公开(公告)号：US07396642B2

公开(公告)日：2008-07-08

申请号：US10483627

申请日：2002-07-17

申请人： Kazuyoshi Yamaoka ,  Kenichiro Takagi ,  Kenichiro Kataoka ,  Masanori Yamamoto ,  Toshihiro Chikanishi

发明人： Kazuyoshi Yamaoka ,  Kenichiro Takagi ,  Kenichiro Kataoka ,  Masanori Yamamoto ,  Toshihiro Chikanishi

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/5079 ,  G01N33/6872

摘要： The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR δ, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function.The present invention provides an agent containing a compound having an effect activating PPAR δ, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPAR δ activating effect.

摘要翻译： 本发明提供一种筛选具有生发增强效果的物质的方法，其含有具有活化PPARδ的作用的化合物，含有该化合物的药剂和具有抗糖尿病，抗胆固醇或内脏积累的降脂功能的药剂。 本发明提供了含有具有活化PPARδ作用的化合物的化合物，其是过氧化物酶体增殖物激活受体，并且具有增强非发热生成（nST）的作用，特别地增强脂肪组织等中的细胞的线粒体中的解偶联呼吸 或线粒体内膜中的质子泄漏，并增加UCP1的表达量，并提供含有该化合物的抗糖尿病药，抗胆碱剂和内脏累积降脂剂。 此外，本发明提供了通过测量PPARδ激活效应来筛选化合物的方法。

公开(公告)号：US20080287544A1

公开(公告)日：2008-11-20

申请号：US12142652

申请日：2008-06-19

申请人： Kazuyoshi YAMAOKA ,  Kenichiro Takagi ,  Kenichiro Kataoka ,  Masanori Yamamoto ,  Toshihiro Chikanishi

发明人： Kazuyoshi YAMAOKA ,  Kenichiro Takagi ,  Kenichiro Kataoka ,  Masanori Yamamoto ,  Toshihiro Chikanishi

IPC分类号： A61K31/19 ,  A61P3/10 ,  A61P9/10

CPC分类号： G01N33/5079 ,  G01N33/6872

摘要： The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPARδ, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function.The present invention provides an agent containing a compound having an effect activating PPARδ, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPARδ activating effect.

摘要翻译： 本发明提供一种筛选具有生发促进效果的物质的方法，其含有具有活化PPARδ的作用的化合物，含有该化合物的药剂和具有抗糖尿病，抗胆固醇或内脏积累的降脂功能的药剂。 本发明提供含有具有激活PPARdta的作用的化合物的药剂，其是过氧化物酶体增殖物激活受体，并且具有增强非发热生成（nST）的作用，特别地增强脂肪组织等中的细胞的线粒体中的解偶联呼吸， 或线粒体内膜中的质子泄漏，并增加UCP1的表达量，并提供含有该化合物的抗糖尿病剂，抗胆碱剂和内脏积累的降脂剂。 此外，本发明提供了通过测量PPARδ激活效应来筛选化合物的方法。

公开(公告)号：US07528140B2

公开(公告)日：2009-05-05

申请号：US10504583

申请日：2003-02-24

申请人： Kenichiro Kataoka ,  Tomomi Kosugi ,  Toshihiro Ishii ,  Takahiro Takeuchi ,  Takaharu Tsutsumi ,  Akira Nakano ,  Gen Unoki ,  Masanori Yamamoto ,  Yuri Sakai

发明人： Kenichiro Kataoka ,  Tomomi Kosugi ,  Toshihiro Ishii ,  Takahiro Takeuchi ,  Takaharu Tsutsumi ,  Akira Nakano ,  Gen Unoki ,  Masanori Yamamoto ,  Yuri Sakai

IPC分类号： C07D487/04 ,  C07D417/12 ,  C07D417/06 ,  C07D413/12 ,  C07D413/06 ,  C07D519/00 ,  A61K31/519 ,  A61K31/541 ,  A61K31/5355 ,  A61K31/497

CPC分类号： C07D487/04

摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.

