公开(公告)号：US5891029A

公开(公告)日：1999-04-06

申请号：US776775

申请日：1997-02-07

申请人： Koji Matsuoka ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

发明人： Koji Matsuoka ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/107 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/1078 ,  A61B5/14532

摘要： To secure a highly accurate measurement value of biological information with minimized variation by positioning a target part of a living body with good reproducibility and by positioning the target part of the living body easily with high reproducibility without pressing blood vessels in the living body. The concentration of a particular component in the living body is measured by the use of a transmitted or reflected spectrum obtained by projecting light onto the target part of the living body. A biological information measuring template 2 includes a shape memory medium 6 having a contact surface which, when the target part is pressed to the contact surface, undergoes change according to the shape of the target part, to thereby store the shape. The target part 1 of the living body is arranged at a store portion of the shape memory medium and is illuminated by light. The spectrum of light transmitted through or reflected from the target part 1 is arithmetically processed in an arithmetic control means 4 to calculate the concentration of the particular component in the living body, a result of calculation being outputted to an output unit 5.

摘要翻译： PCT No.PCT / JP96 / 01551 Sec。 371日期1997年2月7日 102（e）1997年2月7日PCT PCT 1996年6月7日PCT公布。 WO96 / 41568 PCT出版物 日期1996年12月27日为了通过将生物体的目标部分定位好，具有良好的再现性，并且以高再现性容易地定位生物体的目标部分，而不会迫使生物信息的目标部分 活体。 通过使用通过将光投射到生物体的目标部分而获得的透射或反射光谱来测量生物体中特定成分的浓度。 生物信息测量模板2包括：形状记忆介质6，具有接触面，当接触面按压目标部分时，根据目标部位的形状发生变化，从而存储形状。 生物体的目标部分1布置在形状记忆介质的存储部分并被光照射。 通过算术控制装置4对目标部分1透射或反射的光的光谱进行算术处理，以计算生物体中特定成分的浓度，计算结果输出到输出部5。

公开(公告)号：US6147749A

公开(公告)日：2000-11-14

申请号：US817085

申请日：1997-04-29

申请人： Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

发明人： Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N33/48 ,  G01N21/00

CPC分类号： G01N21/27 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6825 ,  A61B5/6842 ,  A61B5/6843

摘要： To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.

摘要翻译： PCT No.PCT / JP96 / 02223 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1996年8月7日PCT PCT。 出版物WO97 / 06423 日期1997年2月20日将测量对象的重复性重新测量投影到测量对象的测量部位，以便测量条件始终保持不变。 光学测量装置配备有光谱分析仪，其检测投射到人手上的测量光的反射光的光谱强度。 光谱分析仪通过移动机构沿X轴，Y轴和Z轴方向移动，Z轴周围移动，在人体测量部位的配准期间，CCD摄像机拍摄 人手，操作员从拍摄图像的图案中选择具有特征的部分，在光谱测定期间，CCD照相机再次拍摄人手的照片，然后光学测量装置检测当前拍摄的注册特征部分 图像，通过移动机构移动光谱分析仪，并将测量光投射到注册的特征部分上。

公开(公告)号：US5475234A

公开(公告)日：1995-12-12

申请号：US280811

申请日：1994-07-26

申请人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

发明人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC分类号： G01N15/06 ,  A61B5/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/85

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/49 ,  G01N2021/1789 ,  G01N2021/1791 ,  G01N2021/4797 ,  G01N21/359

摘要： An apparatus and method for measuring component concentrations which enables accurate measurement of concentrations of component within an object in a non-destructive, non-invasive, and bloodless procedure. The apparatus comprises a light irradiator 1 for projecting pulse laser of different wavelengths toward an object 12 by means of a variable wavelength laser generating unit 11, a photodetector 2 for performing a time resolved measurement of the quantity of transmitted light from the object which is subject to changes with lapse of time after the generation of the pulse laser, and an arithmetic unit 3 for calculating concentrations of components in the object 12 and outputting the calculation result such that the relationship between time lapse and measured quantity of light is converted into a relationship between an optical path length representing the distance of light travel within the object 12 and a change in the measured quantity of light relative to a change in unit concentration so that the optical path length and the quantity of light which is measured when the change in the quantity of light is at a peak are stored in memory for each wavelength, the quantity of light being used as a basis for the calculation.

