Anti-inflammatory agent
    1.
    发明授权
    Anti-inflammatory agent 失效
    抗炎剂

    公开(公告)号:US5872109A

    公开(公告)日:1999-02-16

    申请号:US722131

    申请日:1996-10-04

    IPC分类号: A61K31/737 A01N43/04 C07H5/04

    CPC分类号: A61K31/737

    摘要: Use of a polysaccharide selected from the group consisting of sulfated acid mucopolysaccharides and sulfated dextrans, and physiologically acceptable salts thereof for prophylaxis or treatment of inflammations, particularly an adult respiratory distress syndrome (ARDS), ischemic heart diseases, ischemic cerebral diseases, chronic articular rheumatism, atopic dermatitis, and infiltration after organ implantation.

    摘要翻译: PCT No.PCT / JP96 / 00239 Sec。 371日期1996年10月4日第 102(e)日期1996年10月4日PCT PCT 1996年2月6日PCT公布。 出版物WO96 / 24362 日期1988年8月15日使用选自硫酸酸粘多糖和硫酸葡聚糖的多糖及其生理学上可接受的盐用于预防或治疗炎症,特别是成人呼吸窘迫综合征(ARDS),缺血性心脏病,缺血性脑 疾病,慢性关节风湿病,特应性皮炎和器官移植后的浸润。

    Sulfatides as anti-inflammatory compounds
    3.
    发明授权
    Sulfatides as anti-inflammatory compounds 失效
    磺胺类作为抗炎化合物

    公开(公告)号:US5486536A

    公开(公告)日:1996-01-23

    申请号:US289585

    申请日:1994-08-15

    IPC分类号: A61K31/35

    CPC分类号: A61K31/7028 A61K31/7032

    摘要: Using in vitro adhesion of recombinant rat L-selectin-Ig or rat neutrophils, it has been demonstrated that these materials bind to sulfatide that has been present in solid phase on a plastic surface. The binding activity appears to have structural requirements, with the sulfate group being critically present in position 3 on the pyranose ring of galactose. When used in vivo, it has been demonstrated that sulfated glycolipids such as brain sulfatide and ganglioside, have significantly protective effects in two models of lung inflammation, the first systemic activation of complement and the second occurring after intrapulmonary deposition of immune complexes. Both inflammatory reactions are complement, neutrophil and selectin-dependent. The protective effects of these compounds are linked to their ability to prevent the recruitment of neutrophils into lung tissue. On the basis of these findings, it is demonstrated by sulfatides and related compounds have significant in vivo anti-inflammatory activities. These compounds thus represent a new class of anti-inflammatory agents.

    摘要翻译: 使用重组大鼠L-选择蛋白-Ig或大鼠嗜中性粒细胞的体外粘附,已经证明这些物质结合在固相中存在于塑料表面上的硫苷脂。 结合活性似乎具有结构要求,硫酸根基团严重存在于半乳糖的吡喃糖环上的位置3。 当体内使用时,已经证明硫酸化糖脂例如脑硫酸酯和神经节苷脂在两种模型的肺部炎症中具有显着的保护作用,第一种补体的全身活化和第二次在肺内沉积免疫复合物后发生。 两种炎症反应均为补体,嗜中性粒细胞和选择素依赖性。 这些化合物的保护作用与其预防嗜中性粒细胞募集到肺组织中的能力有关。 在这些发现的基础上,硫酸酯和相关化合物具有显着的体内抗炎活性。 因此,这些化合物代表了一类新的抗炎剂。

    Interior lamp for vehicle
    9.
    发明授权
    Interior lamp for vehicle 有权
    车内灯

    公开(公告)号:US09115860B2

    公开(公告)日:2015-08-25

    申请号:US13978083

    申请日:2012-01-31

    IPC分类号: B60Q1/26 F21S8/10 B60Q3/02

    CPC分类号: F21S48/00 B60Q3/82 F21S43/00

    摘要: An interior lamp includes a design portion and a function portion. A circuit board is attached to the function portion. A light source is mounted on the circuit board. Terminals are mounted on a side portion of the circuit board. A connector is disposed on a side portion of the function portion. Connector terminals are provided on the connector. A switch has a switch knob and a switch body. The switch knob is attached to a side portion of the design portion. The switch body is attached to the side portion of the function portion. The switch knob and the switch body are operated in an interlocked manner to perform electrical connection between the terminals and the connector terminals selectively so as to perform a tuning on or off of the light source.

    摘要翻译: 内部灯包括设计部分和功能部分。 电路板连接到功能部分。 光源安装在电路板上。 端子安装在电路板的侧面。 连接器设置在功能部分的侧部。 连接器端子设置在连接器上。 开关具有开关旋钮和开关体。 开关旋钮连接到设计部分的侧部。 开关体附接到功能部的侧部。 开关旋钮和开关体以互锁的方式操作,以选择性地在端子和连接器端子之间进行电连接,以便执行光源的调谐。