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    EPIDERMAL GROWTH FACTOR (EGF) EXPRESSION AND/OR POLYMORPHISMS THEREOF FOR PREDICTING THE RISK OF DEVELOPING CANCER
    1.
    发明申请
    EPIDERMAL GROWTH FACTOR (EGF) EXPRESSION AND/OR POLYMORPHISMS THEREOF FOR PREDICTING THE RISK OF DEVELOPING CANCER 失效
    表皮生长因子（EGF）用于预测癌症风险的表达和/或多态性

    公开(公告)号：US20100184048A1

    公开(公告)日：2010-07-22

    申请号：US12594010

    申请日：2008-03-28

    申请人： Kenneth Tanabe ,  Bryan Fuchs ,  Hiroshi Kawasaki

    发明人： Kenneth Tanabe ,  Bryan Fuchs ,  Hiroshi Kawasaki

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： The present invention relates to diagnostic and prognostic methods to determine the likelihood of a subject who has a inflammatory disease or liver disease of developing cancer. In particular, the present invention relates to methods for identifying subjects with increased susceptibility to developing cancer, such as hepatocellular carcinoma (HCC) where the subject has an inflammatory disease, such as, but not limited to cirrhosis, by identifying a variance or polymorphism in the human EGF gene. In particular, the methods of the present invention relate to identifying subjects with increased susceptibility to developing cancer such as HCC, where the subject has an inflammatory disease, such as but not limited to cirrhosis, and the subject is identified to have a single nucleotide polymorphism 61A>G in the 5′UTR of the EGF gene. Alternatively, the methods of the present invention relate to identifying subjects with increased susceptibility to developing cancer such as HCC, where the subject has an inflammatory disease, such as but not limited to cirrhosis, and the subject is identified to have increased expression of EGF as compared to a reference level of EGF expression. The present invention also relates to administering an effective amount of an anti-cancer therapy to subjects identified to have an increased susceptibility of developing cancer such as HCC by the methods as disclosed herein, and kits to identify a subject with a 61A>G polymorphism in the 5′UTR of the EGF gene or kits to determine increased EGF expression in subjects with chronic inflammatory disease.

    摘要翻译： 本发明涉及确定具有发展中的癌症的炎性疾病或肝脏疾病的受试者的可能性的诊断和预后方法。 特别地，本发明涉及用于识别对发展中的癌症易感性增加的受试者的方法，例如肝细胞癌（HCC），其中受试者具有炎性疾病，例如但不限于肝硬化，通过鉴定方差或多态性 人类EGF基因。 特别地，本发明的方法涉及识别对发展中的癌症如HCC的易感性增加的受试者，其中受试者具有炎性疾病，例如但不限于肝硬化，并且该受试者被鉴定为具有单核苷酸多态性 61A> G在EGF基因的5'UTR中。 或者，本发明的方法涉及识别对发展中的癌症如HCC的易感性增加的受试者，其中受试者具有炎症性疾病，例如但不限于肝硬化，并且该受试者被鉴定为具有增加的EGF表达作为 与EGF表达的参考水平相比。 本发明还涉及通过本文公开的方法对被鉴定为具有增加的发展癌症易感性（例如HCC）的受试者施用有效量的抗癌疗法，以及用于鉴定具有61A> G多态性的受试者的试剂盒 EGF基因的5'UTR或试剂盒以确定慢性炎性疾病受试者中EGF表达的增加。

    Water-soluble metal working fluid, and coolant for metal working
    2.
    发明授权
    Water-soluble metal working fluid, and coolant for metal working 有权
    水溶性金属加工液和金属加工用冷却液

    公开(公告)号：US08969270B2

    公开(公告)日：2015-03-03

    申请号：US13060171

    申请日：2009-08-14

    申请人： Hiroshi Kawasaki

    发明人： Hiroshi Kawasaki

    IPC分类号： C10M173/02 ,  C10M141/06 ,  C10M173/00

    CPC分类号： C10M173/02 ,  C10M2207/125 ,  C10M2209/107 ,  C10M2209/108 ,  C10M2215/042 ,  C10N2230/06 ,  C10N2230/12 ,  C10N2230/18 ,  C10N2240/401 ,  C10N2240/402

