-
公开(公告)号:US5672583A
公开(公告)日:1997-09-30
申请号:US436347
申请日:1995-05-17
申请人: Kevin Chapman , William Hagmann , Philippe Durette , Craig Esser , Ihor Kopka , Charles Caldwell
发明人: Kevin Chapman , William Hagmann , Philippe Durette , Craig Esser , Ihor Kopka , Charles Caldwell
IPC分类号: C07D275/02 , A61K31/195 , A61K31/275 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5377 , A61K41/00 , A61P1/02 , A61P9/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C237/22 , C07C255/23 , C07C271/22 , C07C275/28 , C07C279/14 , C07D207/16 , C07D209/34 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/55 , C07D213/75 , C07D213/81 , C07D235/16 , C07D261/08 , C07D263/32 , C07D263/56 , C07D277/64 , C07D295/185 , A61K37/02 , C07C237/52 , C07C259/06 , C07D277/62
CPC分类号: C07D209/48 , A61K41/00 , C07C237/22 , C07C255/23 , C07C271/22 , C07C275/28 , C07C279/14 , C07D209/34 , C07D213/75 , C07D235/16 , C07D263/56 , C07D277/64 , C07D295/185 , C07C2101/08
摘要: Novel Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation. ##STR1##
摘要翻译: PCT No.PCT / US93 / 11207 Sec。 371日期1995年5月17日 102(e)日期1995年5月17日PCT 1993年11月18日PCT公布。 WO94 / 12169 PCT出版物 1994年6月9日发现式I的新型羧基肽基化合物是有用的基质金属蛋白酶介导的疾病的抑制剂,包括骨关节炎,类风湿性关节炎,脓毒性关节炎,某些癌症中的肿瘤侵袭,牙周病,角膜溃疡,蛋白尿,疏水性表皮松解 与大动脉粥样硬化斑块破裂相关的冠状动脉血栓形成和动脉瘤性主动脉疾病。 基质金属蛋白酶是含有蛋白酶的家族,包括但不限于基质溶素,胶原酶和明胶酶,其能够降解关节软骨和基底膜的主要成分。 本文所要求的抑制剂也可用于预防可能导致永久性残疾的外伤性损伤后的病理后遗症。 这些化合物也可以通过预防排卵或植入作为避孕的手段。
-
2.
公开(公告)号:US5972975A
公开(公告)日:1999-10-26
申请号:US836953
申请日:1997-05-22
申请人: Craig Esser , William Hagmann , William Hoffman , Shrenik Shah , Kenny Wong , Renee Chabin , Ravindra Guthikonda , Malcolm Maccoss , Charles Caldwell , Philippe Durette
发明人: Craig Esser , William Hagmann , William Hoffman , Shrenik Shah , Kenny Wong , Renee Chabin , Ravindra Guthikonda , Malcolm Maccoss , Charles Caldwell , Philippe Durette
IPC分类号: A61K31/44 , C07D213/75
CPC分类号: A61K31/44
摘要: Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. ##STR1##
摘要翻译: PCT No.PCT / US95 / 16151 Sec。 371日期:1997年5月22日 102(e)日期1997年5月22日PCT提交1995年12月8日PCT公布。 出版物WO96 / 18616 PCT 日期:1996年6月20日公知的可用于治疗一氧化氮合酶介导的疾病和病症的式(I)的取代的2-氨基吡啶化合物和药学上可接受的盐。
-
公开(公告)号:US06260588B1
公开(公告)日:2001-07-17
申请号:US09327843
申请日:1999-06-08
申请人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
发明人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
IPC分类号: F17C1300
CPC分类号: G05D9/12 , B01J4/00 , B01L3/08 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/4402 , C23C16/448 , F17C1/00 , F17C5/002 , F17C5/02 , F17C5/06 , F17C6/00 , F17C7/00 , F17C7/02 , F17C9/00 , F17C13/02 , F17C13/021 , F17C13/04 , F17C13/045 , F17C2201/056 , F17C2205/0111 , F17C2205/0126 , F17C2205/0323 , F17C2221/011 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2223/0123 , F17C2227/044 , F17C2270/0518 , G01F23/24 , G01F23/263 , G01F23/292 , G01F23/70 , G01F23/72 , G01F23/74 , H01J37/3244 , Y10T137/7043
摘要: A bulk chemical delivery system, that includes a cabinet that houses a delivery system. The delivery system may include a canister within the cabinet that is connected to a manifold within the cabinet that includes at least one output line for providing chemical from the canister outside the cabinet. The delivery system may further include an input system that provides input for operation of the delivery system, wherein the input system is housed in an enclosure, and an inert gas line that connects and supplies inert gas to the enclosure.
