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23 条记录 (耗时 0.031 秒)

    Automated electronic personal preference & proxy network
    2.
    发明申请
    Automated electronic personal preference & proxy network 审中-公开
    自动电子个人偏好和代理网络

    公开(公告)号：US20050060417A1

    公开(公告)日：2005-03-17

    申请号：US10942585

    申请日：2004-09-15

    申请人： Keith Rose

    发明人： Keith Rose

    IPC分类号： G06Q10/00 ,  H04L12/18 ,  H04L12/58 ,  H04L29/06 ,  H04L29/08 ,  G06F15/16 ,  G06F15/173

    CPC分类号： G06Q10/00 ,  H04L12/1859 ,  H04L29/06 ,  H04L51/12 ,  H04L67/22 ,  H04L67/30 ,  H04L69/329

    摘要： An automated electronic personal preference & proxy network, that captures and exchanges personal profile information via an electronic means using network infrastructure is provided. Users may update preferences electronically. Permissions are generated in accordance with users permissions. Providers may enter an omnibus contract with an electronic agent, allowing various features such as cross-provider data transfer. An automated regulatory compliance engine is disclosed. An automated activity and offer engine is disclosed, to facilitate relevant offerings to users, and to automatically deepen user profiles. A violation engine for enforcing the contracts and regulations in an automated fashion is disclosed. Various other aspects are also disclosed.

    摘要翻译： 提供了一种自动化的电子个人偏好和代理网络，其通过使用网络基础设施的电子手段捕获和交换个人简档信息。 用户可以电子地更新偏好。 权限根据用户权限生成。 供应商可能会与电子代理商签订总括合同，允许各种功能，如跨供应商数据传输。 公开了一种自动化的监管合规引擎。 公开了一种自动化活动和提供引擎，以便于向用户提供相关产品，并自动深化用户简档。 公开了以自动方式执行合同和规章的违规引擎。 还公开了各种其它方面。

    Hetero-polyoxime compounds and their preparation by parallel assembly
    3.
    发明授权
    Hetero-polyoxime compounds and their preparation by parallel assembly 失效
    异肟化合物及其并联组装制备

    公开(公告)号：US6001364A

    公开(公告)日：1999-12-14

    申请号：US105904

    申请日：1993-08-31

    申请人： Keith Rose ,  Robin E. Offord

    发明人： Keith Rose ,  Robin E. Offord

    IPC分类号： A61K47/48 ,  A61P37/04 ,  C07K1/107 ,  A61K38/385 ,  C07K1/00 ,  C07K16/00

    CPC分类号： A61K47/48192 ,  C07K1/1077

    摘要： Provided by this invention are defined compositions of hetero-polyoximes of defined structure comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a specifically active molecule to the baseplate. Also provided are novel baseplates having a plurality of oxime forming complementary reactive groups and novel specifically reactive molecules having an oxime forming complementary reactive group. Also provided by this invention are methods of preparing these novel compositions of matter by chemoselectively ligating via oxime bond formation a complementary orthogonal reactive group on the baseplate to a complementary reactive orthogonal group on a specifically active molecule. Methods of using these defined compositions of matter as well as pharmaceutical compositions comprising these defined compositions of matter and methods of their use are also provided by this invention.

    摘要翻译： 通过本发明提供了定义结构的杂多肟的定义的组合物，其包含具有多个肟键的基板结构，其中每个肟键将特异性活性分子连接到基板上。 还提供了具有多个形成肟的互补反应性基团的新型基板和具有肟形成互补反应性基团的新型特异性反应性分子。 本发明还提供了通过化学选择性地连接基底板上的互补正交反应基团与特异性活性分子上的互补反应正交基团，通过化学选择性连接来制备这些新物质组合物的方法。 使用这些定义的物质组合物的方法以及包含这些所定义的物质组合物的药物组合物及其使用方法也由本发明提供。

    Polyoxime compounds and their preparation
    5.
    发明申请
    Polyoxime compounds and their preparation 审中-公开
    多肟化合物及其制备方法

