuya Teshima

    发明人： Ken Yamaguchi ,  Shinichiro Kimura ,  Masatada Horiuchi ,  Tatsuya Teshima

    IPC分类号： H01L21/8242 ,  H01L27/108 ,  H01L29/76 ,  H01L29/94

    CPC分类号： H01L27/10808 ,  H01L27/10873

    摘要： In a semiconductor memory device such as a DRAM, a conductive film (1.11') is arranged on the rim portion of a isolation insulating film (1.2) in opposition to a semiconductor substrate (1.1) with a thin insulating film in between. This conductive film (1.11') is electrically connected to a lower electrode (1.11) of a storage capacitor. This novel arrangement can control the location of electrical pn junction independently of the location of metallurgical pn junction, thereby realizing a semiconductor memory device having a long data retention time with the increase in leakage current suppressed.

    摘要翻译： 在诸如DRAM的半导体存储器件中，在隔离绝缘膜（1.2）的与半导体衬底（1.1）相对的边缘部分上布置导电膜（1.11'），其间具有薄的绝缘膜。 该导电膜（1.11'）电连接到存储电容器的下电极（1.11）。 这种新颖的布置可以独立于冶金pn结的位置来控制电pn结的位置，从而实现了抑制泄漏电流增加的数据保持时间长的半导体存储器件。