摘要翻译： 一种用于测量组分浓度的装置和方法，其能够在非破坏性，非侵入性和无血液过程中精确测量物体内的组分的浓度。 该装置包括用于通过可变波长激光产生单元11将不同波长的脉冲激光投射到物体12的光照射器1，用于对来自被摄体的物体的透射光进行时间分辨测量的光电检测器2 在产生脉冲激光之后经过时间的变化，以及用于计算对象12中的分量的浓度的运算单元3，并输出计算结果，使得时间流逝和测量光量之间的关系被转换为关系 在表示物体12内的光行进距离的光路长度与测量的光量相对于单位浓度的变化的变化之间，使得光路长度和当光线长度变化时所测量的光量 光量处于峰值时，存储在每个波长的存储器中，光量为我们 作为计算的基础。

公开(公告)号：US5602647A

公开(公告)日：1997-02-11

申请号：US562785

申请日：1995-11-27

申请人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

发明人： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC分类号： G01N21/27 ,  G01J3/42 ,  G01N21/03 ,  G01N21/31 ,  G01N21/39 ,  G01N21/59 ,  G01N21/00

CPC分类号： G01N21/0303 ,  G01N21/31 ,  G01J3/42 ,  G01N2021/3129 ,  G01N21/39 ,  G01N21/59 ,  G01N2201/066 ,  G01N2201/0668

摘要： An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.

摘要翻译： 用于光学测量组分浓度的装置和方法允许增强浓度的测量精度。 该装置包括单元，光照射器，光电检测器和运算单元。 细胞在不同位置呈现不同的光程长度，并且其中包含样品。 包括可变波长激光发生器和由凸透镜组成的测量系统的光照射器输出准直的，放大的激光束，并使激光束入射到电池上。 光电检测器包括与电池表面平行设置的多个光电检测器，使得其可以检测在距离电池相等距离的位置处已经在不同光程长度上行进的透射光的光强。 运算单元接收来自各个光电检测器的信号，根据最佳光程长度的不同波长的最佳光路长度和最佳光路长度位置处的透射光值，计算样品中的成分浓度，并进一步输出计算结果。

公开(公告)号：US5757002A

公开(公告)日：1998-05-26

申请号：US704987

申请日：1996-08-29

申请人： Yutaka Yamasaki ,  Hisashi Okuda ,  Koji Matsuoka ,  Kexin Xu

发明人： Yutaka Yamasaki ,  Hisashi Okuda ,  Koji Matsuoka ,  Kexin Xu

IPC分类号： A61B5/00 ,  G01N21/35 ,  G01N21/47

CPC分类号： G01N21/359 ,  A61B5/1455 ,  G01N21/4795 ,  G01N2201/1293

摘要： A light source pa light of a plurality of wavelengths of a near infrared region, and a spectroscopic part selects a wavelength subjected to absorption by lactic acid as a measuring wavelength from measuring light of a plurality of wavelengths emitted from the light source part. A probe comes into contact with an organism measuring portion and irradiates the organism measuring portion with the measuring light of the wavelength selected by the spectroscopic part, while a photoreceiving part detects transmitted/scattered light of the measuring light incident upon the organism measuring portion. A light signal detected by the photoreceiving part is converted to absorbance in a signal processing part, so that the concentration of lactic acid is calculated by a host computer serving as an arithmetic-control part and displayed on a display part. No reagent is required, while difference between lactic acid concentrations varied with measuring portions can also be noninvasively measured.

摘要翻译： 近红外区域的多个波长的光源pa光，并且分光部从测量从光源部发射的多个波长的光中选择被乳酸吸收的波长作为测量波长。 探测器与有机体测量部分接触，并且利用由分光部分选择的波长的测量光照射生物体测量部分，而光接收部分检测入射到生物体测量部分上的测量光的透射/散射光。 由光接收部分检测到的光信号在信号处理部分被转换为吸光度，从而通过用作运算控制部分的主计算机计算出乳酸浓度，并显示在显示部分上。 不需要试剂，乳酸浓度随测量部分变化的差异也可以非侵入性地测量。

