公开(公告)号：US5475234A

公开(公告)日：1995-12-12

申请号：US280811

申请日：1994-07-26

申请人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

发明人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC分类号： G01N15/06 ,  A61B5/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/85

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/49 ,  G01N2021/1789 ,  G01N2021/1791 ,  G01N2021/4797 ,  G01N21/359

摘要： An apparatus and method for measuring component concentrations which enables accurate measurement of concentrations of component within an object in a non-destructive, non-invasive, and bloodless procedure. The apparatus comprises a light irradiator 1 for projecting pulse laser of different wavelengths toward an object 12 by means of a variable wavelength laser generating unit 11, a photodetector 2 for performing a time resolved measurement of the quantity of transmitted light from the object which is subject to changes with lapse of time after the generation of the pulse laser, and an arithmetic unit 3 for calculating concentrations of components in the object 12 and outputting the calculation result such that the relationship between time lapse and measured quantity of light is converted into a relationship between an optical path length representing the distance of light travel within the object 12 and a change in the measured quantity of light relative to a change in unit concentration so that the optical path length and the quantity of light which is measured when the change in the quantity of light is at a peak are stored in memory for each wavelength, the quantity of light being used as a basis for the calculation.

摘要翻译： 一种用于测量组分浓度的装置和方法，其能够在非破坏性，非侵入性和无血液过程中精确测量物体内的组分的浓度。 该装置包括用于通过可变波长激光产生单元11将不同波长的脉冲激光投射到物体12的光照射器1，用于对来自被摄体的物体的透射光进行时间分辨测量的光电检测器2 在产生脉冲激光之后经过时间的变化，以及用于计算对象12中的分量的浓度的运算单元3，并输出计算结果，使得时间流逝和测量光量之间的关系被转换为关系 在表示物体12内的光行进距离的光路长度与测量的光量相对于单位浓度的变化的变化之间，使得光路长度和当光线长度变化时所测量的光量 光量处于峰值时，存储在每个波长的存储器中，光量为我们 作为计算的基础。

公开(公告)号：US5602647A

公开(公告)日：1997-02-11

申请号：US562785

申请日：1995-11-27

申请人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

发明人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC分类号： G01N21/27 ,  G01J3/42 ,  G01N21/03 ,  G01N21/31 ,  G01N21/39 ,  G01N21/59 ,  G01N21/00

CPC分类号： G01N21/0303 ,  G01N21/31 ,  G01J3/42 ,  G01N2021/3129 ,  G01N21/39 ,  G01N21/59 ,  G01N2201/066 ,  G01N2201/0668

摘要： An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.

摘要翻译： 用于光学测量组分浓度的装置和方法允许增强浓度的测量精度。 该装置包括单元，光照射器，光电检测器和运算单元。 细胞在不同位置呈现不同的光程长度，并且其中包含样品。 包括可变波长激光发生器和由凸透镜组成的测量系统的光照射器输出准直的，放大的激光束，并使激光束入射到电池上。 光电检测器包括与电池表面平行设置的多个光电检测器，使得其可以检测在距离电池相等距离的位置处已经在不同光程长度上行进的透射光的光强。 运算单元接收来自各个光电检测器的信号，根据最佳光程长度的不同波长的最佳光路长度和最佳光路长度位置处的透射光值，计算样品中的成分浓度，并进一步输出计算结果。

公开(公告)号：US6147749A

公开(公告)日：2000-11-14

申请号：US817085

申请日：1997-04-29

申请人： Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

发明人： Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N33/48 ,  G01N21/00

CPC分类号： G01N21/27 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6825 ,  A61B5/6842 ,  A61B5/6843

摘要： To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.