摘要翻译: 大量化学品输送系统,包括容纳输送系统的机柜。 输送系统可以包括在机柜内的罐,其连接到机柜内的歧管,其包括至少一个输出线,用于从机壳外部的罐提供化学品。 输送系统还可以包括输入系统,该输入系统为输送系统的操作提供输入,其中输入系统被容纳在外壳中;以及惰性气体管线,其将惰性气体连接并提供给外壳。
-
公开(公告)号:US06637475B2
公开(公告)日:2003-10-28
申请号:US10208512
申请日:2002-07-30
申请人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
发明人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
IPC分类号: B65B104
CPC分类号: B67D7/0238 , B01J4/00 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/4402 , C23C16/448 , F17C7/00 , F17C7/02 , F17C9/00 , F17C13/02 , F17C13/04 , F17C2201/056 , F17C2205/0111 , F17C2205/0126 , F17C2205/0323 , F17C2221/011 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2223/0123 , F17C2227/044 , F17C2270/0518
摘要: A bulk chemical delivery system, comprising: a bulk chemical canister that is connected to at least one manifold box, wherein each manifold box has at least two output lines, wherein each output line connects to a secondary canister. In non-limiting representative example, the bulk chemical canister may have a capacity of 200 liters. Also disclosed are novel manifolds for use in delivering chemicals from canisters and a transportation/containment cart.
-
5.
公开(公告)号:US06192919B1
公开(公告)日:2001-02-27
申请号:US09475387
申请日:1999-12-30
申请人: Robert M. Jackson , Craig Esser , Eric Serdahl , John N. Gregg
发明人: Robert M. Jackson , Craig Esser , Eric Serdahl , John N. Gregg
IPC分类号: F17D100
CPC分类号: B67D7/0272 , B67D7/84 , C23C16/448 , F17C7/00 , F17C13/087 , F17C2201/0104 , F17C2203/012 , F17C2203/0629 , F17C2205/0308 , F17C2205/0323 , F17C2270/0518 , Y10T137/598 , Y10T137/6011 , Y10T137/7043 , Y10T137/7062
摘要: This invention concerns a shipping crate, comprising: a base having three sides and one or more doors attached thereto, wheels attached to the base, a top attached to the sides having a tank hole, wherein the base, sides, and doors have been attached to provide a sealed compartment. This invention also concerns a chemical delivery cabinet, comprising: a base, three sides, and one or more doors attached to one or more sides, a valve manifold affixed to an inner wall of the cabinet, process control instrumentation which connects to and controls the valve manifold, wherein at least one of the doors has a touch control pad mounted thereon. This invention is also a chemical refill system, comprising a tank housed in a crate, wherein the crate comprises a base having three sides and one or more doors attached thereto, wheels attached to the base, a top attached to the sides having a tank hole, wherein the top has been fastened to the sides such that the tank hole fits over a vertical sheath on the tank, wherein the base, sides, and doors have been attached to provide a sealed compartment. In one embodiment of this invention, the system is been placed in the chemical delivery cabinet.