    摘要： A water-soluble metalworking fluid contains: at least either one of (A) a block polyalkylene glycol represented by formula (1): HO(EO)a—(PO)b-(EO)cH, and (B) a polyalkylene glycol monoether represented by formula (2): RO(R′O)dH; and (C) an alkanolamine fatty acid salt, in which EO represents —CH2CH2O — and PO represents —CH(CH3)CH2O— or —CH2CH(CH3)O—; each unit of (EO)a, (PO)b and (EO)c is block-bonded; a and c each is an integer of 1 to 30 and b is an integer of 5 to 100; R represents an alkyl group having 1 to 30 carbon atoms and R′O represents PO or EO; mole fraction of EO is less than 100%; and d is an integer of 1 or 50.

    摘要翻译： 水溶性金属加工液含有：（A）由式（1）表示的嵌段聚亚烷基二醇：HO（EO）a-（PO）b-（EO）cH和（B）聚亚烷基二醇 由式（2）表示的单醚：RO（R'O）dH; 和（C）链烷醇胺脂肪酸盐，其中EO表示-CH2CH2O - ，PO表示-CH（CH3）CH2O-或-CH2CH（CH3）O-; （EO）a，（PO）b和（EO）c的每个单元被嵌段键合; a和c各自为1〜30的整数，b为5〜100的整数， R表示碳原子数1〜30的烷基，R 10表示PO或EO; EO的摩尔分数小于100％; d为1或50的整数。

    Two-component curable solventless adhesive
    3.
    发明授权
    Two-component curable solventless adhesive 有权
    双组分固化无溶剂粘合剂

    公开(公告)号：US08716427B2

    公开(公告)日：2014-05-06

    申请号：US11658403

    申请日：2005-02-04

    申请人： Akihiro Imai ,  Kazuaki Imamura ,  Taiji Morimoto ,  Hiroshi Kawasaki ,  Mikio Matsufuji

    发明人： Akihiro Imai ,  Kazuaki Imamura ,  Taiji Morimoto ,  Hiroshi Kawasaki ,  Mikio Matsufuji

    IPC分类号： C08G18/00 ,  C09J4/00 ,  C09J101/00

    CPC分类号： C09J175/04 ,  C08G18/10

    摘要： A two-component curable solventless adhesive which enables a laminated composite film comprising a barrier layer and a plastic film laminated with each other to maintain excellent appearance and adhesive strength for a long period even after a sterilization treatment at high temperature, and to appropriately adjust a reaction between a base resin and a curing agent during a production of the laminated composite film. The two-component curable solventless adhesive comprises a base resin and a curing agent, wherein the base resin contains a polyol having an acid group and a secondary or tertiary terminal hydroxyl group accounting for 30% or more of the entire terminal hydroxyl groups of the polyol, and the curing agent contains an isocyanate group-terminated urethane prepolymer containing at least an aralkyl polyisocyanate and/or a modified substance thereof as a raw polyisocyanate, and a content of a low molecular weight polyisocyanate is defined.

    摘要翻译： 即使在高温下进行灭菌处理后，能够使包含阻挡层和塑料膜的层合复合膜能够长时间保持良好的外观和粘合强度的双组分固化无溶剂粘合剂，并适当地调节 在层合复合膜的制造中，基础树脂与固化剂的反应。 双组分可固化无溶剂粘合剂包括基础树脂和固化剂，其中基础树脂含有具有酸基和仲或叔末端羟基的多元醇占多元醇全部末端羟基的30％以上 ，固化剂含有至少含有芳烷基多异氰酸酯和/或其改性物质的异氰酸酯基封端的氨基甲酸酯预聚物作为原料多异氰酸酯，并且定义了低分子量多异氰酸酯的含量。

    Printed circuit board and method of manufacturing the same
    4.
    发明授权
    Printed circuit board and method of manufacturing the same 有权
    印刷电路板及其制造方法