摘要翻译： 本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。 本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性 脑病，脱发，炎性疾病，癌症和免疫缺陷。

公开(公告)号：US20050277773A1

公开(公告)日：2005-12-15

申请号：US10504583

申请日：2003-02-24

申请人： Kenichiro Kataoka ,  Tomomi Kosugi ,  Toshihiro Ishii ,  Takahiro Takeuchi ,  Takaharu Tsutsumi ,  Akira Nakano ,  Gen Unoki ,  Masanori Yamamoto ,  Yuri Sakai

发明人： Kenichiro Kataoka ,  Tomomi Kosugi ,  Toshihiro Ishii ,  Takahiro Takeuchi ,  Takaharu Tsutsumi ,  Akira Nakano ,  Gen Unoki ,  Masanori Yamamoto ,  Yuri Sakai

IPC分类号： A61P3/10 ,  A61P17/14 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D487/04 ,  A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.

摘要翻译： 本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。 本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性 脑病，脱发，炎性疾病，癌症和免疫缺陷。

公开(公告)号：US08946440B2

公开(公告)日：2015-02-03

申请号：US12989838

申请日：2009-04-27

申请人： Yasumichi Fukuda ,  Yoshikazu Asahina ,  Masanori Takadoi ,  Masanori Yamamoto

发明人： Yasumichi Fukuda ,  Yoshikazu Asahina ,  Masanori Takadoi ,  Masanori Yamamoto

IPC分类号： A61K31/381 ,  C07D277/34 ,  C07F9/6509 ,  C07D213/75 ,  C07D231/38 ,  C07D241/20 ,  C07D261/14 ,  C07D277/20 ,  C07D277/44 ,  C07D277/82 ,  C07D285/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04 ,  C07F9/54 ,  C07F9/6539

CPC分类号： C07C309/77 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/75 ,  C07D231/38 ,  C07D241/20 ,  C07D261/14 ,  C07D277/20 ,  C07D277/44 ,  C07D277/82 ,  C07D285/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04 ,  C07F9/5442 ,  C07F9/650952 ,  C07F9/6539

摘要： A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a C1 to C6 alkylsulfanyl group, a C1 to C6 alkylsulfinyl group, a C1 to C6 alkylsulfonyl group, or a C1 to C6 alkoxy-C1 to C6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).

摘要翻译： 提供具有降血糖作用的化合物。 该化合物及其药学上可接受的盐可用于治疗或预防糖尿病，肥胖症等。 该化合物由通式（1）表示：（其中R 1和R 2各自独立地为氢原子，卤素原子，氨基，羟基，羟基氨基，硝基，氰基，氨磺酰基 C1〜C6烷基，C1〜C6烷氧基，C1〜C6烷基硫烷基，C1〜C6烷基亚磺酰基，C1〜C6烷基磺酰基或C1〜C6烷氧基-C1〜C6烷基磺酰基， A是取代或未取代的杂芳基）。

公开(公告)号：US20100016304A1

公开(公告)日：2010-01-21

申请号：US12448549

申请日：2007-12-21

申请人： Yasumichi Fukuda ,  Yoshikazu Asahina ,  Ayako Nakamura ,  Kenji Fujita ,  Tomohiro Ide ,  Fumiyoshi Kobayashi ,  Shinji Kobayashi ,  Kanji Komatsu ,  Masanori Yamamoto

发明人： Yasumichi Fukuda ,  Yoshikazu Asahina ,  Ayako Nakamura ,  Kenji Fujita ,  Tomohiro Ide ,  Fumiyoshi Kobayashi ,  Shinji Kobayashi ,  Kanji Komatsu ,  Masanori Yamamoto

IPC分类号： A61K31/5377 ,  C07D263/14 ,  A61K31/421 ,  A61K31/426 ,  C07D277/28 ,  C07D513/04 ,  A61K31/4365 ,  C07D417/12 ,  A61P3/10