摘要翻译: 本发明涉及一种运输箱,包括:具有三个侧面的基座和一个或多个连接到其上的门,附接到基座的轮子,附接到具有罐孔的侧面的顶部,其中底座,侧面和门已经被附接 提供一个密封的隔间。 本发明还涉及一种化学输送柜,包括:一个底座,三个侧面,以及连接到一个或多个侧面的一个或多个门,固定在机柜内壁上的阀门歧管,连接到控制器 阀歧管,其中至少一个门具有安装在其上的触摸控制垫。 本发明还是一种化学填充系统,其包括容纳在条板箱中的罐,其中,所述包装箱包括具有三个侧面的基座和连接到其上的一个或多个门,附接到所述基座的轮,附接到具有罐孔的侧面的顶部 其中顶部已经紧固到侧面,使得罐孔安装在罐上的垂直护套上,其中底座,侧面和门已经被附接以提供密封隔室。 在本发明的一个实施例中,该系统被放置在化学输送柜中。
-
公开(公告)号:US06435229B1
公开(公告)日:2002-08-20
申请号:US09462690
申请日:2000-09-01
申请人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
发明人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
IPC分类号: B65B104
CPC分类号: F17C13/04 , B01J4/00 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/448 , F17C7/02 , F17C9/00 , F17C13/02 , F17C2270/0518
摘要: A bulk chemical delivery system, comprising: a bulk chemical canister that is connected to at least one manifold box, wherein each manifold box has at least two output lines, wherein each output line connects to a secondary canister. In non-limiting representative example, the bulk chemical canister may have a capacity of 200 liters. Also disclosed are novel manifolds for use in delivering chemicals from canisters and a transportation/containment cart.
摘要翻译: 一种批量化学品输送系统,包括:大容量化学罐,其连接到至少一个歧管箱,其中每个歧管箱具有至少两条输出线,其中每条输出线连接到次级罐。 在非限制性的代表性示例中,本体化学罐可以具有200升的容量。 还公开了用于从罐输送化学品和运输/收容车的新型歧管。
-
公开(公告)号:US06056024A
公开(公告)日:2000-05-02
申请号:US359985
申请日:1999-07-23
申请人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
发明人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
IPC分类号: B01J4/00 , B01L3/08 , B67D7/02 , B67D7/84 , C23C16/44 , C23C16/448 , F17C1/00 , F17C7/00 , F17C7/02 , F17C9/00 , F17C13/02 , F17C13/04 , G01F23/24 , B65B1/04
CPC分类号: G01F23/24 , B01J4/00 , B01L3/08 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/4402 , C23C16/448 , F17C1/00 , F17C13/02 , F17C13/021 , F17C13/04 , F17C7/00 , F17C7/02 , F17C9/00 , F17C2201/056 , F17C2205/0323 , F17C2223/0153 , F17C2250/0636 , F17C2270/0518
摘要: A bulk chemical delivery system having: a bulk chemical canister that is connected to at least one manifold box, wherein each manifold box has at least two output lines, wherein each output line connects to a secondary canister. The bulk chemical canister may have a capacity of 200 liters.