    公开(公告)号：US08151455B2

    公开(公告)日：2012-04-10

    申请号：US12143214

    申请日：2008-06-20

    申请人： Kazunori Hamada ,  Hiroshi Kawasaki ,  Tomoaki Ozaki

    发明人： Kazunori Hamada ,  Hiroshi Kawasaki ,  Tomoaki Ozaki

    IPC分类号： H05K3/02

    CPC分类号： H05K3/0047 ,  H05K1/0237 ,  H05K1/0268 ,  H05K3/429 ,  H05K2203/0207 ,  H05K2203/0242 ,  Y10T29/49124 ,  Y10T29/49156 ,  Y10T29/49167

    摘要： A method of manufacturing a printed circuit board is provided. The method includes preliminarily forming a plurality of test pattern layers for detecting the depth of an inner layer in a multilayer printed circuit board such that at least a part of a lower test pattern layer is not overlaid with any upper test pattern layer when viewed from a drill entrance side, and preliminarily forming a surface conductor layer; applying a voltage between the surface conductor layer and the test pattern layers; performing drilling toward one test pattern layer, and detecting a current produced when the drill comes into contact with the test pattern to measure the depth of the layer (D1); performing drilling toward the other test pattern layer, and measuring the depth of the layer (D2); and performing drilling up to just before the conductor-wiring layer based on a depth calculated from D1 and D2.

    摘要翻译： 提供一种制造印刷电路板的方法。 该方法包括预先形成多个用于检测多层印刷电路板中的内层的深度的测试图案层，使得当从一个多层印刷电路板观察时，下部测试图案层的至少一部分不与任何上部测试图案层重叠 钻入口侧，并预先形成表面导体层; 在表面导体层和测试图案层之间施加电压; 对一个测试图案层执行钻孔，并且检测当钻头与测试图案接触时产生的电流以测量层（D1）的深度; 对另一测试图案层执行钻孔，并测量层的深度（D2）; 并且基于从D1和D2计算的深度，在导体布线层之前执行钻孔。

    WATER-SOLUBLE METAL WORKING FLUID, AND COOLANT FOR METAL WORKING
    7.
    发明申请
    WATER-SOLUBLE METAL WORKING FLUID, AND COOLANT FOR METAL WORKING 有权
    水溶性金属工作流体和金属加工冷却液

    公开(公告)号：US20110147645A1

    公开(公告)日：2011-06-23

    申请号：US13060171

    申请日：2009-08-14

    申请人： Hiroshi Kawasaki

    发明人： Hiroshi Kawasaki

    IPC分类号： C10M145/18 ,  C09K5/04

    CPC分类号： C10M173/02 ,  C10M2207/125 ,  C10M2209/107 ,  C10M2209/108 ,  C10M2215/042 ,  C10N2230/06 ,  C10N2230/12 ,  C10N2230/18 ,  C10N2240/401 ,  C10N2240/402

    摘要： A water-soluble metalworking fluid contains: at least either one of (A) a block polyalkylene glycol represented by the following formula (1) and (B) a polyalkylene glycol monoether represented by the following formula (2); and (C) an alkanolamine fatty acid salt, HO(EO)a—(PO)b-(EO)cH  (1) in which EO represents —CH2CH2O— and PO represents —CH(CH3)CH2O— or —CH2CH(CH3)O—; each unit of (EO)a, (PO)b and (EO)c is block-bonded; and a and c each is an integer of 1 to 30 and b is an integer of 5 to 100, RO(R′O)dH  (2) in which R represents an alkyl group having 1 to 30 carbon atoms and R′O represents PO or EO; mole fraction of EO is less than 100%; and d is an integer of 1 or 50.

    摘要翻译： 水溶性金属加工液含有：（A）由下式（1）表示的嵌段聚亚烷基二醇和（B）由下式（2）表示的聚亚烷基二醇单醚中的至少一种; 和（C）链烷醇胺脂肪酸盐，HO（EO）a-（PO）b-（EO）cH（1），其中EO表示-CH2CH2O-，PO表示-CH（CH3）CH2O-或-CH2CH（CH3 ）O-; （EO）a，（PO）b和（EO）c的每个单元被嵌段键合; a和c各自为1〜30的整数，b为5〜100的整数，RO（R'O）dH（2）其中R表示碳原子数1〜30的烷基，R'O表示 PO或EO; EO的摩尔分数小于100％; d为1或50的整数。