CPC分类号： C07C317/44 ,  C07C2601/08 ,  C07D213/75 ,  C07D213/80 ,  C07D215/38 ,  C07D217/22 ,  C07D231/40 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D241/28 ,  C07D241/44 ,  C07D261/14 ,  C07D263/48 ,  C07D275/02 ,  C07D277/20 ,  C07D277/46 ,  C07D277/82 ,  C07D285/08 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： A compound represented by the following formula (1): (wherein the carbon atom denoted by * is in the R-configuration; R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfanyl group, a C1-C6 alkylsulfinyl group or a C1-C6 alkylsulfonyl group; and A is a substituted or unsubstituted heteroaryl group), or a pharmaceutically acceptable salt thereof.

摘要翻译： 由下式（1）表示的化合物：（其中由*表示的碳原子为R构型; R 1和R 2各自独立地为氢原子，卤素原子，氨基，羟基，羟基氨基 基团，硝基，氰基，氨磺酰基，C1-C6烷基，C1-C6烷氧基，C1-C6烷基硫烷基，C1-C6烷基亚磺酰基或C1-C6烷基磺酰基;以及 A是取代或未取代的杂芳基）或其药学上可接受的盐。

公开(公告)号：US06688950B2

公开(公告)日：2004-02-10

申请号：US10080563

申请日：2002-02-25

申请人： Nobuyuki Kobayashi ,  Masanori Yamamoto

发明人： Nobuyuki Kobayashi ,  Masanori Yamamoto

IPC分类号： B24B100

CPC分类号： B24B25/00 ,  B24B7/13 ,  B24B7/20 ,  G11B5/84 ,  G11B23/502

摘要： In manufacturing a magnetic tape, a long web of non-magnetic base material is coated with a magnetic layer and, thereafter, subjected to a smoothing process, wherein the surface of the magnetic layer is abraded, ground, and then wiped out. For grinding, sapphire blades are kept in contact with the surface of the magnetic layer with their edges oriented in a transverse direction to the magnetic tape, and are moved back and forth in the transverse direction to the magnetic tape, while the magnetic tape is being conveyed in a lengthwise direction of the magnetic tape. Of the sapphire blades, adjacent two are moved in opposite directions to each other.

摘要翻译： 在制造磁带时，用磁性层涂覆长的非磁性基材卷材，然后进行平滑化处理，其中将磁性层的表面研磨，研磨，然后擦掉。 为了研磨，蓝宝石刀片与磁性层的表面保持接触，其边缘朝向磁带的横向方向定向，并且在磁带的横向方向上前后移动到磁带上 在磁带的长度方向上传送。 在蓝宝石刀片中，相邻的两个相互移动。

公开(公告)号：US06269229B1

公开(公告)日：2001-07-31

申请号：US09531526

申请日：2000-03-21

申请人： Masanori Yamamoto

发明人： Masanori Yamamoto

IPC分类号： G03G1501

CPC分类号： G03G15/0194 ,  G03G2215/0119

摘要： An image forming apparatus has first to fourth photoconductor drums, a driving source (i.e, motor), a transmitting member for transmitting power of the driving source to the photoconductor drums to rotate the photoconductor drums (i.e, gears and belts), a first restricting member being rotatably held and being coupled to the first and second photoconductor drums to restrict rotations of the first and second photoconductor drums (i.e, gear), the first restricting member being a member different from the transmitting member and a second restricting member being rotatably held and being coupled to the third and fourth photoconductor drums to restrict rotations of the third and fourth photoconductor drums (i.e, gear), and the second restricting member being a member different from the transmitting member.

