公开(公告)号：US10744146B2

公开(公告)日：2020-08-18

申请号：US10485456

申请日：2002-01-29

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Yoshiko Ono ,  Hiroshige Okaichi ,  Youko Okaichi

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Yoshiko Ono ,  Hiroshige Okaichi ,  Youko Okaichi

IPC分类号： A23L33/12 ,  A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23L2/52 ,  A61K31/202 ,  A61K31/232 ,  A61K31/557 ,  A61K31/66 ,  A61K31/7024

摘要： The object of the present invention is to provide a composition that has preventive or ameliorative action on symptoms or diseases caused by decreased brain function. This composition contains, as its active ingredient, arachidonic acid and/or a compound having arachidonic acid as a constituent fatty acid and, particularly, an alcohol ester of arachidonic acid or a triglyceride, phospholipid or glycolipid in which all or a portion of the constituent fatty acids are arachidonic acid.

公开(公告)号：US09782377B2

公开(公告)日：2017-10-10

申请号：US10546158

申请日：2004-03-26

申请人： Kengo Akimoto ,  Yoshiko Ono ,  Hiroshi Kawashima ,  Katsuya Nagai

发明人： Kengo Akimoto ,  Yoshiko Ono ,  Hiroshi Kawashima ,  Katsuya Nagai

IPC分类号： A61K31/202 ,  A23L1/30 ,  A23L33/12

CPC分类号： A61K31/202 ,  A23L33/12

摘要： A composition having a normalizing action for infradian rhythm and/or a synchronization promoting action for circadian rhythm (biological clock) containing arachidonic acid and/or an arachidonic acid-containing compound.

公开(公告)号：US20060073187A1

公开(公告)日：2006-04-06

申请号：US10546158

申请日：2004-03-26

申请人： Kengo Akimoto ,  Yoshiko Ono ,  Hiroshi Kawashima ,  Katsuya Nagai

发明人： Kengo Akimoto ,  Yoshiko Ono ,  Hiroshi Kawashima ,  Katsuya Nagai

IPC分类号： A61K47/00 ,  A61K31/225

CPC分类号： A61K31/202 ,  A23L33/12

摘要： A composition having a normalizing action for infradian rhythm and/or a synchronization promoting action for circadian rhythm (biological clock) containing arachidonic acid and/or an arachidonic acid-containing compound.

摘要翻译： 具有花生四烯酸和/或含有花生四烯酸的化合物的昼夜节律（生物钟）的不规律节律的归一化作用和/或同步促进作用的组合物。

公开(公告)号：US20060088573A1

公开(公告)日：2006-04-27

申请号：US10541073

申请日：2004-10-28

申请人： Yoshiyuki Ishikura ,  Chika Horikawa ,  Yoshiko Ono ,  Kengo Akimoto ,  Yasuo Matsumura

发明人： Yoshiyuki Ishikura ,  Chika Horikawa ,  Yoshiko Ono ,  Kengo Akimoto ,  Yasuo Matsumura

IPC分类号： A61K47/00 ,  A61K31/225

CPC分类号： A61K31/66 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/202 ,  A61K31/232 ,  A23V2250/1862

摘要： A composition and food or beverage containing arachidonic acid or a compound having arachidonic acid as a component fatty acid and having an action preventing or alleviating symptoms or diseases due to aging of the blood vessels.

摘要翻译： 含有花生四烯酸或具有花生四烯酸作为组分脂肪酸的化合物的组合物和食品或饮料，并具有预防或减轻由于血管老化引起的症状或疾病的作用。

公开(公告)号：US20050287651A1

公开(公告)日：2005-12-29

申请号：US10530747

申请日：2003-10-09

申请人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

发明人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

IPC分类号： A23D9/02 ,  C12P7/64

CPC分类号： C12P7/6472 ,  A23D9/02

摘要： A process for producing a crude oil having lowered unsaponifiable matter content and/or ester-type sterol content and comprising a highly unsaturated fatty acid as a constituent fatty acid, characterized in that a microorganism capable of producing a fat or oil comprising an unsaturated fatty acid as a constituent fatty acid is cultured in a medium containing a nitrogen source concentration of 2 to 15% within a culture tank equipped with an agitation impeller satisfying the requirement that the ratio of the diameter of agitation impeller (=d) to the inner diameter of the culture tank (=D) is d/D=0.30 to 0.6.

