公开(公告)号：US5476668A

公开(公告)日：1995-12-19

申请号：US168411

申请日：1993-12-17

申请人： Kazuto Kobayashi ,  Junichi Watanabe ,  Shinichiro Nakamura

发明人： Kazuto Kobayashi ,  Junichi Watanabe ,  Shinichiro Nakamura

IPC分类号： A61K9/28 ,  C08B11/00 ,  C08B11/12

CPC分类号： A61K9/2866 ,  C08B11/00

摘要： A cellulose ether having a low degree of polymerization is used as a base for film-coating pharmaceuticals. The cellulose ether having a low degree of polymerization obtained by causticizing a pulp having a copper number of not more than 0.4 g, adding an etherifying agent to form a cellulose ether having a high degree of polymerization, then refining it with hot water, drying by heating, finely pulverizing the dried cellulose ether and depolymerizing the fine powder has high whiteness and is thus suitable for use as a base for film-coating pharmaceuticals. The viscosity of a 2% aqueous solution of the cellulose having a low degree of polymerization is preferably not more than 20 cSt at 20.degree. C. The cellulose having a low degree of polymerization is selected from methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and hydroxybutyl methyl cellulose. The cellulose ether having a high degree of polymerization is pulverized within one minute in an impact pulverizer after drying it at a temperature of atmosphere of not more than 100.degree. C. and that of the cellulose ether per se of 40.degree. to 80.degree. C. to control the moisture content thereof to 1 to 5% by weight, and thus a cellulose ether having a low degree of polymerization and high whiteness can be obtained.

摘要翻译： 使用低聚合度的纤维素醚作为薄膜包衣药物的基质。 通过对铜数不超过0.4g的纸浆进行苛性化而得到的低聚合度的纤维素醚，加入醚化剂形成聚合度高的纤维素醚，然后用热水精制，用 加热干燥后的纤维素醚微粉碎，细粉末解聚白度高，因此适合用作薄膜包衣药物的基质。 低聚合度的纤维素的2％水溶液的粘度在20℃下优选不超过20cSt。聚合度低的纤维素选自甲基纤维素，羟甲基纤维素，羟乙基纤维素，羟丙基纤维素 纤维素，羟丙基甲基纤维素和羟丁基甲基纤维素。 将聚合度高的纤维素醚在冲击式粉碎机中在不高于100℃的气氛和40〜80℃的温度下干燥后，在1分钟内粉碎。 以将其水分含量控制在1〜5重量％，从而可以获得低聚合度和高白度的纤维素醚。

公开(公告)号：US09006411B2

公开(公告)日：2015-04-14

申请号：US13988973

申请日：2011-11-25

申请人： Kazuto Kobayashi

发明人： Kazuto Kobayashi

IPC分类号： C07K14/005 ,  A01N63/00 ,  A01N65/00 ,  C12N15/86 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/0058 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/03 ,  C12N2740/16045 ,  C12N2740/16071 ,  C12N2760/20122 ,  C12N2760/20222 ,  C12N2810/6081

摘要： The present invention provides a lentiviral vector system having a higher titer, while sustaining an excellent retrograde transport ability, particularly, in the brain.The present invention also provides a kit for preparing a retrograde transport viral vector comprising: (1) a packaging plasmid containing the gag gene and the pol gene of HIV-1; (2) a packaging plasmid containing an accessory gene of HIV-1; (3) a transfer plasmid containing an target gene (a transgene); and (4) an envelope plasmid containing, as an envelope gene, a gene encoding a fused polypeptide comprising a fused extracellular domain consisting of the N-terminal region of an extracellular domain of rabies virus glycoprotein (RV-G) and the C-terminal region of an extracellular domain of vesicular stomatitis virus glycoprotein (VSV-G), a transmembrane domain of RV-G or VSV-G, and an intracellular domain of VSV-G, and the like.

摘要翻译： 本发明提供了具有较高滴度的慢病毒载体系统，同时维持优异的逆行转运能力，特别是在脑中。 本发明还提供了用于制备逆行转运病毒载体的试剂盒，其包含：（1）含有HIV-1的gag基因和pol基因的包装质粒; （2）含有HIV-1辅助基因的包装质粒; （3）含有靶基因（转基因）的转移质粒; （4）包含作为包膜基因的包含编码融合多肽的基因的包膜质粒，所述融合多肽包含由狂犬病病毒糖蛋白（RV-G）的细胞外结构域的N末端区域构成的融合细胞外结构域和C-末端 水泡性口炎病毒糖蛋白（VSV-G）的细胞外结构域，RV-G或VSV-G的跨膜结构域和VSV-G的细胞内结构域等。