公开(公告)号：US07899506B2

公开(公告)日：2011-03-01

申请号：US10532669

申请日：2003-09-25

申请人： Kexin Xu ,  Yiwen Ma ,  Renda Wang

发明人： Kexin Xu ,  Yiwen Ma ,  Renda Wang

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  G01J3/10 ,  G01J3/1256 ,  G01N21/359 ,  G01N2021/3144

摘要： The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

摘要翻译： 本发明公开了一种通过连续光源和离散光源的光谱测量方法，以及用于人体组织成分非侵入性检测的测量仪器。 所述仪器包括入射单元，探测器，接收单元和数据处理单元。 所述复合光谱测量方法改善或加强了携带人体内目标成分信息的波长处的输出光强度。 它能够在整个波长范围内进行光谱检测，从而显着提高检测系统的信噪比。 在非侵入式检测仪器中，来自连续光源和离散光源的光可以首先被AOTF选择性地光分裂，或者AOTF对连续光源进行光分裂，而离散光源LD由 空中砍刀 当从所述连续光源和离散光源获得的光谱曲线的数据被处理时，可以比较在不同测量模式下获得的数据。

公开(公告)号：US5796482A

公开(公告)日：1998-08-18

申请号：US741261

申请日：1996-10-30

申请人： Kexin Xu ,  Michio Naka ,  Norihito Suzuki

发明人： Kexin Xu ,  Michio Naka ,  Norihito Suzuki

IPC分类号： G01N21/21 ,  G01B9/02

CPC分类号： G01N21/21

摘要： The optical measuring apparatus of this invention for measuring a physical amount of a specific component contained in a substance to be measured by the use of measurement light which passes through the substance to be measured and the use of predetermined reference light includes: a first interfering polarizing plate for obtaining a first light interference signal by interfering the measurement light; a second interfering polarizing plate for obtaining a second light interference signal by interfering the reference light; a first photoelectric converting section for converting the first light interference signal into a first electric signal; a second photoelectric converting section for converting the second light interference signal into a second electric signal; a first phase expanding section for expanding a phase of the first electric signal; a second phase expanding section for expanding a phase of the second electric signal; a phase difference measuring section for measuring a phase difference between a phase expanded by the first phase expanding section and a phase expanded by the second phase expanding section; and a physical amount determining section for determining the physical amount of the specific component contained in the substance to be measured depending on the phase difference measured by the phase difference measuring section.

摘要翻译： 本发明的光学测量装置用于通过使用通过待测物质的测量光和使用预定参考光来测量待测物质中所含特定成分的物理量的物理量包括：第一干涉极化 用于通过干涉测量光来获得第一光干涉信号; 第二干涉偏振板，用于通过干涉参考光来获得第二光干涉信号; 第一光电转换部分，用于将第一光干涉信号转换成第一电信号; 第二光电转换部分，用于将第二光干涉信号转换成第二电信号; 第一相位扩展部，用于扩大第一电信号的相位; 第二相位扩展部，用于扩大第二电信号的相位; 相位差测量部分，用于测量由第一相位扩展部分扩展的相位与由第二相位扩展部分扩展的相位之间的相位差; 以及物理量确定部，用于根据由相位差测量部测量的相位差确定待测物质中包含的特定成分的物理量。

公开(公告)号：US20180135729A1

公开(公告)日：2018-05-17

申请号：US15578642

申请日：2015-06-10

申请人： Zhengxian Shen ,  Kexin Xu ,  Xinghan Chen ,  Pinshu Chen

发明人： Zhengxian Shen ,  Kexin Xu ,  Xinghan Chen ,  Pinshu Chen

IPC分类号： F16G11/14 ,  F16B45/00

CPC分类号： F16G11/143 ,  A45F3/00 ,  A45F5/102 ,  A45F2003/001 ,  A47G25/08 ,  A47J45/02 ,  F16B45/00

摘要： A dual side-hook structure is a hook unit with four hooks. The hook unit is latched on a horizontal, vertical or inclined rope or a long strip object without shifting to hang up an object without limitation in space. The hook unit includes positioning hooks on an upper end of the hook unit and hanging hooks on a lower end of the hook unit. A rope is enabled to pass through the positioning hooks or hanging hooks at two sides of the hook unit, and then the hook unit is secured on a fixed point on the rope without sliding freely. Edges of the positioning hooks and hanging hooks include abutting devices to prevent the rope from sliding out of the hook unit. The hook unit is positioned on a vertical rope by using the hanging hooks horizontally. The positioning hooks and the hanging hooks are used interchangeably. The entire hook unit is used very flexibly and versatilely without limitation in space, and is especially usable in a wild field, an outdoor area or a camping ground.