摘要翻译： 一种生产具有降低的不皂化物质含量和/或酯类固醇含量并含有高度不饱和脂肪酸作为构成脂肪酸的原油的方法，其特征在于，能够生产包含不饱和脂肪酸的脂肪或油的微生物 作为构成脂肪酸，在含有浓度为2〜15％的氮源的培养基中培养，在配备有搅拌叶轮的培养槽中，搅拌叶轮满足搅拌叶轮直径（= d）与内径 培养罐（= D）为d / D = 0.30〜0.6。

公开(公告)号：US5981588A

公开(公告)日：1999-11-09

申请号：US513084

申请日：1995-08-09

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Tomohito Hamazaki ,  Shigeki Sawazaki

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Tomohito Hamazaki ,  Shigeki Sawazaki

IPC分类号： A23L1/30 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61P17/00 ,  A61P37/00 ,  A61P37/08 ,  C07C57/03

CPC分类号： A61K31/202 ,  A23L33/12 ,  A61K31/201

摘要： A preventive or improving agent for medical symptoms accompanying delayed allergy reactions which contains an .omega.9-unsaturated fatty acid as an effective component is provided.

摘要翻译： 提供了含有ω9-不饱和脂肪酸作为有效成分的伴随延迟的过敏反应的医学症状的预防或改善剂。

公开(公告)号：US5861433A

公开(公告)日：1999-01-19

申请号：US568287

申请日：1995-12-06

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Satomichi Yoshimura ,  Masashi Matsui ,  Tomohito Hamazaki ,  Shigeki Sawazaki ,  Norio Nakamura

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Satomichi Yoshimura ,  Masashi Matsui ,  Tomohito Hamazaki ,  Shigeki Sawazaki ,  Norio Nakamura

IPC分类号： A23L1/30 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61P29/00 ,  A61P37/08 ,  C07C57/03 ,  C07C57/12 ,  C07C69/587

CPC分类号： A61K31/20 ,  A23L33/12 ,  A61K31/201 ,  A61K31/202 ,  A61K31/231 ,  A61K31/232

摘要： A composition such as foods, drinks, pharmaceutical composition, for prevention or improvement of inflammation such as chronic inflammation, comprising an omega 9 series unsaturated fatty acid such as 6,9-octadecadienoic acid, 8,11-eicosadienoic acid, 5,8,11-eicosatrienoic acid etc.

摘要翻译： 包含ω9系列不饱和脂肪酸如6,9-十八碳二烯酸，8,11-二十碳二烯酸，5,8， 11-二十碳三烯酸等

公开(公告)号：US09782378B2

公开(公告)日：2017-10-10

申请号：US11606983

申请日：2006-12-01

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

IPC分类号： C12N1/16 ,  A61K31/202 ,  A23C9/152 ,  A23C11/04 ,  A23D9/00 ,  A23L2/52 ,  A61K8/14 ,  A61K8/92 ,  A61K8/99 ,  A61Q19/00 ,  C12P7/64 ,  C12R1/645 ,  A23K20/158 ,  A61K31/201 ,  A23L31/00 ,  A23L33/12 ,  A23L33/14

CPC分类号： A61K31/202 ,  A23C9/1528 ,  A23C11/04 ,  A23D9/00 ,  A23K20/158 ,  A23L2/52 ,  A23L5/00 ,  A23L31/00 ,  A23L33/12 ,  A23L33/14 ,  A23V2002/00 ,  A61K8/14 ,  A61K8/92 ,  A61K8/925 ,  A61K8/99 ,  A61K31/201 ,  A61Q19/00 ,  C12P7/6472 ,  C12R1/645 ,  A23V2200/224 ,  A23V2250/18 ,  A23V2250/1862 ,  A23V2250/187 ,  A23V2250/1868

摘要： There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid particles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there are provided lipid particles encapsulating a lipid containing unsaturated fatty acids, and foods, cosmetics, and animal feeds comprising said lipid particles added thereto. Artificially treated microorganisms or microorganisms collected from nature are grown on a solid medium, and microbial strains that form lipid particles at the periphery of the colonies and/or microbial strains that, when cultured in a transparent liquid medium, make the culture liquid cloudy are selected. The microorganisms obtained are cultured, lipid-containing lipid particles secreted in the culture liquid, are separated from the culture liquid, and the lipid is separated and purified.