公开(公告)号：US08806880B2

公开(公告)日：2014-08-19

申请号：US12680991

申请日：2008-09-18

申请人： Kazuto Kobayashi ,  Takashi Mogi ,  Eiji Fukuda

发明人： Kazuto Kobayashi ,  Takashi Mogi ,  Eiji Fukuda

IPC分类号： F25B41/06

CPC分类号： F25B41/062 ,  F16K27/02 ,  F25B2341/0683 ,  F25B2500/01

摘要： An expansion valve for reducing the quantity of material required for the valve body by contriving the arrangement of bolt fitting grooves. In the expansion valve (20), displacement of a valve member driver (36) provided in the valve body (21) is transmitted to a valve member by a valve member drive rod (36f) and the valve opening is altered to control the flow rate of the refrigerant. The valve body (21) consists of a body upper portion (40) and a body lower portion (41) narrower than the body upper portion (40), and bolt fitting grooves (43, 43) opening in the flank of the valve body (21), preferably opening obliquely downward, are formed at the boundary (42) of the body upper portion (40) and the body lower portion (41). With such a layout, the material required at the boundary (42) can be reduced furthermore and the quantity of material required for the valve body (21) can be reduced furthermore, as a result. Since the opening width (minimum spatial dimension) w is smaller than the diameter of bolt, a seating surface is assured sufficiently around the bolt fitting groove (43) and the bolt does not drop off from the bolt fitting groove (43).

摘要翻译： 一种膨胀阀，用于通过设计螺栓安装槽来减少阀体所需的材料的数量。 在膨胀阀（20）中，设置在阀体（21）中的阀构件驱动器（36）的位移通过阀构件驱动杆（36f）传递到阀构件，并且改变阀开度以控制流量 制冷剂的比例。 阀体（21）由主体上部（40）和比主体上部（40）窄的主体下部（41）构成，在阀体的侧面开口的螺栓嵌合槽（43,43） （21），优选地向下倾斜地开口，形成在主体上部（40）和主体下部（41）的边界（42）处。 通过这样的布局，可以进一步减少在边界（42）处所需的材料，并且可以进一步降低阀体（21）所需的材料量。 由于开口宽度（最小空间尺寸）w小于螺栓的直径，因此在螺栓配合槽（43）周围充分确保就座面，并且螺栓不会从螺栓配合槽（43）脱落。

公开(公告)号：US08635775B2

公开(公告)日：2014-01-28

申请号：US12096725

申请日：2006-12-05

申请人： Kazuto Kobayashi ,  Yuu Yasuda ,  Kiyoshi Ootsuka

发明人： Kazuto Kobayashi ,  Yuu Yasuda ,  Kiyoshi Ootsuka

IPC分类号： B21K1/40

CPC分类号： B21K1/40 ,  B21J5/02 ,  B21K23/04 ,  F16C19/186 ,  F16C33/64 ,  F16C2326/02 ,  Y10T29/49533 ,  Y10T29/49636 ,  Y10T29/49679 ,  Y10T29/49689

摘要： This invention provided a manufacturing method to process a small-diameter step section 18 on an inside end section of a hub body 13a that comprises an outward facing flange 15 and a positioning cylinder 16 stably and with high precision. In this invention, an intermediate material 40 is pressed between a lower punch 36 and an upper punch 46 with an outer peripheral surface of the intermediate material 40 being held by a lower die 37 and an upper die 43, and then a part of the intermediate material 40 is pressed into the lower punch 36 such that the small-diameter step section 18 is formed by cold plastic working.

摘要翻译： 本发明提供了一种在毂体13a的内端部处处理小直径台阶部18的制造方法，其特征在于，其具有稳定且高精度的向外凸缘15和定位筒16。 在本发明中，中间材料40被压在下冲头36和上冲头46之间，中间材料40的外周面由下模37和上模43保持，然后是中间材料的一部分 材料40被压入下冲头36，使得小直径台阶部分18通过冷塑性加工形成。

公开(公告)号：US08424208B2

公开(公告)日：2013-04-23

申请号：US12522311

申请日：2008-01-16

申请人： Kazuto Kobayashi ,  Hiroshi Koyama

发明人： Kazuto Kobayashi ,  Hiroshi Koyama

IPC分类号： B21D53/10 ,  B21J5/08 ,  F16C33/58

CPC分类号： B23P15/003 ,  B21H1/12 ,  B21J1/00 ,  B21J1/04 ,  B21J5/02 ,  B21J5/10 ,  B21K1/04 ,  B21K21/02 ,  F16C19/184 ,  F16C33/62 ,  F16C33/64 ,  Y10T29/49636 ,  Y10T29/49643 ,  Y10T29/49689

摘要： Provided is a manufacturing method of an outer ring (3) of a back-to-back arrangement double-row angular ball bearing from a raw material (10) comprising a upsetting (A to B), a backward extrusion process (C to D), a punching (D to E), a rolling (E to F) and a finishing, wherein an outer diameter of a first intermediate material (11a) produced by the upsetting is equal to or smaller than an inside diameter of an inner periphery large diameter portion (18) of the inner circumference of a die (13) used in the backward extrusion process and larger than an inside diameter of an inner periphery small portion (19) of the die (13), and in a condition with the first intermediate material (11a) sitting on the inner periphery inclined portion (20) of the die (13), the intermediate material (11a) is pushed toward a base of the die (13) by a punch (14), to thereby the middle metal material (29) with the highest cleanliness of the raw material (10) is exposed to the two outer ring raceways (2) of the outer ring (3).

