公开(公告)号：US06626950B2

公开(公告)日：2003-09-30

申请号：US09893813

申请日：2001-06-28

申请人： Kelly R. Brown ,  Mark C. Zimmerman ,  Yufu Li

发明人： Kelly R. Brown ,  Mark C. Zimmerman ,  Yufu Li

IPC分类号： A61F236

CPC分类号： A61L27/56 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/0646 ,  A61F2/08 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/30756 ,  A61F2/30965 ,  A61F2/3872 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/30011 ,  A61F2002/30028 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30069 ,  A61F2002/30233 ,  A61F2002/30563 ,  A61F2002/30677 ,  A61F2002/30751 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30878 ,  A61F2002/30879 ,  A61F2002/30904 ,  A61F2002/30957 ,  A61F2002/30971 ,  A61F2002/4631 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2250/0023 ,  A61F2250/003 ,  A61F2250/0051 ,  A61F2310/00179 ,  A61F2310/00221 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61F2310/0097 ,  A61L27/425 ,  A61L27/46 ,  B29C44/1214

摘要： A prosthetic implant having a tissue scaffold and a fixation device with a scaffold support and an anchoring post. The anchoring post extends from a surface of the scaffold support at a selected angle with the scaffold support embedded within the scaffold. The scaffold has a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials and embedding the scaffold support portion of the fixation device. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The mutilayered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition.

摘要翻译： 具有组织支架和具有脚手架支撑件和锚固柱的固定装置的假体植入物。 锚固支架从脚手架支撑件的表面以选定的角度延伸，脚手架支架嵌入在支架内。 支架具有多孔陶瓷相和多孔聚合物相。 聚合物在溶于陶瓷孔中的溶液中发泡，以产生互锁多孔材料的相间接合并嵌入固定装置的支架支撑部分。 优选的发泡方法是通过冻干。 可以将支架注入或涂覆各种生物活性材料以诱导向内生长或释放药物。 多层多孔支架可以模拟具有梯度形态和细胞组成的损伤组织结的形态。

公开(公告)号：US06599323B2

公开(公告)日：2003-07-29

申请号：US09747489

申请日：2000-12-21

申请人： Mora Carolynne Melican ,  Yufu Li ,  Kelly R. Brown ,  Iksoo Chun ,  John McAllen, III ,  Alireza Rezania ,  Angelo G. Scopelianos ,  Murty N. Vyakarnam

发明人： Mora Carolynne Melican ,  Yufu Li ,  Kelly R. Brown ,  Iksoo Chun ,  John McAllen, III ,  Alireza Rezania ,  Angelo G. Scopelianos ,  Murty N. Vyakarnam

IPC分类号： A61F236

CPC分类号： A61F2/0045 ,  A61F2/0063 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L31/127 ,  A61L31/128 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148

摘要： A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component is bioabsorbable as well. The tissue implant provided can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

摘要翻译： 提供生物相容性组织植入物，以及制造和使用这种植入物的方法。 优选地，组织植入物是生物可吸收的。 组织植入物包括一层或多层具有开放孔结构的孔的生物可吸收聚合物泡沫。 组织植入物还包括增强部件，其有助于植入物的机械和处理性能。 优选地，增强组分也是生物可吸收的。 提供的组织植入物可用于软组织损伤（例如盆底损伤）的手术修复。

公开(公告)号：US10213195B2

公开(公告)日：2019-02-26

申请号：US12777922

申请日：2010-05-11

申请人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

发明人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/86 ,  A61B17/88

摘要： The present invention provides a fixation device that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the fixation device within tissue and securing the fixation device in the tissue once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, and includes at least one anti-rotational member integral therewith, Fixation device kits utilizing the fixation device, and methods of fixation in tissue are also provided.

公开(公告)号：US09849220B2

公开(公告)日：2017-12-26

申请号：US13124532

申请日：2009-10-16

申请人： Yufu Li ,  Deborah Schachter ,  Raymond S. Shissias ,  Sandra Wechsler

发明人： Yufu Li ,  Deborah Schachter ,  Raymond S. Shissias ,  Sandra Wechsler

IPC分类号： A61F2/82 ,  A61K9/00 ,  A61L31/16 ,  A61L31/10

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/406 ,  A61L2300/608 ,  A61L2420/08 ,  C08L67/04

摘要： An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug which is highly soluble in water, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.

公开(公告)号：US20110104232A1

公开(公告)日：2011-05-05

申请号：US13006586

申请日：2011-01-14

申请人： Yufu Li ,  Stephen Wohlert ,  Chunlin Yang

发明人： Yufu Li ,  Stephen Wohlert ,  Chunlin Yang

IPC分类号： A61K31/665 ,  A61K9/70 ,  A61K35/12 ,  A61P17/02 ,  A61P19/00

CPC分类号： A61K31/375 ,  A61K9/7007 ,  A61L31/16

摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.

摘要翻译： 公开了制备控释组合物的新方法。 具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。 还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。

公开(公告)号：US07936703B2

公开(公告)日：2011-05-03

申请号：US11995047

申请日：2006-09-20

申请人： Yufu Li ,  Xiaohua Cai

发明人： Yufu Li ,  Xiaohua Cai

IPC分类号： H04L12/28

CPC分类号： G06F12/0831

摘要： A spanning tree is assigned to a processing node for each processing node in a point-to-point network that connects a plurality of processing nodes. The spanning tree uses the processing nodes as vertices and links of the network as edges. Each processing node includes input snoop ports that can be configured as either terminating or forwarding. According to the assigned spanning trees and the configuration of the input snoop ports, the network routes snoop messages efficiently and without conflicts.

