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    MEMS OSCILLATOR DRIVE
    1.
    发明申请
    MEMS OSCILLATOR DRIVE 有权
    MEMS振荡器驱动器

    公开(公告)号：US20060176122A1

    公开(公告)日：2006-08-10

    申请号：US11275653

    申请日：2006-01-20

    申请人： Keith Aubin ,  Bojan Ilic ,  Maxim Zalalutdinov ,  Robert Reichenbach ,  Jeevak Parpia ,  Harold Craighead

    发明人： Keith Aubin ,  Bojan Ilic ,  Maxim Zalalutdinov ,  Robert Reichenbach ,  Jeevak Parpia ,  Harold Craighead

    IPC分类号： H03L1/00

    CPC分类号： H03B5/30 ,  B81B3/0029 ,  B81B2203/0118 ,  H03H9/02259 ,  H03H9/2457 ,  H03H2009/02511

    摘要： The temperature of a remote portion of device having a microelectromechanical oscillator is modulated to create oscillation of the oscillators. In one embodiment, a localized heat source is placed on a device layer of a multilayered stack, consisting of device, sacrificial and substrate layers. The localized heat source may be a laser beam in one embodiment. The oscillator is supported by the device layer and may be formed in the device layer in various embodiments. The oscillator may be spaced apart from the localized heat source.

    摘要翻译： 具有微机电振荡器的器件的远端部分的温度被调制以产生振荡器的振荡。 在一个实施例中，将局部热源放置在由器件，牺牲层和衬底层组成的多层叠层的器件层上。 在一个实施例中，局部热源可以是激光束。 振荡器由器件层支撑，并且可以在各种实施例中形成在器件层中。 振荡器可以与局部热源间隔开。

    Local telemetry device and method
    2.
    发明申请
    Local telemetry device and method 审中-公开
    本地遥测装置及方法

    公开(公告)号：US20060210102A1

    公开(公告)日：2006-09-21

    申请号：US11358675

    申请日：2006-02-20

    申请人： Maxim Zalalutdinov ,  Keith Aubin ,  Robert Reichenbach ,  Jeevak Parpia ,  Harold Craighead

    发明人： Maxim Zalalutdinov ,  Keith Aubin ,  Robert Reichenbach ,  Jeevak Parpia ,  Harold Craighead

    IPC分类号： H04R25/00

    CPC分类号： G01S5/26 ,  A61B5/0031 ,  A61B5/07 ,  A61B5/073 ,  A61B8/0833 ,  G01S5/0036

    摘要： Position tracking of a receiving device within a gas or fluidic environment (for example a human body), is performed by measuring acoustic wave propagation parameters to provide real time, high precision telemetry. Multiple synchronized acoustic sources at different known locations transmit signals that are received by a receiver on the device to be located. The coordinates of the receiver can be determined by measuring a difference in the amplitude (coarse positioning) or phase (precise positioning) of the acoustic waves coming from different sources using triangulation calculations.

    摘要翻译： 通过测量声波传播参数来实现气体或流体环境（例如人体）中的接收装置的位置跟踪，以提供实时，高精度的遥测。 在不同已知位置处的多个同步声源传送由要被定位的设备上的接收机接收的信号。 可以通过使用三角测量计算来测量来自不同源的声波的振幅（粗定位）或相位（精确定位）的差异来确定接收器的坐标。

    MEMS controlled oscillator
    3.
    发明申请
    MEMS controlled oscillator 有权
    MEMS控制振荡器

    公开(公告)号：US20070200648A1

    公开(公告)日：2007-08-30

    申请号：US11598097

    申请日：2006-11-09

    申请人： Robert Reichenbach ,  Keith Aubin ,  Maxim Zalalutdinov ,  Jeevak Parpia ,  Harold Craighead

    发明人： Robert Reichenbach ,  Keith Aubin ,  Maxim Zalalutdinov ,  Jeevak Parpia ,  Harold Craighead

    IPC分类号： H03H9/70

    CPC分类号： H03H9/02401 ,  G01S7/032 ,  H01Q3/26 ,  H03H3/0072 ,  H03H9/2436

    摘要： An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one embodiment, the oscillator is disc of material supported by a pillar of much smaller diameter than the disc. The periphery of the disc is heated to modify the resonant frequency (or equivalently the spring constant or stiffness) of the disc. Continuous control of the output phase and frequency may be achieved when the oscillator becomes synchronized with an imposed sinusoidal force of close frequency. The oscillator frequency can be detuned to produce an easily controlled phase differential between the injected signal and the oscillator feedback. A phased array radar may be produced using independent phase controllable oscillators.

    摘要翻译： 微机械振荡器阵列根据其几何形状具有不同的谐振频率。 在一个实施例中，微机械振荡器具有由通过施加热来修改的有效弹簧常数限定的谐振频率。 在一个实施例中，振荡器是由比该盘小得多的直径支柱支撑的材料盘。 加热盘的周边以改变盘的共振频率（或等效地为弹簧常数或刚度）。 当振荡器与施加的接近频率的正弦力同步时，可以实现输出相位和频率的连续控制。 振荡器频率可以失谐，以在注入的信号和振荡器反馈之间产生容易控制的相位差。 可以使用独立的相位可控振荡器来产生相控阵雷达。

    Detection of small bound mass
    7.
    发明申请
    Detection of small bound mass 有权
    检测小的束缚质量