摘要翻译： 本发明提供从包括镦粗（A〜B），向后挤压工序（C〜D）的原料（10）的背靠背排列双列角球轴承的外圈（3）的制造方法 ），冲压（D〜E），轧制（E〜F）和精加工，其中通过镦锻制造的第一中间材料（11a）的外径等于或小于内周的内径 在向后挤压过程中使用的模具（13）的内周的大直径部分（18）大于模具（13）的内周小部分（19）的内径，并且在 第一中间材料（11a）位于模具（13）的内周倾斜部分（20）上，中间材料（11a）通过冲头（14）被推向模具（13）的基部，由此 原料（10）清洁度最高的中间金属材料（29）暴露于t的两个外圈滚道（2） 他外圈（3）。

公开(公告)号：US20130008275A1

公开(公告)日：2013-01-10

申请号：US13581258

申请日：2011-03-31

申请人： Atsushi Watanabe ,  Toru Harada ,  Shouji Yokoyama ,  Kiyoshi Ootsuka ,  Koji Hashimoto ,  Kazuto Kobayashi ,  Toshio Nakamura ,  Shinobu Mogi ,  Shingo Saitou ,  Tomofumi Yamashita

发明人： Atsushi Watanabe ,  Toru Harada ,  Shouji Yokoyama ,  Kiyoshi Ootsuka ,  Koji Hashimoto ,  Kazuto Kobayashi ,  Toshio Nakamura ,  Shinobu Mogi ,  Shingo Saitou ,  Tomofumi Yamashita

IPC分类号： B21K1/70 ,  F16H25/22

CPC分类号： B21K1/70 ,  B21J5/12 ,  B21J13/025 ,  B21K1/04 ,  B21K21/12 ,  B21K21/16 ,  B21K23/00 ,  F16H25/2223 ,  F16H2025/2481 ,  Y10T74/19749 ,  Y10T74/19767 ,  Y10T74/19772

摘要： A method forms a concave constituting a ball return passage directly on an inner circumferential surface of a nut blank by plastic working without damaging a die. Letter S shaped concaves are formed on an inner circumferential surface of a nut blank, by pressing by use of a die having a blank holder, a cam driver, cam sliders, and a cylindrical member. The cam driver has inclined surfaces having the same angle of inclination as the cam sliders. The cam sliders have letter S shaped convexes corresponding to the letter S shaped concaves, and are held by through holes, respectively. When the cam driver is pressed from the top thereof, the cam sliders move outwardly in the radial direction, respectively, and the letter S shaped convexes push the inner circumferential surface of the nut blank for plastic deformation.

摘要翻译： 一种方法通过塑料加工在螺母坯件的内周面上直接形成一个构成球返回通道的凹槽，而不会损坏模具。 通过使用具有坯料保持器，凸轮驱动器，凸轮滑块和圆柱形构件的模具进行压制，在螺母坯料的内周面上形成字母S形凹部。 凸轮驱动器具有与凸轮滑块具有相同倾斜角度的倾斜表面。 凸轮滑块具有对应于字母S形凹部的字母S形凸起，并且分别由通孔保持。 当凸轮驱动器从其顶部按压时，凸轮滑块分别沿径向向外移动，字母S形凸起推动螺母坯件的内圆周表面以塑性变形。

公开(公告)号：US20120295964A1

公开(公告)日：2012-11-22

申请号：US13511873

申请日：2010-11-11

申请人： Kazuto Kobayashi

发明人： Kazuto Kobayashi

IPC分类号： C12N15/86 ,  C12N15/87 ,  A61P25/16 ,  C07K14/145 ,  C12N15/47 ,  C12N5/0783 ,  A61K48/00

CPC分类号： A61K48/0075 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16045 ,  C12N2740/16052 ,  C12N2760/20122 ,  C12N2760/20222 ,  C12N2810/6081

摘要： Provided is a lentiviral vector system which sustains a high-frequency retrograde transportation ability in animal brain and has a higher titer. A kit for preparing a retrograde transport viral vector, which comprises: (1) a packaging plasmid containing the gag gene and pol gene of HIV-1; (2) a packaging plasmid containing an accessory gene of HIV-1; (3) a transfer plasmid containing a target gene; and (4) an envelope plasmid containing, as an envelope gene, a gene encoding a fused polypeptide comprising the extracellular domain of rabies virus glycoprotein (RV-G), the transmembrane domain of rabies virus glycoprotein (RV-G) or vesicular stomatitis virus glycoprotein (VSV-G) and the intracellular domain of vesicular stomatitis virus glycoprotein (VSV-G).