    公开(公告)号：US20050025740A1

    公开(公告)日：2005-02-03

    申请号：US10687711

    申请日：2003-10-20

    申请人： Keith Rose ,  Robin Offord

    发明人： Keith Rose ,  Robin Offord

    IPC分类号： A61K31/785 ,  A61K47/48 ,  C07K1/107 ,  G01N33/53 ,  G01N33/543

    CPC分类号： C07K1/1077 ,  A61K31/785 ,  A61K47/62

    摘要： A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is linked to at least two second organic molecules, which may be the same or different from one another. In the compositions, the linkages between the baseplate and said organic molecules are oxime linkages formed by reaction of an orthogonal reactive group on each the organic molecules with a complementary orthogonal reactive group on the baseplate.

    摘要翻译： 提供均匀的多肟组合物，其中存在的肟基分子包含第一有机底板分子，其是多肽，其中所述底板分子与至少两个第二有机分子连接，所述第二有机分子彼此可以相同或不同。 在组合物中，底板和所述有机分子之间的连接是通过在每个有机分子上的正交反应基团与基板上的互补正交反应基团反应形成的肟键。

    Polyamide chains of precise length
    6.
    发明授权
    Polyamide chains of precise length 失效

    公开(公告)号：US06552167B1

    公开(公告)日：2003-04-22

    申请号：US09379297

    申请日：1999-08-23

    申请人： Keith Rose

    发明人： Keith Rose

    IPC分类号： C07K107

    CPC分类号： C07K1/1077 ,  C08G69/00 ,  C08G69/06 ,  C08G69/10

    摘要： Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.

    Outside-in social network communication and promotion
    8.
    发明申请
    Outside-in social network communication and promotion 审中-公开
    外部社交网络沟通和推广

    公开(公告)号：US20110131100A1

    公开(公告)日：2011-06-02

    申请号：US12804248

    申请日：2010-07-16

    申请人： Harry R. Soza ,  Mark Wayman ,  Keith Rose ,  Jeffrey A. Roberts

    发明人： Harry R. Soza ,  Mark Wayman ,  Keith Rose ,  Jeffrey A. Roberts

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/02 ,  G06Q30/0277

    摘要： A system for spreading promotional content into a social network environment from outside the social network is provided. A computer server system monitors information associated with the promotional content and the communication steps associated with the outside-in communication and further inside communications or spread of the promotional content.

    摘要翻译： 提供了一种从社交网络外部将促销内容传播到社交网络环境中的系统。 计算机服务器系统监视与促销内容相关联的信息以及与外部通信相关联的通信步骤以及促销内容的进一步内部通信或扩展。

    Polypeptide and protein derivatives and process for their preparation
    9.
    发明授权
    Polypeptide and protein derivatives and process for their preparation 失效
    多肽和蛋白衍生物及其制备方法

    公开(公告)号：US07538182B2

    公开(公告)日：2009-05-26

    申请号：US11517568

    申请日：2006-09-08

    申请人： Robin Ewart Offord ,  Keith Rose

    发明人： Robin Ewart Offord ,  Keith Rose

    IPC分类号： C07K16/00 ,  C07K1/00 ,  A61K39/395

    CPC分类号： G01N33/531 ,  A61K38/00 ,  A61K47/65 ,  A61K51/088 ,  A61K51/10 ,  A61K2123/00 ,  C07K14/62 ,  C07K16/00

    摘要： Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH—CH(R)—), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with the same or a different protein or polypeptide, with a reporter group or a cytotoxic agent as well as a process for their preparation and the novel intermediates therefor.

    摘要翻译： 要求蛋白质和多肽衍生物及其盐，其特征在于蛋白质或多肽经由包含至少一个式-C（R）-N-（或-NC（R） - ）基团或-CH （R）-NH-（或-NH-CH（R） - ），其中R是氢或可以被相同或不同的蛋白质或多肽取代的烃残基与报道基团或细胞毒性剂作为 以及其制备过程及其新型中间体。