摘要翻译： 生成树被分配给连接多个处理节点的点对点网络中的每个处理节点的处理节点。 生成树使用处理节点作为边缘的网络的顶点和链接。 每个处理节点包括可配置为终止或转发的输入侦听端口。 根据分配的生成树和输入snoop端口的配置，网络可以有效且无冲突地发送snoop报文。

公开(公告)号：US07856551B2

公开(公告)日：2010-12-21

申请号：US11810434

申请日：2007-06-05

申请人： Xiaohua Cai ,  Yufu Li ,  Murugasamy Nachimuthu ,  Rahul Khanna ,  Koo Heng Daniel AW ,  Wenson Lin

发明人： Xiaohua Cai ,  Yufu Li ,  Murugasamy Nachimuthu ,  Rahul Khanna ,  Koo Heng Daniel AW ,  Wenson Lin

IPC分类号： G06F9/00

CPC分类号： G06F15/17337 ,  G06F15/177

摘要： In one embodiment, the present invention includes a method for dynamically discovering a topology of a system having a plurality of point-to-point (PTP) links via a routine that communicates a link exchanged parameter with at least one component coupled to a system bootstrap processor (SBSP), sets a minimal set of routing infrastructure information based on the communication, and determines presence of a neighboring component to a target component based on a communication from the SBSP to the target component using the minimal set of routing infrastructure information. Other embodiments are described and claimed.

摘要翻译： 在一个实施例中，本发明包括一种用于动态发现具有多个点对点（PTP）链路的系统的拓扑的方法，所述系统经由将链路交换的参数与耦合到系统引导的至少一个组件进行通信的例程 处理器（SBSP）基于通信设置最小的路由基础设施信息集合，并且基于使用最小路由基础设施信息集从SBSP到目标组件的通信来确定邻近组件到目标组件的存在。 描述和要求保护其他实施例。

公开(公告)号：US20100222795A1

公开(公告)日：2010-09-02

申请号：US12777922

申请日：2010-05-11

申请人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

发明人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

IPC分类号： A61B17/00

CPC分类号： A61B17/0401 ,  A61B17/861 ,  A61B17/862 ,  A61B17/866 ,  A61B17/8883 ,  A61B2017/00004 ,  A61B2017/0409 ,  A61B2017/044

摘要： The present invention provides a fixation device that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the fixation device within tissue and securing the fixation device in the tissue once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, and includes at least one anti-rotational member integral therewith, Fixation device kits utilizing the fixation device, and methods of fixation in tissue are also provided.

摘要翻译： 本发明提供了一种固定装置，其包括限定纵向轴线的细长柄部，并且具有用于将固定装置施加在组织内的至少一个接合构件，并且一旦植入其中就将固定装置固定在组织中，以及具有近端 末端，远端和径向横截面几何形状，其中驱动头与细长柄配合，并且包括与其成一体的至少一个防旋转构件，利用固定装置的固定装置套件以及固定在组织中的方法 也提供。

公开(公告)号：US07727235B2

公开(公告)日：2010-06-01

申请号：US11170377

申请日：2005-06-29

申请人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

发明人： Joseph H. Contiliano ,  Yufu Li ,  Zhigang Li

IPC分类号： A61F5/00

CPC分类号： A61B17/0401 ,  A61B17/861 ,  A61B17/862 ,  A61B17/866 ,  A61B17/8883 ,  A61B2017/00004 ,  A61B2017/0409 ,  A61B2017/044

摘要： The present invention provides a fixation device that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the fixation device within tissue and securing the fixation device in the tissue once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, and includes at least one anti-rotational member integral therewith. Fixation device kits utilizing the fixation device, and methods of fixation in tissue are also provided.

摘要翻译： 本发明提供了一种固定装置，其包括限定纵向轴线的细长柄部，并且具有用于将固定装置施加在组织内的至少一个接合构件，并且一旦植入其中就将固定装置固定在组织中，以及具有近端 端部，远端和径向横截面几何形状，其中驱动头与细长柄配合，并且包括与其成一体的至少一个防旋转构件。 还提供了使用固定装置的固定装置套件以及组织中的固定方法。

公开(公告)号：US20090172340A1

公开(公告)日：2009-07-02

申请号：US12006017

申请日：2007-12-28

申请人： Jian Tang ,  Yufu Li ,  Ping Wu

发明人： Jian Tang ,  Yufu Li ,  Ping Wu

IPC分类号： G06F12/06

CPC分类号： G06F12/0246 ,  G06F2212/7202 ,  G06F2212/7211

摘要： Methods and arrangements for remapping the map between logical space and physical space in non-volatile storage are described. Embodiments include transformations, code, state machines or other logic to divide the non-volatile storage of the computing device into two portions, a fixed portion and a floating portion. The embodiments may also include remapping in system firmware of the computing device the current map from logical space to physical space of the floating portion of the non-volatile storage. The embodiments may also include storing the revised map. The embodiments may also include using the revised map to access the floating portion of the non-volatile storage.

摘要翻译： 描述了在非易失性存储器中在逻辑空间和物理空间之间重映射映射的方法和布置。 实施例包括转换，代码，状态机或将计算设备的非易失性存储器分成两部分，固定部分和浮动部分的其他逻辑。 实施例还可以包括将当前映射从计算设备的系统固件重新映射到非易失性存储器的浮动部分的逻辑空间到物理空间。 实施例还可以包括存储修改的地图。 实施例还可以包括使用修改的映射来访问非易失性存储器的浮动部分。