摘要翻译： 提供了一种在动物脑中维持高频逆行运输能力并具有较高滴度的慢病毒载体系统。 一种用于制备逆行转运病毒载体的试剂盒，其包括：（1）含有HIV-1的gag基因和pol基因的包装质粒; （2）含有HIV-1辅助基因的包装质粒; （3）含有靶基因的转移质粒; （4）包含作为包膜基因的包含狂犬病病毒糖蛋白（RV-G）细胞外结构域，狂犬病病毒糖蛋白（RV-G）或水泡性口炎病毒的跨膜结构域的融合多肽的基因的包膜质粒 糖蛋白（VSV-G）和水泡性口炎病毒糖蛋白（VSV-G）的细胞内结构域。

公开(公告)号：US08149819B2

公开(公告)日：2012-04-03

申请号：US11166236

申请日：2005-06-27

申请人： Kazuto Kobayashi ,  Akira Miyajima

发明人： Kazuto Kobayashi ,  Akira Miyajima

IPC分类号： G06F15/16 ,  H04L12/66

CPC分类号： H04M7/006

摘要： An ENUM system includes a Web server and an ENUM server. The Web server stores first NAPTR records corresponding to an ENUM client and another ENUM client on an IP network. The ENUM server stores second NAPTR records in which first URIs are associated with predetermined information for being linked to the Web server. In the ENUM system, the ENUM client transmits, to the ENUM server, a query for the second NAPTR record of the another ENUM client. The ENUM client then transmits, to the Web server, a request for access to the first URI included in the received second NAPTR record, and obtains the first NAPTR record corresponding to the another ENUM client.

摘要翻译： ENUM系统包括Web服务器和ENUM服务器。 Web服务器在IP网络上存储对应于ENUM客户端和另一个ENUM客户端的第一个NAPTR记录。 ENUM服务器存储第二个NAPTR记录，其中第一个URI与预定的信息相关联，以链接到Web服务器。 在ENUM系统中，ENUM客户端向ENUM服务器发送另一个ENUM客户端的第二个NAPTR记录的查询。 然后，ENUM客户端向Web服务器发送访问包括在接收的第二NAPTR记录中的第一URI的请求，并且获得与另一ENUM客户端对应的第一NAPTR记录。

公开(公告)号：USD647597S1

公开(公告)日：2011-10-25

申请号：US29371564

申请日：2011-04-25

申请人： Kazuto Kobayashi ,  Takashi Mogi

设计人： Kazuto Kobayashi ,  Takashi Mogi

公开(公告)号：US07957367B2

公开(公告)日：2011-06-07

申请号：US11140907

申请日：2005-06-01

申请人： Kazuto Kobayashi ,  Akira Miyajima

发明人： Kazuto Kobayashi ,  Akira Miyajima

IPC分类号： H04L12/66

CPC分类号： H04L61/157 ,  H04L29/1216 ,  H04M3/42042 ,  H04M7/0057 ,  H04M7/006

摘要： An ENUM server stores NAPTR records including PSTN telephone numbers and the corresponding IP telephone numbers of a source IP telephone apparatus and a destination IP telephone apparatus. When the ENUM server receives an ENUM query from the source IP telephone apparatus, the ENUM query setting a domain name based on the PSTN telephone number, the ENUM server searches for a NAPTR record corresponding to the domain name and returns, to the source IP telephone apparatus, an ENUM response including the NAPTR record. When receiving the ENUM response from the ENUM server, the source IP telephone apparatus retrieves the IP telephone number of the destination IP telephone apparatus, the IP telephone number being specified in the NAPTR record contained in the ENUM response, and starts a call connection sequence with the destination IP telephone apparatus.

摘要翻译： ENUM服务器存储包括PSTN电话号码和源IP电话设备和目的IP电话设备的相应IP电话号码的NAPTR记录。 当ENUM服务器从源IP电话设备接收到ENUM查询时，ENUM查询根据PSTN电话号码设置域名，ENUM服务器搜索与域名对应的NAPTR记录，并返回到源IP电话 设备，包括NAPTR记录的ENUM响应。 当从ENUM服务器接收到ENUM响应时，源IP电话设备检索目的地IP电话设备的IP电话号码，该IP电话号码在ENUM响应中包含的NAPTR记录中指定，并开始一个呼叫连接序列， 目的IP电话设备。