摘要翻译： 图像形成装置具有第一至第四感光鼓，驱动源（即，马达），用于将驱动源的功率传递到感光鼓以将光导鼓（即，齿轮和带）旋转的传送部件，第一限制 构件可旋转地保持并联接到第一和第二感光鼓，以限制第一和第二感光鼓（即，齿轮）的旋转，第一限制构件是不同于传递构件的构件，以及可旋转地保持的第二限制构件 并且耦合到第三和第四感光鼓，以限制第三和第四感光鼓（即，齿轮）的旋转，并且第二限制构件是不同于透射构件的构件。

公开(公告)号：US06191933B1

公开(公告)日：2001-02-20

申请号：US09226918

申请日：1999-01-05

申请人： Takaya Ishigaki ,  Masatoshi Ishikawa ,  Takashi Kamiya ,  Shunji Itakura ,  Yuji Aiba ,  Masanori Yamamoto

发明人： Takaya Ishigaki ,  Masatoshi Ishikawa ,  Takashi Kamiya ,  Shunji Itakura ,  Yuji Aiba ,  Masanori Yamamoto

IPC分类号： H01G4228

CPC分类号： H01G4/232 ,  H01F2027/295 ,  H01G4/38 ,  H05K3/3426 ,  Y02P70/613 ,  Y10T29/43 ,  Y10T29/435 ,  Y10T29/49144 ,  Y10T29/49149

摘要： The present invention relates to a ceramic capacitor having metal plate terminals that absorb thermal stress and mechanical stress caused by flexure of the substrate. A ceramic capacitor element is provided with terminal electrodes at the two side end surfaces facing opposite each other. The metal plate terminals are each connected to one of the terminal electrodes at one end thereof, are each provided with a folded portion in a middle area and a terminal portion to be connected to the outside toward the other end from the folded portion.

公开(公告)号：US5770644A

公开(公告)日：1998-06-23

申请号：US806651

申请日：1997-02-26

申请人： Masanori Yamamoto ,  Shintarou Kishimoto

发明人： Masanori Yamamoto ,  Shintarou Kishimoto

IPC分类号： C08K5/3492 ,  C08K5/523 ,  C08K5/5399 ,  C08L67/02 ,  C08K5/49 ,  C08K5/51 ,  C08K5/52

CPC分类号： C08K5/5399 ,  C08K5/34928 ,  C08K5/523 ,  C08L67/02

摘要： A fire retardant polyester resin composition comprising (A) 95 to 30 parts by weight of a polyester resin and (B) 5.0 to 70 parts by weight of a polyphenylene ether resin and/or polyphenylene sulfide resin, and, for 100 parts by weight in total of the components (A) and (B), (C) 0.05 to 10 parts by weight of a compatibilizing agent, (D) 2.0 to 45 parts by weight of a phosphoric ester compound or phosphonitrile compound, (E) 0 to 150 parts by weight of a reinforcing filler, (F) 0.001 to 15 parts by weight of an anti-dripping agent, (G) 0 to 45 parts by weight of a melamine cyanurate, and (H) 0 to 15 parts by weight of a polystyrene resin having epoxy group, provided that the amount of the component (G) is from 0.5 to 45 parts by weight for 100 parts by weight in total of the components (A) and (B) when the amount of the component (B) is less than 35 parts by weight. The polyester resin composition scarcely corrodes a metal mold when it is molded, and is excellent in fire retardancy.

摘要翻译： 一种阻燃性聚酯树脂组合物，其包含（A）95〜30重量份的聚酯树脂和（B）5.0〜70重量份的聚苯醚树脂和/或聚苯硫醚树脂，并且对于100重量份 组分（A）和（B），（C）0.05〜10重量份相容剂，（D）2.0〜45重量份磷酸酯化合物或磷腈化合物，（E）0〜150 （F）0.001-15重量份抗滴落剂，（G）0至45重量份三聚氰胺氰尿酸酯，和（H）0至15重量份的增塑填料， 当组分（B）的量为100重量份时，组分（G）的用量相对于组分（A）和（B）为100重量份，为0.5〜45重量份， 小于35重量份。 聚酯树脂组合物在模塑时几乎不腐蚀金属模具，并且阻燃性优异。