公开(公告)号：US20110132077A1

公开(公告)日：2011-06-09

申请号：US12737693

申请日：2009-07-22

申请人： Kevin P. Killeen ,  Karsten Kraiczek ,  Hubert Kuderer

发明人： Kevin P. Killeen ,  Karsten Kraiczek ,  Hubert Kuderer

IPC分类号： G01N30/00 ,  G01N30/74 ,  F21V11/00

CPC分类号： G01N30/74 ,  G01J2003/102 ,  G01N21/05 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/3129 ,  G01N2021/3133 ,  G01N2021/3148 ,  G01N2021/317 ,  G01N2030/027 ,  G01N2201/06153 ,  G01N2201/0627 ,  G01N2201/0638

摘要： A fluid separation system (10) for separating compounds of a sample fluid in a mobile phase comprises a detector (50) adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal to the optical stimulus signal. The detector (50) comprises a light source (100) adapted to provide an output light beam (230) as the optical stimulus signal. The light source (100) comprises a plurality of light emitting elements (200, 200A, 200Z) each adapted to emit a light beam (210, 210A1, 210A2, 210Z1, 210Z2) having a respective wavelength, and a diffracting element (220). The plurality of light emitting elements (200, 200A, 200Z) are arranged that emitted light beams (210, 210A1, 210A2, 210Z1, 210Z2) impinging, on the diffracting element (220) are diffracted by the diffracting element (220) to form the output light beam (230).

摘要翻译： 用于分离流动相中的样品流体的化合物的流体分离系统（10）包括适于通过向样品流体提供光学刺激信号并且接收对光学刺激信号的响应信号来检测分离的化合物的检测器（50）。 检测器（50）包括适于提供输出光束（230）作为光学刺激信号的光源（100）。 光源（100）包括多个发光元件（200,200A，200Z），每个发光元件适于发射具有相应波长的光束（210,210A1,210A2,210Z1,210Z2​​）和衍射元件（220）， 。 多个发光元件（200,200A，200Z）被布置成入射到衍射元件（220）上的发射光束（210,210A1,210A2,210Z1,210Z2​​）被衍射元件（220）衍射以形成 输出光束（230）。

公开(公告)号：US4958928A

公开(公告)日：1990-09-25

申请号：US338265

申请日：1989-04-14

申请人： Hubert Kuderer

发明人： Hubert Kuderer

IPC分类号： G01J3/02 ,  G01J1/44 ,  G01J3/06 ,  G01J3/28 ,  G01J3/36 ,  G01J3/18 ,  G01J3/42

CPC分类号： G01J3/2803 ,  G01J1/44

摘要： A photodiode array spectrometer comprises an arry (40) of photosensitive elements for receiving a beam of light. Light impinging on a photodiode causes discharging of the associated capacitors. The capacitors are recharged periodically by a charge amplifier via a video line (30) by closing transfer switches (SW1, . . . , SW 768) associated with the photosensitive elements, repectively. The switches are group together in several segments which are independently addressable such that during a recharge scan only selected groups of photodioldes are recharged. The information which segments are to be sctivated, i.e. which groups of switches are to be closed, is contained in a segment control block (43). An integration control block (46) additionally permits to adjust the time intervals between successive recharge cycles separately for each selected segment. The invention permits to select regions of interest of the photodiode array for a specific application, whereas other regions are ignored for that application, leading to a reduced data rate with high spectral resolution and sensitivity.

公开(公告)号：US20140095082A1

公开(公告)日：2014-04-03

申请号：US14122451

申请日：2011-05-31

申请人： Hubert Kuderer

发明人： Hubert Kuderer

IPC分类号： G01N21/59

CPC分类号： G01N21/59 ,  G01N15/06 ,  G01N21/031 ,  G01N21/17 ,  G01N21/62 ,  G01N21/85 ,  G01N30/78

摘要： A sample detection apparatus (200) for detecting a fluidic sample flowing through a first flow cell (202) and flowing through a second flow cell (204) of a sample separation system (10), wherein the first flow cell (202) has a first path length (D) and the second flow cell (204) has a second path length (d) being smaller than the first path length (D), wherein the sample detection apparatus (200) comprises a data determining unit (206) configured for determining first data indicative of a first relation between a detection signal intensity and a concentration of the fluidic sample in the first flow cell (202), and configured for determining second data indicative of a second relation between a detection signal intensity and the concentration of the fluidic sample in the second flow cell (204), and a data combining unit (208) configured for combining the first data and the second data in accordance with a continuous weighting function to thereby derive a weighted relation between detection signal intensity and concentration of the fluidic sample so that the weighted relation continuously reduces the contribution of the first data and continuously increases the contribution of the second data with increasing concentration.