    3-Dimensional shape measuring method and device thereof
    9.
    发明授权
    3-Dimensional shape measuring method and device thereof 有权
    三维形状测量方法及其装置

    公开(公告)号：US07724379B2

    公开(公告)日：2010-05-25

    申请号：US11920265

    申请日：2005-05-12

    申请人： Hiroshi Kawasaki ,  Ryo Furukawa

    发明人： Hiroshi Kawasaki ,  Ryo Furukawa

    IPC分类号： G01B11/24

    CPC分类号： G01B11/2545 ,  G01B11/2509 ,  G06T7/521 ,  G06T7/80

    摘要： It is possible to measure a 3-dimensional shape by using a projector and an imaging device without requiring calibration in advance. A pattern light is applied from a projector to an object and this is imaged by an imaging device to capture an image as an input. An in-camera parameter, an in-projector parameter, a parameter of positional relationship between the camera and the projector are estimated. By using the estimation results, a 3-dimensional shape of the object is measured. When a laser pointer is attached to the projector and a laser is applied to the object for capturing an image as an input, scaling of the object shape can also be estimated. Moreover, when measuring a plurality of objects or measuring the same objects a plurality of times, the accuracy of the 3-dimensional shape respectively obtained can be increased by simultaneously processing the inputs. Moreover, when one of projector and the camera is fixed and the other is moved while measuring the same object a plurality of times, the accuracy of the 3-dimensional shape obtained as a result can be increased by performing bundle adjustment.

    摘要翻译： 可以通过使用投影仪和成像装置来预测不需要校准来测量三维形状。 图案光从投影仪施加到物体，并且其由成像装置成像以捕获图像作为输入。 估计摄像机内参数，投影机内参数，相机与投影机之间的位置关系参数。 通过使用估计结果，测量物体的三维形状。 当激光指示器附接到投影仪并且激光被施加到物体以捕获图像作为输入时，也可以估计对象形状的缩放。 此外，当测量多个对象或多次测量相同的对象时，可以通过同时处理输入来分别获得所获得的三维形状的精度。 此外，当投影仪和相机中的一个被固定并且另一个在同时测量相同的对象的同时被移动时，通过执行束调整可以提高作为结果而获得的三维形状的精度。

    Drilling method
    10.
    发明授权
    Drilling method 有权
    钻孔方法

    公开(公告)号：US07637702B2

    公开(公告)日：2009-12-29

    申请号：US11489491

    申请日：2006-07-20

    申请人： Takao Furukawa ,  Hiroshi Kawasaki ,  Toshiyuki Iwata ,  Katsuhiro Nagasawa ,  Takahiko Yamashita

    发明人： Takao Furukawa ,  Hiroshi Kawasaki ,  Toshiyuki Iwata ,  Katsuhiro Nagasawa ,  Takahiko Yamashita

    IPC分类号： B23B35/00

    CPC分类号： B23B35/00 ,  B23B39/161 ,  B23B39/24 ,  B23B2228/36 ,  B23B2270/486 ,  B23B2270/54 ,  H05K3/0008 ,  H05K3/0047 ,  H05K3/0097 ,  Y10T408/03 ,  Y10T408/175

    摘要： There is provided a drilling method capable of improving machining accuracy of a printed board drilling apparatus as a whole by decreasing dispersion of the machining accuracy even if it is a multi-spindle printed board drilling apparatus. A misalignment of an axial center of a drill with respect to a designed axial center in X and Y directions is detected in advance per a certain number of revolutions of each spindle that rotates the drill. Holes of two or more types of diameter are made on a printed board by making holes of at least one diameter, e.g., an exposure master hole, per each spindle and by making holes of all other diameters almost simultaneously by all of the spindles.

    摘要翻译： 提供了一种能够通过降低加工精度的分散来提高印刷板钻孔设备的加工精度的钻孔方法，即使它是多轴印刷板钻孔设备。 在旋转钻头的每个主轴的一定转数中，预先检测钻头的轴心在X和Y方向上相对于设计的轴向中心的偏移。 通过为每个主轴制造至少一个直径的孔，例如曝光主孔，并且通过所有其他直径的孔几乎同时由所有主轴制成两个或更多种直径的孔。