    公开(公告)号：US20060219010A1

    公开(公告)日：2006-10-05

    申请号：US11093008

    申请日：2005-03-29

    申请人： Bojan Ilic ,  Harold Craighead

    发明人： Bojan Ilic ,  Harold Craighead

    IPC分类号： G01N29/02

    CPC分类号： G01N29/022 ,  B82Y30/00 ,  B82Y35/00 ,  G01N29/036 ,  G01N29/2418 ,  G01N2291/02491 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

    摘要： Prefabricated catalyzing adsorption sites are incorporated into small oscillators. In one embodiment, the sites are formed of precisely positioned gold anchors on surface micromachined oscillators. The micromachined oscillators may be formed of silicon, such as polysilicon, or silicon nitride in various embodiments. The sites allow special control of chemical surface functionality for the detection of analytes of interest. Thiolate molecules may be adsorbed from solution onto the gold anchors, creating a dense thiol monolayer with a tail end group pointing outwards from the surface of the gold anchor. This results in a thiolate self-assembled monolayer (SAM), creating a strong interaction between the functional group and the gold anchor.

    摘要翻译： 预制的催化吸附位点并入小振荡器。 在一个实施例中，这些位置由精确定位的金锚形成在表面微机械振荡器上。 在各种实施例中，微机械振荡器可以由诸如多晶硅的硅或氮化硅形成。 这些位点允许特殊的化学表面功能控制来检测感兴趣的分析物。 硫醇分子可以从溶液中吸附到金锚上，形成致密的硫醇单层，尾端组从金锚的表面向外指向。 这导致硫醇自组装单层（SAM），在功能基团和​​金锚之间产生强烈的相互作用。

    Methods for analyzing nucleic acid sequences
    9.
    发明申请
    Methods for analyzing nucleic acid sequences 有权
    分析核酸序列的方法

    公开(公告)号：US20060154288A1

    公开(公告)日：2006-07-13

    申请号：US11336122

    申请日：2006-01-19

    申请人： Jonas Korlach ,  Watt Webb ,  Michael Levene ,  Stephen Turner ,  Harold Craighead ,  Mathieu Foquet

    发明人： Jonas Korlach ,  Watt Webb ,  Michael Levene ,  Stephen Turner ,  Harold Craighead ,  Mathieu Foquet

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6874 ,  C12Q1/6869 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/537 ,  C12Q2537/149 ,  C12Q2561/113 ,  C12Q2521/543 ,  C12Q2565/518 ,  C12Q2561/12

    摘要： The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined.

    摘要翻译： 本发明涉及对具有多个碱基的靶核酸分子进行测序的方法。 在其原理中，聚合反应中碱添加的时间顺序是在核酸分子上测量的，即核酸聚合酶在待测序的模板核酸分子上的活性被实时跟踪。 通过在碱添加序列的每个步骤中通过核酸聚合酶的催化活性鉴定哪个碱基被掺入靶核酸的生长互补链中来推断该序列。 在靶核酸分子复合物上提供聚合酶，其适于沿着靶核酸分子移动并在活性位点延伸寡核苷酸引物。 多个标记类型的核苷酸类似物在活性位点附近提供，每种可区分类型的核苷酸类似物与靶核酸序列中的不同核苷酸互补。 生长的核酸链通过使用聚合酶延伸到活性位点处的核酸链的核苷酸类似物，其中加入的核苷酸类似物与活性位点上的靶核酸的核苷酸互补。 鉴定作为聚合步骤的结果添加到寡核苷酸引物中的核苷酸类似物。 重复提供标记的核苷酸类似物，聚合生长的核酸链和鉴定添加的核苷酸类似物的步骤，使得核酸链进一步延长并确定靶核酸的序列。

    Methods for detecting nucleic acid analyte
    10.
    发明申请
    Methods for detecting nucleic acid analyte 审中-公开
    检测核酸分析物的方法

    公开(公告)号：US20060134666A1

    公开(公告)日：2006-06-22

    申请号：US11271033

    申请日：2005-11-10

    申请人： Jonas Korlach ,  Watt Webb ,  Michael Levene ,  Stephen Turner ,  Harold Craighead ,  Mathieu Foquet

    发明人： Jonas Korlach ,  Watt Webb ,  Michael Levene ,  Stephen Turner ,  Harold Craighead ,  Mathieu Foquet

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6874 ,  C12Q1/6869 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/537 ,  C12Q2537/149 ,  C12Q2561/113 ,  C12Q2521/543 ,  C12Q2565/518 ,  C12Q2561/12

    摘要： The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined.

    摘要翻译： 本发明涉及对具有多个碱基的靶核酸分子进行测序的方法。 在其原理中，聚合反应中碱添加的时间顺序是在核酸分子上测量的，即核酸聚合酶在待测序的模板核酸分子上的活性被实时跟踪。 通过在碱添加序列的每个步骤中通过核酸聚合酶的催化活性鉴定哪个碱基被掺入靶核酸的生长互补链中来推断该序列。 在靶核酸分子复合物上提供聚合酶，其适于沿着靶核酸分子移动并在活性位点延伸寡核苷酸引物。 多个标记类型的核苷酸类似物在活性位点附近提供，每种可区分类型的核苷酸类似物与靶核酸序列中的不同核苷酸互补。 生长的核酸链通过使用聚合酶延伸到活性位点处的核酸链的核苷酸类似物，其中加入的核苷酸类似物与活性位点上的靶核酸的核苷酸互补。 鉴定作为聚合步骤的结果添加到寡核苷酸引物中的核苷酸类似物。 重复提供标记的核苷酸类似物，聚合生长的核酸链和鉴定添加的核苷酸类似物的步骤，使得核酸链进一步延长并确定靶核酸的序列。