摘要翻译： PCT No.PCT / JP96 / 02223 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1996年8月7日PCT PCT。 出版物WO97 / 06423 日期1997年2月20日将测量对象的重复性重新测量投影到测量对象的测量部位，以便测量条件始终保持不变。 光学测量装置配备有光谱分析仪，其检测投射到人手上的测量光的反射光的光谱强度。 光谱分析仪通过移动机构沿X轴，Y轴和Z轴方向移动，Z轴周围移动，在人体测量部位的配准期间，CCD摄像机拍摄 人手，操作员从拍摄图像的图案中选择具有特征的部分，在光谱测定期间，CCD照相机再次拍摄人手的照片，然后光学测量装置检测当前拍摄的注册特征部分 图像，通过移动机构移动光谱分析仪，并将测量光投射到注册的特征部分上。

公开(公告)号：US5891029A

公开(公告)日：1999-04-06

申请号：US776775

申请日：1997-02-07

申请人： Koji Matsuoka ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

发明人： Koji Matsuoka ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/107 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/1078 ,  A61B5/14532

摘要： To secure a highly accurate measurement value of biological information with minimized variation by positioning a target part of a living body with good reproducibility and by positioning the target part of the living body easily with high reproducibility without pressing blood vessels in the living body. The concentration of a particular component in the living body is measured by the use of a transmitted or reflected spectrum obtained by projecting light onto the target part of the living body. A biological information measuring template 2 includes a shape memory medium 6 having a contact surface which, when the target part is pressed to the contact surface, undergoes change according to the shape of the target part, to thereby store the shape. The target part 1 of the living body is arranged at a store portion of the shape memory medium and is illuminated by light. The spectrum of light transmitted through or reflected from the target part 1 is arithmetically processed in an arithmetic control means 4 to calculate the concentration of the particular component in the living body, a result of calculation being outputted to an output unit 5.

摘要翻译： PCT No.PCT / JP96 / 01551 Sec。 371日期1997年2月7日 102（e）1997年2月7日PCT PCT 1996年6月7日PCT公布。 WO96 / 41568 PCT出版物 日期1996年12月27日为了通过将生物体的目标部分定位好，具有良好的再现性，并且以高再现性容易地定位生物体的目标部分，而不会迫使生物信息的目标部分 活体。 通过使用通过将光投射到生物体的目标部分而获得的透射或反射光谱来测量生物体中特定成分的浓度。 生物信息测量模板2包括：形状记忆介质6，具有接触面，当接触面按压目标部分时，根据目标部位的形状发生变化，从而存储形状。 生物体的目标部分1布置在形状记忆介质的存储部分并被光照射。 通过算术控制装置4对目标部分1透射或反射的光的光谱进行算术处理，以计算生物体中特定成分的浓度，计算结果输出到输出部5。

公开(公告)号：US5772606A

公开(公告)日：1998-06-30

申请号：US397953

申请日：1995-03-03

申请人： Emi Ashibe ,  Takeshi Sakura ,  Harumi Uenoyama ,  Xu Kexin ,  Hiroko Kubo

发明人： Emi Ashibe ,  Takeshi Sakura ,  Harumi Uenoyama ,  Xu Kexin ,  Hiroko Kubo

IPC分类号： G01N21/35 ,  G01N33/483 ,  G01N33/493 ,  A61B5/00

CPC分类号： G01N33/493 ,  G01N21/359

摘要： A urinal is provided on its forward end with a cell, which internally communicates with the urinal to outwardly project from the same. A measuring part comprises a light source part for applying a measuring beam of the visible or near infrared wavelength region to the cell which is set in a cell setting part and a light receiving part for receiving and detecting the measuring beam transmitted through the cell, and measures absorbances of uric components to be measured at wavelengths selected therefor respectively. A sensor part is adapted to detect that the cell is set in the cell setting part, so that the measuring part starts a measuring operation on the basis of a signal indicating that the sensor detects the cell. It is possible to carry out a urine test on a person who lies on bed.