摘要翻译: 一种批量化学品输送系统,其具有:连接到至少一个歧管箱的主体化学罐,其中每个歧管箱具有至少两条输出线,其中每条输出线连接到次级罐。 批量化学罐可能容量为200升。
-
公开(公告)号:US6029718A
公开(公告)日:2000-02-29
申请号:US105423
申请日:1998-06-26
申请人: Robert M. Jackson , Craig Esser , Eric Serdahl , John N. Gregg
发明人: Robert M. Jackson , Craig Esser , Eric Serdahl , John N. Gregg
IPC分类号: B01J4/00 , B67D7/02 , B67D7/84 , C23C16/44 , C23C16/448 , F17C7/00 , F17C7/02 , F17C9/00 , F17C13/02 , F17C13/04 , F17C13/08 , B65B1/04
CPC分类号: F17C13/087 , B01J4/00 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/4402 , C23C16/448 , F17C13/02 , F17C13/04 , F17C7/00 , F17C7/02 , F17C9/00 , F17C2201/0104 , F17C2203/012 , F17C2203/0629 , F17C2205/0308 , F17C2205/0323 , F17C2270/0518
摘要: This invention concerns a shipping and containment cart, comprising: a base having three sides and one or more doors attached thereto, wheels attached to the base, a top attached to the sides having a tank hole, wherein the base, sides, and doors have been attached to provide a sealed compartment. This invention also concerns a chemical delivery cabinet, comprising: a base, three sides, and one or more doors attached to one or more sides, a valve manifold affixed to an inner wall of the cabinet, process control instrumentation which connects to and controls the valve manifold, wherein at least one of the doors has a touch control pad mounted thereon. This invention is also a chemical refill system, comprising a canister housed in a transportation cart, wherein the cart comprises a base having three sides and one or more doors attached thereto, wheels attached to the base, a top attached to the sides having a canister hole, wherein the top has been fastened to the sides such that the canister hole fits over a vertical sheath on the canister, wherein the base, sides, and doors have been attached to provide a sealed compartment. In one embodiment of this invention, the system is been placed in the chemical delivery cabinet.
摘要翻译: 本发明涉及一种运输和安全壳推车,包括:具有三个侧面和一个或多个门的基座,一个或多个门附接到其上,附接到基座的轮子,附接到具有罐孔的侧面的顶部,其中底座,侧面和门具有 被附接以提供密封隔室。 本发明还涉及一种化学输送柜,包括:一个底座,三个侧面,以及连接到一个或多个侧面的一个或多个门,固定在机柜内壁上的阀门歧管,连接到控制器 阀歧管,其中至少一个门具有安装在其上的触摸控制垫。 本发明还是一种化学填充系统,其包括容纳在运输车中的罐,其中,所述推车包括具有三个侧面的基座和附接到其上的一个或多个门,附接到所述基座的轮子,附接到具有罐的侧面的顶部 孔,其中顶部已经紧固到侧面,使得罐孔安装在罐上的垂直护套上,其中底座,侧面和门已经被附接以提供密封隔室。 在本发明的一个实施例中,该系统被放置在化学输送柜中。
-
公开(公告)号:US5950693A
公开(公告)日:1999-09-14
申请号:US46907
申请日:1998-03-24
申请人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
发明人: Craig M. Noah , John N. Gregg , Robert M. Jackson , Craig Esser
IPC分类号: B01J4/00 , B01L3/08 , B67D7/02 , B67D7/84 , C23C16/44 , C23C16/448 , F17C1/00 , F17C7/00 , F17C7/02 , F17C9/00 , F17C13/02 , F17C13/04 , G01F23/24 , B65B1/04
CPC分类号: G01F23/24 , B01J4/00 , B01L3/08 , B67D7/0272 , B67D7/0277 , B67D7/84 , B67D7/845 , C23C16/4402 , C23C16/448 , F17C1/00 , F17C13/02 , F17C13/021 , F17C13/04 , F17C7/00 , F17C7/02 , F17C9/00 , F17C2201/056 , F17C2205/0323 , F17C2223/0153 , F17C2250/0636 , F17C2270/0518 , Y10T137/6116
摘要: A bulk chemical delivery system, having a bulk chemical canister that is connected to at least one manifold box, wherein each manifold box has at least two output lines, wherein each output line connects to a secondary canister. The bulk chemical canister may have a capacity of 200 liters. The bulk canister is housed within a transportation and containment cart that is housed within a cabinet.
摘要翻译: 一种批量化学品输送系统,其具有连接至少一个歧管箱的大容积化学罐,其中每个歧管箱具有至少两条输出管线,其中每条输出管线连接到次级罐。 批量化学罐可能容量为200升。 散装罐容纳在容纳在柜内的运输和收容车内。
-
-
-
-
-
-
-
-