公开(公告)号：US08349258B2

公开(公告)日：2013-01-08

申请号：US12867964

申请日：2008-11-26

申请人： Kexin Xu ,  Dachao Li

发明人： Kexin Xu ,  Dachao Li

IPC分类号： G01N33/00

CPC分类号： G01N33/66 ,  G01N29/036 ,  G01N33/5438 ,  G01N2291/0256 ,  G01N2291/0427

摘要： Disclosed is a sensor for measuring the amount of an analyte to be detected in human interstitial fluid, comprising a micro-cantilever sensing unit which includes: a first substrate; a micro-cantilever which is substantially in parallel with the first substrate and one end of which is supported onto the first substrate; a gold film formed onto at least one side of the micro-cantilever; a protein layer formed on the gold film, the protein layer being used to adsorb, at a surface thereof, the analyte to be detected in human interstitial fluid; a driving electrode provided on the first substrate; a micro-cantilever electrode which is provided on the first substrate at a position where the micro-cantilever is supported, and which is cooperated with the driving electrode so as to drive the micro-cantilever to produce resonance in a direction perpendicular to the first substrate; and a detecting electrode which is provided on the first substrate and which is cooperated with the micro-cantilever electrode so as to detect resonance frequency of the micro-cantilever. The present invention also relates to a fluid channel unit, a sensor system, and a method for measuring the amount of an analyte to be detected in human interstitial fluid.

摘要翻译： 公开了一种用于测量人间质液中要检测的分析物的量的传感器，包括微悬臂感测单元，其包括：第一基板; 基本上与第一基板平行的微悬臂，其一端被支撑在第一基板上; 形成在微悬臂梁的至少一侧上的金膜; 形成在金膜上的蛋白质层，所述蛋白质层用于在其表面吸附要在人间质液中检测的分析物; 设置在所述第一基板上的驱动电极; 微悬臂电极，其设置在所述第一基板上的所述微悬臂支撑的位置处，并且与所述驱动电极配合，以便驱动所述微悬臂以在垂直于所述第一基板的方向上产生共振 ; 以及检测电极，其设置在所述第一基板上，并且与所述微悬臂电极配合，以检测所述微悬臂的共振频率。 本发明还涉及一种流体通道单元，传感器系统和用于测量在人类间质液中待检测的分析物的量的方法。

公开(公告)号：US5973822A

公开(公告)日：1999-10-26

申请号：US998042

申请日：1997-12-23

申请人： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

发明人： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

IPC分类号： G02F1/33 ,  G02F1/11

CPC分类号： G02F1/116

摘要： In a non-collinear type acousto-optic tunable filter, the incident angle of a source light beam L.sub.1 radiated from a light source 6 onto an acoustic medium 1 is set at an equivalence incident angle for which the wavelength .lambda..sub.i of the diffracted ordinary ray L.sub.3 and the wavelength .lambda..sub.i ' of the diffracted extraordinary ray L.sub.4 become approximately identical. Further, the diffracted ordinary ray L.sub.3 and the diffracted extraordinary ray L.sub.4 of the approximately identical wavelength are superposed, and the intensity of the superposed ray is detected. Consequently, spectrometry is performed based on the superposed diffracted ray having twice the intensity and a very sharp waveform, so that accurate spectroscopy can be made possible even if the intensity of the source light beam is low.

摘要翻译： 在非共线型声光可调滤波器中，从光源6辐射到声学介质1上的源光束L1的入射角被设定为等于入射角，对于该入射角，衍射普通光线的波长λi L3和衍射异常射线L4的波长λi'变得大致相同。 此外，将衍射的普通光线L3和大致相同波长的衍射非凡光线L4重叠，并且检测叠加的光线的强度。 因此，基于具有两倍强度和非常尖锐的波形的叠加衍射光线进行光谱测定，使得即使源光束的强度低，也可以使精确的光谱学成为可能。