摘要翻译： 在其前端设有一个小便器，一个细胞，其内部与小便器通信以向外突出。 测量部分包括用于将可见光或近红外波长区域的测量光束施加到设置在单元设置部分中的单元的光源部分和用于接收和检测透过单元的测量光束的光接收部分，以及 测量在分别选择的波长处测量的尿液成分的吸光度。 传感器部分适于检测单元设置在单元设置部分中，使得测量部件基于表示传感器检测到单元的信号开始测量操作。 可以对躺在床上的人进行尿检。

公开(公告)号：US5741660A

公开(公告)日：1998-04-21

申请号：US594205

申请日：1996-01-30

申请人： Xiaoming Dou ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Yoshinori Yamaguchi

发明人： Xiaoming Dou ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Yoshinori Yamaguchi

IPC分类号： C12Q1/26 ,  G01N21/65

CPC分类号： G01N21/65 ,  C12Q1/26 ,  G01N2021/651

摘要： As to reaction solutions in which the amount of each potassium ferricyanate, glucose oxidase and glucose substrate are set at a constant value while glucose concentrations are varied, intensity changes of peaks at a shift wavenumber of 2081 cm.sup.-1 in light scattering spectra are measured every 10 seconds, the maximum values of the intensity changes of the peaks at the respective glucose concentrations obtained, for obtaining a calibration curve from correlations between the maximum values of the reaction velocities and the glucose concentrations. The calibration curve is employed for carrying out quantitative measurement of an unknown sample.

摘要翻译： 对于在葡萄糖浓度变化时将铁氰化钾，葡萄糖氧化酶和葡萄糖底物的量设定为恒定值的反应溶液，每个测量光散射光谱中在2081cm -1的位移波数处的峰的强度变化 10秒，获得所得各葡萄糖浓度下峰的强度变化的最大值，以从反应速度的最大值与葡萄糖浓度之间的相关性获得校准曲线。 采用校准曲线进行未知样品的定量测量。

公开(公告)号：US5751418A

公开(公告)日：1998-05-12

申请号：US644202

申请日：1996-05-10

申请人： Eiichi Kimura ,  Naoki Yanai ,  Motonobu Shiomi ,  Emi Ashibe ,  Yutaka Yamasaki ,  Harumi Uenoyama

发明人： Eiichi Kimura ,  Naoki Yanai ,  Motonobu Shiomi ,  Emi Ashibe ,  Yutaka Yamasaki ,  Harumi Uenoyama

IPC分类号： G01N21/27 ,  G01N21/31 ,  G01N21/00

CPC分类号： G01N21/314

摘要： In an optical measuring apparatus of the present invention, a spectroscopic optical system emits a measuring light beam that contains a measure light component of a measure wavelength domain where a measured object absorbs part of the light and a reference light component of a reference wavelength domain where the measured object almost completely absorbs the light, and separates the beam into beams, a photometric unit measures the light incident on an integrating sphere when a reference sample is inserted in the light path and stores the measurements in a memory and also measures the light incident on an integrating sphere when a measured object is inserted in the light path, and an arithmetic circuit calculates a light intensity ratio of the compensation light component for the measured object to the compensation light component stored in memory and then estimates background intensities during the measurement by multiplying the measurements stored in the memory by the intensity ratio.

摘要翻译： 在本发明的光学测量装置中，分光光学系统发射测量光束，其包含测量对象吸收部分光的测量波长域的测量光分量和参考波长域的参考光分量， 测量对象几乎完全吸收光，并将光束分成光束，当测量参考样本插入光路中时，光度单元测量入射在积分球上的光，并将测量值存储在存储器中，并测量光入射 在测量对象被插入到光路中的积分球上，并且运算电路将测量对象的补偿光分量的光强度比与存储在存储器中的补偿光分量进行计算，然后估计测量期间的背景强度 将存储在存储器中的测量值乘以强度比 。

公开(公告)号：US5754288A

公开(公告)日：1998-05-19

申请号：US694342

申请日：1996-08-08

申请人： Hiroshi Yamamoto ,  Harumi Uenoyama ,  Xiaoming Dou ,  Yung Xiang Wang ,  Kentaro Shimada