摘要翻译： 一种用于检测流过第一流动池（202）并流过样品分离系统（10）的第二流动池（204）的流体样品的样本检测装置（200），其中第一流动池（202）具有 第一路径长度（D）和第二流通池（204）具有小于第一路径长度（D）的第二路径长度（d），其中，样本检测装置（200）包括数据确定单元（206） 用于确定指示第一流动池（202）中的检测信号强度和流体样品的浓度之间的第一关系的第一数据，并且被配置用于确定指示检测信号强度和浓度之间的第二关系的第二数据 第二流通池（204）中的流体样品和数据组合单元（208），其被配置为根据连续加权函数组合第一数据和第二数据，从而导出检测 离子信号强度和流体样品的浓度，使得加权关系连续地降低第一数据的贡献，并且随着浓度的增加不断增加第二数据的贡献。

公开(公告)号：US06788402B2

公开(公告)日：2004-09-07

申请号：US09880361

申请日：2001-06-13

申请人： Hubert Kuderer ,  Konrad Teitz ,  Detlev Hadbawnik

发明人： Hubert Kuderer ,  Konrad Teitz ,  Detlev Hadbawnik

IPC分类号： G01N2141

CPC分类号： G01N30/74 ,  G01N21/4133 ,  G01N30/30

摘要： A method of reducing the effects of varying environmental conditions on a measuring instrument includes thermally insulating a measuring unit such that the effects of variations of environmental conditions on selected components of the measuring unit are substantially reduced, while allowing dissipated heat generated within the measuring unit to leave the measuring unit. The method also includes controlling a first temperature in the measuring unit by means of a control loop which includes a temperature sensor and means to influence the first temperature in the measuring unit in such a way that temperatures at locations with selected components are kept substantially constant.

摘要翻译： 减少测量仪器上环境条件变化的影响的方法包括对测量单元进行隔热，使得测量单元的选定部件的环境条件变化的影响大大降低，同时允许在测量单元内产生的散热 离开测量单元。 该方法还包括通过控制回路来控制测量单元中的第一温度，所述控制回路包括温度传感器和在所述测量单元中影响所述第一温度的装置，使得所选部件的位置处的温度保持基本恒定。

公开(公告)号：US20080079942A1

公开(公告)日：2008-04-03

申请号：US11986403

申请日：2007-11-21

申请人： Christian Buettner ,  Hubert Kuderer

发明人： Christian Buettner ,  Hubert Kuderer

IPC分类号： G01N21/00

CPC分类号： G01N21/274 ,  G01N21/0303 ,  G01N21/05 ,  G01N2021/0346

摘要： A Method of correcting a multi-path absorbance measuring system is suggested. The multi-path absorbance measuring system has a plurality of n measuring path: The method is executed by correcting the signal of the measuring paths based on a determined linearization function.

摘要翻译： 建议校正多径吸光度测量系统的方法。 多路径吸光度测量系统具有多个n个测量路径：该方法通过基于确定的线性化函数校正测量路径的信号来执行。

公开(公告)号：US5116123A

公开(公告)日：1992-05-26

申请号：US454371

申请日：1989-12-21

申请人： Hubert Kuderer

发明人： Hubert Kuderer

IPC分类号： G01J3/36 ,  G01J3/28

CPC分类号： G01J3/2803

摘要： A photodiode array spectrometer for determining the spectral composition of a polychromatic beam of radiation comprises an array of photosensitive elements intercepting different wavelengths of the polychromatic beam of radiation. An output signal representative of the charge accumulated by a charge amplifier circuit is obtained each time a predetermined number greater than 1 of photosensitive elements is scanned such that the output signal is representative of the integral of a plurality of the amounts of radiation intercepted by a corresponding plurality of the photosensitive elements.

公开(公告)号：US07847944B2

公开(公告)日：2010-12-07

申请号：US11986403

申请日：2007-11-21

申请人： Christian Buettner ,  Hubert Kuderer

发明人： Christian Buettner ,  Hubert Kuderer

IPC分类号： G01N21/00

CPC分类号： G01N21/274 ,  G01N21/0303 ,  G01N21/05 ,  G01N2021/0346

摘要： A Method of correcting a multi-path absorbance measuring system is suggested. The multi-path absorbance measuring system has a plurality of n measuring path: The method is executed by correcting the signal of the measuring paths based on a determined linearization function.

摘要翻译： 建议校正多径吸光度测量系统的方法。 多路径吸光度测量系统具有多个n个测量路径：该方法通过基于确定的线性化函数校正测量路径的信号来执行。

公开(公告)号：US07117109B2

公开(公告)日：2006-10-03

申请号：US10180611

申请日：2002-06-26

申请人： Hubert Kuderer

发明人： Hubert Kuderer

IPC分类号： G01D18/00 ,  G06F19/00

CPC分类号： G01N30/8665 ,  G01N2030/625

摘要： A method for processing measuring data and a device to perform the method, wherein the measuring data can be determined by using a measurement system, more particularly a chromatographic analyzing system, for the measurement of measuring values that correspond to certain information about, or of, a technical process and that depend on at least two variables.