公开(公告)号：US07972855B2

公开(公告)日：2011-07-05

申请号：US11607032

申请日：2006-12-01

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

IPC分类号： C12N15/04 ,  C12N15/01 ,  C12N1/15 ,  C12N1/13 ,  C12P1/00 ,  C12P7/64 ,  C12P1/02

CPC分类号： A61K31/202 ,  A23C9/1528 ,  A23C11/04 ,  A23D9/00 ,  A23K20/158 ,  A23L2/52 ,  A23L5/00 ,  A23L31/00 ,  A23L33/12 ,  A23L33/14 ,  A23V2002/00 ,  A61K8/14 ,  A61K8/92 ,  A61K8/925 ,  A61K8/99 ,  A61K31/201 ,  A61Q19/00 ,  C12P7/6472 ,  C12R1/645 ,  A23V2200/224 ,  A23V2250/18 ,  A23V2250/1862 ,  A23V2250/187 ,  A23V2250/1868

摘要： There are provided microorganisms, for example, Mortierella alpina, having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there are provided lipid vesicles encapsulating a lipid containing unsaturated fatty acids, and foods, cosmetics, and animal feeds comprising said lipid vesicles added thereto. Artificially treated microorganisms or microorganisms collected from nature are grown on a solid medium, and microbial strains that form lipid vesicles at the periphery of the colonies and/or microbial strains that, when cultured in a transparent liquid medium, make the culture liquid cloudy are selected. The microorganisms obtained are cultured, lipid-containing lipid vesicles secreted in the culture liquid, are separated from the culture liquid, and the lipid is separated and purified.

摘要翻译： 提供了微生物，例如高山被孢霉，其具有产生含有不饱和脂肪酸的脂质作为构成脂肪酸的特性，并且细胞外分泌包封在脂质囊泡中的产生的脂质，筛选所述微生物的方法以及有效生产的方法 使用所述微生物的含脂肪酸的脂质。 此外，提供了包含含有不饱和脂肪酸的脂质的脂质囊泡，以及包含所述脂质囊泡的食品，化妆品和动物饲料。 人造处理的微生物或自然界收集的微生物在固体培养基上生长，并且在菌落和/或微生物菌株的周围形成脂质囊泡的微生物菌株，当在透明液体培养基中培养时，选择培养液混浊 。 培养得到的微生物，分泌到培养液中的含有脂质的脂质囊泡与培养液分离，分离纯化脂质。

公开(公告)号：US06812020B1

公开(公告)日：2004-11-02

申请号：US09634851

申请日：2000-08-08

申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

IPC分类号： C12N120

CPC分类号： C12P7/6427 ,  C12P7/6472

摘要： The present invention discloses a process for producing lipid containing omega-9 highly unsaturated fatty acid by culturing in a medium a mutant strain obtained by mutation on a microorganism having the ability to produce arachidonic acid belonging to the genus Mortierella and so forth, in which &Dgr;12 desaturation activity is decreased or lost, but at least one of &Dgr;5 desaturation activity, &Dgr;6 desaturation activity and chain length elongation activity is elevated. Moreover, the present invention also discloses a process for producing omega-9 highly unsaturated fatty acid by collecting omega-9 highly unsaturated fatty acid from the culture or lipid described above.

摘要翻译： 本发明公开了一种生产含有ω-9高度不饱和脂肪酸的脂质的方法，该方法是在培养基中培养由具有产生属于被孢霉属属的花生四烯酸的能力的微生物的突变获得的突变菌株等，其中Delta12 去饱和活性降低或丧失，但Delta5去饱和活性，Delta6去饱和活性和链长伸长活性中的至少一种升高。 此外，本发明还公开了通过从上述培养物或脂质中收集ω-9高度不饱和脂肪酸来生产ω-9高度不饱和脂肪酸的方法。