发明人： Hiroshi Yamamoto ,  Harumi Uenoyama ,  Xiaoming Dou ,  Yung Xiang Wang ,  Kentaro Shimada

IPC分类号： G01J3/44 ,  G01N21/65 ,  G01N33/497

CPC分类号： G01N21/65 ,  G01J3/44

摘要： As to respective expiration components to be measured, wavelengths having excellent correlations between component concentrations and Raman spectral intensity values are previously selected as measuring wavelengths which are specific to the components, an expiration specimen is irradiated with Raman excitation light, Raman spectra at the measuring wavelength which is specific to nitrogen and those at the measuring wavelengths previously selected for the components to be measured respectively are measured, Raman spectral intensity ratios of the components to the Raman spectral intensity of nitrogen are obtained, and the respective expiration components are quantitatively analyzed through a calibration curve which is previously prepared as to the Raman spectral intensity ratios of the respective components to nitrogen and concentrations. It is possible to provide a measuring method utilizing Raman spectroscopy, which can directly determine intra- expiratory components in a short time with no requirement for expendable items.

摘要翻译： 对于要测量的各个到期组分，预先选择组分浓度和拉曼光谱强度值之间具有优异相关性的波长作为测定组分特有的波长，用拉曼激发光照射呼出样品，在测量波长处照射拉曼光谱 测量分别对于氮和特定于测量波长的测量波长的测量波长，并获得组分与氮的拉曼光谱强度的拉曼光谱强度比，并通过一个 校准曲线，其预先制备了各组分对氮和浓度的拉曼光谱强度比。 可以提供使用拉曼光谱的测量方法，其可以在短时间内直接确定呼气成分，而不需要消耗品。

公开(公告)号：US5696580A

公开(公告)日：1997-12-09

申请号：US434717

申请日：1995-05-04

申请人： Hiroko Kubo ,  Xu Kexin ,  Harumi Uenoyama

发明人： Hiroko Kubo ,  Xu Kexin ,  Harumi Uenoyama

IPC分类号： G01N21/03 ,  G01N21/41 ,  G01N21/00

CPC分类号： G01N21/4133 ,  G01N21/0303

摘要： A measuring beam is incident upon a triangular cell storing a liquid sample, and transmitted light thereof is received by a linear sensor so that both transmitted light intensity and a position of the beam are detected. A refractive index calculating part calculates refractive indices from the position detected by the linear sensor, while an absorbance calculating part calculates absorbance values dependent on component concentration values correcting influence by transmittance change at the triangular cell through the transmitted light intensity values and the refractive indices of the sample calculated at the refractive index calculating part. A component concentration calculating part performs a multivariate analytical operation on the basis of the absorbance values dependent on the component concentration values at a plurality of measuring wavelengths calculated at the absorbance calculating part.

摘要翻译： 测量光束入射在存储液体样品的三角形单元上，并且其透射光被线性传感器接收，从而检测透射光强度和光束位置。 折射率计算部分从由线性传感器检测的位置计算折射率，而吸光度计算部分通过透射光强度值和透射光强度值来计算依赖于三角形单元的透射率变化校正影响的成分浓度值的吸光度值， 在折射率计算部分计算的样本。 成分浓度计算部根据在吸光度计算部计算出的多个测定波长的成分浓度值的吸光度值，进行多变量分析。

公开(公告)号：US5332479A

公开(公告)日：1994-07-26

申请号：US883367

申请日：1992-05-15

申请人： Harumi Uenoyama ,  Hisashi Okuda

发明人： Harumi Uenoyama ,  Hisashi Okuda

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N27/416 ,  G01N27/26

CPC分类号： C12Q1/004 ,  Y10S435/817

摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.

摘要翻译： 电化学检测与液体样品中的特定化合物与生物活性物质或其相关物质的反应相关的材料的生物传感器，其中生物活性物质或任选使用的介体放置在远离 充当电化学检测器装置的电极的位置，以及任选的生物活性材料或介体的聚合物层被覆盖。