摘要翻译： 一种用于处理测量数据的方法和用于执行该方法的装置，其中可以通过使用测量系统，更具体地，色谱分析系统来测量测量数据，用于测量对应于某些信息的测量值， 一个技术过程，这取决于至少两个变量。

公开(公告)号：US5303027A

公开(公告)日：1994-04-12

申请号：US900953

申请日：1992-06-18

申请人： Hubert Kuderer ,  Stefan Rohrer

发明人： Hubert Kuderer ,  Stefan Rohrer

IPC分类号： G01J1/42 ,  G01J1/44 ,  G01J1/46 ,  G01J3/28 ,  G01J3/36 ,  H01L31/10 ,  H04N1/028 ,  G01J3/42 ,  H01J40/14

CPC分类号： G01J3/2803 ,  G01J1/46 ,  G01J2001/446

摘要： A photodiode array comprises a plurality of n channels, each channel having a photodiode which is reverse biased such that it acts as a current source. Each channel further comprises an A/D converter for providing a digital output signal (DATA) which is representative o the photo current (Iph) provided by the photodiode and therefore of the intensity of the light impinging on the photodiode. The A/D converter comprises a controllable current source, an integrator circuit, a comparator for comparing the output signal (Vout) of the integrator with a predetermined signal (Vthreshold), a logic circuit for controlling the current source in response to the output signal (Vcomp) of the comparator such that Vout is kept within a certain range. Preferably, the current source provides current in the form of charge dumps to and/or from the integrator. The number of dumps in one direction is counted by a counter and is a digital measure of the photo current (Iph). The photodiode array is particularly useful in spectrophotometers since the provision of a separate A/D converter for each channel allow simultaneous processing of all the photosignals in the array so that spectra distortions arising from time delays in processing the photosignals are avoided.

摘要翻译： 光电二极管阵列包括多个n个通道，每个通道具有反向偏置的光电二极管，使得其用作电流源。 每个通道还包括用于提供数字输出信号（DATA）的A / D转换器，该数字输出信号（DATA）代表由光电二极管提供的光电流（Iph），因此代表入射在光电二极管上的光的强度。 A / D转换器包括可控电流源，积分器电路，用于将积分器的输出信号（Vout）与预定信号（Vth threshold）进行比较的比较器，用于响应于输出信号控制电流源的逻辑电路 （Vcomp），使得Vout保持在一定范围内。 优选地，电流源以向积分器和/或来自积分器的电荷转储的形式提供电流。 一个方向的转储次数由计数器计数，是光电流（Iph）的数字测量。 光电二极管阵列在分光光度计中特别有用，因为为每个通道提供单独的A / D转换器允许同时处理阵列中的所有光信号，从而避免在处理光信号时由时间延迟引起的光谱失真。

公开(公告)号：US06608293B2

公开(公告)日：2003-08-19

申请号：US09738899

申请日：2000-12-18

申请人： Hubert Kuderer

发明人： Hubert Kuderer

IPC分类号： H01J4114

CPC分类号： G01J1/08 ,  G01J1/32 ,  G01J2001/0481

摘要： The invention concerns a method and device to carry out the method to provide quality control for a photosensor, especially a photodiode array, whose output signal depends on the intensity of an input signal formed by electromagnetic waves. The photosensor to be tested receives stimulation signals forming the input signals while the stimulation signal intensity of the stimulation signals is varied. The associated output signals of the photosensor to be tested are measured and recorded for evaluation purposes. The photosensor preferably receives at least two independently controllable, superposed individual stimulation signals with individual intensities. The different stimulation signal intensities of the individual stimulation signals are set with the aid of a controller coupled to stimulation signal source, and the output signals of the photosensor are measured and recorded using a measurement data recorder unit.

摘要翻译： 本发明涉及一种执行方法和装置，该方法为光电传感器，特别是其输出信号取决于由电磁波形成的输入信号的强度的光电传感器阵列提供质量控制。 待测试的光电传感器在刺激信号的刺激信号强度变化的同时接收形成输入信号的刺激信号。 测量和记录要测试的光电传感器的相关输出信号用于评估目的。 光传感器优选地接收具有各个强度的至少两个可独立控制的重叠的个体刺激信号。 借助于耦合到刺激信号源的控制器来设置各个刺激信号的不同刺激信号强度，并且使用测量数据记录器单元测量和记录光传感器的输出信号。